메뉴 건너뛰기




Volumn 26, Issue 4, 2012, Pages 487-503

The role of resistance in HCV treatment

Author keywords

Direct acting antivirals; Hepatitis C virus; Resistance; Sequencing

Indexed keywords

ACH 1625; AMINO ACID; BI 207127; BOCEPREVIR; FALDAPREVIR; FILIBUVIR; HOST FACTOR; LOMIBUVIR; MERICITABINE; MK 5172; RNA DIRECTED RNA POLYMERASE INHIBITOR; SERINE PROTEINASE INHIBITOR; SETROBUVIR; SIMEPREVIR; TEGOBUVIR; TELAPREVIR; UNCLASSIFIED DRUG;

EID: 84870413046     PISSN: 15216918     EISSN: 15321916     Source Type: Journal    
DOI: 10.1016/j.bpg.2012.09.011     Document Type: Article
Times cited : (115)

References (98)
  • 1
    • 1642288430 scopus 로고    scopus 로고
    • World Health Organization Accessed Online on June28, 2012 [html]
    • World Health Organization Hepatitis C factsheet no. 164 2011 Accessed Online on June28, 2012 http://www.whoint/mediacentre/factsheets/fs164/en/index [html]
    • (2011) Hepatitis C Factsheet No. 164
  • 3
    • 0035934568 scopus 로고    scopus 로고
    • Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: A randomised trial
    • M.P. Manns, J.G. McHutchison, S.C. Gordon, V.K. Rustgi, M. Shiffman, and R. Reindollar Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial Lancet 358 9286 2001 958 965
    • (2001) Lancet , vol.358 , Issue.9286 , pp. 958-965
    • Manns, M.P.1    McHutchison, J.G.2    Gordon, S.C.3    Rustgi, V.K.4    Shiffman, M.5    Reindollar, R.6
  • 4
  • 5
    • 78751626828 scopus 로고    scopus 로고
    • New HCV therapies on the horizon
    • J. Vermehren, and C. Sarrazin New HCV therapies on the horizon Clin Microbiol Infect 17 2 2011 122 134
    • (2011) Clin Microbiol Infect , vol.17 , Issue.2 , pp. 122-134
    • Vermehren, J.1    Sarrazin, C.2
  • 11
    • 34548758435 scopus 로고    scopus 로고
    • Telaprevir and pegylated interferon-alpha-2a inhibit wild-type and resistant genotype 1 hepatitis C virus replication in patients
    • T.L. Kieffer, C. Sarrazin, J.S. Miller, M.W. Welker, N. Forestier, and H.W. Reesink Telaprevir and pegylated interferon-alpha-2a inhibit wild-type and resistant genotype 1 hepatitis C virus replication in patients Hepatology 46 3 2007 631 639
    • (2007) Hepatology , vol.46 , Issue.3 , pp. 631-639
    • Kieffer, T.L.1    Sarrazin, C.2    Miller, J.S.3    Welker, M.W.4    Forestier, N.5    Reesink, H.W.6
  • 12
    • 34247594930 scopus 로고    scopus 로고
    • Dynamic hepatitis C virus genotypic and phenotypic changes in patients treated with the protease inhibitor telaprevir
    • C. Sarrazin, T.L. Kieffer, D. Bartels, B. Hanzelka, U. Muh, and M. Welker Dynamic hepatitis C virus genotypic and phenotypic changes in patients treated with the protease inhibitor telaprevir Gastroenterology 132 5 2007 1767 1777
    • (2007) Gastroenterology , vol.132 , Issue.5 , pp. 1767-1777
    • Sarrazin, C.1    Kieffer, T.L.2    Bartels, D.3    Hanzelka, B.4    Muh, U.5    Welker, M.6
  • 13
    • 73149113353 scopus 로고    scopus 로고
    • Characterization of resistance to the protease inhibitor boceprevir in hepatitis C virus-infected patients
    • S. Susser, C. Welsch, Y. Wang, M. Zettler, F.S. Domingues, and U. Karey Characterization of resistance to the protease inhibitor boceprevir in hepatitis C virus-infected patients Hepatology 50 6 2009 1709 1718
    • (2009) Hepatology , vol.50 , Issue.6 , pp. 1709-1718
    • Susser, S.1    Welsch, C.2    Wang, Y.3    Zettler, M.4    Domingues, F.S.5    Karey, U.6
  • 14
    • 84855860795 scopus 로고    scopus 로고
    • Mutations selected in the hepatitis C virus NS3 protease domain during sequential treatment with boceprevir with and without pegylated interferon alfa-2b
    • J. Vermehren, S. Susser, C.M. Lange, N. Forestier, U. Karey, and E. Hughes Mutations selected in the hepatitis C virus NS3 protease domain during sequential treatment with boceprevir with and without pegylated interferon alfa-2b J Viral Hepat 19 2 2012 120 127
    • (2012) J Viral Hepat , vol.19 , Issue.2 , pp. 120-127
    • Vermehren, J.1    Susser, S.2    Lange, C.M.3    Forestier, N.4    Karey, U.5    Hughes, E.6
  • 15
    • 0032475822 scopus 로고    scopus 로고
    • Hepatitis C viral dynamics in vivo and the antiviral efficacy of interferon-alpha therapy
    • A.U. Neumann, N.P. Lam, H. Dahari, D.R. Gretch, T.E. Wiley, and T.J. Layden Hepatitis C viral dynamics in vivo and the antiviral efficacy of interferon-alpha therapy Science 282 5386 1998 103 107
    • (1998) Science , vol.282 , Issue.5386 , pp. 103-107
    • Neumann, A.U.1    Lam, N.P.2    Dahari, H.3    Gretch, D.R.4    Wiley, T.E.5    Layden, T.J.6
  • 16
    • 0026538287 scopus 로고
    • Hepatitis C virus (HCV) circulates as a population of different but closely related genomes: Quasispecies nature of HCV genome distribution
    • M. Martell, J.I. Esteban, J. Quer, J. Genesca, A. Weiner, and R. Esteban Hepatitis C virus (HCV) circulates as a population of different but closely related genomes: quasispecies nature of HCV genome distribution J Virol 66 5 1992 3225 3229
    • (1992) J Virol , vol.66 , Issue.5 , pp. 3225-3229
    • Martell, M.1    Esteban, J.I.2    Quer, J.3    Genesca, J.4    Weiner, A.5    Esteban, R.6
  • 17
    • 77953013128 scopus 로고    scopus 로고
    • Rapid emergence of protease inhibitor resistance in hepatitis C virus
    • L. Rong, H. Dahari, R.M. Ribeiro, and A.S. Perelson Rapid emergence of protease inhibitor resistance in hepatitis C virus Sci Transl Med 2 30 2010 30ra2
    • (2010) Sci Transl Med , vol.2 , Issue.30
    • Rong, L.1    Dahari, H.2    Ribeiro, R.M.3    Perelson, A.S.4
  • 18
    • 84855509792 scopus 로고    scopus 로고
    • Contribution of a mutational bias in hepatitis C virus replication to the genetic barrier in the development of drug resistance
    • M.H. Powdrill, E.P. Tchesnokov, R.A. Kozak, R.S. Russell, R. Martin, and E.S. Svarovskaia Contribution of a mutational bias in hepatitis C virus replication to the genetic barrier in the development of drug resistance Proc Natl Acad Sci U S A 108 51 2011 20509 20513
    • (2011) Proc Natl Acad Sci U S A , vol.108 , Issue.51 , pp. 20509-20513
    • Powdrill, M.H.1    Tchesnokov, E.P.2    Kozak, R.A.3    Russell, R.S.4    Martin, R.5    Svarovskaia, E.S.6
  • 19
    • 75149151884 scopus 로고    scopus 로고
    • Resistance to direct antiviral agents in patients with hepatitis C virus infection
    • C. Sarrazin, and S. Zeuzem Resistance to direct antiviral agents in patients with hepatitis C virus infection Gastroenterology 138 2 2010 447 462
    • (2010) Gastroenterology , vol.138 , Issue.2 , pp. 447-462
    • Sarrazin, C.1    Zeuzem, S.2
  • 20
    • 45749088957 scopus 로고    scopus 로고
    • Why are there different dynamics in the selection of drug resistance in HIV and hepatitis B and C viruses?
    • V. Soriano, A.S. Perelson, and F. Zoulim Why are there different dynamics in the selection of drug resistance in HIV and hepatitis B and C viruses? J Antimicrob Chemother 62 1 2008 1 4
    • (2008) J Antimicrob Chemother , vol.62 , Issue.1 , pp. 1-4
    • Soriano, V.1    Perelson, A.S.2    Zoulim, F.3
  • 21
    • 67651085608 scopus 로고    scopus 로고
    • Antiretroviral medication adherence and the development of class-specific antiretroviral resistance
    • E.M. Gardner, W.J. Burman, J.F. Steiner, P.L. Anderson, and D.R. Bangsberg Antiretroviral medication adherence and the development of class-specific antiretroviral resistance AIDS 23 9 2009 1035 1046
    • (2009) AIDS , vol.23 , Issue.9 , pp. 1035-1046
    • Gardner, E.M.1    Burman, W.J.2    Steiner, J.F.3    Anderson, P.L.4    Bangsberg, D.R.5
  • 22
    • 84866244136 scopus 로고    scopus 로고
    • SVR4 and SVR12 with an interferon-free regimen of BI 201335 and BI 207127, ± ribavirin, in treatment-naive patients with chronic genotype-1 HCV infection: Interim results of sound-C2
    • S. Zeuzem, V. Soriano, T. Asselah, J.P. Bronowicki, A. Lohse, and B. Mullhaupt SVR4 and SVR12 with an interferon-free regimen of BI 201335 and BI 207127, ± ribavirin, in treatment-naive patients with chronic genotype-1 HCV infection: interim results of sound-C2 J Hepatol 56 2012 S45-S
    • (2012) J Hepatol , vol.56
    • Zeuzem, S.1    Soriano, V.2    Asselah, T.3    Bronowicki, J.P.4    Lohse, A.5    Mullhaupt, B.6
  • 24
    • 79960720423 scopus 로고    scopus 로고
    • Telaprevir substantially improved SVR rates across all IL28B genotypes in the advance trial
    • I.M. Jacobson, I. Catlett, P. Marcellin, N.H. Bzowej, A.J. Muir, and N. Adda Telaprevir substantially improved SVR rates across all IL28B genotypes in the advance trial J Hepatol 54 2011 S542 S543
    • (2011) J Hepatol , vol.54
    • Jacobson, I.M.1    Catlett, I.2    Marcellin, P.3    Bzowej, N.H.4    Muir, A.J.5    Adda, N.6
  • 25
    • 80052123459 scopus 로고    scopus 로고
    • Differential efficacy of protease inhibitors against HCV genotypes 2a, 3a, 5a, and 6a NS3/4A protease recombinant viruses
    • J.M. Gottwein, T.K.H. Scheel, T.B. Jensen, L. Ghanem, and J. Bukh Differential efficacy of protease inhibitors against HCV genotypes 2a, 3a, 5a, and 6a NS3/4A protease recombinant viruses Gastroenterology 141 3 2011 1067 1079
    • (2011) Gastroenterology , vol.141 , Issue.3 , pp. 1067-1079
    • Gottwein, J.M.1    Scheel, T.K.H.2    Jensen, T.B.3    Ghanem, L.4    Bukh, J.5
  • 26
    • 77956116880 scopus 로고    scopus 로고
    • Resistance analysis of the hepatitis C virus NS5A inhibitor BMS-790052 in an in vitro replicon system
    • R.A. Fridell, D.K. Qiu, C.F. Wang, L. Valera, and M. Gao Resistance analysis of the hepatitis C virus NS5A inhibitor BMS-790052 in an in vitro replicon system Antimicrobial Agents Chemother 54 9 2010 3641 3650
    • (2010) Antimicrobial Agents Chemother , vol.54 , Issue.9 , pp. 3641-3650
    • Fridell, R.A.1    Qiu, D.K.2    Wang, C.F.3    Valera, L.4    Gao, M.5
  • 27
    • 77952035218 scopus 로고    scopus 로고
    • Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect
    • M. Gao, R.E. Nettles, M. Belema, L.B. Snyder, V.N. Nguyen, and R.A. Fridell Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect Nature 465 7294 2010 96-U108
    • (2010) Nature , vol.465 , Issue.7294
    • Gao, M.1    Nettles, R.E.2    Belema, M.3    Snyder, L.B.4    Nguyen, V.N.5    Fridell, R.A.6
  • 28
    • 79960735084 scopus 로고    scopus 로고
    • Evolution of treatment-emergent resistant variants in telaprevir phase 3 clinical trials
    • J.C. Sullivan, S. De Meyer, D.J. Bartels, I. Dierynck, E. Zhang, and J. Spanks Evolution of treatment-emergent resistant variants in telaprevir phase 3 clinical trials J Hepatol 54 2011 S4
    • (2011) J Hepatol , vol.54 , pp. 4
    • Sullivan, J.C.1    De Meyer, S.2    Bartels, D.J.3    Dierynck, I.4    Zhang, E.5    Spanks, J.6
  • 29
    • 34247205808 scopus 로고    scopus 로고
    • SCH 503034, a novel hepatitis C virus protease inhibitor, plus pegylated interferon alpha-2b for genotype 1 nonresponders
    • C. Sarrazin, R. Rouzier, F. Wagner, N. Forestier, D. Larrey, and S.K. Gupta SCH 503034, a novel hepatitis C virus protease inhibitor, plus pegylated interferon alpha-2b for genotype 1 nonresponders Gastroenterology 132 2007 1270 1278
    • (2007) Gastroenterology , vol.132 , pp. 1270-1278
    • Sarrazin, C.1    Rouzier, R.2    Wagner, F.3    Forestier, N.4    Larrey, D.5    Gupta, S.K.6
  • 30
    • 51749123143 scopus 로고    scopus 로고
    • Natural prevalence of hepatitis C virus variants with decreased sensitivity to NS3/4A protease inhibitors in treatment-naive subjects
    • D.J. Bartels, Y. Zhou, E.Z. Zhang, M. Marcial, R.A. Byrn, and T. Pfeiffer Natural prevalence of hepatitis C virus variants with decreased sensitivity to NS3/4A protease inhibitors in treatment-naive subjects J Infect Dis 198 6 2008 800 807
    • (2008) J Infect Dis , vol.198 , Issue.6 , pp. 800-807
    • Bartels, D.J.1    Zhou, Y.2    Zhang, E.Z.3    Marcial, M.4    Byrn, R.A.5    Pfeiffer, T.6
  • 31
    • 58149388300 scopus 로고    scopus 로고
    • Naturally occurring dominant resistance mutations to hepatitis C virus protease and polymerase inhibitors in treatment-naive patients
    • T. Kuntzen, J. Timm, A. Berical, N. Lennon, A.M. Berlin, and S.K. Young Naturally occurring dominant resistance mutations to hepatitis C virus protease and polymerase inhibitors in treatment-naive patients Hepatology 48 6 2008 1769 1778
    • (2008) Hepatology , vol.48 , Issue.6 , pp. 1769-1778
    • Kuntzen, T.1    Timm, J.2    Berical, A.3    Lennon, N.4    Berlin, A.M.5    Young, S.K.6
  • 32
    • 84870410201 scopus 로고    scopus 로고
    • TMC435 in combination with peginterferon alpha-2a/ribavirin in treatment-naive patients infected with HCV genotype 1: Virology analysis of the pillar study
    • O. Lenz, B. Fevery, L. Vijgen, J. Verbeeck, M. Peeters, and M. Beumont TMC435 in combination with peginterferon alpha-2a/ribavirin in treatment-naive patients infected with HCV genotype 1: virology analysis of the pillar study Hepatology 54 2011 985A
    • (2011) Hepatology , vol.54
    • Lenz, O.1    Fevery, B.2    Vijgen, L.3    Verbeeck, J.4    Peeters, M.5    Beumont, M.6
  • 33
    • 84858690642 scopus 로고    scopus 로고
    • Naturally occurring hepatitis C virus (HCV) NS3/4A protease inhibitor resistance-related mutations in HCV genotype 1-infected subjects in Italy
    • I. Vicenti, A. Rosi, F. Saladini, G. Meini, F. Pippi, and B. Rossetti Naturally occurring hepatitis C virus (HCV) NS3/4A protease inhibitor resistance-related mutations in HCV genotype 1-infected subjects in Italy J Antimicrob Chemother 67 4 2012 984 987
    • (2012) J Antimicrob Chemother , vol.67 , Issue.4 , pp. 984-987
    • Vicenti, I.1    Rosi, A.2    Saladini, F.3    Meini, G.4    Pippi, F.5    Rossetti, B.6
  • 34
    • 82455192239 scopus 로고    scopus 로고
    • Genotypic and phenotypic analysis of variants resistant to hepatitis C virus nonstructural protein 5A replication complex inhibitor BMS-790052 in humans: In vitro and in vivo correlations
    • R.A. Fridell, C.F. Wang, J.H. Sun, D.R. O'Boyle, P. Nower, and L. Valera Genotypic and phenotypic analysis of variants resistant to hepatitis C virus nonstructural protein 5A replication complex inhibitor BMS-790052 in humans: in vitro and in vivo correlations Hepatology 54 6 2011 1924 1935
    • (2011) Hepatology , vol.54 , Issue.6 , pp. 1924-1935
    • Fridell, R.A.1    Wang, C.F.2    Sun, J.H.3    O'Boyle, D.R.4    Nower, P.5    Valera, L.6
  • 35
    • 84867278904 scopus 로고    scopus 로고
    • No detection of variants bearing NS5B S282T mericitabine (MCB) resistance mutation in DAA treatment-naive HCV genotype 1 (G1)-infected patients using ultra-deep pyrosequencing (UDPS)
    • S. Margeridon, S. Le Pogam, T.F. Liu, B. Hanczaruk, B.B. Simen, and N. Shulman No detection of variants bearing NS5B S282T mericitabine (MCB) resistance mutation in DAA treatment-naive HCV genotype 1 (G1)-infected patients using ultra-deep pyrosequencing (UDPS) Hepatology 54 2011 532A
    • (2011) Hepatology , vol.54
    • Margeridon, S.1    Le Pogam, S.2    Liu, T.F.3    Hanczaruk, B.4    Simen, B.B.5    Shulman, N.6
  • 36
    • 65449157987 scopus 로고    scopus 로고
    • Hepatitis C virus drug resistance and immune-driven adaptations: Relevance to new antiviral therapy
    • S. Gaudieri, A. Rauch, K. Pfafferott, E. Barnes, W. Cheng, and G. McCaughan Hepatitis C virus drug resistance and immune-driven adaptations: relevance to new antiviral therapy Hepatology 49 4 2009 1069 1082
    • (2009) Hepatology , vol.49 , Issue.4 , pp. 1069-1082
    • Gaudieri, S.1    Rauch, A.2    Pfafferott, K.3    Barnes, E.4    Cheng, W.5    McCaughan, G.6
  • 37
    • 79960468479 scopus 로고    scopus 로고
    • Natural variation in drug susceptibility to HCV polymerase inhibitors in treatment-naive HCV patient isolates
    • S.C.C. Sun, A. Bae, X. Qi, J. Harris, K.A. Wong, and M.D. Miller Natural variation in drug susceptibility to HCV polymerase inhibitors in treatment-naive HCV patient isolates J Viral Hepat 18 12 2011 861 870
    • (2011) J Viral Hepat , vol.18 , Issue.12 , pp. 861-870
    • Sun, S.C.C.1    Bae, A.2    Qi, X.3    Harris, J.4    Wong, K.A.5    Miller, M.D.6
  • 38
    • 82955172365 scopus 로고    scopus 로고
    • Molecular characterization of HCV resistance to telaprevir by means of ultra-deep pyrosequencing: Preexisting resistant variants and dynamics of resistant populations
    • S. Chevaliez, C. Rodriguez, A. Soulier, A. Ahmed-Belkacem, C. Hezode, and J.M. Pawlotsky Molecular characterization of HCV resistance to telaprevir by means of ultra-deep pyrosequencing: preexisting resistant variants and dynamics of resistant populations J Hepatol 54 2011 S30
    • (2011) J Hepatol , vol.54 , pp. 30
    • Chevaliez, S.1    Rodriguez, C.2    Soulier, A.3    Ahmed-Belkacem, A.4    Hezode, C.5    Pawlotsky, J.M.6
  • 39
    • 84855224933 scopus 로고    scopus 로고
    • Characterisation of HCV variants in non-SVR patients in the realize study suggests that telaprevir exhibits a consistent resistance profile irrespective of a lead-in
    • S. de Meyer, I. Dierynck, A. Ghys, M. Beumont, B. Daems, and B. van Baelen Characterisation of HCV variants in non-SVR patients in the realize study suggests that telaprevir exhibits a consistent resistance profile irrespective of a lead-in J Hepatol 54 2011 S475
    • (2011) J Hepatol , vol.54 , pp. 475
    • De Meyer, S.1    Dierynck, I.2    Ghys, A.3    Beumont, M.4    Daems, B.5    Van Baelen, B.6
  • 40
    • 82755182674 scopus 로고    scopus 로고
    • Analysis of long-term persistence of resistance mutations within the hepatitis C virus NS3 protease after treatment with telaprevir or boceprevir
    • S. Susser, J. Vermehren, N. Forestier, M.W. Welker, N. Grigorian, and C. Fuller Analysis of long-term persistence of resistance mutations within the hepatitis C virus NS3 protease after treatment with telaprevir or boceprevir J Clin Virol 52 4 2011 321 327
    • (2011) J Clin Virol , vol.52 , Issue.4 , pp. 321-327
    • Susser, S.1    Vermehren, J.2    Forestier, N.3    Welker, M.W.4    Grigorian, N.5    Fuller, C.6
  • 41
    • 84856903158 scopus 로고    scopus 로고
    • Follow-up of SVR durability and viral resistance in patients with chronic hepatitis C treated with telaprevir-based regimens: Interim analysis of the extend study
    • K.E. Sherman, M.S. Sulkowski, F. Zoulim, A. Alberti, L.J. Wei, and J. Sullivan Follow-up of SVR durability and viral resistance in patients with chronic hepatitis C treated with telaprevir-based regimens: interim analysis of the extend study Hepatology 54 2011 485A 486A
    • (2011) Hepatology , vol.54
    • Sherman, K.E.1    Sulkowski, M.S.2    Zoulim, F.3    Alberti, A.4    Wei, L.J.5    Sullivan, J.6
  • 42
    • 84867688570 scopus 로고    scopus 로고
    • Analysis of resistance-associated amino acid variants (RAVS) in non-SVR patients enrolled in a retrospective long-term follow-up analysis of boceprevir phase 3 clinical studies
    • R.J. Barnard, S. Zeuzem, J.M. Vierling, M.S. Sulkowski, M.P. Manns, and J.M. Long Analysis of resistance-associated amino acid variants (RAVS) in non-SVR patients enrolled in a retrospective long-term follow-up analysis of boceprevir phase 3 clinical studies Hepatology 54 2011 440A 441A
    • (2011) Hepatology , vol.54
    • Barnard, R.J.1    Zeuzem, S.2    Vierling, J.M.3    Sulkowski, M.S.4    Manns, M.P.5    Long, J.M.6
  • 43
    • 84863670207 scopus 로고    scopus 로고
    • Treatment outcome and resistance analysis in HCV genotype 1 patients previously exposed to TMC435 monotherapy and re-treated with TMC435 in combination with pegIFN alpha-2a/ribavirin
    • O. Lenz, J. de Bruijne, L. Vijgen, T. Verbinnen, C.J. Weegink, and H. van Marck Treatment outcome and resistance analysis in HCV genotype 1 patients previously exposed to TMC435 monotherapy and re-treated with TMC435 in combination with pegIFN alpha-2a/ribavirin J Hepatol 54 2011 S482 S483
    • (2011) J Hepatol , vol.54
    • Lenz, O.1    De Bruijne, J.2    Vijgen, L.3    Verbinnen, T.4    Weegink, C.J.5    Van Marck, H.6
  • 44
    • 84858759479 scopus 로고    scopus 로고
    • Retreatment with telaprevir/peg-IFN/RBV after a short exposure to telaprevir in phase i studies: Interim results from a phase IIIb rollover trial (C219)
    • C. Sarrazin, H.W. Reesink, S. Zeuzem, C.J. Weegink, D.H. Luo, and J. Witek Retreatment with telaprevir/peg-IFN/RBV after a short exposure to telaprevir in phase I studies: interim results from a phase IIIb rollover trial (C219) Hepatology 54 2011 377A 378A
    • (2011) Hepatology , vol.54
    • Sarrazin, C.1    Reesink, H.W.2    Zeuzem, S.3    Weegink, C.J.4    Luo, D.H.5    Witek, J.6
  • 45
    • 84860273551 scopus 로고    scopus 로고
    • New virologic tools for management of chronic hepatitis B and C
    • S. Chevaliez, C. Rodriguez, and J.M. Pawlotsky New virologic tools for management of chronic hepatitis B and C Gastroenterology 142 6 2012 1303 1313
    • (2012) Gastroenterology , vol.142 , Issue.6 , pp. 1303-1313
    • Chevaliez, S.1    Rodriguez, C.2    Pawlotsky, J.M.3
  • 46
    • 79952290371 scopus 로고    scopus 로고
    • Sequence and phenotypic analysis for resistance monitoring in hepatitis C virus drug development: Recommendations from the HCV DRAG
    • A.D. Kwong, I. Najera, J. Bechtel, S. Bowden, J. Fitzgibbon, and P. Harrington Sequence and phenotypic analysis for resistance monitoring in hepatitis C virus drug development: recommendations from the HCV DRAG Gastroenterology 140 3 2011 755 760
    • (2011) Gastroenterology , vol.140 , Issue.3 , pp. 755-760
    • Kwong, A.D.1    Najera, I.2    Bechtel, J.3    Bowden, S.4    Fitzgibbon, J.5    Harrington, P.6
  • 47
    • 79955103901 scopus 로고    scopus 로고
    • Treatment failure and resistance with direct-acting antiviral drugs against hepatitis C virus
    • J.M. Pawlotsky Treatment failure and resistance with direct-acting antiviral drugs against hepatitis C virus Hepatology 53 5 2011 1742 1751
    • (2011) Hepatology , vol.53 , Issue.5 , pp. 1742-1751
    • Pawlotsky, J.M.1
  • 48
    • 79953764145 scopus 로고    scopus 로고
    • Long-term outcomes following combination treatment with boceprevir plus PEG-Intron/ribavirin (P/R) in patients with chronic hepatitis C, genotype 1 (CHC-G1)
    • J.M. Vierling, R. Ralston, E. Lawitz, J. McCone, S.C. Gordon, and D. Pound Long-term outcomes following combination treatment with boceprevir plus PEG-Intron/ribavirin (P/R) in patients with chronic hepatitis C, genotype 1 (CHC-G1) J Hepatol 52 2010 S470 S471
    • (2010) J Hepatol , vol.52
    • Vierling, J.M.1    Ralston, R.2    Lawitz, E.3    McCone, J.4    Gordon, S.C.5    Pound, D.6
  • 50
    • 0344201903 scopus 로고    scopus 로고
    • An NS3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus
    • D. Lamarre, P.C. Anderson, M. Bailey, P. Beaulieu, G. Bolger, and P. Bonneau An NS3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus Nature 426 6963 2003 186 189
    • (2003) Nature , vol.426 , Issue.6963 , pp. 186-189
    • Lamarre, D.1    Anderson, P.C.2    Bailey, M.3    Beaulieu, P.4    Bolger, G.5    Bonneau, P.6
  • 51
    • 2342420348 scopus 로고    scopus 로고
    • In vitro resistance studies of hepatitis C virus serine protease inhibitors, VX-950 and BILN 2061: Structural analysis indicates different resistance mechanisms
    • C. Lin, K. Lin, Y.P. Luong, B.G. Rao, Y.Y. Wei, and D.L. Brennan In vitro resistance studies of hepatitis C virus serine protease inhibitors, VX-950 and BILN 2061: structural analysis indicates different resistance mechanisms J Biol Chem 279 17 2004 17508 17514
    • (2004) J Biol Chem , vol.279 , Issue.17 , pp. 17508-17514
    • Lin, C.1    Lin, K.2    Luong, Y.P.3    Rao, B.G.4    Wei, Y.Y.5    Brennan, D.L.6
  • 53
    • 84867687761 scopus 로고    scopus 로고
    • Deep sequencing screening for telaprevir-resistant viral variants in previous null responders fails to identify those patients at risk of failing telaprevir plus peginterferon/ribavirin therapy
    • S. De Meyer, K. Thys, I. Dierynck, A. Ghys, J. Aerssens, and G. Picchio Deep sequencing screening for telaprevir-resistant viral variants in previous null responders fails to identify those patients at risk of failing telaprevir plus peginterferon/ribavirin therapy J Hepatol 56 2012 S465
    • (2012) J Hepatol , vol.56 , pp. 465
    • De Meyer, S.1    Thys, K.2    Dierynck, I.3    Ghys, A.4    Aerssens, J.5    Picchio, G.6
  • 54
    • 33646036163 scopus 로고    scopus 로고
    • Identification and analysis of fitness of resistance mutations against the HCV protease inhibitor SCH 503034
    • X. Tong, R. Chase, A. Skelton, T. Chen, J. Wright-Minogue, and B.A. Malcolm Identification and analysis of fitness of resistance mutations against the HCV protease inhibitor SCH 503034 Antiviral Res 70 2 2006 28 38
    • (2006) Antiviral Res , vol.70 , Issue.2 , pp. 28-38
    • Tong, X.1    Chase, R.2    Skelton, A.3    Chen, T.4    Wright-Minogue, J.5    Malcolm, B.A.6
  • 55
    • 77956268467 scopus 로고    scopus 로고
    • Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): An open-label, randomised, multicentre phase 2 trial
    • P.Y. Kwo, E.J. Lawitz, J. McCone, E.R. Schiff, J.M. Vierling, and D. Pound Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trial Lancet 376 9742 2010 705 716
    • (2010) Lancet , vol.376 , Issue.9742 , pp. 705-716
    • Kwo, P.Y.1    Lawitz, E.J.2    McCone, J.3    Schiff, E.R.4    Vierling, J.M.5    Pound, D.6
  • 56
    • 84868657922 scopus 로고    scopus 로고
    • Genotypic and phenotypic correlates of resistance in HCV genotype 1a and 1b infected patients treated with boceprevir plus peginterferon alpha and ribavirin
    • R.A. Ogert, P. McMonagle, S. Black, S. Curry, Z.Y. Guo, and C. Lesburg Genotypic and phenotypic correlates of resistance in HCV genotype 1a and 1b infected patients treated with boceprevir plus peginterferon alpha and ribavirin Hepatology 54 2011 794A 795A
    • (2011) Hepatology , vol.54
    • Ogert, R.A.1    McMonagle, P.2    Black, S.3    Curry, S.4    Guo, Z.Y.5    Lesburg, C.6
  • 57
    • 84455201507 scopus 로고    scopus 로고
    • Characterization of resistant mutants selected in vitro by the HCV NS3/4A protease inhibitor BI 201335
    • G. Kukolj, C. Bousquet, N. Dansereau, F. Do, L. Lagace, and M. Llinas-Brunet Characterization of resistant mutants selected in vitro by the HCV NS3/4A protease inhibitor BI 201335 J Hepatol 52 2010 S295
    • (2010) J Hepatol , vol.52 , pp. 295
    • Kukolj, G.1    Bousquet, C.2    Dansereau, N.3    Do, F.4    Lagace, L.5    Llinas-Brunet, M.6
  • 59
    • 78049529146 scopus 로고    scopus 로고
    • Kinetic analysis of viral rebound and drug-resistant viral variant dynamics in patients treated with ITMN-191 (R7227) monotherapy suggest a high barrier to viral escape
    • C. Sarrazin, S. Lim, X.L. Qin, S. Susser, C.M. Lange, and W.Z. Bradford Kinetic analysis of viral rebound and drug-resistant viral variant dynamics in patients treated with ITMN-191 (R7227) monotherapy suggest a high barrier to viral escape Hepatology 50 4 2009 953A 954A
    • (2009) Hepatology , vol.50 , Issue.4
    • Sarrazin, C.1    Lim, S.2    Qin, X.L.3    Susser, S.4    Lange, C.M.5    Bradford, W.Z.6
  • 60
    • 84867666185 scopus 로고    scopus 로고
    • Characterization of HCV NS3 variants that emerged during virologic breakthrough and relapse from BI 201335 phase 2 silen-C1 study
    • G. Kukolj, L. Legace, M. Cartier, M. Marquis, I. Triki, and M.S. Sulkowski Characterization of HCV NS3 variants that emerged during virologic breakthrough and relapse from BI 201335 phase 2 silen-C1 study Hepatology 54 2011 Oct 991A
    • (2011) Hepatology , vol.54
    • Kukolj, G.1    Legace, L.2    Cartier, M.3    Marquis, M.4    Triki, I.5    Sulkowski, M.S.6
  • 61
    • 84864387126 scopus 로고    scopus 로고
    • MK-5172, a selective inhibitor of hepatitis C virus NS3/4A protease with broad activity across genotypes and resistant variants
    • Epub ahead of print
    • V. Summa, S.W. Ludmerer, J.A. McCauley, C. Fandozzi, C. Burlein, and G. Claudio MK-5172, a selective inhibitor of hepatitis C virus NS3/4A protease with broad activity across genotypes and resistant variants Antimicrobial Agents Chemother 2012 Epub ahead of print
    • (2012) Antimicrobial Agents Chemother
    • Summa, V.1    Ludmerer, S.W.2    McCauley, J.A.3    Fandozzi, C.4    Burlein, C.5    Claudio, G.6
  • 62
    • 84870408744 scopus 로고    scopus 로고
    • Evaluation of NS3 amino acid variants in a phase 1b study of genotype 1 (GT1) and GT3 infected patients with the HCV protease inhibitor, MK-5172
    • J.M. Strizki, R.J.O. Barnard, C. Cheney, C. McHale, D. Graham, and A. Himmelberger Evaluation of NS3 amino acid variants in a phase 1b study of genotype 1 (GT1) and GT3 infected patients with the HCV protease inhibitor, MK-5172 J Hepatol 56 2012 S479
    • (2012) J Hepatol , vol.56 , pp. 479
    • Strizki, J.M.1    Barnard, R.J.O.2    Cheney, C.3    McHale, C.4    Graham, D.5    Himmelberger, A.6
  • 63
    • 84870475161 scopus 로고    scopus 로고
    • Characterization of HCV NS3 protease variants from patients enrolled in a 28-day phase 2a trial of ACH-1625 daily dosing plus pegIFN-alpha 2a/RBV
    • J. Fabrycki, D. Patel, G. Yang, Y. Zhao, S. Podos, and H. Robison Characterization of HCV NS3 protease variants from patients enrolled in a 28-day phase 2a trial of ACH-1625 daily dosing plus pegIFN-alpha 2a/RBV J Hepatol 56 2012 S468
    • (2012) J Hepatol , vol.56 , pp. 468
    • Fabrycki, J.1    Patel, D.2    Yang, G.3    Zhao, Y.4    Podos, S.5    Robison, H.6
  • 64
    • 84855494000 scopus 로고    scopus 로고
    • Biochemical activities of the HCV NS5B RNA-dependent RNA polymerase
    • S.L. Tan, 1st ed. Horizon Bioscience Norfolk
    • C.T. Ranjith-Kumar, and C. Cheng Kao Biochemical activities of the HCV NS5B RNA-dependent RNA polymerase S.L. Tan, Hepatitis C viruses: genomes and molecular biology 1st ed. 2006 Horizon Bioscience Norfolk 293 310
    • (2006) Hepatitis C Viruses: Genomes and Molecular Biology , pp. 293-310
    • Ranjith-Kumar, C.T.1    Cheng Kao, C.2
  • 65
    • 34548789741 scopus 로고    scopus 로고
    • Valopicitabine (NM283), alone or with peginterferon, compared to peginterferon/ribavirin (pegIFN/RBV) retreatment in patients with HCV-1 infection and prior non-response to pegIFN/RBV: One-year results
    • N.H. Afdhal, C. O'Brien, E. Godofsky, M. Rodriguez-Torres, S.C. Pappas, and E. Lawitz Valopicitabine (NM283), alone or with peginterferon, compared to peginterferon/ribavirin (pegIFN/RBV) retreatment in patients with HCV-1 infection and prior non-response to pegIFN/RBV: one-year results J Hepatol 46 2007 S5
    • (2007) J Hepatol , vol.46 , pp. 5
    • Afdhal, N.H.1    O'Brien, C.2    Godofsky, E.3    Rodriguez-Torres, M.4    Pappas, S.C.5    Lawitz, E.6
  • 66
    • 84866119318 scopus 로고    scopus 로고
    • Interferon-free treatment with a combination of mericitabine and danoprevir/R with or without ribavirin in treatment-naive HCV genotype 1-infected patients
    • E.J. Gane, P. Pockros, S. Zeuzem, P. Marcellin, A. Shikhman, and C. Bernaards Interferon-free treatment with a combination of mericitabine and danoprevir/R with or without ribavirin in treatment-naive HCV genotype 1-infected patients J Hepatol 56 2012 S555 S556
    • (2012) J Hepatol , vol.56
    • Gane, E.J.1    Pockros, P.2    Zeuzem, S.3    Marcellin, P.4    Shikhman, A.5    Bernaards, C.6
  • 67
    • 84855233736 scopus 로고    scopus 로고
    • Once-daily PSI-7977 plus peg/RBV in treatment-naive patients with HCV GT1: Robust end of treatment response rates are sustained post-treatment
    • E. Lawitz, J.P. Lalezari, T. Hassanein, K.V. Kowdley, F.F. Poordad, and A.M. Sheikh Once-daily PSI-7977 plus peg/RBV in treatment-naive patients with HCV GT1: robust end of treatment response rates are sustained post-treatment Hepatology 54 2011 472A 473A
    • (2011) Hepatology , vol.54
    • Lawitz, E.1    Lalezari, J.P.2    Hassanein, T.3    Kowdley, K.V.4    Poordad, F.F.5    Sheikh, A.M.6
  • 69
    • 84863678711 scopus 로고    scopus 로고
    • Potent viral suppression with all-oral combination of daclatasvir (NS5A inhibitor) and GS-7977 (NS5B inhibitor), ± ribavirin, in treatment-naive patients with chronic HCV GT1, 2, or 3
    • M. Sulkowski, D. Gardiner, E. Lawitz, F. Hinestrosa, D. Nelson, and P. Thuluvath Potent viral suppression with all-oral combination of daclatasvir (NS5A inhibitor) and GS-7977 (NS5B inhibitor), ± ribavirin, in treatment-naive patients with chronic HCV GT1, 2, or 3 J Hepatol 56 2012 S560
    • (2012) J Hepatol , vol.56 , pp. 560
    • Sulkowski, M.1    Gardiner, D.2    Lawitz, E.3    Hinestrosa, F.4    Nelson, D.5    Thuluvath, P.6
  • 70
    • 84863650706 scopus 로고    scopus 로고
    • SVR-12 among G1/4 treatment-naive patients receiving mericitabine in combination with peg-IFN alpha-2a/RBV: Interim analysis from the jump-C study
    • P. Pockros, D. Jensen, N. Tsai, R. Taylor, A. Ramji, and C. Cooper SVR-12 among G1/4 treatment-naive patients receiving mericitabine in combination with peg-IFN alpha-2a/RBV: interim analysis from the jump-C study J Hepatol 56 2012 Apr S477 S478
    • (2012) J Hepatol , vol.56
    • Pockros, P.1    Jensen, D.2    Tsai, N.3    Taylor, R.4    Ramji, A.5    Cooper, C.6
  • 71
    • 84863680448 scopus 로고    scopus 로고
    • Efficacy and safety of mericitabine (MCB) in combination with peg-IFN alpha-2a/RBV in G1/4 treatment naive HCV patients: Final analysis from the propel study
    • H. Wedemeyer, D. Jensen, R. Herring, P. Ferenci, M.M. Ma, and S. Zeuzem Efficacy and safety of mericitabine (MCB) in combination with peg-IFN alpha-2a/RBV in G1/4 treatment naive HCV patients: final analysis from the propel study J Hepatol 56 2012 S481 S482
    • (2012) J Hepatol , vol.56
    • Wedemeyer, H.1    Jensen, D.2    Herring, R.3    Ferenci, P.4    Ma, M.M.5    Zeuzem, S.6
  • 72
    • 80052070428 scopus 로고    scopus 로고
    • The HCV NS5B nucleoside and non-nucleoside inhibitors
    • F.E. Membreno, and E.J. Lawitz The HCV NS5B nucleoside and non-nucleoside inhibitors Clin Liver Dis 15 3 2011 611 626
    • (2011) Clin Liver Dis , vol.15 , Issue.3 , pp. 611-626
    • Membreno, F.E.1    Lawitz, E.J.2
  • 73
    • 80051820156 scopus 로고    scopus 로고
    • Mechanistic characterization of GS-9190 (tegobuvir), a novel nonnucleoside inhibitor of hepatitis C virus NS5B polymerase
    • I.H. Shih, I. Vliegen, B. Peng, H. Yang, C. Hebner, and J. Paeshuyse Mechanistic characterization of GS-9190 (tegobuvir), a novel nonnucleoside inhibitor of hepatitis C virus NS5B polymerase Antimicrobial Agents Chemother 55 9 2011 4196 4203
    • (2011) Antimicrobial Agents Chemother , vol.55 , Issue.9 , pp. 4196-4203
    • Shih, I.H.1    Vliegen, I.2    Peng, B.3    Yang, H.4    Hebner, C.5    Paeshuyse, J.6
  • 74
    • 84355163756 scopus 로고    scopus 로고
    • Genotypic and phenotypic analysis of the NS5B polymerase region from viral isolates of HCV chronically infected patients treated with BI 207127 for 5-days monotherapy
    • L. Lagace, M. Cartier, G. Laflamme, C. Lawetz, M. Marquis, and I. Triki Genotypic and phenotypic analysis of the NS5B polymerase region from viral isolates of HCV chronically infected patients treated with BI 207127 for 5-days monotherapy Hepatology 52 2010 1205A 1206A
    • (2010) Hepatology , vol.52
    • Lagace, L.1    Cartier, M.2    Laflamme, G.3    Lawetz, C.4    Marquis, M.5    Triki, I.6
  • 75
    • 64349088294 scopus 로고    scopus 로고
    • Discovery of (R)-6-cyclopentyl-6-(2-(2,6-diethylpyridin-4-yl)ethyl)-3- ((5,7-dimethyl-[1,2,4]tr iazolo[1,5-a]pyrimidin-2-yl)methyl)-4-hydroxy-5,6- dihydropyran-2-one (PF-00868554) as a potent and orally available hepatitis C virus polymerase inhibitor
    • H. Li, J. Tatlock, A. Linton, J. Gonzalez, T. Jewell, and L. Patel Discovery of (R)-6-cyclopentyl-6-(2-(2,6-diethylpyridin-4-yl)ethyl)-3-((5,7- dimethyl-[1,2,4]tr iazolo[1,5-a]pyrimidin-2-yl)methyl)-4-hydroxy-5,6- dihydropyran-2-one (PF-00868554) as a potent and orally available hepatitis C virus polymerase inhibitor J Med Chem 52 5 2009 1255 1258
    • (2009) J Med Chem , vol.52 , Issue.5 , pp. 1255-1258
    • Li, H.1    Tatlock, J.2    Linton, A.3    Gonzalez, J.4    Jewell, T.5    Patel, L.6
  • 76
    • 83555163165 scopus 로고    scopus 로고
    • Genotypic characterisation of filibuvir (PF-00868554) resistance in patients receiving four weeks co-administration of filibuvir with pegIFN/RBV (12 week analysis)
    • J. Mori, J.L. Hammond, S. Srinivasan, S. Jagannatha, and E. van der Ryst Genotypic characterisation of filibuvir (PF-00868554) resistance in patients receiving four weeks co-administration of filibuvir with pegIFN/RBV (12 week analysis) J Hepatol 52 2010 S15
    • (2010) J Hepatol , vol.52 , pp. 15
    • Mori, J.1    Hammond, J.L.2    Srinivasan, S.3    Jagannatha, S.4    Van Der Ryst, E.5
  • 77
    • 84865418147 scopus 로고    scopus 로고
    • VX-222/telaprevir in combination with peginterferon-alfa-2a and ribavirin in treatment-naive genotype 1 HCV patients treated for 12 weeks: Zenith study, SVR12 interim analysis
    • D.R. Nelson, E.J. Gane, I.M. Jacobson, A.M. Di Bisceglie, K. Alves, and M.J. Koziel VX-222/telaprevir in combination with peginterferon-alfa-2a and ribavirin in treatment-naive genotype 1 HCV patients treated for 12 weeks: zenith study, SVR12 interim analysis Hepatology 54 2011 1435A
    • (2011) Hepatology , vol.54
    • Nelson, D.R.1    Gane, E.J.2    Jacobson, I.M.3    Di Bisceglie, A.M.4    Alves, K.5    Koziel, M.J.6
  • 78
    • 84870438909 scopus 로고    scopus 로고
    • Characterization of HCV variants in genotype 1 treatment-naive patients administered the combination of TVR and VX-222 in dual arms of zenith study
    • E.Z. Zhang, A. Tigges, M. Jiang, J. Dorrian, J. Spanks, and A. Ardzinski Characterization of HCV variants in genotype 1 treatment-naive patients administered the combination of TVR and VX-222 in dual arms of zenith study J Hepatol 56 2012 S468 S469
    • (2012) J Hepatol , vol.56
    • Zhang, E.Z.1    Tigges, A.2    Jiang, M.3    Dorrian, J.4    Spanks, J.5    Ardzinski, A.6
  • 79
    • 78751637124 scopus 로고    scopus 로고
    • Safety and antiviral activity of ANA598 in combination with pegylated interferon alpha 2a plus ribavirin in treatment-naive genotype-1 chronic HCV patients
    • E. Lawitz, M. Rodriguez-Torres, V.K. Rustgi, T. Hassanein, M.H. Rahimy, and C.A. Crowley Safety and antiviral activity of ANA598 in combination with pegylated interferon alpha 2a plus ribavirin in treatment-naive genotype-1 chronic HCV patients Hepatology 52 4 2010 334A 335A
    • (2010) Hepatology , vol.52 , Issue.4
    • Lawitz, E.1    Rodriguez-Torres, M.2    Rustgi, V.K.3    Hassanein, T.4    Rahimy, M.H.5    Crowley, C.A.6
  • 80
    • 84859083700 scopus 로고    scopus 로고
    • Factors affecting HCV viral load response to the non-nucleoside polymerase inhibitors ABT-072 and ABT-333
    • T. Middleton, J. He, J. Beyer, I.A. Gaultier, D.E. Cohen, and T.J. Podsadecki Factors affecting HCV viral load response to the non-nucleoside polymerase inhibitors ABT-072 and ABT-333 J Hepatol 54 2011 S483 S484
    • (2011) J Hepatol , vol.54
    • Middleton, T.1    He, J.2    Beyer, J.3    Gaultier, I.A.4    Cohen, D.E.5    Podsadecki, T.J.6
  • 81
    • 84867566926 scopus 로고    scopus 로고
    • A 12-week interferon-free regimen of ABT-450/R, ABT-072, and ribavirin was well tolerated and achieved sustained virologic response in 91% treatment-naive HCV IL28B-CC genotype-1-infected subjects
    • E. Lawitz, F. Poordad, K.V. Kowdley, D. Jensen, D.E. Cohen, and S. Siggelkow A 12-week interferon-free regimen of ABT-450/R, ABT-072, and ribavirin was well tolerated and achieved sustained virologic response in 91% treatment-naive HCV IL28B-CC genotype-1-infected subjects J Hepatol 56 2012 S7
    • (2012) J Hepatol , vol.56 , pp. 7
    • Lawitz, E.1    Poordad, F.2    Kowdley, K.V.3    Jensen, D.4    Cohen, D.E.5    Siggelkow, S.6
  • 82
    • 84864379265 scopus 로고    scopus 로고
    • 12-Week interferon-free regimen of ABT-450/R + ABT-333 + Ribavirin achieved SVR12 in more than 90% of treatment-naive HCV genotype-1-infected subjects and 47% of previous non-responders
    • F. Poordad, E. Lawitz, K.V. Kowdley, G.T. Everson, B. Freilich, and D. Cohen 12-Week interferon-free regimen of ABT-450/R + ABT-333 + Ribavirin achieved SVR12 in more than 90% of treatment-naive HCV genotype-1-infected subjects and 47% of previous non-responders J Hepatol 56 2012 S549 S550
    • (2012) J Hepatol , vol.56
    • Poordad, F.1    Lawitz, E.2    Kowdley, K.V.3    Everson, G.T.4    Freilich, B.5    Cohen, D.6
  • 83
    • 84862206878 scopus 로고    scopus 로고
    • The HCV non-nucleoside inhibitor tegobuvir utilizes a novel mechanism of action to inhibit NS5B polymerase function
    • C.M. Hebner, B. Han, K.M. Brendza, M. Nash, M. Sulfab, and Y. Tian The HCV non-nucleoside inhibitor tegobuvir utilizes a novel mechanism of action to inhibit NS5B polymerase function PloS One 7 6 2012 e39163
    • (2012) PloS One , vol.7 , Issue.6 , pp. 39163
    • Hebner, C.M.1    Han, B.2    Brendza, K.M.3    Nash, M.4    Sulfab, M.5    Tian, Y.6
  • 84
    • 78751633456 scopus 로고    scopus 로고
    • Antiviral response and resistance analysis of treatment-naive HCV infected subjects receiving single and multiple doses of GS-9190
    • J. Harris, A. Bae, S.C. Sun, E.S. Svarovskaia, M.D. Miller, and H.M. Mo Antiviral response and resistance analysis of treatment-naive HCV infected subjects receiving single and multiple doses of GS-9190 Hepatology 52 2010 722A
    • (2010) Hepatology , vol.52
    • Harris, J.1    Bae, A.2    Sun, S.C.3    Svarovskaia, E.S.4    Miller, M.D.5    Mo, H.M.6
  • 85
    • 84856440468 scopus 로고    scopus 로고
    • Emergence and persistence of NS5B mutations following combination treatment with tegobuvir (GS-9190) plus standard of care-long-term follow-up from the phase IIb study GS-Us-196-0103
    • C.M. Hebner, J. Harris, D. Oldach, M.D. Miller, and H. Mo Emergence and persistence of NS5B mutations following combination treatment with tegobuvir (GS-9190) plus standard of care-long-term follow-up from the phase IIb study GS-Us-196-0103 J Hepatol 54 2011 S478 S479
    • (2011) J Hepatol , vol.54
    • Hebner, C.M.1    Harris, J.2    Oldach, D.3    Miller, M.D.4    Mo, H.5
  • 86
    • 82955248788 scopus 로고    scopus 로고
    • Four-week treatment with GS-9256 and tegobuvir (GS-9190), ± RBV ± PEG, results in enhanced viral suppression on follow-up PEG/RBV therapy, in genotype 1a/1b HCV patients
    • G.R. Foster, P. Buggisch, P. Marcellin, S. Zeuzem, K. Agarwal, and M. Manns Four-week treatment with GS-9256 and tegobuvir (GS-9190), ± RBV ± PEG, results in enhanced viral suppression on follow-up PEG/RBV therapy, in genotype 1a/1b HCV patients J Hepatol 54 2011 S172
    • (2011) J Hepatol , vol.54 , pp. 172
    • Foster, G.R.1    Buggisch, P.2    Marcellin, P.3    Zeuzem, S.4    Agarwal, K.5    Manns, M.6
  • 87
    • 84863678711 scopus 로고    scopus 로고
    • High sustained virologic response rate in treatment-naive HCV genotype 1a and 1b patients treated for 12 weeks with an interferon-free all-oral quad regimen: Interim results
    • M. Sulkowski, M. Rodriguez-Torres, E. Lawitz, M. Shiffman, S. Pol, and R. Herring High sustained virologic response rate in treatment-naive HCV genotype 1a and 1b patients treated for 12 weeks with an interferon-free all-oral quad regimen: interim results J Hepatol 56 2012 S560
    • (2012) J Hepatol , vol.56 , pp. 560
    • Sulkowski, M.1    Rodriguez-Torres, M.2    Lawitz, E.3    Shiffman, M.4    Pol, S.5    Herring, R.6
  • 88
    • 19644393931 scopus 로고    scopus 로고
    • Structure of the zinc-binding domain of an essential component of the hepatitis C virus replicase
    • T.L. Tellinghuisen, J. Marcotrigiano, and C.M. Rice Structure of the zinc-binding domain of an essential component of the hepatitis C virus replicase Nature 435 7040 2005 374 379
    • (2005) Nature , vol.435 , Issue.7040 , pp. 374-379
    • Tellinghuisen, T.L.1    Marcotrigiano, J.2    Rice, C.M.3
  • 89
    • 84865285928 scopus 로고    scopus 로고
    • Daclatasvir for previously untreated chronic hepatitis C genotype-1 infection: A randomised, parallel-group, double-blind, placebo-controlled, dose-finding, phase 2a trial
    • Epub ahead of print
    • S. Pol, R.H. Ghalib, V.K. Rustgi, C. Martorell, G.T. Everson, and H.A. Tatum Daclatasvir for previously untreated chronic hepatitis C genotype-1 infection: a randomised, parallel-group, double-blind, placebo-controlled, dose-finding, phase 2a trial Lancet Infect Dis 2012 Epub ahead of print
    • (2012) Lancet Infect Dis
    • Pol, S.1    Ghalib, R.H.2    Rustgi, V.K.3    Martorell, C.4    Everson, G.T.5    Tatum, H.A.6
  • 90
    • 84873054024 scopus 로고    scopus 로고
    • A description of virologic escape in HCV genotype 1-infected patients treated with daclatasvir (BMS-790052) in combination with ribavirin and peginterferon alfa-2a or peginterferon alfa-2b
    • F. McPhee, D. Hernandez, F. Yu, J. Ueland, K. Chayama, and J. Toyota A description of virologic escape in HCV genotype 1-infected patients treated with daclatasvir (BMS-790052) in combination with ribavirin and peginterferon alfa-2a or peginterferon alfa-2b J Hepatol 56 2012 S473
    • (2012) J Hepatol , vol.56 , pp. 473
    • McPhee, F.1    Hernandez, D.2    Yu, F.3    Ueland, J.4    Chayama, K.5    Toyota, J.6
  • 91
    • 84865290463 scopus 로고    scopus 로고
    • Confirmation that quadruple therapy with daclatasvir (NS5A inhibitor), asunaprevir (NS3 inhibitor) and peginterferon/ribavirin results in high rate of SVR4 in HCV genotype 1 null responders
    • A. Lok, D. Gardiner, C. Hezode, E. Lawitz, M. Bourliere, and G. Everson Confirmation that quadruple therapy with daclatasvir (NS5A inhibitor), asunaprevir (NS3 inhibitor) and peginterferon/ribavirin results in high rate of SVR4 in HCV genotype 1 null responders J Hepatol 56 2012 S557
    • (2012) J Hepatol , vol.56 , pp. 557
    • Lok, A.1    Gardiner, D.2    Hezode, C.3    Lawitz, E.4    Bourliere, M.5    Everson, G.6
  • 92
    • 84866786074 scopus 로고    scopus 로고
    • Safety and antiviral activity of ABT-267, a novel NS5A inhibitor, during 3-day monotherapy: First study in HCV genotype-1 (GT1)-infected treatment-naive subjects
    • E. Lawitz, T. Marbury, A. Campbell, E. Dumas, M. Kapoor, and T. Pilot-Matias Safety and antiviral activity of ABT-267, a novel NS5A inhibitor, during 3-day monotherapy: first study in HCV genotype-1 (GT1)-infected treatment-naive subjects J Hepatol 56 2012 S469 S470
    • (2012) J Hepatol , vol.56
    • Lawitz, E.1    Marbury, T.2    Campbell, A.3    Dumas, E.4    Kapoor, M.5    Pilot-Matias, T.6
  • 93
    • 84870411432 scopus 로고    scopus 로고
    • Persistence of NS5A GS-5885 drug resistance mutations following 3 days of monotherapy in genotype-1 HCV patients is dependent on the HCV subtype and specific mutation
    • K.A. Wong, A. Worth, D.M. Brainard, E. Lawitz, M.D. Miller, and H. Mo Persistence of NS5A GS-5885 drug resistance mutations following 3 days of monotherapy in genotype-1 HCV patients is dependent on the HCV subtype and specific mutation J Hepatol 56 2012 S482
    • (2012) J Hepatol , vol.56 , pp. 482
    • Wong, K.A.1    Worth, A.2    Brainard, D.M.3    Lawitz, E.4    Miller, M.D.5    Mo, H.6
  • 94
    • 65449171953 scopus 로고    scopus 로고
    • Telaprevir and peginterferon with or without ribavirin for chronic HCV infection
    • C. Hezode, N. Forestier, G. Dusheiko, P. Ferenci, S. Pol, and T. Goeser Telaprevir and peginterferon with or without ribavirin for chronic HCV infection N Engl J Med 360 18 2009 1839 1850
    • (2009) N Engl J Med , vol.360 , Issue.18 , pp. 1839-1850
    • Hezode, C.1    Forestier, N.2    Dusheiko, G.3    Ferenci, P.4    Pol, S.5    Goeser, T.6
  • 96
    • 84864354805 scopus 로고    scopus 로고
    • Refinement of stopping rules during treatment of hepatitis C-genotype 1 infection with boceprevir combined with peginterferon/ribavirin
    • Epub ahead of print
    • I.M. Jacobson, P. Marcellin, S. Zeuzem, M.S. Sulkowski, R. Esteban, and F. Poordad Refinement of stopping rules during treatment of hepatitis C-genotype 1 infection with boceprevir combined with peginterferon/ribavirin Hepatology 2012 Epub ahead of print
    • (2012) Hepatology
    • Jacobson, I.M.1    Marcellin, P.2    Zeuzem, S.3    Sulkowski, M.S.4    Esteban, R.5    Poordad, F.6
  • 97
    • 78049527728 scopus 로고    scopus 로고
    • Oral combination therapy with a nucleoside polymerase inhibitor (RG7128) and danoprevir for chronic hepatitis C genotype 1 infection (INFORM-1): A randomised, double-blind, placebo-controlled, dose-escalation trial
    • E.J. Gane, S.K. Roberts, C.A. Stedman, P.W. Angus, B. Ritchie, and R. Elston Oral combination therapy with a nucleoside polymerase inhibitor (RG7128) and danoprevir for chronic hepatitis C genotype 1 infection (INFORM-1): a randomised, double-blind, placebo-controlled, dose-escalation trial Lancet 376 9751 2010 1467 1475
    • (2010) Lancet , vol.376 , Issue.9751 , pp. 1467-1475
    • Gane, E.J.1    Roberts, S.K.2    Stedman, C.A.3    Angus, P.W.4    Ritchie, B.5    Elston, R.6
  • 98
    • 84865280447 scopus 로고    scopus 로고
    • Dual oral therapy with the NS5A inhibitor daclatasvir (BMS-790052) and NS3 protease inhibitor asunaprevir (BMS-650032) in HCV genotype 1b-Infected null responders or ineligible/intolerant to peginterferon/ribavirin
    • F. Suzuki, K. Ikeda, J. Toyota, Y. Karino, T. Ohmura, and K. Chayama Dual oral therapy with the NS5A inhibitor daclatasvir (BMS-790052) and NS3 protease inhibitor asunaprevir (BMS-650032) in HCV genotype 1b-Infected null responders or ineligible/intolerant to peginterferon/ribavirin J Hepatol 56 2012 S7 S8
    • (2012) J Hepatol , vol.56
    • Suzuki, F.1    Ikeda, K.2    Toyota, J.3    Karino, Y.4    Ohmura, T.5    Chayama, K.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.