PGC-1α overexpression by in vivo transfection attenuates mitochondrial deterioration of skeletal muscle caused by immobilization

FASEB Journal

Volumn 29, Issue 10, 2015, Pages 4092-4106

  Kang, Chounghun ^a   Goodman, Craig A ^b   Hornberger, Troy A ^b   Ji, Li Li ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Atrophy; Inflammation; Oxidative stress

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALPHA TUBULIN; ATROGIN 1; CATALASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYTOCHROME C; CYTOCHROME C OXIDASE; ESTROGEN RELATED RECEPTOR ALPHA; GLUTATHIONE DISULFIDE; GLUTATHIONE PEROXIDASE 1; GLUTATHIONE REDUCTASE; HISTONE H2B; HYDROGEN PEROXIDE; I KAPPA B ALPHA; I KAPPA B BETA; INTERLEUKIN 1BETA; INTERLEUKIN 6; MANGANESE SUPEROXIDE DISMUTASE; MESSENGER RNA; MITOCHONDRIAL PROTEIN; MITOCHONDRIAL TRANSCRIPTION FACTOR A; MONOCYTE CHEMOTACTIC PROTEIN 1; MUSCLE RING FINGER 1 PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PORIN; SIRTUIN 3; TRANSCRIPTION FACTOR FKHRL1; TRANSCRIPTION FACTOR NRF1; TRANSCRIPTION FACTOR RELA; AUTACOID; CYTOKINE; PPARGC1A PROTEIN, MOUSE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOGENESIS; CELL NUCLEUS; CONTROLLED STUDY; CYTOSOL; DEACETYLATION; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENZYME ACTIVITY; FEMALE; GENE OVEREXPRESSION; GENETIC TRANSFECTION; IMMOBILIZATION; IN VIVO GENE TRANSFER; MOUSE; MUSCLE MASS; MUSCLE MITOCHONDRION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; TIBIALIS ANTERIOR MUSCLE; UPREGULATION; ADVERSE EFFECTS; ANIMAL; CELL LINE; ELECTRON MICROSCOPY; EXERCISE; GENE EXPRESSION; GENETICS; METABOLISM; MITOCHONDRION; MUSCULAR ATROPHY; OXIDATION REDUCTION REACTION; PATHOPHYSIOLOGY; PHYSIOLOGY; PROCEDURES; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKELETAL MUSCLE; SKELETAL MUSCLE CELL; TIME FACTOR; ULTRASTRUCTURE; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CELL LINE; CYTOKINES; FEMALE; GENE EXPRESSION; INFLAMMATION MEDIATORS; MICE; MICROSCOPY, ELECTRON; MITOCHONDRIA; MUSCLE FIBERS, SKELETAL; MUSCLE, SKELETAL; MUSCULAR ATROPHY; OXIDATION-REDUCTION; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA COACTIVATOR 1-ALPHA; REACTIVE OXYGEN SPECIES; RESTRAINT, PHYSICAL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SUPEROXIDE DISMUTASE; TIME FACTORS; TRANSCRIPTION FACTORS; TRANSFECTION;

EID: 84946945269     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.14-266619     Document Type: Article

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