Phosphatidylcholine-specific phospholipase C activation is required for CCR5-dependent, NF-kB-driven CCL2 secretion elicited in response to HIV-1 gp120 in human primary macrophages

Blood

Volumn 111, Issue 7, 2008, Pages 3355-3363

  Fantuzzi, Laura ^a   Spadaro, Francesca ^a   Purificato, Cristina ^a   Cecchetti, Serena ^a   Podo, Franca ^a   Belardelli, Filippo ^a   Gessani, Sandra ^a   Ramoni, Carlo ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR5; GLYCOPROTEIN GP 120; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 1; PHOSPHATIDYLCHOLINE SPECIFIC PHOSPHOLIPASE C; PHOSPHOLIPASE C; UNCLASSIFIED DRUG; CCL2 PROTEIN, HUMAN; CCL4 PROTEIN, HUMAN; GP120 PROTEIN, HUMAN IMMUNODEFICIENCY VIRUS 1; PHOSPHATIDYLCHOLINE-SPECIFIC PHOSPHOLIPASE C;

ARTICLE; BYSTANDER EFFECT; CELLULAR DISTRIBUTION; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ASSAY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; MACROPHAGE; MONOCYTE DERIVED MACROPHAGE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; UPREGULATION; VIRUS REPLICATION; CELL CULTURE; CONFOCAL MICROSCOPY; GENETICS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; METABOLISM; PATHOLOGY; SECRETION; TIME; VIROLOGY;

BYSTANDER EFFECT; CELLS, CULTURED; CHEMOKINE CCL2; CHEMOKINE CCL4; ENZYME ACTIVATION; HIV ENVELOPE PROTEIN GP120; HIV INFECTIONS; HIV-1; HUMANS; MACROPHAGES; MICROSCOPY, CONFOCAL; NF-KAPPA B; RECEPTORS, CCR5; SIGNAL TRANSDUCTION; TIME FACTORS; TYPE C PHOSPHOLIPASES; VIRUS REPLICATION;

EID: 43549122154     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2007-08-104901     Document Type: Article

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