Small molecules detected by second-harmonic generation modulate the conformation of monomeric α-synuclein and reduce its aggregation in cells

Journal of Biological Chemistry

Volumn 290, Issue 46, 2015, Pages 27582-27593

  Moree, Ben ^a   Yin, Guowei ^b   Lázaro, Diana F ^c   Munari, Francesca ^b,d   Strohäker, Timo ^b   Giller, Karin ^b   Becker, Stefan ^b   Outeiro, Tiago F ^c   Zweckstetter, Markus ^b,d   Salafsky, Joshua ^a  

^a Biodesy Inc   (United States)

^b MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

^c UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

^d GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; CONFORMATIONS; DISEASE CONTROL; MOLECULES; NONLINEAR OPTICS; PROTEINS;

BIOLOGICAL NETWORKS; CONFORMATIONAL CHANGE; NEURONAL CELL CULTURE; PARKINSON DISEASE; PHYSIOLOGICAL ENVIRONMENT; PROTEIN CONFORMATION; PROTEIN FUNCTIONS; THERAPEUTIC STRATEGY;

HARMONIC GENERATION;

ALPHA SYNUCLEIN; BIOD 303; CHEMICAL COMPOUND; SPERMINE; UNCLASSIFIED DRUG; ANTIPARKINSON AGENT; LIGAND; MOLECULAR LIBRARY; PROTEIN AGGREGATE;

ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; FLUORESCENCE IMAGING; HUMAN; HUMAN CELL; IN VITRO STUDY; MOLECULE; NERVE CELL CULTURE; NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PARAMAGNETIC RELAXATION ENHANCEMENT; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN BINDING; PROTEIN CONFORMATION; SECOND HARMONIC GENERATION; CHEMISTRY; DRUG EFFECTS; ISOLATION AND PURIFICATION; METABOLISM; MOLECULAR LIBRARY; NERVE CELL; PHARMACOLOGY; PROTEIN AGGREGATION, PATHOLOGICAL; TUMOR CELL LINE;

ALPHA-SYNUCLEIN; ANTIPARKINSON AGENTS; CELL LINE, TUMOR; HUMANS; LIGANDS; NEURONS; PARKINSON DISEASE; PROTEIN AGGREGATES; PROTEIN AGGREGATION, PATHOLOGICAL; PROTEIN CONFORMATION; SMALL MOLECULE LIBRARIES;

EID: 84946949732     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.636027     Document Type: Article

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