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Volumn 11, Issue 12, 2009, Pages 1301-1308

Nuclear magnetic resonance detects phosphoinositide 3-kinase/AKT- independent traits common to pluripotent murine embryonic stem cells and their malignant counterparts

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; CHOLINE; GLYCEROPHOSPHORYLCHOLINE; INOSITOL PHOSPHATE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOLIPID; PHOSPHORYLCHOLINE; PROTEIN KINASE B;

EID: 72949106484     PISSN: 15228002     EISSN: 14765586     Source Type: Journal    
DOI: 10.1593/neo.09850     Document Type: Article
Times cited : (22)

References (50)
  • 1
    • 33747595791 scopus 로고    scopus 로고
    • Identification of genes involved in tumor-like properties of embryonic stem cells
    • Takahashi K, Ichisaka T, and Yamanaka S (2006). Identification of genes involved in tumor-like properties of embryonic stem cells. Methods Mol Biol 329, 449-458.
    • (2006) Methods Mol Biol , vol.329 , pp. 449-458
    • Takahashi, K.1    Ichisaka, T.2    Yamanaka, S.3
  • 2
    • 41449087009 scopus 로고    scopus 로고
    • Cancer: Inappropriate expression of stem cell programs?
    • Wang Y and Armstrong SA (2008). Cancer: inappropriate expression of stem cell programs? Cell Stem Cell 2, 297-299.
    • (2008) Cell Stem Cell , vol.2 , pp. 297-299
    • Wang, Y.1    Armstrong, S.A.2
  • 3
    • 42649112047 scopus 로고    scopus 로고
    • An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors
    • Ben-Porath I, Thomson MW, Carey VJ, Ge R, Bell GW, Regev A, and Weinberg RA (2008). An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors. Nat Genet 40, 499-507.
    • (2008) Nat Genet , vol.40 , pp. 499-507
    • Ben-Porath, I.1    Thomson, M.W.2    Carey, V.J.3    Ge, R.4    Bell, G.W.5    Regev, A.6    Weinberg, R.A.7
  • 4
    • 0038100185 scopus 로고    scopus 로고
    • Role of ERas in promoting tumour-like properties in mouse embryonic stem cells
    • Takahashi K, Mitsui K, and Yamanaka S (2003). Role of ERas in promoting tumour-like properties in mouse embryonic stem cells. Nature 423, 541-545.
    • (2003) Nature , vol.423 , pp. 541-545
    • Takahashi, K.1    Mitsui, K.2    Yamanaka, S.3
  • 5
    • 48649093780 scopus 로고    scopus 로고
    • Nuclear magnetic resonance metabolomic footprinting of human hepatic stem cells and hepatoblasts cultured in hyaluronan-matrix hydrogels
    • Turner WS, Seagle C, Galanko JA, Favorov O, Prestwich GD, Macdonald JM, and Reid LM (2008). Nuclear magnetic resonance metabolomic footprinting of human hepatic stem cells and hepatoblasts cultured in hyaluronan-matrix hydrogels. Stem Cells 26, 1547-1555.
    • (2008) Stem Cells , vol.26 , pp. 1547-1555
    • Turner, W.S.1    Seagle, C.2    Galanko, J.A.3    Favorov, O.4    Prestwich, G.D.5    Macdonald, J.M.6    Reid, L.M.7
  • 6
    • 0141954157 scopus 로고    scopus 로고
    • Choline phospholipid metabolism: A target in cancer cells?
    • Ackerstaff E, Glunde K, and Bhujwalla ZM (2003). Choline phospholipid metabolism: a target in cancer cells? J Cell Biochem 90, 525-533.
    • (2003) J Cell Biochem , vol.90 , pp. 525-533
    • Ackerstaff, E.1    Glunde, K.2    Bhujwalla, Z.M.3
  • 7
    • 3042562283 scopus 로고    scopus 로고
    • Molecular causes of the aberrant choline phospholipid metabolism in breast cancer
    • Glunde K, Jie C, and Bhujwalla ZM (2004). Molecular causes of the aberrant choline phospholipid metabolism in breast cancer. Cancer Res 64, 4270-4276.
    • (2004) Cancer Res , vol.64 , pp. 4270-4276
    • Glunde, K.1    Jie, C.2    Bhujwalla, Z.M.3
  • 8
    • 0035328487 scopus 로고    scopus 로고
    • Detection of increased choline compounds with proton nuclear magnetic resonance spectroscopy subsequent to malignant transformation of human prostatic epithelial cells
    • Ackerstaff E, Pflug BR, Nelson JB, and Bhujwalla ZM (2001). Detection of increased choline compounds with proton nuclear magnetic resonance spectroscopy subsequent to malignant transformation of human prostatic epithelial cells. Cancer Res 61, 3599-3603.
    • (2001) Cancer Res , vol.61 , pp. 3599-3603
    • Ackerstaff, E.1    Pflug, B.R.2    Nelson, J.B.3    Bhujwalla, Z.M.4
  • 11
    • 0032893756 scopus 로고    scopus 로고
    • Malignant transformation alters membrane choline phospholipid metabolism of human mammary epithelial cells
    • Aboagye EO and Bhujwalla ZM (1999). Malignant transformation alters membrane choline phospholipid metabolism of human mammary epithelial cells. Cancer Res 59, 80-84.
    • (1999) Cancer Res , vol.59 , pp. 80-84
    • Aboagye, E.O.1    Bhujwalla, Z.M.2
  • 12
    • 0035793795 scopus 로고    scopus 로고
    • Magnetic resonance detects changes in phosphocholine associated with Ras activation and inhibition in NIH 3T3 cells
    • Ronen SM, Jackson LE, Beloueche M, and Leach MO (2001). Magnetic resonance detects changes in phosphocholine associated with Ras activation and inhibition in NIH 3T3 cells. Br J Cancer 84, 691-696.
    • (2001) Br J Cancer , vol.84 , pp. 691-696
    • Ronen, S.M.1    Jackson, L.E.2    Beloueche, M.3    Leach, M.O.4
  • 14
    • 34748816222 scopus 로고    scopus 로고
    • Choline kinase α in cancer prognosis and treatment
    • Glunde K and Bhujwalla ZM (2007). Choline kinase α in cancer prognosis and treatment. Lancet Oncol 8, 855-857.
    • (2007) Lancet Oncol , vol.8 , pp. 855-857
    • Glunde, K.1    Bhujwalla, Z.M.2
  • 15
    • 34748827371 scopus 로고    scopus 로고
    • Ramirez de Molina A, Sarmentero-Estrada J, Belda-Iniesta C, Taron M, Ramirez dMV, Cejas P, Skrzypski M, Gallego-Ortega D, de Castro J, Casado E, et al. (2007). Expression of choline kinase α to predict outcome in patients with early-stage non-small-cell lung cancer: a retrospective study. Lancet Oncol 8, 889-897.
    • Ramirez de Molina A, Sarmentero-Estrada J, Belda-Iniesta C, Taron M, Ramirez dMV, Cejas P, Skrzypski M, Gallego-Ortega D, de Castro J, Casado E, et al. (2007). Expression of choline kinase α to predict outcome in patients with early-stage non-small-cell lung cancer: a retrospective study. Lancet Oncol 8, 889-897.
  • 16
    • 65949115729 scopus 로고    scopus 로고
    • Pharmaco-dynamic markers for choline kinase down-regulation in breast cancer cells
    • Nimmagadda S, Glunde K, Pomper MG, and Bhujwalla ZM (2009). Pharmaco-dynamic markers for choline kinase down-regulation in breast cancer cells. Neoplasia 11, 477-484.
    • (2009) Neoplasia , vol.11 , pp. 477-484
    • Nimmagadda, S.1    Glunde, K.2    Pomper, M.G.3    Bhujwalla, Z.M.4
  • 17
    • 22544467022 scopus 로고    scopus 로고
    • Phosphorylation of the yeast choline kinase by protein kinase C. Identification of Ser25 and Ser30 as major sites of phosphorylation
    • Choi MG, Kurnov V, Kersting MC, Sreenivas A, and Carman GM (2005). Phosphorylation of the yeast choline kinase by protein kinase C. Identification of Ser25 and Ser30 as major sites of phosphorylation. J Biol Chem 280, 26105-26112.
    • (2005) J Biol Chem , vol.280 , pp. 26105-26112
    • Choi, M.G.1    Kurnov, V.2    Kersting, M.C.3    Sreenivas, A.4    Carman, G.M.5
  • 18
    • 0037203980 scopus 로고    scopus 로고
    • Regulation of choline kinase activity by Ras proteins involves Ral-GDS and PI3K
    • Ramirez de Molina A, Penalva V, Lucas L, and Lacal JC (2002). Regulation of choline kinase activity by Ras proteins involves Ral-GDS and PI3K. Oncogene 21, 937-946.
    • (2002) Oncogene , vol.21 , pp. 937-946
    • Ramirez de Molina, A.1    Penalva, V.2    Lucas, L.3    Lacal, J.C.4
  • 20
    • 0018713123 scopus 로고
    • The induction of antigenic changes in a teratocarcinoma stem cell line (F9) by retinoic acid
    • Solter D, Shevinsky L, Knowles BB, and Strickland S (1979). The induction of antigenic changes in a teratocarcinoma stem cell line (F9) by retinoic acid. Dev Biol 70, 515-521.
    • (1979) Dev Biol , vol.70 , pp. 515-521
    • Solter, D.1    Shevinsky, L.2    Knowles, B.B.3    Strickland, S.4
  • 21
    • 34347238237 scopus 로고    scopus 로고
    • Global gene expression profiling reveals similarities and differences among mouse pluripotent stem cells of different origins and strains
    • Sharova LV, Sharov AA, Piao Y, Shaik N, Sullivan T, Stewart CL, Hogan BL, and Ko MS (2007). Global gene expression profiling reveals similarities and differences among mouse pluripotent stem cells of different origins and strains. Dev Biol 307, 446-459.
    • (2007) Dev Biol , vol.307 , pp. 446-459
    • Sharova, L.V.1    Sharov, A.A.2    Piao, Y.3    Shaik, N.4    Sullivan, T.5    Stewart, C.L.6    Hogan, B.L.7    Ko, M.S.8
  • 23
    • 36148989929 scopus 로고    scopus 로고
    • High-throughput tissue extraction protocol for NMR- and MS-based metabolomics
    • Wu H, Southam AD, Hines A, and Viant MR (2008). High-throughput tissue extraction protocol for NMR- and MS-based metabolomics. Anal Biochem 372, 204-212.
    • (2008) Anal Biochem , vol.372 , pp. 204-212
    • Wu, H.1    Southam, A.D.2    Hines, A.3    Viant, M.R.4
  • 24
    • 79960698472 scopus 로고
    • Water suppression that works - excitation sculpting using arbitrary waveforms and pulsed field gradients
    • Hwang TL and Shaka AJ (1995). Water suppression that works - excitation sculpting using arbitrary waveforms and pulsed field gradients. J Magn Reson A 112, 275-279.
    • (1995) J Magn Reson A , vol.112 , pp. 275-279
    • Hwang, T.L.1    Shaka, A.J.2
  • 25
    • 15844388806 scopus 로고    scopus 로고
    • Suppression of strong coupling artefacts in J -spectra
    • Thrippleton MJ, Edden RA, and Keeler J (2005). Suppression of strong coupling artefacts in J -spectra. J Magn Reson 174, 97-109.
    • (2005) J Magn Reson , vol.174 , pp. 97-109
    • Thrippleton, M.J.1    Edden, R.A.2    Keeler, J.3
  • 26
    • 0347269282 scopus 로고    scopus 로고
    • NMRLaB-advanced NMR data processing in MATLAB
    • Günther UL, Ludwig C, and Rüterjans H (2000). NMRLaB-advanced NMR data processing in MATLAB. J Magn Reson 145, 201-208.
    • (2000) J Magn Reson , vol.145 , pp. 201-208
    • Günther, U.L.1    Ludwig, C.2    Rüterjans, H.3
  • 29
    • 0034028901 scopus 로고    scopus 로고
    • Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells
    • Niwa H, Miyazaki J, and Smith AG (2000). Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells. Nat Genet 24, 372-376.
    • (2000) Nat Genet , vol.24 , pp. 372-376
    • Niwa, H.1    Miyazaki, J.2    Smith, A.G.3
  • 30
    • 0021333676 scopus 로고
    • Characterization of a pluripotent stem cell line derived from a mouse embryo
    • Wobus AM, Holzhausen H, Jakel P, and Schoneich J (1984). Characterization of a pluripotent stem cell line derived from a mouse embryo. Exp Cell Res 152, 212-219.
    • (1984) Exp Cell Res , vol.152 , pp. 212-219
    • Wobus, A.M.1    Holzhausen, H.2    Jakel, P.3    Schoneich, J.4
  • 31
    • 33646549601 scopus 로고    scopus 로고
    • Activation of Akt signaling is sufficient to maintain pluripotency in mouse and primate embryonic stem cells
    • Watanabe S, Umehara H, Murayama K, Okabe M, Kimura T, and Nakano T (2006). Activation of Akt signaling is sufficient to maintain pluripotency in mouse and primate embryonic stem cells. Oncogene 25, 2697-2707.
    • (2006) Oncogene , vol.25 , pp. 2697-2707
    • Watanabe, S.1    Umehara, H.2    Murayama, K.3    Okabe, M.4    Kimura, T.5    Nakano, T.6
  • 32
    • 0037103988 scopus 로고    scopus 로고
    • Differential contributions of ERK and PI3-kinase to the regulation of cyclin D1 expression and to the control of the G1/S transition in mouse embryonic stem cells
    • Jirmanova L, Afanassieff M, Gobert-Gosse S, Markossian S, and Savatier P (2002). Differential contributions of ERK and PI3-kinase to the regulation of cyclin D1 expression and to the control of the G1/S transition in mouse embryonic stem cells. Oncogene 21, 5515-5528.
    • (2002) Oncogene , vol.21 , pp. 5515-5528
    • Jirmanova, L.1    Afanassieff, M.2    Gobert-Gosse, S.3    Markossian, S.4    Savatier, P.5
  • 33
    • 3342946059 scopus 로고    scopus 로고
    • PI 3-kinase activity is necessary for F9 mouse embryonic carcinoma cell proliferation
    • Lianguzova MS, Chuikin IA, and Pospelov VA (2004). PI 3-kinase activity is necessary for F9 mouse embryonic carcinoma cell proliferation. Tsitologiia 46, 26-34.
    • (2004) Tsitologiia , vol.46 , pp. 26-34
    • Lianguzova, M.S.1    Chuikin, I.A.2    Pospelov, V.A.3
  • 34
    • 0033371680 scopus 로고    scopus 로고
    • Tumour phospholipid metabolism
    • Podo F (1999). Tumour phospholipid metabolism. NMR Biomed 12, 413-439.
    • (1999) NMR Biomed , vol.12 , pp. 413-439
    • Podo, F.1
  • 35
    • 0030036565 scopus 로고    scopus 로고
    • Variations in energy and phospholipid metabolism in normal and cancer human mammary epithelial cells
    • Ting YL, Sherr D, and Degani H (1996). Variations in energy and phospholipid metabolism in normal and cancer human mammary epithelial cells. Anticancer Res 16, 1381-1388.
    • (1996) Anticancer Res , vol.16 , pp. 1381-1388
    • Ting, Y.L.1    Sherr, D.2    Degani, H.3
  • 36
    • 28844506274 scopus 로고    scopus 로고
    • Role of the phosphoinositide 3-kinase pathway in mouse embryonic stem (ES) cells
    • Takahashi K, Murakami M, and Yamanaka S (2005). Role of the phosphoinositide 3-kinase pathway in mouse embryonic stem (ES) cells. Biochem Soc Trans 33, 1522-1525.
    • (2005) Biochem Soc Trans , vol.33 , pp. 1522-1525
    • Takahashi, K.1    Murakami, M.2    Yamanaka, S.3
  • 37
    • 9144239955 scopus 로고    scopus 로고
    • Regulation of embryonic stem cell self-renewal by phosphoinositide 3-kinase-dependent signaling
    • Paling NR, Wheadon H, Bone HK, and Welham MJ (2004). Regulation of embryonic stem cell self-renewal by phosphoinositide 3-kinase-dependent signaling. J Biol Chem 279, 48063-48070.
    • (2004) J Biol Chem , vol.279 , pp. 48063-48070
    • Paling, N.R.1    Wheadon, H.2    Bone, H.K.3    Welham, M.J.4
  • 38
    • 19944429003 scopus 로고    scopus 로고
    • Contribution of the PI3K/Akt/PKB signal pathway to maintenance of self-renewal in human embryonic stem cells
    • Kim SJ, Cheon SH, Yoo SJ, Kwon J, Park JH, Kim CG, Rhee K, You S, Lee JY, Roh SI, et al. (2005). Contribution of the PI3K/Akt/PKB signal pathway to maintenance of self-renewal in human embryonic stem cells. FEBS Lett 579, 534-540.
    • (2005) FEBS Lett , vol.579 , pp. 534-540
    • Kim, S.J.1    Cheon, S.H.2    Yoo, S.J.3    Kwon, J.4    Park, J.H.5    Kim, C.G.6    Rhee, K.7    You, S.8    Lee, J.Y.9    Roh, S.I.10
  • 40
    • 0001715433 scopus 로고    scopus 로고
    • Choline kinase: A novel target for antitumor drugs
    • Lacal JC (2001). Choline kinase: a novel target for antitumor drugs. IDrugs 4, 419-426.
    • (2001) IDrugs , vol.4 , pp. 419-426
    • Lacal, J.C.1
  • 41
    • 0028957571 scopus 로고
    • Role of phospholipase D in laminin induced production of gelatinase A (MMP-2) in metastatic cells
    • Reich R, Blumenthal M, and Liscovitch M (1995). Role of phospholipase D in laminin induced production of gelatinase A (MMP-2) in metastatic cells. Clin Exp Metastasis 2, 134-140.
    • (1995) Clin Exp Metastasis , vol.2 , pp. 134-140
    • Reich, R.1    Blumenthal, M.2    Liscovitch, M.3
  • 42
    • 1342310966 scopus 로고    scopus 로고
    • Antisense targeting protein kinase A type I as a drug for integrated strategies of cancer therapy
    • Tortora G and Ciardiello F (2003). Antisense targeting protein kinase A type I as a drug for integrated strategies of cancer therapy. Ann N Y Acad Sci 1002, 236-243.
    • (2003) Ann N Y Acad Sci , vol.1002 , pp. 236-243
    • Tortora, G.1    Ciardiello, F.2
  • 43
    • 34250902930 scopus 로고    scopus 로고
    • Targeting the protein kinase C family: Are we there yet?
    • Mackay HJ and Twelves CJ (2007). Targeting the protein kinase C family: are we there yet? Nat Rev Cancer 7, 554-562.
    • (2007) Nat Rev Cancer , vol.7 , pp. 554-562
    • Mackay, H.J.1    Twelves, C.J.2
  • 45
    • 33746459740 scopus 로고    scopus 로고
    • Stem cell self-renewal and cancer cell proliferation are regulated by common networks that balance the activation of proto-oncogenes and tumor suppressors
    • Pardal R, Molofsky AV, He S, and Morrison SJ (2005). Stem cell self-renewal and cancer cell proliferation are regulated by common networks that balance the activation of proto-oncogenes and tumor suppressors. Cold Spring Harb Symp Quant Biol 70, 177-185.
    • (2005) Cold Spring Harb Symp Quant Biol , vol.70 , pp. 177-185
    • Pardal, R.1    Molofsky, A.V.2    He, S.3    Morrison, S.J.4
  • 46
  • 49
    • 0242367242 scopus 로고    scopus 로고
    • Comment on "'Stemness': Transcriptional profiling of embryonic and adult stem cells" and "a stem cell molecular signature
    • Fortunel NO, Otu HH, Ng HH, Chen J, Mu X, Chevassut T, Li X, Joseph M, Bailey C, Hatzfeld JA, et al. (2003). Comment on "'Stemness': transcriptional profiling of embryonic and adult stem cells" and "a stem cell molecular signature". Science 302, 393.
    • (2003) Science , vol.302 , pp. 393
    • Fortunel, N.O.1    Otu, H.H.2    Ng, H.H.3    Chen, J.4    Mu, X.5    Chevassut, T.6    Li, X.7    Joseph, M.8    Bailey, C.9    Hatzfeld, J.A.10
  • 50
    • 33751356224 scopus 로고    scopus 로고
    • Systems biology, metabolic modelling and metabolomics in drug discovery and development
    • Kell DB (2006). Systems biology, metabolic modelling and metabolomics in drug discovery and development. Drug Discov Today 11, 1085-1092.
    • (2006) Drug Discov Today , vol.11 , pp. 1085-1092
    • Kell, D.B.1


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