Inhibition of phosphatidylcholine-specific phospholipase C interferes with proliferation and survival of tumor initiating cells in squamous cell carcinoma

PLoS ONE

Volumn 10, Issue 9, 2015, Pages

  Cecchetti, Serena ^a   Bortolomai, Ileana ^b   Ferri, Renata ^b   Mercurio, Laura ^a   Canevari, Silvana ^b   Podo, Franca ^a   Miotti, Silvia ^b   Iorio, Egidio ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^b NATIONAL CANCER INSTITUTE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDE DEHYDROGENASE ISOENZYME 1; MESSENGER RNA; NESTIN; OCTAMER TRANSCRIPTION FACTOR 4; PHOSPHATIDYLCHOLINE SPECIFIC PHOSPHOLIPASE C; PHOSPHOLIPASE C; TRANSCRIPTION FACTOR NANOG; TRICYCLO[4.3.0.1]DECAN 9 YL XANTHOGENATE; UNCLASSIFIED DRUG; BRIDGED COMPOUND; EPIDERMAL GROWTH FACTOR RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLCHOLINE-SPECIFIC PHOSPHOLIPASE C; PROTEIN KINASE B; THIOKETONE; TRICYCLODECANE-9-YL-XANTHOGENATE;

ALDH1 GENE; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CELL PROLIFERATION; CELL SURVIVAL; CELL VIABILITY; CELLULAR DISTRIBUTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INHIBITION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; IC50; KERATINOCYTE; NANOG GENE; NESTIN GENE; OCT4 GENE; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SQUAMOUS CELL CARCINOMA; SQUAMOUS CELL CARCINOMA CELL LINE; TUMOR CELL; TUMOR INITIATING CELL; ANTAGONISTS AND INHIBITORS; CANCER STEM CELL; CELL SELF-RENEWAL; DRUG EFFECTS; METABOLISM; PHOSPHORYLATION; PROTEIN TRANSPORT; TUMOR CELL LINE;

BRIDGED-RING COMPOUNDS; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SELF RENEWAL; CELL SURVIVAL; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; KERATINOCYTES; NEOPLASTIC STEM CELLS; PHOSPHORYLATION; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, EPIDERMAL GROWTH FACTOR; THIONES; TYPE C PHOSPHOLIPASES;

EID: 84946907955     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0136120     Document Type: Article

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