The effect of resveratrol and its methylthio-derivatives on EGFR and Stat3 activation in human HaCaT and A431 cells

Molecular and Cellular Biochemistry

Volumn 396, Issue 1-2, 2014, Pages 221-228

  Cichocki, Michal ^a   Szaefer, Hanna ^a   Krajka Kuźniak, Violetta ^a   Baer Dubowska, Wanda ^a  

^a POZNAN UNIVERSITY OF MEDICAL SCIENCES   (Poland)

Author keywords

A431; EGFR; HaCaT; Methylthiostilbenes; Resveratrol; Stat3

Indexed keywords

3,5-DIMETHOXY-4'-METHYLTHIOSTILBENE; 3-METHOXY-4'-METHYLTHIOSTILBENE; EGFR PROTEIN, HUMAN; EPIDERMAL GROWTH FACTOR RECEPTOR; RESVERATROL; STAT3 PROTEIN; STAT3 PROTEIN, HUMAN; STILBENE DERIVATIVE; SULFIDE;

CELL SURVIVAL; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; HUMAN; KERATINOCYTE; METABOLISM; PHOSPHORYLATION; STRUCTURE ACTIVITY RELATION; TUMOR CELL LINE;

CELL LINE, TUMOR; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; KERATINOCYTES; PHOSPHORYLATION; RECEPTOR, EPIDERMAL GROWTH FACTOR; STAT3 TRANSCRIPTION FACTOR; STILBENES; STRUCTURE-ACTIVITY RELATIONSHIP; SULFIDES;

EID: 84907590384     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-014-2157-5     Document Type: Article

References (30)

1. Pastore S, Mascia F, Mariani V, Girolomoni G (2008) The epidermal growth factor receptor system in skin repair and inflammation. Invest Dermatol 128(6):1365-1374
2. Herbst RS (2004) Review of epidermal growth factor receptor biology. Int J Radiat Oncol Biol Phys 59(2 Suppl):21-26
3. Pastore S, Lulli D, Fidanza P, Potapovich AI, Kostyuk VA, De Luca C, Mikhal'chik E, Korkina LG (2012) Plant polyphenols regulate chemokine expression and tissue repair in human keratinocytes through interaction with cytoplasmic and nuclear components of epidermal growth factor receptor system. Antioxid Redox Signal 16(4):314-328
4. Macias E, Rao D, DiGiovanni J (2013) Role of stat3 in skin carcinogenesis: insights gained from relevant mouse models. J Skin Cancer 2013:684050. doi: 10.1155/2013/684050
5. Yu LJ, Wu ML, Li H, Chen XY, Wang Q, Sun Y, Kong QY, Liu J (2008) Inhibition of STAT3 expression and signaling in resveratrol-differentiated medulloblastoma cells. Neoplasia 10(7):736-744
6. Carpenter RL, Lo HW (2014) STAT3 target genes relevant to human cancers. Cancers (Basel) 6(2):897-925
7. Korkina LG, Pastore S, De Luca C, Kostyuk VA (2008) Metabolism of plant polyphenols in the skin: beneficial versus deleterious effects. Curr Drug Metab 9(8):710-729
8. Nakata R, Takahashi S, Inoue H (2012) Recent advances in the study on resveratrol. Biol Pharm Bull 35(3):273-279
9. Aluyen JK, Ton QN, Tran T, Yang AE, Gottlieb HB, Bellanger RA (2012) Resveratrol: potential as anticancer agent. J Diet Suppl 9(1):45-56
10. Ndiaye M, Kumar R, Ahmad N (2011) Resveratrol in cancer management: where are we and where we go from here? Ann N Y Acad Sci 1215:144-149
11. Szekeres T, Fritzer-Szekeres M, Saiko P, Jäger W (2010) Resveratrol and resveratrol analogues-structure-activity relationship. Pharm Res 27(6):1042-1048
12. Mikstacka R, Baer-Dubowska W, Wieczorek M, Sobiak S (2008) Thiomethylstilbenes as inhibitors of CYP1A1, CYP1A2 and CYP1B1 activities. Mol Nutr Food Res 52(Suppl 1):S77-S83
13. Mikstacka R, Rimando AM, Dutkiewicz Z, Stefański T, Sobiak S (2012) Design, synthesis and evaluation of the inhibitory selectivity of novel trans-resveratrol analogues on human recombinant CYP1A1, CYP1A2 and CYP1B1. Bioorg Med Chem 20(17):5117-5126
14. Yang H, Baur JA, Chen A, Miller C, Sinclair DA (2007) Design and synthesis of compounds that extend yeast replicative lifespan. Aging Cell 6(1):35-43
15. Szaefer H, Cichocki M, Krajka-Kuźniak V, Stefański T, Sobiak S, Licznerska B, Baer-Dubowska W (2014) The effect of resveratrol and its methylthio-derivatives on NF-κB and AP-1 signaling pathways in HaCaT keratinocytes. Pharmacol Rep 66(5):732-740. doi: 10.1016/j.pharep.2014.03.012
16. Laemmli UK (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227(5259):680-685
17. Towbin H, Staehelin T, Gordon J (1979) Electrophoretic transfer of proteins from polyarylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci USA 76(9):4350-4354
18. Jin S, Lu D, Ye S, Ye H, Zhu L, Feng Z, Liu S, Wang D, Hu Q (2005) A simplified probe preparation for ELISA-based NF-kappaB activity assay. J Biochem Biophys Methods 65(1):20-29
19. Craven RJ, Lightfoot H, Cance WG (2003) A decade of tyrosine kinases: from gene discovery to therapeutics. Surg Oncol 12(1):39-49
20. Lin SY, Makino K, Xia W, Matin A, Wen Y, Kwong KY, Bourguignon L, Hung MC (2001) Nuclear localization of EGF receptor and its potential new role as a transcription factor. Nat Cell Biol 3(9):802-808
21. Offterdinger M, Schöfer C, Weipoltshammer K, Grunt TW (2002) c-erbB-3: a nuclear protein in mammary epithelial cells. J Cell Biol 157(6):929-939
22. Dowlati A, Nethery D, Kern JA (2004) Combined inhibition of epidermal growth factor receptor and JAK/STAT pathways results in greater growth inhibition in vitro than single agent therapy. Mol Cancer Ther 3(4):459-463
23. Whitlock NC, Baek SJ (2012) The anticancer effects of resveratrol: modulation of transcription factors. Nutr Cancer 64(4):493-502
24. Quadros MR, Peruzzi F, Kari C, Rodeck U (2004) Complex regulation of signal transducers and activators of transcription 3 activation in normal and malignant keratinocytes. Cancer Res 64(11):3934-3939
25. Abe M, Kuroda Y, Hirose M, Watanabe Y, Nakano M, Handa T (2006) Inhibition of autophosphorylation of epidermal growth factor receptor by small peptides in vitro. Br J Pharmacol 147(4):402-411
26. Eden ER, Huang F, Sorkin A, Futter CE (2012) The role of EGF receptor ubiquitination in regulating its intracellular traffic. Traffic 13(2):329-337
27. Kondratov KA, Chernorudskiy AL, Amosova AP, Kornilova ES (2009) Termination of tyrphostin AG1478 application results in different recovery of EGF receptor tyrosine residues 1045 and 1173 phosphorylation in A431 cells. Cell Biol Int 34(1):81-87
28. Kundu JK, Shin YK, Kim SH, Surh YJ (2006) Resveratrol inhibits phorbol ester-induced expression of COX-2 and activation of NF-kappaB in mouse skin by blocking IkappaB kinase activity. Carcinogenesis 27(7):1465-1474
29. Cichocki M, Szamałek M, Baer-Dubowska W (2012) Correlation between EGFR Y1068 tyrosine phosphorylation and AP-1 activation by tumor promoter 12-O-tetradecanoylphorbol-13-acetate in mouse skin. Environ Toxicol Pharmacol 33(1):92-97
30. Lo HW, Hsu SC, Ali-Seyed M, Gunduz M, Xia W, Wei Y, Bartholomeusz G, Shih JY, Hung MC (2005) Nuclear interaction of EGFR and STAT3 in the activation of the iNOS/NO pathway. Cancer Cell 7(6):575-589