-
1
-
-
0034721924
-
Calcineurin and beyond: Cardiac hypertrophic signaling
-
Molkentin, J.D. 2000. Calcineurin and beyond: cardiac hypertrophic signaling. Circ. Res. 87:731-738.
-
(2000)
Circ. Res.
, vol.87
, pp. 731-738
-
-
Molkentin, J.D.1
-
2
-
-
0035089266
-
Prognostic implications of left ventricular hypertrophy
-
Vakili, B.A., Okin, P.M., and Devereux, R.B. 2001. Prognostic implications of left ventricular hypertrophy. Am. Heart J. 141:334-341.
-
(2001)
Am. Heart J.
, vol.141
, pp. 334-341
-
-
Vakili, B.A.1
Okin, P.M.2
Devereux, R.B.3
-
3
-
-
0033520388
-
Stress pathways and heart failure
-
Chien, K.R. 1999. Stress pathways and heart failure. Cell. 98:555-558.
-
(1999)
Cell
, vol.98
, pp. 555-558
-
-
Chien, K.R.1
-
4
-
-
0032540267
-
A calcineurin-dependent transcriptional pathway for cardiac hypertrophy
-
Molkentin, J.D., et al. 1998. A calcineurin-dependent transcriptional pathway for cardiac hypertrophy. Cell. 93:215-228.
-
(1998)
Cell
, vol.93
, pp. 215-228
-
-
Molkentin, J.D.1
-
5
-
-
0034687814
-
Calsarcins, a novel family of sarcomeric calcineurin-binding proteins
-
Frey, N., Richardson, J.A., and Olson, E.N. 2000. Calsarcins, a novel family of sarcomeric calcineurin-binding proteins. Proc. Natl. Acad. Sci. U. S. A. 97:14632-14637.
-
(2000)
Proc. Natl. Acad. Sci. U. S. A.
, vol.97
, pp. 14632-14637
-
-
Frey, N.1
Richardson, J.A.2
Olson, E.N.3
-
6
-
-
0037007016
-
Impaired cardiac hypertrophic response in Calcineurin Abeta-deficient mice
-
Bueno, O.F., et al. 2002. Impaired cardiac hypertrophic response in Calcineurin Abeta-deficient mice. Proc. Natl. Acad. Sci. U. S. A. 99:4586-4591.
-
(2002)
Proc. Natl. Acad. Sci. U. S. A.
, vol.99
, pp. 4586-4591
-
-
Bueno, O.F.1
-
7
-
-
0035853161
-
Targeted inhibition of calcineurin attenuates cardiac hypertrophy in vivo
-
De Windt, L.J., et al. 2001. Targeted inhibition of calcineurin attenuates cardiac hypertrophy in vivo. Proc. Natl. Acad. Sci. U. S. A. 98:3322-3327.
-
(2001)
Proc. Natl. Acad. Sci. U. S. A.
, vol.98
, pp. 3322-3327
-
-
De Windt, L.J.1
-
8
-
-
0033981108
-
Targeted inhibition of calcineurin prevents agonist-induced cardiomyocyte hypertrophy
-
Taigen, T., De Windt, L.J., Lim, H.W., and Molkentin, J.D. 2000. Targeted inhibition of calcineurin prevents agonist-induced cardiomyocyte hypertrophy. Proc. Natl. Acad. Sci. U. S. A. 97:1196-1201.
-
(2000)
Proc. Natl. Acad. Sci. U. S. A.
, vol.97
, pp. 1196-1201
-
-
Taigen, T.1
De Windt, L.J.2
Lim, H.W.3
Molkentin, J.D.4
-
9
-
-
0028943777
-
Association of protein kinase A and protein phosphatase 2B with a common anchoring protein
-
Coghlan, V.M., et al. 1995. Association of protein kinase A and protein phosphatase 2B with a common anchoring protein. Science. 267:108-111.
-
(1995)
Science
, vol.267
, pp. 108-111
-
-
Coghlan, V.M.1
-
10
-
-
0037119382
-
Multiple domains of MCIP1 contribute to inhibition of calcineurin activity
-
Vega, R.B., Yang, J., Rothermel, B.A., Bassel-Duby, R., and Williams, R.S. 2002. Multiple domains of MCIP1 contribute to inhibition of calcineurin activity. J. Biol. Chem. 277:30401-30407.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 30401-30407
-
-
Vega, R.B.1
Yang, J.2
Rothermel, B.A.3
Bassel-Duby, R.4
Williams, R.S.5
-
11
-
-
0035941020
-
Identification of ubiquitin ligases required for skeletal muscle atrophy
-
Bodine, S.C., et al. 2001. Identification of ubiquitin ligases required for skeletal muscle atrophy. Science. 294:1704-1708.
-
(2001)
Science
, vol.294
, pp. 1704-1708
-
-
Bodine, S.C.1
-
12
-
-
0035807969
-
Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy
-
Gomes, M.D., Lecker, S.H., Jagoe, R.T., Navon, A., and Goldberg, A.L. 2001. Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy. Proc. Natl. Acad. Sci. U. S. A. 98:14440-14445.
-
(2001)
Proc. Natl. Acad. Sci. U. S. A.
, vol.98
, pp. 14440-14445
-
-
Gomes, M.D.1
Lecker, S.H.2
Jagoe, R.T.3
Navon, A.4
Goldberg, A.L.5
-
13
-
-
0034308251
-
The lore of the RINGs: Substrate recognition and catalysis by ubiquitin ligases
-
Jackson, P.K., et al. 2000. The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligases. Trends Cell Biol. 10:429-439.
-
(2000)
Trends Cell Biol.
, vol.10
, pp. 429-439
-
-
Jackson, P.K.1
-
14
-
-
0036282703
-
The SCF ubiquitin ligase: An extended look
-
Jackson, P.K., and Eldridge, A.G. 2002. The SCF ubiquitin ligase: an extended look. Mol. Cell. 9:923-925.
-
(2002)
Mol. Cell.
, vol.9
, pp. 923-925
-
-
Jackson, P.K.1
Eldridge, A.G.2
-
15
-
-
0033838874
-
A calcineurin-NFATc3-dependent pathway regulates skeletal muscle differentiation and slow myosin heavy-chain expression
-
Delling, U., et al. 2000. A calcineurin-NFATc3-dependent pathway regulates skeletal muscle differentiation and slow myosin heavy-chain expression. Mol. Cell. Biol. 20:6600-6611.
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 6600-6611
-
-
Delling, U.1
-
16
-
-
0037073786
-
Requirement of nuclear factor of activated T-cells in calcineurin-mediated cardiomyocyte hypertrophy
-
van Rooij, E., et al. 2002. Requirement of nuclear factor of activated T-cells in calcineurin-mediated cardiomyocyte hypertrophy. J. Biol. Chem. 277:48617-48626.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 48617-48626
-
-
Rooij, E.1
-
17
-
-
0033279836
-
SCF and Cullin/Ring H2-based ubiquitin ligases
-
Deshaies, R.J. 1999. SCF and Cullin/Ring H2-based ubiquitin ligases. Annu. Rev. Cell Dev. Biol. 15:435-467.
-
(1999)
Annu. Rev. Cell Dev. Biol.
, vol.15
, pp. 435-467
-
-
Deshaies, R.J.1
-
18
-
-
0035900793
-
CHIP is a U-box-dependent E3 ubiquitin ligase: Identification of Hsc70 as a target for ubiquitylation
-
Jiang, J., et al. 2001. CHIP is a U-box-dependent E3 ubiquitin ligase: identification of Hsc70 as a target for ubiquitylation. J. Biol. Chem. 276:42938-42944.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 42938-42944
-
-
Jiang, J.1
-
19
-
-
0043208904
-
A transgenic mouse model of the ubiquitin/proteasome system
-
Lindsten, K., Menendez-Benito, V., Masucci, M.G., and Dantuma, N.P. 2003. A transgenic mouse model of the ubiquitin/proteasome system. Nat. Biotechnol. 21:897-902.
-
(2003)
Nat. Biotechnol.
, vol.21
, pp. 897-902
-
-
Lindsten, K.1
Menendez-Benito, V.2
Masucci, M.G.3
Dantuma, N.P.4
-
20
-
-
0026342911
-
Tissue-specific regulation of the alpha-myosin heavy chain gene promoter in transgenic mice
-
Subramaniam, A., et al. 1991. Tissue-specific regulation of the alpha-myosin heavy chain gene promoter in transgenic mice. J. Biol. Chem. 266:24613-24620.
-
(1991)
J. Biol. Chem.
, vol.266
, pp. 24613-24620
-
-
Subramaniam, A.1
-
21
-
-
2442420976
-
MCIP1 overexpression suppresses left ventricular remodeling and sustains cardiac function after myocardial infarction
-
van Rooij, E., et al. 2004. MCIP1 overexpression suppresses left ventricular remodeling and sustains cardiac function after myocardial infarction. Circ. Res. 94:e18-e26.
-
(2004)
Circ. Res.
, vol.94
-
-
Van Rooij, E.1
-
22
-
-
0141707989
-
Control of cardiac growth and function by calcineurin signaling
-
Vega, R.B., Bassel-Duby, R., and Olson, E.N. 2003. Control of cardiac growth and function by calcineurin signaling. J. Biol. Chem. 278:36981-36984.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 36981-36984
-
-
Vega, R.B.1
Bassel-Duby, R.2
Olson, E.N.3
-
23
-
-
0347320747
-
Calcineurin/NFAT coupling participates in pathological, but not physiological, cardiac hypertrophy
-
Wilkins, B.J., et al. 2004. Calcineurin/NFAT coupling participates in pathological, but not physiological, cardiac hypertrophy. Circ. Res. 94:110-118.
-
(2004)
Circ. Res.
, vol.94
, pp. 110-118
-
-
Wilkins, B.J.1
-
24
-
-
0036143851
-
Genetic alterations that inhibit in vivo pressure-overload hypertrophy prevent cardiac dysfunction despite increased wall stress
-
Esposito, G., et al. 2002. Genetic alterations that inhibit in vivo pressure-overload hypertrophy prevent cardiac dysfunction despite increased wall stress. Circulation. 105:85-92.
-
(2002)
Circulation
, vol.105
, pp. 85-92
-
-
Esposito, G.1
-
25
-
-
0037155929
-
Targeted inhibition of calcineurin in pressure-overload cardiac hypertrophy. Preservation of systolic function
-
Hill, J.A., et al. 2002. Targeted inhibition of calcineurin in pressure-overload cardiac hypertrophy. Preservation of systolic function. J. Biol. Chem. 277:10251-10255.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 10251-10255
-
-
Hill, J.A.1
-
26
-
-
0033595816
-
Apoptosis of T cells mediated by Ca2+-induced release of the transcription factor MEF2
-
Youn, H.D., Sun, L., Prywes, R., and Liu, J.O. 1999. Apoptosis of T cells mediated by Ca2+-induced release of the transcription factor MEF2. Science. 286:790-793.
-
(1999)
Science
, vol.286
, pp. 790-793
-
-
Youn, H.D.1
Sun, L.2
Prywes, R.3
Liu, J.O.4
-
27
-
-
1542297759
-
A small molecular activator of cardiac hypertrophy uncovered in a chemical screen for modifiers of the calcineurin signaling pathway
-
Bush, E., et al. 2004. A small molecular activator of cardiac hypertrophy uncovered in a chemical screen for modifiers of the calcineurin signaling pathway. Proc. Natl. Acad. Sci. U. S. A. 101:2870-2875.
-
(2004)
Proc. Natl. Acad. Sci. U. S. A.
, vol.101
, pp. 2870-2875
-
-
Bush, E.1
-
28
-
-
0024468921
-
Regulation of calcineurin by phosphorylation. Identification of the regulatory site phosphorylated by Ca2+/calmodulin-dependent protein kinase II and protein kinase C
-
Hashimoto, Y., and Soderling, T.R. 1989. Regulation of calcineurin by phosphorylation. Identification of the regulatory site phosphorylated by Ca2+/calmodulin-dependent protein kinase II and protein kinase C. J. Biol. Chem. 264:16524-16529.
-
(1989)
J. Biol. Chem.
, vol.264
, pp. 16524-16529
-
-
Hashimoto, Y.1
Soderling, T.R.2
-
29
-
-
0037184992
-
The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy
-
Knoll, R., et al. 2002. The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy. Cell. 111:943-955.
-
(2002)
Cell
, vol.111
, pp. 943-955
-
-
Knoll, R.1
-
30
-
-
0031051519
-
Interaction of PKN with alpha-actinin
-
Mukai, H., et al. 1997. Interaction of PKN with alpha-actinin. J. Biol. Chem. 272:4740-4746.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 4740-4746
-
-
Mukai, H.1
-
31
-
-
0034685851
-
α-Actinin is a potent regulator of G protein-coupled receptor kinase activity and substrate specificity in vitro
-
Freeman, J.L., Pitcher, J.A., Li, X., Bennett, V., and Lefkowitz, R.J. 2000. α-Actinin is a potent regulator of G protein-coupled receptor kinase activity and substrate specificity in vitro. FEBS Lett. 473:280-284.
-
(2000)
FEBS Lett.
, vol.473
, pp. 280-284
-
-
Freeman, J.L.1
Pitcher, J.A.2
Li, X.3
Bennett, V.4
Lefkowitz, R.J.5
-
32
-
-
0033794506
-
Amplification of the MLL region in acute myeloid leukemia
-
Park, J.P., et al. 2000. Amplification of the MLL region in acute myeloid leukemia. Cancer Genet. Cytogenet. 121:198-205.
-
(2000)
Cancer Genet. Cytogenet.
, vol.121
, pp. 198-205
-
-
Park, J.P.1
-
33
-
-
18344391432
-
Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex
-
Zheng, N., et al. 2002. Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex. Nature. 416:703-709.
-
(2002)
Nature
, vol.416
, pp. 703-709
-
-
Zheng, N.1
-
34
-
-
0030602813
-
SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box
-
Bai, C., et al. 1996. SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box. Cell. 86:263-274.
-
(1996)
Cell
, vol.86
, pp. 263-274
-
-
Bai, C.1
-
35
-
-
0030662523
-
F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex
-
Skowyra, D., Craig, K.L., Tyers, M., Elledge, S.J., and Harper J.W. 1997. F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex. Cell. 91:209-219.
-
(1997)
Cell
, vol.91
, pp. 209-219
-
-
Skowyra, D.1
Craig, K.L.2
Tyers, M.3
Elledge, S.J.4
Harper, J.W.5
-
36
-
-
0030695025
-
A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p
-
Feldman, R.M., Correll, C.C., Kaplan, K.B., and Deshaies, R.J. 1997. A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p. Cell. 91:221-230.
-
(1997)
Cell
, vol.91
, pp. 221-230
-
-
Feldman, R.M.1
Correll, C.C.2
Kaplan, K.B.3
Deshaies, R.J.4
-
37
-
-
0034705070
-
Calcineurin expression, activation, and function in cardiac pressure-overload hypertrophy
-
Lim, H.W., et al. 2000. Calcineurin expression, activation, and function in cardiac pressure-overload hypertrophy. Circulation. 101:2431-2437.
-
(2000)
Circulation
, vol.101
, pp. 2431-2437
-
-
Lim, H.W.1
-
38
-
-
2042425906
-
The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors
-
Stitt, T.N., et al. 2004. The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors. Mol. Cell. 14:395-403.
-
(2004)
Mol. Cell.
, vol.14
, pp. 395-403
-
-
Stitt, T.N.1
-
39
-
-
11144356337
-
Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy
-
Sandri, M., et al. 2004. Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy. Cell. 117:399-412.
-
(2004)
Cell
, vol.117
, pp. 399-412
-
-
Sandri, M.1
-
40
-
-
1842579393
-
Hypertrophy of the heart: A new therapeutic target?
-
Frey, N., Katus, H.A., Olson, E.N., and Hill, J.A. 2004. Hypertrophy of the heart: a new therapeutic target? Circulation. 109:1580-1589.
-
(2004)
Circulation
, vol.109
, pp. 1580-1589
-
-
Frey, N.1
Katus, H.A.2
Olson, E.N.3
Hill, J.A.4
-
41
-
-
0034925479
-
Cyclosporine reduces left ventricular mass with chronic aortic banding in mice, which could be due to apoptosis and fibrosis
-
Yang, G., et al. 2001. Cyclosporine reduces left ventricular mass with chronic aortic banding in mice, which could be due to apoptosis and fibrosis. J. Mol. Cell. Cardiol. 33:1505-1514.
-
(2001)
J. Mol. Cell. Cardiol.
, vol.33
, pp. 1505-1514
-
-
Yang, G.1
-
42
-
-
0037453589
-
NFAT transcription factors are critical survival factors that inhibit cardiomyocyte apoptosis during phenylephrine stimulation in vitro
-
Pu, W.T., Ma, Q., and Izumo, S. 2003. NFAT transcription factors are critical survival factors that inhibit cardiomyocyte apoptosis during phenylephrine stimulation in vitro. Circ. Res. 92:725-731.
-
(2003)
Circ. Res.
, vol.92
, pp. 725-731
-
-
Pu, W.T.1
Ma, Q.2
Izumo, S.3
-
43
-
-
1342272916
-
How the cyclin became a cyclin: Regulated proteolysis in the cell cycle
-
Koepp, D., Harper, J., and Elledge, S. 1999. How the cyclin became a cyclin: regulated proteolysis in the cell cycle. Cell. 97:431-434.
-
(1999)
Cell
, vol.97
, pp. 431-434
-
-
Koepp, D.1
Harper, J.2
Elledge, S.3
-
44
-
-
0025280867
-
Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study
-
Levy, D., Garrison, R.J., Savage, D.D., Kannel, W.B., and Castelli, W.P. 1990. Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study. N. Engl. J. Med. 322:1561-1566.
-
(1990)
N. Engl. J. Med.
, vol.322
, pp. 1561-1566
-
-
Levy, D.1
Garrison, R.J.2
Savage, D.D.3
Kannel, W.B.4
Castelli, W.P.5
-
45
-
-
0031963796
-
Prognostic significance of serial changes in left ventricular mass in essential hypertension
-
Verdecchia, P., et al. 1998. Prognostic significance of serial changes in left ventricular mass in essential hypertension. Circulation. 97:48-54.
-
(1998)
Circulation
, vol.97
, pp. 48-54
-
-
Verdecchia, P.1
-
46
-
-
0348025801
-
Megaprimer PCR: Application in mutagenesis and gene fusion
-
Burke, E., and Barik, S. 2003. Megaprimer PCR: application in mutagenesis and gene fusion. Methods Mol. Biol. 226:525-532.
-
(2003)
Methods Mol. Biol.
, vol.226
, pp. 525-532
-
-
Burke, E.1
Barik, S.2
-
47
-
-
0032529188
-
A calcineurin-dependent transcriptional pathway controls skeletal muscle fiber type
-
Chin, E.R., et al. 1998. A calcineurin-dependent transcriptional pathway controls skeletal muscle fiber type. Genes Dev. 12:2499-2509.
-
(1998)
Genes Dev.
, vol.12
, pp. 2499-2509
-
-
Chin, E.R.1
-
48
-
-
0026643141
-
Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation
-
Clipstone, N.A., and Crabtree, G.R. 1992. Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation. Nature. 357:695-697.
-
(1992)
Nature
, vol.357
, pp. 695-697
-
-
Clipstone, N.A.1
Crabtree, G.R.2
-
49
-
-
0034708825
-
A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling
-
Rothermel, B., et al. 2000. A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling. J. Biol. Chem. 275:8719-8725.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 8719-8725
-
-
Rothermel, B.1
-
50
-
-
10744223839
-
CHIP activates HSF1 and confers protection against apoptosis and cellular stress
-
Dai, Q., et al. 2003. CHIP activates HSF1 and confers protection against apoptosis and cellular stress. EMBO J. 22:5446-5458.
-
(2003)
EMBO J.
, vol.22
, pp. 5446-5458
-
-
Dai, Q.1
-
51
-
-
0033013126
-
Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions
-
Ballinger, C.A., et al. 1999. Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions. Mol. Cell. Biol. 19:4535-4545.
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 4535-4545
-
-
Ballinger, C.A.1
-
52
-
-
0035866402
-
Phosphorylation-and Skp1-independent in vitro ubiquitination of E2F1 by multiple ROC-cullin ligases
-
Ohta, T., and Xiong, Y. 2001. Phosphorylation-and Skp1-independent in vitro ubiquitination of E2F1 by multiple ROC-cullin ligases. Cancer Res. 61:1347-1353.
-
(2001)
Cancer Res.
, vol.61
, pp. 1347-1353
-
-
Ohta, T.1
Xiong, Y.2
-
53
-
-
10244221064
-
Ablation of the murine alpha myosin heavy chain gene leads to dosage effects and functional deficits in the heart
-
Jones, W.K., et al. 1996. Ablation of the murine alpha myosin heavy chain gene leads to dosage effects and functional deficits in the heart. J. Clin. Invest. 98:1906-1917.
-
(1996)
J. Clin. Invest.
, vol.98
, pp. 1906-1917
-
-
Jones, W.K.1
-
54
-
-
0034691296
-
Cardiac hypertrophy is not a required compensatory response to short-term pressure overload
-
Hill, J.A., et al. 2000. Cardiac hypertrophy is not a required compensatory response to short-term pressure overload. Circulation. 101:2863-2869.
-
(2000)
Circulation
, vol.101
, pp. 2863-2869
-
-
Hill, J.A.1
|