Tumor formation and drug resistance properties of human glioblastoma side population cells

Molecular Medicine Reports

Volumn 11, Issue 6, 2015, Pages 4309-4314

  Chen, Dong ^a  

^a TIANJIN HUANHU HOSPITAL   (China)

Author keywords

Cancer stem cells; Chemotherapy; Glioblastoma; Multidrug resistance; Side population

Indexed keywords

ADAPTOR MOLECULE APOPTOSIS ASSOCIATED SPECK LIKE PROTEIN; CRYOPYRIN; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; MESSENGER RNA; PROTEIN; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; BIOLOGICAL MARKER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CYTOKINE RELEASE; DOWN REGULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; HYPERBARIC OXYGEN; MALE; MOTOR PERFORMANCE; NONHUMAN; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SHAM PROCEDURE; SPINAL CORD INJURY; SPRAGUE DAWLEY RAT; THERAPY EFFECT; TISSUE HOMOGENATE; WESTERN BLOTTING; CANCER STEM CELL; CELL TRANSFORMATION; DRUG EFFECTS; DRUG RESISTANCE; GENE EXPRESSION; GENETICS; GLIOBLASTOMA; HUMAN; IMMUNOPHENOTYPING; METABOLISM; MULTICELLULAR SPHEROID; SIDE POPULATION CELL; TUMOR CELL CULTURE; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; BIOMARKERS; CELL LINE, TUMOR; CELL TRANSFORMATION, NEOPLASTIC; DRUG RESISTANCE, NEOPLASM; GENE EXPRESSION; GLIOBLASTOMA; HUMANS; IMMUNOPHENOTYPING; NEOPLASTIC STEM CELLS; SIDE-POPULATION CELLS; SPHEROIDS, CELLULAR; TUMOR CELLS, CULTURED;

EID: 84924690043     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2015.3279     Document Type: Article

References (30)

1. Holland EC: Gliomagenesis: genetic alterations and mouse models. Nat Rev Genet 2: 120-129, 2001.
2. Kleihues P, Louis DN, Scheithauer BW, et al: The WHO classification of tumors of the nervous system. J Neuropathol Exp Neurol 61: 215-225, 2002.
3. Fukaya R, Ohta S, Yamaguchi M, et al: Isolation of cancer stem-like cells from a side population of a human glioblastoma cell line, SK-MG-1. Cancer Lett 291: 150-157, 2010.
4. Hirschmann-Jax C, Foster AE, Wulf GG, et al: A distinct 'side population of cells' with high drug efflux capacity in human tumor cells. Proc Natl Acad Sci USA 101: 14228-14233, 2004.
5. Patrawala L, Calhoun T, Schneider-Broussard R, Zhou J, Claypool K and Tang DG: Side population is enriched in tumorigenic, stem-like cancer cells, whereas ABCG2+ and ABCG2-cancer cells are similarly tumorigenic. Cancer Res 65: 6207-6219, 2005.
6. Lee TK, Castilho A, Ma S and Ng IO: Liver cancer stem cells: implications for a new therapeutic target. Liver Int 29: 955-965, 2009.
7. Al-Hajj M, Wicha MS, Benito-Hernandez A, Morrison SJ and Clarke MF: Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci USA 100: 3983-3988, 2003.
8. Dalerba P, Dylla SJ, Park IK, Liu R, Wang X, Cho RW, et al: Phenotypic characterization of human colorectal cancer stem cells. Proc Natl Acad Sci USA 104: 10158-10163, 2007.
9. Singh SK, Clarke ID, Terasaki M, et al: Identification of a cancer stem cell in human brain tumors, Cancer Res 63: 5821-5828, 2003.
10. Singh SK1, Hawkins C, Clarke ID, et al: Identification of human brain tumour initiating cells. Nature 432: 396-401, 2004.
11. Challen GA and Little MH: A side order of stem cells: the SP phenotype. Stem Cells 24: 3-12, 2006.
12. Ramachandran C and Melnick SJ: Multidrug resistance in human tumors-molecular diagnosis and clinical significance. Mol Diagn 4: 81-94, 1999.
13. Kondo T, Setoguchi T and Taga T: Persistence of a small subpopulation of cancer stem-like cells in the C6 glioma cell line. Proc Natl Acad Sci USA 101: 781-786, 2004.
14. Harris MA, Yang H and Low BE: Cancer stem cells are enriched in the side population cells in a mouse model of glioma. Cancer Res 68: 10051-10059, 2008.
15. Yanamoto S, Kawasaki G, Yamada S, et al: Isolation and characterization of cancer stem-like side population cells in human oral cancer cells. Oral Oncol 47: 855-860, 2011.
16. Yanamoto S, Kawasaki G, Yoshitomi I, Iwamoto T, Hirata K and Mizuno A: Clinicopathologic significance of EpCAM expression in squamous cell carcinoma of the tongue and its possibility as a potential target for tongue cancer gene therapy. Oral Oncol 43: 869-877, 2007.
17. Goodell MA, Brose K, Paradis G, Conner AS and Mulligan RC: Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo. J Exp Med 183: 1797-1806, 1996.
18. Diestra JE, Scheffer GL, Català I, et al: Frequent expression of the multi-drug resistance-associated protein BCRP/MXR/ABCP/ ABCG2 in human tumours detected by the BXP-21 monoclonal antibody in paraffin-embedded material. J Pathol 198: 213-219, 2002.
19. Lee J, Kotliarova S, Kotliarov Y, et al: Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines. Cancer Cell 9: 391-403, 2006.
20. Calabrese C, Poppleton H, Kocak M, et al: A perivascular niche for brain tumor stem cells. Cancer Cell 11: 69-82, 2007.
21. Bleau AM, Hambardzumyan D, Ozawa T, et al: PTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells. Cell Stem Cell 4: 226-235, 2009.
22. Gil J, Stembalska A, Pesz KA and Sasiadek MM: Cancer stem cells: the theory and perspectives in cancer therapy. J App Genet 49: 193-199, 2008.
23. Dean M, Fojo T and Bates S: Tumor stem cells and drug resistance. Nat Rev Cancer 5: 275-284, 2004.
24. Eramo A, Ricci-Vitiani L, Zeuner A, et al: Chemotherapy resistance of glioblastoma stem cells. Cell Death Differ 13: 1238-1241, 2006.
25. Zheng X, Shen G, Yang X and Liu W: Most C6 cells are cancer stem cells: evidence from clonal and population analyses. Cancer Res 67: 3691-3697, 2007.
26. Britton KM, Eyre R, Harvey IJ, et al: Breast cancer, side population cells and ABCG2 expression. Cancer Lett 323: 97-105, 2012.
27. Robey RW, Shukla S, Finley EM, Oldham RK, et al: Inhibition of P-glycoprotein (ABCB1)-and multidrug resistance-associated protein 1 (ABCC1)-mediated transport by the orally administered inhibitor, CBT-1((R)). Biochem Pharmacol 75: 1302-1312, 2008.
28. Shih AH and Holland EC: Notch signaling enhances nestin expression in gliomas, Neoplasia 8: 1072-1082, 2006.
29. Solecki DJ, Liu XL, Tomoda T, Fang Y and Hatten ME: Activated Notch2 signaling inhibits differentiation of cerebellar granule neuron precursors by maintaining proliferation. Neuron 31: 557-568, 2001.
30. Du Z, Jia D, Liu S, et al: Oct4 is expressed in human gliomas and promotes colony formation in glioma cells. Glia 57: 724-733, 2009.