Human α-defensins are immune-related Kv1.3 channel inhibitors: New support for their roles in adaptive immunity

FASEB Journal

Volumn 29, Issue 10, 2015, Pages 4324-4333

  Xie, Zili ^a   Feng, Jing ^a   Yang, Weishan ^a   Xiang, Fang ^a   Yang, Fan ^a   Zhao, Yonghui ^a   Cao, Zhijian ^a   Li, Wenxin ^a   Chen, Zongyun ^a   Wu, Yingliang ^a  

^a WUHAN UNIVERSITY   (China)

Author keywords

HD5; HNP1; Immune modulation; Interaction mechanism; Potassium channel modifier

Indexed keywords

ALPHA DEFENSIN; HUMAN NEUTROPHIL PEPTIDE 1; HUMAN NEUTROPHIL PEPTIDE 5; INTERLEUKIN 2; PEPTIDE; POTASSIUM CHANNEL HERG; POTASSIUM CHANNEL KV1.3; UNCLASSIFIED DRUG; ALPHA-DEFENSIN 5, HUMAN; PROTEIN BINDING;

ADAPTIVE IMMUNITY; ARTICLE; CD3+ T LYMPHOCYTE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE RELEASE; HEK293 CELL LINE; HUMAN; HUMAN CELL; IC50; IMMUNOMODULATION; NEUTROPHIL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SEQUENCE ALIGNMENT; AMINO ACID SEQUENCE; CELL CULTURE; CHANNEL GATING; DRUG EFFECTS; GENETICS; KINETICS; MEMBRANE POTENTIAL; METABOLISM; MOLECULAR GENETICS; PATCH CLAMP TECHNIQUE; PHYSIOLOGY; SEQUENCE HOMOLOGY;

ADAPTIVE IMMUNITY; ALPHA-DEFENSINS; AMINO ACID SEQUENCE; CELLS, CULTURED; HEK293 CELLS; HUMANS; ION CHANNEL GATING; KINETICS; KV1.3 POTASSIUM CHANNEL; MEMBRANE POTENTIALS; MOLECULAR SEQUENCE DATA; PATCH-CLAMP TECHNIQUES; PROTEIN BINDING; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 84946950063     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.15-274787     Document Type: Article

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