Quantitative mass spectrometry defines an oxidative hotspot in hemoglobin that is specifically protected by haptoglobin

Journal of Proteome Research

Volumn 9, Issue 8, 2010, Pages 4061-4070

  Pimenova, Tatiana ^a   Pereira, Claudia P ^c   Gehrig, Peter ^a   Buehler, Paul W ^b   Schaer, Dominik J ^c   Zenobi, Renato ^a  

^a ETH ZURICH   (Switzerland)

^b CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^c UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

haptoglobin; hemoglobin oxidation; iTRAQ; mass spectrometry; quantification

Indexed keywords

CYSTINE; DIMER; HAPTOGLOBIN; HEMOGLOBIN; PEROXIDE; TETRAMER; TYROSINE;

ARTICLE; BINDING AFFINITY; CHEMICAL MODIFICATION; COMPLEX FORMATION; DIMERIZATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; OXIDATION; PHENOTYPE; PRIORITY JOURNAL; PROTEOMICS; PURIFICATION; QUANTITATIVE ANALYSIS;

CHROMATOGRAPHY, GEL; DIMERIZATION; FREE RADICALS; HAPTOGLOBINS; HEMOGLOBINS; HYDROGEN PEROXIDE; MODELS, MOLECULAR; OXIDATION-REDUCTION; OXIDATIVE STRESS; PEPTIDES; PROTEIN BINDING; PROTEOMICS; TANDEM MASS SPECTROMETRY;

EID: 77955437788     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr100252e     Document Type: Article

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