메뉴 건너뛰기




Volumn 7, Issue 11, 2015, Pages 5746-5766

Resistance of hepatitis C virus to inhibitors: Complexity and clinical implications

Author keywords

Antiviral treatment; Hepatitis C virus; Viral quasi species; Viral resistance

Indexed keywords

ALISPORIVIR; ANTIVIRUS AGENT; BOCEPREVIR; CYCLOPHILIN A; DACLATASVIR; DANOPREVIR; DASABUVIR; GUANOSINE TRIPHOSPHATE; INTERFERON; LEDIPASVIR; OMBITASVIR; OMBITASVIR PLUS PARITAPREVIR PLUS RITONAVIR; PARITAPREVIR; RIBAVIRIN; RITONAVIR; RNA DIRECTED RNA POLYMERASE; SIMEPREVIR; TELAPREVIR; VANIPREVIR; VIRUS ENZYME;

EID: 84946925215     PISSN: None     EISSN: 19994915     Source Type: Journal    
DOI: 10.3390/v7112902     Document Type: Review
Times cited : (40)

References (159)
  • 1
    • 77950020240 scopus 로고    scopus 로고
    • Unfinished stories on viral quasispecies and Darwinian views of evolution
    • [CrossRef] [PubMed]
    • Mas, A.; Lopez-Galindez, C.; Cacho, I.; Gomez, J.; Martinez, M.A. Unfinished stories on viral quasispecies and Darwinian views of evolution. J. Mol. Biol. 2010, 397, 865-877. [CrossRef] [PubMed]
    • (2010) J. Mol Biol , vol.397 , pp. 865-877
    • Mas, A.1    Lopez-Galindez, C.2    Cacho, I.3    Gomez, J.4    Martinez, M.A.5
  • 2
    • 81555214151 scopus 로고    scopus 로고
    • Quasispecies as a matter of fact: Viruses and beyond
    • [CrossRef] [PubMed]
    • Ojosnegros, S.; Perales, C.; Mas, A.; Domingo, E. Quasispecies as a matter of fact: Viruses and beyond. Virus Res. 2011, 162, 203-215. [CrossRef] [PubMed]
    • (2011) Virus Res , vol.162 , pp. 203-215
    • Ojosnegros, S.1    Perales, C.2    Mas, A.3    Domingo, E.4
  • 3
    • 84958086067 scopus 로고    scopus 로고
    • Academic Press: Waltham, MA, USA; Elsevier: Amsterdam, The Netherlands
    • Domingo, E. Virus as Populations ; Academic Press: Waltham, MA, USA; Elsevier: Amsterdam, The Netherlands, 2015.
    • (2015) Virus as Populations
    • Domingo, E.1
  • 4
    • 84946945492 scopus 로고    scopus 로고
    • What is a quasispecies? Historical origins and current scope
    • in press
    • Domingo, E.; Schuster, P. What is a quasispecies? Historical origins and current scope. Curr. Top. Microbiol. Immunol. 2015. in press.
    • (2015) Curr. Top. Microbiol. Immunol
    • Domingo, E.1    Schuster, P.2
  • 5
    • 84926622123 scopus 로고    scopus 로고
    • Dynamics of HCV genotype 4 resistance-associated variants during virologic escape with pIFN/RBV + daclatasvir: A case study using ultra deep pyrosequencing
    • [CrossRef] [PubMed]
    • Bartolini, B.; Lionetti, R.; Giombini, E.; Sias, C.; Taibi, C.; Montalbano, M.; Gianpiero, D.; McPhee, F.; Hughes, E.A.; Zhou, N.; et al. Dynamics of HCV genotype 4 resistance-associated variants during virologic escape with pIFN/RBV + daclatasvir: A case study using ultra deep pyrosequencing. J. Clin. Virol. 2015, 66, 38-43. [CrossRef] [PubMed]
    • (2015) J. Clin Virol , vol.66 , pp. 38-43
    • Bartolini, B.1    Lionetti, R.2    Giombini, E.3    Sias, C.4    Taibi, C.5    Montalbano, M.6    Gianpiero, D.7    McPhee, F.8    Hughes, E.A.9    Zhou, N.10
  • 6
    • 84921294287 scopus 로고    scopus 로고
    • Next generation sequencing of the hepatitis C virus NS5B gene reveals potential novel S282 drug resistance mutations
    • [CrossRef] [PubMed]
    • Ji, H.; Kozak, R.A.; Biondi, M.J.; Pilon, R.; Vallee, D.; Liang, B.B.; La, D.; Kim, J.; van Domselaar, G.; Leonard, L.; et al. Next generation sequencing of the hepatitis C virus NS5B gene reveals potential novel S282 drug resistance mutations. Virology 2015, 477, 1-9. [CrossRef] [PubMed]
    • (2015) Virology , vol.477 , pp. 1-9
    • Ji, H.1    Kozak, R.A.2    Biondi, M.J.3    Pilon, R.4    Vallee, D.5    Liang, B.B.6    La, D.7    Kim, J.8    van Domselaar, G.9    Leonard, L.10
  • 7
    • 84924103954 scopus 로고    scopus 로고
    • Deconvoluting the composition of low-frequency hepatitis C viral quasispecies: Comparison of genotypes and NS3 resistance-associated variants between HCV/HIV coinfected hemophiliacs and HCV monoinfected patients in Japan
    • [CrossRef] [PubMed]
    • Ogishi, M.; Yotsuyanagi, H.; Tsutsumi, T.; Gatanaga, H.; Ode, H.; Sugiura, W.; Moriya, K.; Oka, S.; Kimura, S.; Koike, K. Deconvoluting the composition of low-frequency hepatitis C viral quasispecies: Comparison of genotypes and NS3 resistance-associated variants between HCV/HIV coinfected hemophiliacs and HCV monoinfected patients in Japan. PLoS ONE 2015, 10, e0119145. [CrossRef] [PubMed]
    • (2015) PLoS ONE , vol.10
    • Ogishi, M.1    Yotsuyanagi, H.2    Tsutsumi, T.3    Gatanaga, H.4    Ode, H.5    Sugiura, W.6    Moriya, K.7    Oka, S.8    Kimura, S.9    Koike, K.10
  • 8
    • 84931568272 scopus 로고    scopus 로고
    • HCV NS5A resistance-associated variants in a group of real-world Japanese patients chronically infected with HCV genotype 1b
    • [CrossRef] [PubMed]
    • Hirotsu, Y.; Kanda, T.; Matsumura, H.; Moriyama, M.; Yokosuka, O.; Omata, M. HCV NS5A resistance-associated variants in a group of real-world Japanese patients chronically infected with HCV genotype 1b. Hepatol. Int. 2015, 9, 424-430. [CrossRef] [PubMed]
    • (2015) Hepatol Int , vol.9 , pp. 424-430
    • Hirotsu, Y.1    Kanda, T.2    Matsumura, H.3    Moriyama, M.4    Yokosuka, O.5    Omata, M.6
  • 9
    • 84928958187 scopus 로고    scopus 로고
    • Performance assessment of the Illumina massively parallel sequencing platform for deep sequencing analysis of viral minority variants
    • [CrossRef] [PubMed]
    • Thys, K.; Verhasselt, P.; Reumers, J.; Verbist, B.M.; Maes, B.; Aerssens, J. Performance assessment of the Illumina massively parallel sequencing platform for deep sequencing analysis of viral minority variants. J. Virol. Methods 2015, 221, 29-38. [CrossRef] [PubMed]
    • (2015) J. Virol Methods , vol.221 , pp. 29-38
    • Thys, K.1    Verhasselt, P.2    Reumers, J.3    Verbist, B.M.4    Maes, B.5    Aerssens, J.6
  • 12
    • 0343867213 scopus 로고    scopus 로고
    • Molecular intermediates of fitness gain of an RNA virus: Characterization of a mutant spectrum by biological and molecular cloning
    • [CrossRef] [PubMed]
    • Arias, A.; Lázaro, E.; Escarmís, C.; Domingo, E. Molecular intermediates of fitness gain of an RNA virus: Characterization of a mutant spectrum by biological and molecular cloning. J. Gen. Virol. 2001, 82, 1049-1060. [CrossRef] [PubMed]
    • (2001) J. Gen Virol , vol.82 , pp. 1049-1060
    • Arias, A.1    Lázaro, E.2    Escarmís, C.3    Domingo, E.4
  • 14
    • 19944428265 scopus 로고    scopus 로고
    • Multiple, linked human immunodeficiency virus type 1 drug resistance mutations in treatment-experienced patients are missed by standard genotype analysis
    • [CrossRef] [PubMed]
    • Palmer, S.; Kearney, M.; Maldarelli, F.; Halvas, E.K.; Bixby, C.J.; Bazmi, H.; Rock, D.; Falloon, J.; Davey, R.T., Jr.; Dewar, R.L.; et al. Multiple, linked human immunodeficiency virus type 1 drug resistance mutations in treatment-experienced patients are missed by standard genotype analysis. J. Clin. Microbiol. 2005, 43, 406-413. [CrossRef] [PubMed]
    • (2005) J. Clin Microbiol , vol.43 , pp. 406-413
    • Palmer, S.1    Kearney, M.2    Maldarelli, F.3    Halvas, E.K.4    Bixby, C.J.5    Bazmi, H.6    Rock, D.7    Falloon, J.8    Davey, R.T.9    Dewar, R.L.10
  • 15
    • 84907500717 scopus 로고    scopus 로고
    • Review of current methods, applications, and data management for the bioinformatics analysis of whole exome sequencing
    • [PubMed]
    • Bao, R.; Huang, L.; Andrade, J.; Tan, W.; Kibbe, W.A.; Jiang, H.; Feng, G. Review of current methods, applications, and data management for the bioinformatics analysis of whole exome sequencing. Cancer Inform. 2014, 13, 67-82. [PubMed]
    • (2014) Cancer Inform , vol.13 , pp. 67-82
    • Bao, R.1    Huang, L.2    Andrade, J.3    Tan, W.4    Kibbe, W.A.5    Jiang, H.6    Feng, G.7
  • 17
    • 84892698555 scopus 로고    scopus 로고
    • Next-generation sequence assembly: Four stages of data processing and computational challenges
    • [CrossRef] [PubMed]
    • El-Metwally, S.; Hamza, T.; Zakaria, M.; Helmy, M. Next-generation sequence assembly: Four stages of data processing and computational challenges. PLoS Comput. Biol. 2013, 9, e1003345. [CrossRef] [PubMed]
    • (2013) PLoS Comput Biol , vol.9
    • El-Metwally, S.1    Hamza, T.2    Zakaria, M.3    Helmy, M.4
  • 18
    • 79952083912 scopus 로고    scopus 로고
    • Bioinformatics for next generation sequencing data
    • [CrossRef] [PubMed]
    • Magi, A.; Benelli, M.; Gozzini, A.; Girolami, F.; Torricelli, F.; Brandi, M.L. Bioinformatics for next generation sequencing data. Genes 2010, 1, 294-307. [CrossRef] [PubMed]
    • (2010) Genes , vol.1 , pp. 294-307
    • Magi, A.1    Benelli, M.2    Gozzini, A.3    Girolami, F.4    Torricelli, F.5    Brandi, M.L.6
  • 20
    • 84875994350 scopus 로고    scopus 로고
    • A comparative study of ultra-deep pyrosequencing and cloning to quantitatively analyze the viral quasispecies using hepatitis B virus infection as a model
    • [CrossRef] [PubMed]
    • Ramirez, C.; Gregori, J.; Buti, M.; Tabernero, D.; Camos, S.; Casillas, R.; Quer, J.; Esteban, R.; Homs, M.; Rodriguez-Frias, F. A comparative study of ultra-deep pyrosequencing and cloning to quantitatively analyze the viral quasispecies using hepatitis B virus infection as a model. Antivir. Res. 2013, 98, 273-283. [CrossRef] [PubMed]
    • (2013) Antivir Res , vol.98 , pp. 273-283
    • Ramirez, C.1    Gregori, J.2    Buti, M.3    Tabernero, D.4    Camos, S.5    Casillas, R.6    Quer, J.7    Esteban, R.8    Homs, M.9    Rodriguez-Frias, F.10
  • 21
    • 84861337035 scopus 로고    scopus 로고
    • A new approach for detecting low-level mutations in next-generation sequence data
    • [CrossRef] [PubMed]
    • Li, M.; Stoneking, M. A new approach for detecting low-level mutations in next-generation sequence data. Genome Biol. 2012, 13. [CrossRef] [PubMed]
    • (2012) Genome Biol , pp. 13
    • Li, M.1    Stoneking, M.2
  • 23
    • 79751526431 scopus 로고    scopus 로고
    • Identification of errors introduced during high throughput sequencing of the T cell receptor repertoire
    • [CrossRef] [PubMed]
    • Nguyen, P.; Ma, J.; Pei, D.; Obert, C.; Cheng, C.; Geiger, T.L. Identification of errors introduced during high throughput sequencing of the T cell receptor repertoire. BMC Genom. 2011, 12. [CrossRef] [PubMed]
    • (2011) BMC Genom , pp. 12
    • Nguyen, P.1    Ma, J.2    Pei, D.3    Obert, C.4    Cheng, C.5    Geiger, T.L.6
  • 26
    • 84889677831 scopus 로고    scopus 로고
    • Mutational and fitness landscapes of an RNA virus revealed through population sequencing
    • [CrossRef] [PubMed]
    • Acevedo, A.; Brodsky, L.; Andino, R. Mutational and fitness landscapes of an RNA virus revealed through population sequencing. Nature 2014, 505, 686-690. [CrossRef] [PubMed]
    • (2014) Nature , vol.505 , pp. 686-690
    • Acevedo, A.1    Brodsky, L.2    Andino, R.3
  • 27
    • 0015133749 scopus 로고
    • Self-organization of matter and the evolution of biological macromolecules
    • [CrossRef] [PubMed]
    • Eigen, M. Self-organization of matter and the evolution of biological macromolecules. Naturwissenschaften 1971, 58, 465-523. [CrossRef] [PubMed]
    • (1971) Naturwissenschaften , vol.58 , pp. 465-523
    • Eigen, M.1
  • 28
    • 0003901399 scopus 로고
    • A Principle of Natural Self-Organization ; Springer: Berlin, Germany
    • Eigen, M.; Schuster, P. The Hypercycle. A Principle of Natural Self-Organization ; Springer: Berlin, Germany, 1979.
    • (1979) The Hypercycle
    • Eigen, M.1    Schuster, P.2
  • 29
    • 0036426078 scopus 로고    scopus 로고
    • Unifying evolutionary dynamics
    • [CrossRef]
    • Page, K.M.; Nowak, M.A. Unifying evolutionary dynamics. J. Theor. Biol. 2002, 219, 93-98. [CrossRef]
    • (2002) J. Theor Biol , vol.219 , pp. 93-98
    • Page, K.M.1    Nowak, M.A.2
  • 30
    • 70549097349 scopus 로고    scopus 로고
    • Structural insights into replication initiation and elongation processes by the FMDV RNA-dependent RNA polymerase
    • [CrossRef] [PubMed]
    • Ferrer-Orta, C.; Agudo, R.; Domingo, E.; Verdaguer, N. Structural insights into replication initiation and elongation processes by the FMDV RNA-dependent RNA polymerase. Curr. Opin. Struct. Biol. 2009, 19, 752-758. [CrossRef] [PubMed]
    • (2009) Curr. Opin. Struct Biol , vol.19 , pp. 752-758
    • Ferrer-Orta, C.1    Agudo, R.2    Domingo, E.3    Verdaguer, N.4
  • 31
    • 84919427801 scopus 로고    scopus 로고
    • Structure-function relationships underlying the replication fidelity of viral RNA-dependent RNA polymerases
    • [CrossRef] [PubMed]
    • Campagnola, G.; McDonald, S.; Beaucourt, S.; Vignuzzi, M.; Peersen, O.B. Structure-function relationships underlying the replication fidelity of viral RNA-dependent RNA polymerases. J. Virol. 2015, 89, 275-286. [CrossRef] [PubMed]
    • (2015) J Virol , vol.89 , pp. 275-286
    • Campagnola, G.1    McDonald, S.2    Beaucourt, S.3    Vignuzzi, M.4    Peersen, O.B.5
  • 33
    • 15544373334 scopus 로고
    • Sequence space and quasispecies distribution
    • Domingo, E., Ahlquist, P., Holland, J.J., Eds.; CRC Press: Boca Raton, FL, USA
    • Eigen, M.; Biebricher, C.K. Sequence space and quasispecies distribution. In RNA Genetics ; Domingo, E., Ahlquist, P., Holland, J.J., Eds.; CRC Press: Boca Raton, FL, USA, 1988; Volume 3, pp. 211-245.
    • (1988) RNA Genetics , vol.3 , pp. 211-245
    • Eigen, M.1    Biebricher, C.K.2
  • 34
    • 77957658175 scopus 로고    scopus 로고
    • Quasispecies theory and the behavior of RNA viruses
    • [CrossRef] [PubMed]
    • Lauring, A.S.; Andino, R. Quasispecies theory and the behavior of RNA viruses. PLoS Pathog. 2010, 6, e1001005. [CrossRef] [PubMed]
    • (2010) PLoS Pathog , vol.6
    • Lauring, A.S.1    Andino, R.2
  • 37
    • 84941224725 scopus 로고    scopus 로고
    • Rational Design and Adaptive Management of Combination Therapies for Hepatitis C Virus Infection
    • [CrossRef] [PubMed]
    • Ke, R.; Loverdo, C.; Qi, H.; Sun, R.; Lloyd-Smith, J.O. Rational Design and Adaptive Management of Combination Therapies for Hepatitis C Virus Infection. PLoS Comput. Biol. 2015, 11, e1004040. [CrossRef] [PubMed]
    • (2015) PLoS Comput Biol , vol.11
    • Ke, R.1    Loverdo, C.2    Qi, H.3    Sun, R.4    Lloyd-Smith, J.O.5
  • 38
    • 0002830145 scopus 로고
    • Coxsackie A9 virus: Mutation from drug dependence to drug independence
    • [CrossRef] [PubMed]
    • Eggers, H.J.; Tamm, I. Coxsackie A9 virus: Mutation from drug dependence to drug independence. Science 1965, 148, 97-98. [CrossRef] [PubMed]
    • (1965) Science , vol.148 , pp. 97-98
    • Eggers, H.J.1    Tamm, I.2
  • 39
    • 0007185438 scopus 로고
    • Rapid development of drug-resistant mutants of poliovirus
    • [CrossRef]
    • Melnick, J.L.; Crowther, D.; Barrera-Oro, J. Rapid development of drug-resistant mutants of poliovirus. Science 1961, 134. [CrossRef]
    • (1961) Science , pp. 134
    • Melnick, J.L.1    Crowther, D.2    Barrera-Oro, J.3
  • 40
    • 0024342524 scopus 로고
    • RNA virus evolution and the control of viral disease
    • [PubMed]
    • Domingo, E. RNA virus evolution and the control of viral disease. Prog. Drug Res. 1989, 33, 93-133. [PubMed]
    • (1989) Prog Drug Res , vol.33 , pp. 93-133
    • Domingo, E.1
  • 41
    • 0004097811 scopus 로고    scopus 로고
    • John Wiley and Sons Inc.: New York, NY, USA
    • Richman, D.D., Ed.; Antiviral Drug Resistance ; John Wiley and Sons Inc.: New York, NY, USA, 1996.
    • (1996) Antiviral Drug Resistance
    • Richman, D.D.1
  • 42
    • 0031009603 scopus 로고    scopus 로고
    • Dose-dependent acute clearance of hepatitis C genotype 1 virus with interferon α
    • [CrossRef] [PubMed]
    • Lam, N.P.; Neumann, A.U.; Gretch, D.R.; Wiley, T.E.; Perelson, A.S.; Layden, T.J. Dose-dependent acute clearance of hepatitis C genotype 1 virus with interferon α. Hepatology 1997, 26, 226-231. [CrossRef] [PubMed]
    • (1997) Hepatology , vol.26 , pp. 226-231
    • Lam, N.P.1    Neumann, A.U.2    Gretch, D.R.3    Wiley, T.E.4    Perelson, A.S.5    Layden, T.J.6
  • 43
    • 0030039045 scopus 로고    scopus 로고
    • Effect of interferon α on the dynamics of hepatitis C virus turnover in vivo
    • [CrossRef] [PubMed]
    • Zeuzem, S.; Schmidt, J.M.; Lee, J.H.; Ruster, B.; Roth, W.K. Effect of interferon α on the dynamics of hepatitis C virus turnover in vivo. Hepatology 1996, 23, 366-371. [CrossRef] [PubMed]
    • (1996) Hepatology , vol.23 , pp. 366-371
    • Zeuzem, S.1    Schmidt, J.M.2    Lee, J.H.3    Ruster, B.4    Roth, W.K.5
  • 44
    • 84880353282 scopus 로고    scopus 로고
    • Response of hepatitis C virus to long-term passage in the presence of α interferon: Multiple mutations and a common phenotype
    • [CrossRef] [PubMed]
    • Perales, C.; Beach, N.M.; Gallego, I.; Soria, M.E.; Quer, J.; Esteban, J.I.; Rice, C.; Domingo, E.; Sheldon, J. Response of hepatitis C virus to long-term passage in the presence of α interferon: Multiple mutations and a common phenotype. J. Virol. 2013, 87, 7593-7607. [CrossRef] [PubMed]
    • (2013) J Virol , vol.87 , pp. 7593-7607
    • Perales, C.1    Beach, N.M.2    Gallego, I.3    Soria, M.E.4    Quer, J.5    Esteban, J.I.6    Rice, C.7    Domingo, E.8    Sheldon, J.9
  • 46
  • 47
    • 0035934568 scopus 로고    scopus 로고
    • Peginterferon α-2b plus ribavirin compared with interferon α-2b plus ribavirin for initial treatment of chronic hepatitis C: A randomised trial
    • [CrossRef]
    • Manns, M.P.; McHutchison, J.G.; Gordon, S.C.; Rustgi, V.K.; Shiffman, M.; Reindollar, R.; Goodman, Z.D.; Koury, K.; Ling, M.; Albrecht, J.K. Peginterferon α-2b plus ribavirin compared with interferon α-2b plus ribavirin for initial treatment of chronic hepatitis C: A randomised trial. Lancet 2001, 358, 958-965. [CrossRef]
    • (2001) Lancet , vol.358 , pp. 958-965
    • Manns, M.P.1    McHutchison, J.G.2    Gordon, S.C.3    Rustgi, V.K.4    Shiffman, M.5    Reindollar, R.6    Goodman, Z.D.7    Koury, K.8    Ling, M.9    Albrecht, J.K.10
  • 48
    • 17844403232 scopus 로고    scopus 로고
    • A randomized, double-blind trial comparing pegylated interferon α-2b to interferon alfa-2b as initial treatment for chronic hepatitis C
    • [CrossRef] [PubMed]
    • Lindsay, K.L.; Trepo, C.; Heintges, T.; Shiffman, M.L.; Gordon, S.C.; Hoefs, J.C.; Schiff, E.R.; Goodman, Z.D.; Laughlin, M.; Yao, R.; et al. A randomized, double-blind trial comparing pegylated interferon α-2b to interferon alfa-2b as initial treatment for chronic hepatitis C. Hepatology 2001, 34, 395-403. [CrossRef] [PubMed]
    • (2001) Hepatology , vol.34 , pp. 395-403
    • Lindsay, K.L.1    Trepo, C.2    Heintges, T.3    Shiffman, M.L.4    Gordon, S.C.5    Hoefs, J.C.6    Schiff, E.R.7    Goodman, Z.D.8    Laughlin, M.9    Yao, R.10
  • 49
    • 1542378867 scopus 로고    scopus 로고
    • Peginterferon-α2a and ribavirin combination therapy in chronic hepatitis C: A randomized study of treatment duration and ribavirin dose
    • [CrossRef] [PubMed]
    • Hadziyannis, S.J.; Sette, H., Jr.; Morgan, T.R.; Balan, V.; Diago, M.; Marcellin, P.; Ramadori, G.; Bodenheimer, H., Jr.; Bernstein, D.; Rizzetto, M.; et al. Peginterferon-α2a and ribavirin combination therapy in chronic hepatitis C: A randomized study of treatment duration and ribavirin dose. Ann. Intern. Med. 2004, 140, 346-355. [CrossRef] [PubMed]
    • (2004) Ann. Intern Med , vol.140 , pp. 346-355
    • Hadziyannis, S.J.1    Sette, H.2    Morgan, T.R.3    Balan, V.4    Diago, M.5    Marcellin, P.6    Ramadori, G.7    Bodenheimer, H.8    Bernstein, D.9    Rizzetto, M.10
  • 50
    • 2442683905 scopus 로고    scopus 로고
    • Peginterferon α-2b plus ribavirin for treatment of chronic hepatitis C in previously untreated patients infected with HCV genotypes 2 or 3
    • [CrossRef] [PubMed]
    • Zeuzem, S.; Hultcrantz, R.; Bourliere, M.; Goeser, T.; Marcellin, P.; Sanchez-Tapias, J.; Sarrazin, C.; Harvey, J.; Brass, C.; Albrecht, J. Peginterferon α-2b plus ribavirin for treatment of chronic hepatitis C in previously untreated patients infected with HCV genotypes 2 or 3. J. Hepatol. 2004, 40, 993-999. [CrossRef] [PubMed]
    • (2004) J Hepatol , vol.40 , pp. 993-999
    • Zeuzem, S.1    Hultcrantz, R.2    Bourliere, M.3    Goeser, T.4    Marcellin, P.5    Sanchez-Tapias, J.6    Sarrazin, C.7    Harvey, J.8    Brass, C.9    Albrecht, J.10
  • 51
    • 26444432835 scopus 로고    scopus 로고
    • Prevalence and treatment of hepatitis C virus genotypes 4, 5, and 6
    • [CrossRef]
    • Nguyen, M.H.; Keeffe, E.B. Prevalence and treatment of hepatitis C virus genotypes 4, 5, and 6. Clin. Gastroenterol. Hepatol. 2005, 3, S97-S101. [CrossRef]
    • (2005) Clin. Gastroenterol Hepatol , vol.3 , pp. S97-S101
    • Nguyen, M.H.1    Keeffe, E.B.2
  • 52
    • 41549169618 scopus 로고    scopus 로고
    • Efficacy of interferon plus ribavirin in the treatment of hepatitis C virus genotype 5
    • [CrossRef] [PubMed]
    • Antaki, N.; Hermes, A.; Hadad, M.; Ftayeh, M.; Antaki, F.; Abdo, N.; Kebbewar, K. Efficacy of interferon plus ribavirin in the treatment of hepatitis C virus genotype 5. J. Viral Hepat. 2008, 15, 383-386. [CrossRef] [PubMed]
    • (2008) J Viral Hepat , vol.15 , pp. 383-386
    • Antaki, N.1    Hermes, A.2    Hadad, M.3    Ftayeh, M.4    Antaki, F.5    Abdo, N.6    Kebbewar, K.7
  • 53
    • 21144449073 scopus 로고    scopus 로고
    • Peginterferon α-2b and ribavirin therapy in chronic hepatitis C genotype 4: Impact of treatment duration and viral kinetics on sustained virological response
    • [CrossRef] [PubMed]
    • Kamal, S.M.; el Tawil, A.A.; Nakano, T.; He, Q.; Rasenack, J.; Hakam, S.A.; Saleh, W.A.; Ismail, A.; Aziz, A.A.; Madwar, M.A. Peginterferon α-2b and ribavirin therapy in chronic hepatitis C genotype 4: impact of treatment duration and viral kinetics on sustained virological response. Gut 2005, 54, 858-866. [CrossRef] [PubMed]
    • (2005) Gut , vol.54 , pp. 858-866
    • Kamal, S.M.1    el Tawil, A.A.2    Nakano, T.3    He, Q.4    Rasenack, J.5    Hakam, S.A.6    Saleh, W.A.7    Ismail, A.8    Aziz, A.A.9    Madwar, M.A.10
  • 54
    • 0031904587 scopus 로고    scopus 로고
    • Sequential versus concomitant administration of ribavirin and interferon α-n3 in patients with chronic hepatitis C not responding to interferon alone: Results of a randomized, controlled trial
    • [CrossRef] [PubMed]
    • Sostegni, R.; Ghisetti, V.; Pittaluga, F.; Marchiaro, G.; Rocca, G.; Borghesio, E.; Rizzetto, M.; Saracco, G. Sequential versus concomitant administration of ribavirin and interferon α-n3 in patients with chronic hepatitis C not responding to interferon alone: Results of a randomized, controlled trial. Hepatology 1998, 28, 341-346. [CrossRef] [PubMed]
    • (1998) Hepatology , vol.28 , pp. 341-346
    • Sostegni, R.1    Ghisetti, V.2    Pittaluga, F.3    Marchiaro, G.4    Rocca, G.5    Borghesio, E.6    Rizzetto, M.7    Saracco, G.8
  • 55
    • 24344467918 scopus 로고    scopus 로고
    • Mutagenic effects of ribavirin and response to interferon/ribavirin combination therapy in chronic hepatitis C
    • [CrossRef] [PubMed]
    • Asahina, Y.; Izumi, N.; Enomoto, N.; Uchihara, M.; Kurosaki, M.; Onuki, Y.; Nishimura, Y.; Ueda, K.; Tsuchiya, K.; Nakanishi, H.; et al. Mutagenic effects of ribavirin and response to interferon/ribavirin combination therapy in chronic hepatitis C. J. Hepatol. 2005, 43, 623-629. [CrossRef] [PubMed]
    • (2005) J Hepatol , vol.43 , pp. 623-629
    • Asahina, Y.1    Izumi, N.2    Enomoto, N.3    Uchihara, M.4    Kurosaki, M.5    Onuki, Y.6    Nishimura, Y.7    Ueda, K.8    Tsuchiya, K.9    Nakanishi, H.10
  • 56
    • 66149098217 scopus 로고    scopus 로고
    • Effect of ribavirin on the mutation rate and spectrum of hepatitis C virus in vivo
    • [CrossRef] [PubMed]
    • Cuevas, J.M.; Gonzalez-Candelas, F.; Moya, A.; Sanjuan, R. Effect of ribavirin on the mutation rate and spectrum of hepatitis C virus in vivo. J. Virol. 2009, 83, 5760-5764. [CrossRef] [PubMed]
    • (2009) J Virol , vol.83 , pp. 5760-5764
    • Cuevas, J.M.1    Gonzalez-Candelas, F.2    Moya, A.3    Sanjuan, R.4
  • 57
    • 84878169408 scopus 로고    scopus 로고
    • Deep sequencing reveals mutagenic effects of ribavirin during monotherapy of hepatitis C virus genotype 1-infected patients
    • [CrossRef] [PubMed]
    • Dietz, J.; Schelhorn, S.E.; Fitting, D.; Mihm, U.; Susser, S.; Welker, M.W.; Fuller, C.; Daumer, M.; Teuber, G.; Wedemeyer, H.; et al. Deep sequencing reveals mutagenic effects of ribavirin during monotherapy of hepatitis C virus genotype 1-infected patients. J. Virol. 2013, 87, 6172-6181. [CrossRef] [PubMed]
    • (2013) J Virol , vol.87 , pp. 6172-6181
    • Dietz, J.1    Schelhorn, S.E.2    Fitting, D.3    Mihm, U.4    Susser, S.5    Welker, M.W.6    Fuller, C.7    Daumer, M.8    Teuber, G.9    Wedemeyer, H.10
  • 58
    • 11144330097 scopus 로고    scopus 로고
    • Modelling how ribavirin improves interferon response rates in hepatitis C virus infection
    • [CrossRef] [PubMed]
    • Dixit, N.M.; Layden-Almer, J.E.; Layden, T.J.; Perelson, A.S. Modelling how ribavirin improves interferon response rates in hepatitis C virus infection. Nature 2004, 432, 922-924. [CrossRef] [PubMed]
    • (2004) Nature , vol.432 , pp. 922-924
    • Dixit, N.M.1    Layden-Almer, J.E.2    Layden, T.J.3    Perelson, A.S.4
  • 59
    • 34247552260 scopus 로고    scopus 로고
    • Mutation rate of the hepatitis C virus NS5B in patients undergoing treatment with ribavirin monotherapy
    • [CrossRef] [PubMed]
    • Lutchman, G.; Danehower, S.; Song, B.C.; Liang, T.J.; Hoofnagle, J.H.; Thomson, M.; Ghany, M.G. Mutation rate of the hepatitis C virus NS5B in patients undergoing treatment with ribavirin monotherapy. Gastroenterology 2007, 132, 1757-1766. [CrossRef] [PubMed]
    • (2007) Gastroenterology , vol.132 , pp. 1757-1766
    • Lutchman, G.1    Danehower, S.2    Song, B.C.3    Liang, T.J.4    Hoofnagle, J.H.5    Thomson, M.6    Ghany, M.G.7
  • 61
    • 0141755411 scopus 로고    scopus 로고
    • Identification of a ribavirin-resistant NS5B mutation of hepatitis C virus during ribavirin monotherapy
    • [CrossRef] [PubMed]
    • Young, K.C.; Lindsay, K.L.; Lee, K.J.; Liu, W.C.; He, J.W.; Milstein, S.L.; Lai, M.M. Identification of a ribavirin-resistant NS5B mutation of hepatitis C virus during ribavirin monotherapy. Hepatology 2003, 38, 869-878. [CrossRef] [PubMed]
    • (2003) Hepatology , vol.38 , pp. 869-878
    • Young, K.C.1    Lindsay, K.L.2    Lee, K.J.3    Liu, W.C.4    He, J.W.5    Milstein, S.L.6    Lai, M.M.7
  • 62
    • 66149132168 scopus 로고    scopus 로고
    • Reduced ribavirin antiviral efficacy via nucleoside transporter-mediated drug resistance
    • [CrossRef] [PubMed]
    • Ibarra, K.D.; Pfeiffer, J.K. Reduced ribavirin antiviral efficacy via nucleoside transporter-mediated drug resistance. J. Virol. 2009, 83, 4538-4547. [CrossRef] [PubMed]
    • (2009) J Virol , vol.83 , pp. 4538-4547
    • Ibarra, K.D.1    Pfeiffer, J.K.2
  • 63
    • 13444310882 scopus 로고    scopus 로고
    • Ribavirin resistance in hepatitis C virus replicon-containing cell lines conferred by changes in the cell line or mutations in the replicon RNA
    • [CrossRef] [PubMed]
    • Pfeiffer, J.K.; Kirkegaard, K. Ribavirin resistance in hepatitis C virus replicon-containing cell lines conferred by changes in the cell line or mutations in the replicon RNA. J. Virol. 2005, 79, 2346-2355. [CrossRef] [PubMed]
    • (2005) J Virol , vol.79 , pp. 2346-2355
    • Pfeiffer, J.K.1    Kirkegaard, K.2
  • 64
    • 76949098025 scopus 로고    scopus 로고
    • Identification of hepatitis C virus genotype 2a replicon variants with reduced susceptibility to ribavirin
    • [CrossRef] [PubMed]
    • Hmwe, S.S.; Aizaki, H.; Date, T.; Murakami, K.; Ishii, K.; Miyamura, T.; Koike, K.; Wakita, T.; Suzuki, T. Identification of hepatitis C virus genotype 2a replicon variants with reduced susceptibility to ribavirin. Antivir. Res. 2010, 85, 520-524. [CrossRef] [PubMed]
    • (2010) Antivir Res , vol.85 , pp. 520-524
    • Hmwe, S.S.1    Aizaki, H.2    Date, T.3    Murakami, K.4    Ishii, K.5    Miyamura, T.6    Koike, K.7    Wakita, T.8    Suzuki, T.9
  • 65
    • 80051590863 scopus 로고    scopus 로고
    • Selection of hepatitis C virus resistant to ribavirin
    • [CrossRef] [PubMed]
    • Feigelstock, D.A.; Mihalik, K.B.; Feinstone, S.M. Selection of hepatitis C virus resistant to ribavirin. Virol. J. 2011, 8. [CrossRef] [PubMed]
    • (2011) Virol. J , pp. 8
    • Feigelstock, D.A.1    Mihalik, K.B.2    Feinstone, S.M.3
  • 66
    • 84928992313 scopus 로고    scopus 로고
    • Hepatitis C virus: Is it time to say goodbye yet? Perspectives and challenges for the next decade
    • [CrossRef] [PubMed]
    • Barth, H. Hepatitis C virus: Is it time to say goodbye yet? Perspectives and challenges for the next decade. World J. Hepatol. 2015, 7, 725-737. [CrossRef] [PubMed]
    • (2015) World J Hepatol , vol.7 , pp. 725-737
    • Barth, H.1
  • 67
    • 84936804505 scopus 로고    scopus 로고
    • Successes and Challenges on the Road to Cure Hepatitis C
    • [CrossRef] [PubMed]
    • Horner, S.M.; Naggie, S. Successes and Challenges on the Road to Cure Hepatitis C. PLoS Pathog. 2015, 11, e1004854. [CrossRef] [PubMed]
    • (2015) PLoS Pathog , vol.11
    • Horner, S.M.1    Naggie, S.2
  • 68
    • 84923875654 scopus 로고    scopus 로고
    • Hepatitis C treatment: The data flood goes on-an update from the liver meeting 2014
    • [CrossRef] [PubMed]
    • Pawlotsky, J.M. Hepatitis C treatment: The data flood goes on-an update from the liver meeting 2014. Gastroenterology 2015, 148, 468-479. [CrossRef] [PubMed]
    • (2015) Gastroenterology , vol.148 , pp. 468-479
    • Pawlotsky, J.M.1
  • 69
    • 84888870992 scopus 로고    scopus 로고
    • Therapy of chronic hepatitis C virus infection in the era of direct-acting and host-targeting antiviral agents
    • [CrossRef] [PubMed]
    • Conteduca, V.; Sansonno, D.; Russi, S.; Pavone, F.; Dammacco, F. Therapy of chronic hepatitis C virus infection in the era of direct-acting and host-targeting antiviral agents. J. Infect. 2014, 68, 1-20. [CrossRef] [PubMed]
    • (2014) J Infect , vol.68 , pp. 1-20
    • Conteduca, V.1    Sansonno, D.2    Russi, S.3    Pavone, F.4    Dammacco, F.5
  • 70
    • 84901586232 scopus 로고    scopus 로고
    • Hepatitis C treatment: An incipient therapeutic revolution
    • [CrossRef] [PubMed]
    • DeLemos, A.S.; Chung, R.T. Hepatitis C treatment: An incipient therapeutic revolution. Trends Mol. Med. 2014, 20, 315-321. [CrossRef] [PubMed]
    • (2014) Trends Mol Med , vol.20 , pp. 315-321
    • DeLemos, A.S.1    Chung, R.T.2
  • 71
    • 84896132104 scopus 로고    scopus 로고
    • The beginning of the end: What is the future of interferon therapy for chronic hepatitis C? Antivir
    • [CrossRef] [PubMed]
    • Feld, J.J. The beginning of the end: What is the future of interferon therapy for chronic hepatitis C? Antivir. Res. 2014, 105, 32-38. [CrossRef] [PubMed]
    • (2014) Res , vol.105 , pp. 32-38
    • Feld, J.J.1
  • 72
    • 84930379996 scopus 로고    scopus 로고
    • Emerging treatments for chronic hepatitis C
    • [CrossRef] [PubMed]
    • Hayes, C.N.; Chayama, K. Emerging treatments for chronic hepatitis C. J. Formos. Med. Assoc. 2015, 114, 204-215. [CrossRef] [PubMed]
    • (2015) J. Formos. Med Assoc , vol.114 , pp. 204-215
    • Hayes, C.N.1    Chayama, K.2
  • 73
    • 84914689390 scopus 로고    scopus 로고
    • Nationwide experience of treatment with protease inhibitors in chronic hepatitis C patients in denmark: Identification of viral resistance mutations
    • [CrossRef] [PubMed]
    • Solund, C.; Krarup, H.; Ramirez, S.; Thielsen, P.; Roge, B.T.; Lunding, S.; Barfod, T.S.; Madsen, L.G.; Tarp, B.; Christensen, P.B.; et al. Nationwide experience of treatment with protease inhibitors in chronic hepatitis C patients in denmark: Identification of viral resistance mutations. PLoS ONE 2014, 9, e113034. [CrossRef] [PubMed]
    • (2014) PLoS ONE , vol.9
    • Solund, C.1    Krarup, H.2    Ramirez, S.3    Thielsen, P.4    Roge, B.T.5    Lunding, S.6    Barfod, T.S.7    Madsen, L.G.8    Tarp, B.9    Christensen, P.B.10
  • 74
    • 84870413046 scopus 로고    scopus 로고
    • The role of resistance in HCV treatment
    • [CrossRef] [PubMed]
    • Vermehren, J.; Sarrazin, C. The role of resistance in HCV treatment. Best Pract. Res. Clin. Gastroenterol. 2012, 26, 487-503. [CrossRef] [PubMed]
    • (2012) Best Pract. Res. Clin Gastroenterol , vol.26 , pp. 487-503
    • Vermehren, J.1    Sarrazin, C.2
  • 76
    • 84874107832 scopus 로고    scopus 로고
    • Perspectives and challenges of interferon-free therapy for chronic hepatitis C
    • [CrossRef] [PubMed]
    • Lange, C.M.; Zeuzem, S. Perspectives and challenges of interferon-free therapy for chronic hepatitis C. J. Hepatol. 2013, 58, 583-592. [CrossRef] [PubMed]
    • (2013) J Hepatol , vol.58 , pp. 583-592
    • Lange, C.M.1    Zeuzem, S.2
  • 77
    • 82955162670 scopus 로고    scopus 로고
    • Resistance to anti-HCV protease inhibitors
    • [CrossRef] [PubMed]
    • Thompson, A.J.; Locarnini, S.A.; Beard, M.R. Resistance to anti-HCV protease inhibitors. Curr. Opin. Virol. 2011, 1, 599-606. [CrossRef] [PubMed]
    • (2011) Curr. Opin Virol , vol.1 , pp. 599-606
    • Thompson, A.J.1    Locarnini, S.A.2    Beard, M.R.3
  • 78
    • 75149151884 scopus 로고    scopus 로고
    • Resistance to direct antiviral agents in patients with hepatitis C virus infection
    • [CrossRef] [PubMed]
    • Sarrazin, C.; Zeuzem, S. Resistance to direct antiviral agents in patients with hepatitis C virus infection. Gastroenterology 2010, 138, 447-462. [CrossRef] [PubMed]
    • (2010) Gastroenterology , vol.138 , pp. 447-462
    • Sarrazin, C.1    Zeuzem, S.2
  • 79
    • 84873604286 scopus 로고    scopus 로고
    • Antiviral resistance and the future landscape of hepatitis C virus infection therapy
    • [CrossRef] [PubMed]
    • Wyles, D.L. Antiviral resistance and the future landscape of hepatitis C virus infection therapy. J. Infect. Dis. 2013, 207, S33-S39. [CrossRef] [PubMed]
    • (2013) J. Infect Dis , vol.207 , pp. S33-S39
    • Wyles, D.L.1
  • 80
    • 84885949784 scopus 로고    scopus 로고
    • Antiviral activity and resistance of HCV NS5A replication complex inhibitors
    • [CrossRef] [PubMed]
    • Gao, M. Antiviral activity and resistance of HCV NS5A replication complex inhibitors. Curr. Opin. Virol. 2013, 3, 514-520. [CrossRef] [PubMed]
    • (2013) Curr. Opin Virol , vol.3 , pp. 514-520
    • Gao, M.1
  • 81
    • 84855246805 scopus 로고    scopus 로고
    • Future treatment of chronic hepatitis C with direct acting antivirals: Is resistance important?
    • [CrossRef] [PubMed]
    • Halfon, P.; Sarrazin, C. Future treatment of chronic hepatitis C with direct acting antivirals: Is resistance important? Liver Int. 2012, 32, 79-87. [CrossRef] [PubMed]
    • (2012) Liver Int , vol.32 , pp. 79-87
    • Halfon, P.1    Sarrazin, C.2
  • 82
    • 84896460675 scopus 로고    scopus 로고
    • Hepatitis C virus NS5A inhibitors and drug resistance mutations
    • [CrossRef] [PubMed]
    • Nakamoto, S.; Kanda, T.; Wu, S.; Shirasawa, H.; Yokosuka, O. Hepatitis C virus NS5A inhibitors and drug resistance mutations. World J. Gastroenterol. 2014, 20, 2902-2912. [CrossRef] [PubMed]
    • (2014) World J Gastroenterol , vol.20 , pp. 2902-2912
    • Nakamoto, S.1    Kanda, T.2    Wu, S.3    Shirasawa, H.4    Yokosuka, O.5
  • 83
    • 82455188181 scopus 로고    scopus 로고
    • Multiple ascending dose study of BMS-790052, a nonstructural protein 5A replication complex inhibitor, in patients infected with hepatitis C virus genotype 1
    • [CrossRef] [PubMed]
    • Nettles, R.E.; Gao, M.; Bifano, M.; Chung, E.; Persson, A.; Marbury, T.C.; Goldwater, R.; DeMicco, M.P.; Rodriguez-Torres, M.; Vutikullird, A.; et al. Multiple ascending dose study of BMS-790052, a nonstructural protein 5A replication complex inhibitor, in patients infected with hepatitis C virus genotype 1. Hepatology 2011, 54, 1956-1965. [CrossRef] [PubMed]
    • (2011) Hepatology , vol.54 , pp. 1956-1965
    • Nettles, R.E.1    Gao, M.2    Bifano, M.3    Chung, E.4    Persson, A.5    Marbury, T.C.6    Goldwater, R.7    DeMicco, M.P.8    Rodriguez-Torres, M.9    Vutikullird, A.10
  • 85
    • 84920945807 scopus 로고    scopus 로고
    • Clinical evidence and bioinformatics characterization of potential hepatitis C virus resistance pathways for sofosbuvir
    • [CrossRef] [PubMed]
    • Donaldson, E.F.; Harrington, P.R.; O'Rear, J.J.; Naeger, L.K. Clinical evidence and bioinformatics characterization of potential hepatitis C virus resistance pathways for sofosbuvir. Hepatology 2015, 61, 56-65. [CrossRef] [PubMed]
    • (2015) Hepatology , vol.61 , pp. 56-65
    • Donaldson, E.F.1    Harrington, P.R.2    O'Rear, J.J.3    Naeger, L.K.4
  • 86
    • 84894271490 scopus 로고    scopus 로고
    • In vivo emergence of a novel mutant L159F/L320F in the NS5B polymerase confers low-level resistance to the HCV polymerase inhibitors mericitabine and sofosbuvir
    • [CrossRef] [PubMed]
    • Tong, X.; le Pogam, S.; Li, L.; Haines, K.; Piso, K.; Baronas, V.; Yan, J.M.; So, S.S.; Klumpp, K.; Najera, I. In vivo emergence of a novel mutant L159F/L320F in the NS5B polymerase confers low-level resistance to the HCV polymerase inhibitors mericitabine and sofosbuvir. J. Infect. Dis. 2014, 209, 668-675. [CrossRef] [PubMed]
    • (2014) J. Infect Dis , vol.209 , pp. 668-675
    • Tong, X.1    le Pogam, S.2    Li, L.3    Haines, K.4    Piso, K.5    Baronas, V.6    Yan, J.M.7    So, S.S.8    Klumpp, K.9    Najera, I.10
  • 87
    • 84923645476 scopus 로고    scopus 로고
    • Simeprevir and sofosbuvir for treatment of chronic hepatitis C infection
    • [CrossRef] [PubMed]
    • Childs-Kean, L.M.; Hand, E.O. Simeprevir and sofosbuvir for treatment of chronic hepatitis C infection. Clin. Ther. 2015, 37, 243-267. [CrossRef] [PubMed]
    • (2015) Clin Ther , vol.37 , pp. 243-267
    • Childs-Kean, L.M.1    Hand, E.O.2
  • 90
    • 84921276609 scopus 로고    scopus 로고
    • Infrequent development of resistance in genotype 1-6 hepatitis C virus-infected subjects treated with sofosbuvir in phase 2 and 3 clinical trials
    • [CrossRef] [PubMed]
    • Svarovskaia, E.S.; Dvory-Sobol, H.; Parkin, N.; Hebner, C.; Gontcharova, V.; Martin, R.; Ouyang, W.; Han, B.; Xu, S.; Ku, K.; et al. Infrequent development of resistance in genotype 1-6 hepatitis C virus-infected subjects treated with sofosbuvir in phase 2 and 3 clinical trials. Clin. Infect. Dis. 2014, 59, 1666-1674. [CrossRef] [PubMed]
    • (2014) Clin. Infect Dis , vol.59 , pp. 1666-1674
    • Svarovskaia, E.S.1    Dvory-Sobol, H.2    Parkin, N.3    Hebner, C.4    Gontcharova, V.5    Martin, R.6    Ouyang, W.7    Han, B.8    Xu, S.9    Ku, K.10
  • 91
    • 84883089005 scopus 로고    scopus 로고
    • Sofosbuvir and ribavirin for hepatitis C genotype 1 in patients with unfavorable treatment characteristics: A randomized clinical trial
    • [CrossRef] [PubMed]
    • Osinusi, A.; Meissner, E.G.; Lee, Y.J.; Bon, D.; Heytens, L.; Nelson, A.; Sneller, M.; Kohli, A.; Barrett, L.; Proschan, M.; et al. Sofosbuvir and ribavirin for hepatitis C genotype 1 in patients with unfavorable treatment characteristics: A randomized clinical trial. JAMA 2013, 310, 804-811. [CrossRef] [PubMed]
    • (2013) JAMA , vol.310 , pp. 804-811
    • Osinusi, A.1    Meissner, E.G.2    Lee, Y.J.3    Bon, D.4    Heytens, L.5    Nelson, A.6    Sneller, M.7    Kohli, A.8    Barrett, L.9    Proschan, M.10
  • 92
    • 84894621765 scopus 로고    scopus 로고
    • Sofosbuvir and ledipasvir fixed-dose combination with and without ribavirin in treatment-naive and previously treated patients with genotype 1 hepatitis C virus infection (LONESTAR): An open-label, randomised, phase 2 trial
    • [CrossRef]
    • Lawitz, E.; Poordad, F.F.; Pang, P.S.; Hyland, R.H.; Ding, X.; Mo, H.; Symonds, W.T.; McHutchison, J.G.; Membreno, F.E. Sofosbuvir and ledipasvir fixed-dose combination with and without ribavirin in treatment-naive and previously treated patients with genotype 1 hepatitis C virus infection (LONESTAR): An open-label, randomised, phase 2 trial. Lancet 2014, 383, 515-523. [CrossRef]
    • (2014) Lancet , vol.383 , pp. 515-523
    • Lawitz, E.1    Poordad, F.F.2    Pang, P.S.3    Hyland, R.H.4    Ding, X.5    Mo, H.6    Symonds, W.T.7    McHutchison, J.G.8    Membreno, F.E.9
  • 93
    • 84937417148 scopus 로고    scopus 로고
    • Lack of the NS5B S282T mutation in HCV isolates from liver tissue of treatment-naive patients with HCV genotype-1b infection
    • [CrossRef] [PubMed]
    • Maimone, S.; Tripodi, G.; Musolino, C.; Cacciola, I.; Pollicino, T.; Raimondo, G. Lack of the NS5B S282T mutation in HCV isolates from liver tissue of treatment-naive patients with HCV genotype-1b infection. Antivir. Ther. 2015, 20, 245-247. [CrossRef] [PubMed]
    • (2015) Antivir Ther , vol.20 , pp. 245-247
    • Maimone, S.1    Tripodi, G.2    Musolino, C.3    Cacciola, I.4    Pollicino, T.5    Raimondo, G.6
  • 94
    • 84894707183 scopus 로고    scopus 로고
    • Expanded classification of hepatitis C virus into 7 genotypes and 67 subtypes: Updated criteria and genotype assignment web resource
    • [CrossRef] [PubMed]
    • Smith, D.B.; Bukh, J.; Kuiken, C.; Muerhoff, A.S.; Rice, C.M.; Stapleton, J.T.; Simmonds, P. Expanded classification of hepatitis C virus into 7 genotypes and 67 subtypes: Updated criteria and genotype assignment web resource. Hepatology 2014, 59, 318-327. [CrossRef] [PubMed]
    • (2014) Hepatology , vol.59 , pp. 318-327
    • Smith, D.B.1    Bukh, J.2    Kuiken, C.3    Muerhoff, A.S.4    Rice, C.M.5    Stapleton, J.T.6    Simmonds, P.7
  • 95
    • 66149128046 scopus 로고    scopus 로고
    • GT-1a or GT-1b subtype-specific resistance profiles for hepatitis C virus inhibitors telaprevir and HCV-796
    • [CrossRef] [PubMed]
    • McCown, M.F.; Rajyaguru, S.; Kular, S.; Cammack, N.; Najera, I. GT-1a or GT-1b subtype-specific resistance profiles for hepatitis C virus inhibitors telaprevir and HCV-796. Antimicrob. Agents Chemother. 2009, 53, 2129-2132. [CrossRef] [PubMed]
    • (2009) Antimicrob Agents Chemother , vol.53 , pp. 2129-2132
    • McCown, M.F.1    Rajyaguru, S.2    Kular, S.3    Cammack, N.4    Najera, I.5
  • 97
    • 84946910816 scopus 로고    scopus 로고
    • (accessed on 19 February 2015)
    • Los Alamos database. Available online: https://hcv.lanl.gov/content/sequence/HCV/ToolsOutline.html (accessed on 19 February 2015).
    • Los Alamos database
  • 98
    • 84903317598 scopus 로고    scopus 로고
    • Molecular basis of interferon resistance in hepatitis C virus
    • [CrossRef] [PubMed]
    • Perales, C.; Beach, N.M.; Sheldon, J.; Domingo, E. Molecular basis of interferon resistance in hepatitis C virus. Curr. Opin. Virol. 2014, 8C, 38-44. [CrossRef] [PubMed]
    • (2014) Curr. Opin. Virol , vol.8 C , pp. 38-44
    • Perales, C.1    Beach, N.M.2    Sheldon, J.3    Domingo, E.4
  • 99
    • 33846471075 scopus 로고    scopus 로고
    • Evolutionary constraints on chaperone-mediated folding provide an antiviral approach refractory to development of drug resistance
    • [CrossRef] [PubMed]
    • Geller, R.; Vignuzzi, M.; Andino, R.; Frydman, J. Evolutionary constraints on chaperone-mediated folding provide an antiviral approach refractory to development of drug resistance. Genes Dev. 2007, 21, 195-205. [CrossRef] [PubMed]
    • (2007) Genes Dev , vol.21 , pp. 195-205
    • Geller, R.1    Vignuzzi, M.2    Andino, R.3    Frydman, J.4
  • 100
    • 75749110945 scopus 로고    scopus 로고
    • SCY-635, a novel nonimmunosuppressive analog of cyclosporine that exhibits potent inhibition of hepatitis C virus RNA replication in vitro
    • [CrossRef] [PubMed]
    • Hopkins, S.; Scorneaux, B.; Huang, Z.; Murray, M.G.; Wring, S.; Smitley, C.; Harris, R.; Erdmann, F.; Fischer, G.; Ribeill, Y. SCY-635, a novel nonimmunosuppressive analog of cyclosporine that exhibits potent inhibition of hepatitis C virus RNA replication in vitro. Antimicrob. Agents Chemother. 2010, 54, 660-672. [CrossRef] [PubMed]
    • (2010) Antimicrob Agents Chemother , vol.54 , pp. 660-672
    • Hopkins, S.1    Scorneaux, B.2    Huang, Z.3    Murray, M.G.4    Wring, S.5    Smitley, C.6    Harris, R.7    Erdmann, F.8    Fischer, G.9    Ribeill, Y.10
  • 101
    • 79959989133 scopus 로고    scopus 로고
    • Targeting the human DEAD-box polypeptide 3 (DDX3) RNA helicase as a novel strategy to inhibit viral replication
    • [CrossRef] [PubMed]
    • Garbelli, A.; Radi, M.; Falchi, F.; Beermann, S.; Zanoli, S.; Manetti, F.; Dietrich, U.; Botta, M.; Maga, G. Targeting the human DEAD-box polypeptide 3 (DDX3) RNA helicase as a novel strategy to inhibit viral replication. Curr. Med. Chem. 2011, 18, 3015-3027. [CrossRef] [PubMed]
    • (2011) Curr. Med Chem , vol.18 , pp. 3015-3027
    • Garbelli, A.1    Radi, M.2    Falchi, F.3    Beermann, S.4    Zanoli, S.5    Manetti, F.6    Dietrich, U.7    Botta, M.8    Maga, G.9
  • 102
    • 79952408660 scopus 로고    scopus 로고
    • Receptor tyrosine kinase inhibitors block multiple steps of influenza a virus replication
    • [CrossRef] [PubMed]
    • Kumar, N.; Liang, Y.; Parslow, T.G.; Liang, Y. Receptor tyrosine kinase inhibitors block multiple steps of influenza a virus replication. J. Virol. 2011, 85, 2818-2827. [CrossRef] [PubMed]
    • (2011) J Virol , vol.85 , pp. 2818-2827
    • Kumar, N.1    Liang, Y.2    Parslow, T.G.3    Liang, Y.4
  • 103
    • 84922659357 scopus 로고    scopus 로고
    • Stimulation of the antiviral innate immune response by pyrimidine biosynthesis inhibitors: A surprise of phenotypic screening
    • Vidalain, P.O.; Lucas-Hourani, M.; Helynck, O.; Tangy, F.; Munier-Lehmann, H. Stimulation of the antiviral innate immune response by pyrimidine biosynthesis inhibitors: A surprise of phenotypic screening. Med. Sci. 2015, 31, 98-104.
    • (2015) Med Sci , vol.31 , pp. 98-104
    • Vidalain, P.O.1    Lucas-Hourani, M.2    Helynck, O.3    Tangy, F.4    Munier-Lehmann, H.5
  • 104
    • 84896127983 scopus 로고    scopus 로고
    • What are the pros and cons of the use of host-targeted agents against hepatitis C? Antivir
    • [CrossRef] [PubMed]
    • Pawlotsky, J.M. What are the pros and cons of the use of host-targeted agents against hepatitis C? Antivir. Res. 2014, 105, 22-25. [CrossRef] [PubMed]
    • (2014) Res , vol.105 , pp. 22-25
    • Pawlotsky, J.M.1
  • 105
    • 77951046665 scopus 로고    scopus 로고
    • HCV resistance to cyclosporin A does not correlate with a resistance of the NS5A-cyclophilin A interaction to cyclophilin inhibitors
    • [CrossRef] [PubMed]
    • Chatterji, U.; Lim, P.; Bobardt, M.D.; Wieland, S.; Cordek, D.G.; Vuagniaux, G.; Chisari, F.; Cameron, C.E.; Targett-Adams, P.; Parkinson, T.; et al. HCV resistance to cyclosporin A does not correlate with a resistance of the NS5A-cyclophilin A interaction to cyclophilin inhibitors. J. Hepatol. 2010, 53, 50-56. [CrossRef] [PubMed]
    • (2010) J Hepatol , vol.53 , pp. 50-56
    • Chatterji, U.1    Lim, P.2    Bobardt, M.D.3    Wieland, S.4    Cordek, D.G.5    Vuagniaux, G.6    Chisari, F.7    Cameron, C.E.8    Targett-Adams, P.9    Parkinson, T.10
  • 106
    • 80051810561 scopus 로고    scopus 로고
    • Comparative Study of the Genetic Barriers and Pathways towards Resistance of Selective Inhibitors of Hepatitis C Virus Replication
    • [CrossRef] [PubMed]
    • Delang, L.; Vliegen, I.; Froeyen, M.; Neyts, J. Comparative Study of the Genetic Barriers and Pathways towards Resistance of Selective Inhibitors of Hepatitis C Virus Replication. Antimicrob. Agents Chemother. 2011, 55, 4103-4113. [CrossRef] [PubMed]
    • (2011) Antimicrob Agents Chemother , vol.55 , pp. 4103-4113
    • Delang, L.1    Vliegen, I.2    Froeyen, M.3    Neyts, J.4
  • 109
    • 84929617895 scopus 로고    scopus 로고
    • Deep sequencing and phylogenetic analysis of variants resistant to interferon-based protease inhibitor therapy in chronic hepatitis induced by genotype 1b hepatitis C virus
    • [CrossRef] [PubMed]
    • Sato, M.; Maekawa, S.; Komatsu, N.; Tatsumi, A.; Miura, M.; Muraoka, M.; Suzuki, Y.; Amemiya, F.; Takano, S.; Fukasawa, M.; et al. Deep sequencing and phylogenetic analysis of variants resistant to interferon-based protease inhibitor therapy in chronic hepatitis induced by genotype 1b hepatitis C virus. J. Virol. 2015, 89, 6105-6116. [CrossRef] [PubMed]
    • (2015) J Virol , vol.89 , pp. 6105-6116
    • Sato, M.1    Maekawa, S.2    Komatsu, N.3    Tatsumi, A.4    Miura, M.5    Muraoka, M.6    Suzuki, Y.7    Amemiya, F.8    Takano, S.9    Fukasawa, M.10
  • 110
    • 84890289271 scopus 로고    scopus 로고
    • Naturally occurring resistance mutations to inhibitors of HCV NS5A region and NS5B polymerase in DAA treatment-naive patients
    • [CrossRef] [PubMed]
    • Paolucci, S.; Fiorina, L.; Mariani, B.; Gulminetti, R.; Novati, S.; Barbarini, G.; Bruno, R.; Baldanti, F. Naturally occurring resistance mutations to inhibitors of HCV NS5A region and NS5B polymerase in DAA treatment-naive patients. Virol. J. 2013, 10. [CrossRef] [PubMed]
    • (2013) Virol. J , pp. 10
    • Paolucci, S.1    Fiorina, L.2    Mariani, B.3    Gulminetti, R.4    Novati, S.5    Barbarini, G.6    Bruno, R.7    Baldanti, F.8
  • 111
    • 84863860109 scopus 로고    scopus 로고
    • Prevalence of hepatitis C virus variants resistant to NS3 protease inhibitors or the NS5A inhibitor (BMS-790052) in hepatitis patients with genotype 1b
    • [CrossRef] [PubMed]
    • Suzuki, F.; Sezaki, H.; Akuta, N.; Suzuki, Y.; Seko, Y.; Kawamura, Y.; Hosaka, T.; Kobayashi, M.; Saito, S.; Arase, Y.; et al. Prevalence of hepatitis C virus variants resistant to NS3 protease inhibitors or the NS5A inhibitor (BMS-790052) in hepatitis patients with genotype 1b. J. Clin. Virol. 2012, 54, 352-354. [CrossRef] [PubMed]
    • (2012) J. Clin Virol , vol.54 , pp. 352-354
    • Suzuki, F.1    Sezaki, H.2    Akuta, N.3    Suzuki, Y.4    Seko, Y.5    Kawamura, Y.6    Hosaka, T.7    Kobayashi, M.8    Saito, S.9    Arase, Y.10
  • 112
    • 84921260778 scopus 로고    scopus 로고
    • Similar prevalence of low-abundance drug-resistant variants in treatment-naive patients with genotype 1a and 1b hepatitis C virus infections as determined by ultradeep pyrosequencing
    • [CrossRef] [PubMed]
    • Margeridon-Thermet, S.; le Pogam, S.; Li, L.; Liu, T.F.; Shulman, N.; Shafer, R.W.; Najera, I. Similar prevalence of low-abundance drug-resistant variants in treatment-naive patients with genotype 1a and 1b hepatitis C virus infections as determined by ultradeep pyrosequencing. PLoS ONE 2014, 9, e105569. [CrossRef] [PubMed]
    • (2014) PLoS ONE , vol.9
    • Margeridon-Thermet, S.1    le Pogam, S.2    Li, L.3    Liu, T.F.4    Shulman, N.5    Shafer, R.W.6    Najera, I.7
  • 113
    • 84875804486 scopus 로고    scopus 로고
    • Natural prevalence of NS5A polymorphisms in subjects infected with hepatitis C virus genotype 3 and their effects on the antiviral activity of NS5A inhibitors
    • [CrossRef] [PubMed]
    • Hernandez, D.; Zhou, N.; Ueland, J.; Monikowski, A.; McPhee, F. Natural prevalence of NS5A polymorphisms in subjects infected with hepatitis C virus genotype 3 and their effects on the antiviral activity of NS5A inhibitors. J. Clin. Virol. 2013, 57, 13-18. [CrossRef] [PubMed]
    • (2013) J. Clin Virol , vol.57 , pp. 13-18
    • Hernandez, D.1    Zhou, N.2    Ueland, J.3    Monikowski, A.4    McPhee, F.5
  • 114
    • 84877580079 scopus 로고    scopus 로고
    • The presence of resistance mutations to protease and polymerase inhibitors in Hepatitis C virus sequences from the Los Alamos databank
    • [CrossRef] [PubMed]
    • Alves, R.; Queiroz, A.T.; Pessoa, M.G.; da Silva, E.F.; Mazo, D.F.; Carrilho, F.J.; Carvalho-Filho, R.J.; de Carvalho, I.M. The presence of resistance mutations to protease and polymerase inhibitors in Hepatitis C virus sequences from the Los Alamos databank. J. Viral Hepat. 2013, 20, 414-421. [CrossRef] [PubMed]
    • (2013) J Viral Hepat , vol.20 , pp. 414-421
    • Alves, R.1    Queiroz, A.T.2    Pessoa, M.G.3    da Silva, E.F.4    Mazo, D.F.5    Carrilho, F.J.6    Carvalho-Filho, R.J.7    de Carvalho, I.M.8
  • 115
    • 84888152433 scopus 로고    scopus 로고
    • Dynamic and rapid changes in viral quasispecies by UDPS in chronic hepatitis C patients receiving telaprevir-based therapy
    • [CrossRef] [PubMed]
    • Trimoulet, P.; Pinson, P.; Papuchon, J.; Foucher, J.; Vergniol, J.; Chermak, F.; Wittkop, L.; Castaing, N.; Merrouche, W.; Reigadas, S.; et al. Dynamic and rapid changes in viral quasispecies by UDPS in chronic hepatitis C patients receiving telaprevir-based therapy. Antivir. Ther. 2013, 18, 723-727. [CrossRef] [PubMed]
    • (2013) Antivir Ther , vol.18 , pp. 723-727
    • Trimoulet, P.1    Pinson, P.2    Papuchon, J.3    Foucher, J.4    Vergniol, J.5    Chermak, F.6    Wittkop, L.7    Castaing, N.8    Merrouche, W.9    Reigadas, S.10
  • 116
    • 84946490901 scopus 로고    scopus 로고
    • Predominance of hepatitis C virus Q80K among NS3 baseline-resistance-associated amino acid variants in direct-antiviral-agent-naive patients with chronic hepatitis: Single-centre experience
    • in press. [CrossRef] [PubMed]
    • Ruggiero, T.; Proietti, A.; Boglione, L.; Milia, M.G.; Allice, T.; Burdino, E.; Orofino, G.; Bonora, S.; di Perri, G.; Ghisetti, V. Predominance of hepatitis C virus Q80K among NS3 baseline-resistance-associated amino acid variants in direct-antiviral-agent-naive patients with chronic hepatitis: Single-centre experience. Arch. Virol. 2015. in press. [CrossRef] [PubMed]
    • (2015) Arch. Virol
    • Ruggiero, T.1    Proietti, A.2    Boglione, L.3    Milia, M.G.4    Allice, T.5    Burdino, E.6    Orofino, G.7    Bonora, S.8    di Perri, G.9    Ghisetti, V.10
  • 118
    • 84926667719 scopus 로고    scopus 로고
    • Global origin and transmission of hepatitis C virus nonstructural protein 3 Q80K polymorphism
    • [CrossRef] [PubMed]
    • McCloskey, R.M.; Liang, R.H.; Joy, J.B.; Krajden, M.; Montaner, J.S.; Harrigan, P.R.; Poon, A.F. Global origin and transmission of hepatitis C virus nonstructural protein 3 Q80K polymorphism. J. Infect. Dis. 2015, 211, 1288-1295. [CrossRef] [PubMed]
    • (2015) J. Infect Dis , vol.211 , pp. 1288-1295
    • McCloskey, R.M.1    Liang, R.H.2    Joy, J.B.3    Krajden, M.4    Montaner, J.S.5    Harrigan, P.R.6    Poon, A.F.7
  • 120
    • 84940942461 scopus 로고    scopus 로고
    • Resistance Analysis of Baseline and Treatment-Emergent Variants in the AVIATOR Study With Paritaprevir/r, Ombitasvir and Dasabuvir in HCV Genotype 1
    • [CrossRef] [PubMed]
    • Krishnan, P.; Tripathi, R.; Schnell, G.; Reisch, T.; Beyer, J.; Irvin, M.; Xie, W.; Larsen, L.; Cohen, D.; Podsadecki, T.; et al. Resistance Analysis of Baseline and Treatment-Emergent Variants in the AVIATOR Study With Paritaprevir/r, Ombitasvir and Dasabuvir in HCV Genotype 1. Antimicrob. Agents Chemother. 2015, 59, 5445-5454. [CrossRef] [PubMed]
    • (2015) Antimicrob Agents Chemother , vol.59 , pp. 5445-5454
    • Krishnan, P.1    Tripathi, R.2    Schnell, G.3    Reisch, T.4    Beyer, J.5    Irvin, M.6    Xie, W.7    Larsen, L.8    Cohen, D.9    Podsadecki, T.10
  • 122
    • 0038499539 scopus 로고    scopus 로고
    • Memory in retroviral quasispecies: Experimental evidence and theoretical model for human immunodeficiency virus
    • [CrossRef]
    • Briones, C.; Domingo, E.; Molina-París, C. Memory in retroviral quasispecies: Experimental evidence and theoretical model for human immunodeficiency virus. J. Mol. Biol. 2003, 331, 213-229. [CrossRef]
    • (2003) J. Mol Biol , vol.331 , pp. 213-229
    • Briones, C.1    Domingo, E.2    Molina-París, C.3
  • 123
    • 48449092074 scopus 로고    scopus 로고
    • Minority report: Hidden memory genomes in HIV-1 quasispecies and possible clinical implications
    • [PubMed]
    • Briones, C.; Domingo, E. Minority report: Hidden memory genomes in HIV-1 quasispecies and possible clinical implications. AIDS Rev. 2008, 10, 93-109. [PubMed]
    • (2008) AIDS Rev , vol.10 , pp. 93-109
    • Briones, C.1    Domingo, E.2
  • 124
    • 84911919899 scopus 로고    scopus 로고
    • Long-term follow-up of patients receiving boceprevir for treatment of chronic hepatitis C
    • [CrossRef] [PubMed]
    • Howe, A.Y.; Long, J.; Nickle, D.; Barnard, R.; Thompson, S.; Howe, J.; Alves, K.; Wahl, J. Long-term follow-up of patients receiving boceprevir for treatment of chronic hepatitis C. Antivir. Res. 2015, 113, 71-78. [CrossRef] [PubMed]
    • (2015) Antivir Res , vol.113 , pp. 71-78
    • Howe, A.Y.1    Long, J.2    Nickle, D.3    Barnard, R.4    Thompson, S.5    Howe, J.6    Alves, K.7    Wahl, J.8
  • 125
    • 82755182674 scopus 로고    scopus 로고
    • Analysis of long-term persistence of resistance mutations within the hepatitis C virus NS3 protease after treatment with telaprevir or boceprevir
    • [CrossRef] [PubMed]
    • Susser, S.; Vermehren, J.; Forestier, N.; Welker, M.W.; Grigorian, N.; Fuller, C.; Perner, D.; Zeuzem, S.; Sarrazin, C. Analysis of long-term persistence of resistance mutations within the hepatitis C virus NS3 protease after treatment with telaprevir or boceprevir. J. Clin. Virol. 2011, 52, 321-327. [CrossRef] [PubMed]
    • (2011) J. Clin Virol , vol.52 , pp. 321-327
    • Susser, S.1    Vermehren, J.2    Forestier, N.3    Welker, M.W.4    Grigorian, N.5    Fuller, C.6    Perner, D.7    Zeuzem, S.8    Sarrazin, C.9
  • 126
    • 84940582565 scopus 로고    scopus 로고
    • Long term persistence of NS5A inhibitor-resistant hepatitis C virus in patients who failed daclatasvir and asunaprevir therapy
    • [CrossRef] [PubMed]
    • Yoshimi, S.; Imamura, M.; Murakami, E.; Hiraga, N.; Tsuge, M.; Kawakami, Y.; Aikata, H.; Abe, H.; Hayes, C.N.; Sasaki, T.; et al. Long term persistence of NS5A inhibitor-resistant hepatitis C virus in patients who failed daclatasvir and asunaprevir therapy. J. Med. Virol. 2015, 87, 1913-1920. [CrossRef] [PubMed]
    • (2015) J. Med Virol , vol.87 , pp. 1913-1920
    • Yoshimi, S.1    Imamura, M.2    Murakami, E.3    Hiraga, N.4    Tsuge, M.5    Kawakami, Y.6    Aikata, H.7    Abe, H.8    Hayes, C.N.9    Sasaki, T.10
  • 128
    • 0345188811 scopus 로고    scopus 로고
    • Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line
    • [CrossRef] [PubMed]
    • Lohmann, V.; Korner, F.; Koch, J.; Herian, U.; Theilmann, L.; Bartenschlager, R. Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line. Science 1999, 285, 110-113. [CrossRef] [PubMed]
    • (1999) Science , vol.285 , pp. 110-113
    • Lohmann, V.1    Korner, F.2    Koch, J.3    Herian, U.4    Theilmann, L.5    Bartenschlager, R.6
  • 129
    • 84896289180 scopus 로고    scopus 로고
    • On the history of hepatitis C virus cell culture systems
    • [CrossRef] [PubMed]
    • Lohmann, V.; Bartenschlager, R. On the history of hepatitis C virus cell culture systems. J. Med. Chem. 2014, 57, 1627-1642. [CrossRef] [PubMed]
    • (2014) J. Med Chem , vol.57 , pp. 1627-1642
    • Lohmann, V.1    Bartenschlager, R.2
  • 130
  • 135
    • 38949168945 scopus 로고    scopus 로고
    • Development of JFH1-based cell culture systems for hepatitis C virus genotype 4a and evidence for cross-genotype neutralization
    • [CrossRef] [PubMed]
    • Scheel, T.K.; Gottwein, J.M.; Jensen, T.B.; Prentoe, J.C.; Hoegh, A.M.; Alter, H.J.; Eugen-Olsen, J.; Bukh, J. Development of JFH1-based cell culture systems for hepatitis C virus genotype 4a and evidence for cross-genotype neutralization. Proc. Natl. Acad. Sci. USA 2008, 105, 997-1002. [CrossRef] [PubMed]
    • (2008) Proc. Natl. Acad. Sci USA , vol.105 , pp. 997-1002
    • Scheel, T.K.1    Gottwein, J.M.2    Jensen, T.B.3    Prentoe, J.C.4    Hoegh, A.M.5    Alter, H.J.6    Eugen-Olsen, J.7    Bukh, J.8
  • 136
    • 56749131299 scopus 로고    scopus 로고
    • Highly efficient JFH1-based cell-culture system for hepatitis C virus genotype 5a: Failure of homologous neutralizing-antibody treatment to control infection
    • [CrossRef] [PubMed]
    • Jensen, T.B.; Gottwein, J.M.; Scheel, T.K.; Hoegh, A.M.; Eugen-Olsen, J.; Bukh, J. Highly efficient JFH1-based cell-culture system for hepatitis C virus genotype 5a: Failure of homologous neutralizing-antibody treatment to control infection. J. Infect. Dis. 2008, 198, 1756-1765. [CrossRef] [PubMed]
    • (2008) J. Infect Dis , vol.198 , pp. 1756-1765
    • Jensen, T.B.1    Gottwein, J.M.2    Scheel, T.K.3    Hoegh, A.M.4    Eugen-Olsen, J.5    Bukh, J.6
  • 137
    • 61949320778 scopus 로고    scopus 로고
    • Development and characterization of hepatitis C virus genotype 1-7 cell culture systems: Role of CD81 and scavenger receptor class B type I and effect of antiviral drugs
    • [CrossRef] [PubMed]
    • Gottwein, J.M.; Scheel, T.K.; Jensen, T.B.; Lademann, J.B.; Prentoe, J.C.; Knudsen, M.L.; Hoegh, A.M.; Bukh, J. Development and characterization of hepatitis C virus genotype 1-7 cell culture systems: Role of CD81 and scavenger receptor class B type I and effect of antiviral drugs. Hepatology 2009, 49, 364-377. [CrossRef] [PubMed]
    • (2009) Hepatology , vol.49 , pp. 364-377
    • Gottwein, J.M.1    Scheel, T.K.2    Jensen, T.B.3    Lademann, J.B.4    Prentoe, J.C.5    Knudsen, M.L.6    Hoegh, A.M.7    Bukh, J.8
  • 139
    • 33846111662 scopus 로고    scopus 로고
    • Compensatory mutations in E1, p7, NS2, and NS3 enhance yields of cell culture-infectious intergenotypic chimeric hepatitis C virus
    • [CrossRef] [PubMed]
    • Yi, M.; Ma, Y.; Yates, J.; Lemon, S.M. Compensatory mutations in E1, p7, NS2, and NS3 enhance yields of cell culture-infectious intergenotypic chimeric hepatitis C virus. J. Virol. 2007, 81, 629-638. [CrossRef] [PubMed]
    • (2007) J Virol , vol.81 , pp. 629-638
    • Yi, M.1    Ma, Y.2    Yates, J.3    Lemon, S.M.4
  • 140
    • 35648963197 scopus 로고    scopus 로고
    • Robust hepatitis C genotype 3a cell culture releasing adapted intergenotypic 3a/2a (S52/JFH1) viruses
    • [CrossRef] [PubMed]
    • Gottwein, J.M.; Scheel, T.K.; Hoegh, A.M.; Lademann, J.B.; Eugen-Olsen, J.; Lisby, G.; Bukh, J. Robust hepatitis C genotype 3a cell culture releasing adapted intergenotypic 3a/2a (S52/JFH1) viruses. Gastroenterology 2007, 133, 1614-1626. [CrossRef] [PubMed]
    • (2007) Gastroenterology , vol.133 , pp. 1614-1626
    • Gottwein, J.M.1    Scheel, T.K.2    Hoegh, A.M.3    Lademann, J.B.4    Eugen-Olsen, J.5    Lisby, G.6    Bukh, J.7
  • 141
    • 79952416361 scopus 로고    scopus 로고
    • Efficient culture adaptation of hepatitis C virus recombinants with genotype-specific core-NS2 by using previously identified mutations
    • [CrossRef] [PubMed]
    • Scheel, T.K.; Gottwein, J.M.; Carlsen, T.H.; Li, Y.P.; Jensen, T.B.; Spengler, U.; Weis, N.; Bukh, J. Efficient culture adaptation of hepatitis C virus recombinants with genotype-specific core-NS2 by using previously identified mutations. J. Virol. 2011, 85, 2891-2906. [CrossRef] [PubMed]
    • (2011) J Virol , vol.85 , pp. 2891-2906
    • Scheel, T.K.1    Gottwein, J.M.2    Carlsen, T.H.3    Li, Y.P.4    Jensen, T.B.5    Spengler, U.6    Weis, N.7    Bukh, J.8
  • 142
    • 79551700091 scopus 로고    scopus 로고
    • Hypervariable region 1 differentially impacts viability of hepatitis C virus strains of genotypes 1 to 6 and impairs virus neutralization
    • [CrossRef] [PubMed]
    • Prentoe, J.; Jensen, T.B.; Meuleman, P.; Serre, S.B.; Scheel, T.K.; Leroux-Roels, G.; Gottwein, J.M.; Bukh, J. Hypervariable region 1 differentially impacts viability of hepatitis C virus strains of genotypes 1 to 6 and impairs virus neutralization. J. Virol. 2011, 85, 2224-2234. [CrossRef] [PubMed]
    • (2011) J Virol , vol.85 , pp. 2224-2234
    • Prentoe, J.1    Jensen, T.B.2    Meuleman, P.3    Serre, S.B.4    Scheel, T.K.5    Leroux-Roels, G.6    Gottwein, J.M.7    Bukh, J.8
  • 143
    • 58149390243 scopus 로고    scopus 로고
    • Genotype-dependent sensitivity of hepatitis C virus to inhibitors of the p7 ion channel
    • [CrossRef] [PubMed]
    • Griffin, S.; Stgelais, C.; Owsianka, A.M.; Patel, A.H.; Rowlands, D.; Harris, M. Genotype-dependent sensitivity of hepatitis C virus to inhibitors of the p7 ion channel. Hepatology 2008, 48, 1779-1790. [CrossRef] [PubMed]
    • (2008) Hepatology , vol.48 , pp. 1779-1790
    • Griffin, S.1    Stgelais, C.2    Owsianka, A.M.3    Patel, A.H.4    Rowlands, D.5    Harris, M.6
  • 144
    • 80052123459 scopus 로고    scopus 로고
    • Differential efficacy of protease inhibitors against HCV genotypes 2a, 3a, 5a, and 6a NS3/4A protease recombinant viruses
    • [CrossRef] [PubMed]
    • Gottwein, J.M.; Scheel, T.K.; Jensen, T.B.; Ghanem, L.; Bukh, J. Differential efficacy of protease inhibitors against HCV genotypes 2a, 3a, 5a, and 6a NS3/4A protease recombinant viruses. Gastroenterology 2011, 141, 1067-1079. [CrossRef] [PubMed]
    • (2011) Gastroenterology , vol.141 , pp. 1067-1079
    • Gottwein, J.M.1    Scheel, T.K.2    Jensen, T.B.3    Ghanem, L.4    Bukh, J.5
  • 145
    • 79952296871 scopus 로고    scopus 로고
    • Recombinant HCV variants with NS5A from genotypes 1-7 have different sensitivities to an NS5A inhibitor but not interferon-α
    • [CrossRef] [PubMed]
    • Scheel, T.K.; Gottwein, J.M.; Mikkelsen, L.S.; Jensen, T.B.; Bukh, J. Recombinant HCV variants with NS5A from genotypes 1-7 have different sensitivities to an NS5A inhibitor but not interferon-α. Gastroenterology 2011, 140, 1032-1042. [CrossRef] [PubMed]
    • (2011) Gastroenterology , vol.140 , pp. 1032-1042
    • Scheel, T.K.1    Gottwein, J.M.2    Mikkelsen, L.S.3    Jensen, T.B.4    Bukh, J.5
  • 146
    • 84863682657 scopus 로고    scopus 로고
    • Analysis of functional differences between hepatitis C virus NS5A of genotypes 1-7 in infectious cell culture systems
    • [CrossRef] [PubMed]
    • Scheel, T.K.; Prentoe, J.; Carlsen, T.H.; Mikkelsen, L.S.; Gottwein, J.M.; Bukh, J. Analysis of functional differences between hepatitis C virus NS5A of genotypes 1-7 in infectious cell culture systems. PLoS Pathog. 2012, 8, e1002696. [CrossRef] [PubMed]
    • (2012) PLoS Pathog , vol.8
    • Scheel, T.K.1    Prentoe, J.2    Carlsen, T.H.3    Mikkelsen, L.S.4    Gottwein, J.M.5    Bukh, J.6
  • 147
    • 84884186559 scopus 로고    scopus 로고
    • Analysis of hepatitis C virus core/NS5A protein co-localization using novel cell culture systems expressing core-NS2 and NS5A of genotypes 1-7
    • [CrossRef] [PubMed]
    • Galli, A.; Scheel, T.K.; Prentoe, J.C.; Mikkelsen, L.S.; Gottwein, J.M.; Bukh, J. Analysis of hepatitis C virus core/NS5A protein co-localization using novel cell culture systems expressing core-NS2 and NS5A of genotypes 1-7. J. Gen. Virol. 2013, 94, 2221-2235. [CrossRef] [PubMed]
    • (2013) J. Gen Virol , vol.94 , pp. 2221-2235
    • Galli, A.1    Scheel, T.K.2    Prentoe, J.C.3    Mikkelsen, L.S.4    Gottwein, J.M.5    Bukh, J.6
  • 148
    • 84874095900 scopus 로고    scopus 로고
    • Combination treatment with hepatitis C virus protease and NS5A inhibitors is effective against recombinant genotype 1a, 2a, and 3a viruses
    • [CrossRef] [PubMed]
    • Gottwein, J.M.; Jensen, S.B.; Li, Y.P.; Ghanem, L.; Scheel, T.K.; Serre, S.B.; Mikkelsen, L.; Bukh, J. Combination treatment with hepatitis C virus protease and NS5A inhibitors is effective against recombinant genotype 1a, 2a, and 3a viruses. Antimicrob. Agents Chemother. 2013, 57, 1291-1303. [CrossRef] [PubMed]
    • (2013) Antimicrob Agents Chemother , vol.57 , pp. 1291-1303
    • Gottwein, J.M.1    Jensen, S.B.2    Li, Y.P.3    Ghanem, L.4    Scheel, T.K.5    Serre, S.B.6    Mikkelsen, L.7    Bukh, J.8
  • 149
    • 84887485664 scopus 로고    scopus 로고
    • Adapted J6/JFH1-based Hepatitis C virus recombinants with genotype-specific NS4A show similar efficacies against lead protease inhibitors, alpha interferon, and a putative NS4A inhibitor
    • [CrossRef] [PubMed]
    • Gottwein, J.M.; Jensen, S.B.; Serre, S.B.; Ghanem, L.; Scheel, T.K.; Jensen, T.B.; Krarup, H.; Uzcategui, N.; Mikkelsen, L.S.; Bukh, J. Adapted J6/JFH1-based Hepatitis C virus recombinants with genotype-specific NS4A show similar efficacies against lead protease inhibitors, alpha interferon, and a putative NS4A inhibitor. Antimicrob. Agents Chemother. 2013, 57, 6034-6049. [CrossRef] [PubMed]
    • (2013) Antimicrob Agents Chemother , vol.57 , pp. 6034-6049
    • Gottwein, J.M.1    Jensen, S.B.2    Serre, S.B.3    Ghanem, L.4    Scheel, T.K.5    Jensen, T.B.6    Krarup, H.7    Uzcategui, N.8    Mikkelsen, L.S.9    Bukh, J.10
  • 150
    • 84894378216 scopus 로고    scopus 로고
    • Differential sensitivity of 5'UTR-NS5A recombinants of hepatitis C virus genotypes 1-6 to protease and NS5A inhibitors
    • [CrossRef] [PubMed]
    • Li, Y.P.; Ramirez, S.; Humes, D.; Jensen, S.B.; Gottwein, J.M.; Bukh, J. Differential sensitivity of 5'UTR-NS5A recombinants of hepatitis C virus genotypes 1-6 to protease and NS5A inhibitors. Gastroenterology 2014, 146, 812-821. [CrossRef] [PubMed]
    • (2014) Gastroenterology , vol.146 , pp. 812-821
    • Li, Y.P.1    Ramirez, S.2    Humes, D.3    Jensen, S.B.4    Gottwein, J.M.5    Bukh, J.6
  • 151
    • 84940487299 scopus 로고    scopus 로고
    • SEC14L2 enables pan-genotype HCV replication in cell culture
    • [CrossRef] [PubMed]
    • Saeed, M.; Andreo, U.; Chung, H.Y.; Espiritu, C.; Branch, A.D.; Silva, J.M.; Rice, C.M. SEC14L2 enables pan-genotype HCV replication in cell culture. Nature 2015, 524, 471-475. [CrossRef] [PubMed]
    • (2015) Nature , vol.524 , pp. 471-475
    • Saeed, M.1    Andreo, U.2    Chung, H.Y.3    Espiritu, C.4    Branch, A.D.5    Silva, J.M.6    Rice, C.M.7
  • 152
    • 33144471074 scopus 로고    scopus 로고
    • Production of infectious genotype 1a hepatitis C virus (Hutchinson strain) in cultured human hepatoma cells
    • [CrossRef] [PubMed]
    • Yi, M.; Villanueva, R.A.; Thomas, D.L.; Wakita, T.; Lemon, S.M. Production of infectious genotype 1a hepatitis C virus (Hutchinson strain) in cultured human hepatoma cells. Proc. Natl. Acad. Sci. USA 2006, 103, 2310-2315. [CrossRef] [PubMed]
    • (2006) Proc. Natl. Acad. Sci USA , vol.103 , pp. 2310-2315
    • Yi, M.1    Villanueva, R.A.2    Thomas, D.L.3    Wakita, T.4    Lemon, S.M.5
  • 153
    • 84870372937 scopus 로고    scopus 로고
    • Highly efficient full-length hepatitis C virus genotype 1 (strain TN) infectious culture system
    • [CrossRef] [PubMed]
    • Li, Y.P.; Ramirez, S.; Jensen, S.B.; Purcell, R.H.; Gottwein, J.M.; Bukh, J. Highly efficient full-length hepatitis C virus genotype 1 (strain TN) infectious culture system. Proc. Natl. Acad. Sci. USA 2012, 109, 19757-19762. [CrossRef] [PubMed]
    • (2012) Proc. Natl. Acad. Sci USA , vol.109 , pp. 19757-19762
    • Li, Y.P.1    Ramirez, S.2    Jensen, S.B.3    Purcell, R.H.4    Gottwein, J.M.5    Bukh, J.6
  • 154
    • 84919431426 scopus 로고    scopus 로고
    • Efficient Infectious Cell Culture Systems of the Hepatitis C Virus (HCV) Prototype Strains HCV-1 and H77
    • [CrossRef] [PubMed]
    • Li, Y.P.; Ramirez, S.; Mikkelsen, L.; Bukh, J. Efficient Infectious Cell Culture Systems of the Hepatitis C Virus (HCV) Prototype Strains HCV-1 and H77. J. Virol. 2015, 89, 811-823. [CrossRef] [PubMed]
    • (2015) J Virol , vol.89 , pp. 811-823
    • Li, Y.P.1    Ramirez, S.2    Mikkelsen, L.3    Bukh, J.4
  • 155
    • 79251561245 scopus 로고    scopus 로고
    • Protease Inhibitor-Resistant Hepatitis C Virus Mutants with Reduced Fitness from Impaired Production of Infectious Virus
    • [CrossRef] [PubMed]
    • Shimakami, T.; Welsch, C.; Yamane, D.; McGivern, D.; Yi, M.; Zeuzem, S.; Lemon, S.M. Protease Inhibitor-Resistant Hepatitis C Virus Mutants with Reduced Fitness from Impaired Production of Infectious Virus. Gastroenterology 2011, 140, 667-675. [CrossRef] [PubMed]
    • (2011) Gastroenterology , vol.140 , pp. 667-675
    • Shimakami, T.1    Welsch, C.2    Yamane, D.3    McGivern, D.4    Yi, M.5    Zeuzem, S.6    Lemon, S.M.7
  • 158
    • 84946945495 scopus 로고    scopus 로고
    • Management of Direct Antiviral Agent Failures
    • [CrossRef] [PubMed]
    • Buti, M.; Riveiro-Barciela, M.; Esteban, R. Management of Direct Antiviral Agent Failures. J. Hepatol. 2015. [CrossRef] [PubMed]
    • (2015) J. Hepatol
    • Buti, M.1    Riveiro-Barciela, M.2    Esteban, R.3
  • 159
    • 84869506027 scopus 로고    scopus 로고
    • The impact of quasispecies dynamics on the use of therapeutics
    • [CrossRef] [PubMed]
    • Perales, C.; Iranzo, J.; Manrubia, S.C.; Domingo, E. The impact of quasispecies dynamics on the use of therapeutics. Trends Microbiol. 2012, 20, 595-603. [CrossRef] [PubMed]
    • (2012) Trends Microbiol , vol.20 , pp. 595-603
    • Perales, C.1    Iranzo, J.2    Manrubia, S.C.3    Domingo, E.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.