The Prooxidant Action of Dietary Antioxidants Leading to Cellular DNA Breakage and Anticancer Effects: Implications for Chemotherapeutic Action Against Cancer

Cell Biochemistry and Biophysics

Volumn 67, Issue 2, 2013, Pages 431-438

  Ullah, M F ^a,c   Ahmad, Aamir ^b   Khan, Husain Y ^a   Zubair, H ^a   Sarkar, Fazlul H ^b   Hadi, S M ^a  

^a ALIGARH MUSLIM UNIVERSITY   (India)

^b WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF TENNESSEE   (United States)

Author keywords

Anticancer; Antioxidants; Copper; DNA breakage; Prooxidant action; Reactive oxygen species

Indexed keywords

ANIMALIA;

2,9 DIMETHYL 1,10 PHENANTHROLINE; ANTINEOPLASTIC AGENT; ANTIOXIDANT; COPPER; ISOFLAVONE DERIVATIVE; PHENANTHROLINE DERIVATIVE; REACTIVE OXYGEN METABOLITE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; THIOUREA;

ARTICLE; CELL DEATH; CELL NUCLEUS; CELL PROLIFERATION; CHEMISTRY; DIET; DNA STRAND BREAKAGE; DRUG EFFECT; DRUG INTERACTION; ELECTRON TRANSPORT; GENETICS; HUMAN; LYMPHOCYTE; MCF 7 CELL LINE; METABOLISM; OXIDATIVE STRESS;

ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; CELL DEATH; CELL NUCLEUS; CELL PROLIFERATION; COPPER; DIET; DNA BREAKS; DRUG INTERACTIONS; ELECTRON TRANSPORT; HUMANS; ISOFLAVONES; LYMPHOCYTES; MCF-7 CELLS; OXIDATIVE STRESS; PHENANTHROLINES; REACTIVE OXYGEN SPECIES; THIOBARBITURIC ACID REACTIVE SUBSTANCES; THIOUREA;

EID: 84886597790     PISSN: 10859195     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12013-011-9303-4     Document Type: Article

References (46)

1. Adlercreutz, H., Goldin, B. R., Gorbach, S. L., Hockerstedt, K., et al. (1995). Soybean phytoestrogens intake and cancer risk. Journal of Nutrition, 125, 757S-770S.
2. Park, O. J., & Sur, Y. J. (2004). Chemopreventive potential of epigallocatechin gallate and genistein: Evidence from epidemiological and laboratory studies. Toxicology Letters, 150, 43-56.
3. Barnes, S., Peterson, G., Grubbs, C., & Setchell, K. (1994). Potential role of dietary isoflavones in the prevention of cancer. Advances in Experimental Medicine and Biology, 354, 135-147.
4. Surh, Y. J. (2003). Cancer chemoprevention with dietary phytochemicals. Nature Reviews Cancer, 3, 768-780.
5. Schumacker, P. T. (2006). Reactive oxygen species in cancer cells: Live by the sword, die by the sword. Cancer Cell, 10, 175-176.
6. Chen, Q., Espey, M. G., Sun, A. Y., Pooput, C., Kirk, K. L., Krishna, M. C., et al. (2008). Pharmacologic doses of ascorbate act as a prooxidant and decrease growth aggressive tumor xenografts in mice. Proceedings of the National Academy of Sciences of the United States of America, 105, 11105-11109.
7. Inoue, M., Suzuki, R., Koide, T., Sakaguchi, N., Ogihara, Y., & Yabu, Y. (1994). Antioxidant, gallic acid, induces apoptosis in HL60RG cells. Biochemical and Biophysical Research Communications, 204, 898-904.
8. Ahmad, N., Feyes, D. K., Nieminen, A. L., Agarwal, R., & Mukhtar, H. (1997). Green tea constituent epigallocatechin-3-gallate, and induction of cell cycle arrest in human carcinoma cells. Journal of the National Cancer Institute, 89, 1881-1886.
9. Clement, M. V., Hirpara, J. L., Chawdhury, S. H., & Pervaiz, S. (1998). Chemopreventive agent resveratrol, a natural product derived from grapes, triggers CD95 signalling-dependent apoptosis in human tumor cells. Blood, 92, 996-1002.
10. Kuo, M. L., Huang, T. S., & Lin, J. K. (1996). Curcumin, an antioxidant and antitumor promoter, induces apoptosis in human leukemia cells. Biochimica et Biophysica Acta, 1317, 95-100.
11. Chang, K. L., Cheng, H. L., Huang, L. W., Hseih, B. S., et al. (2008). Combined effects of terazosin and genistein on a metastatic, hormone-independent human prostate cancer cell line. Cancer Letters, 276, 14-20.
12. Gupta, S., Hastak, K., Ahmad, N., Lewin, J. S., & Mukhtar, H. (2001). Inhibition of prostate carcinogenesis in TRAMP mice by oral infusion of green tea polyphenols. Proceedings of the National Academy of Sciences of the United States of America, 98, 10350-10355.
13. Orsolic, N., Terzic, S., Sver, L., & Basic, I. (2005). Honey-bee products in the prevention and therapy of murine transplantable tumors. Journal of the Science of Food and Agriculture, 85, 363-370.
14. Wang, Y., Eltoum, I. E., & Lamatiniere, C. A. (2007). Genistein chemoprevention of prostate cancer in TRAMP mice. Journal of Carcinogenesis, 6, 3-9.
15. Chen, Q., Espey, M. G., Krishna, M. C., Mitchell, J. B., Corpe, C. P., Buettner, G. R., et al. (2005). Pharmacologic ascorbic acid concentrations selectively kill cancer cells: Action as a pro-drug to deliver hydrogen peroxide to tissues. Proceedings of the National Academy of Sciences of the United States of America, 102, 13604-13609.
16. Chen, Z. P., Schell, J. B., Ho, C. T., & Chen, K. Y. (1998). Green tea epigallocatechin gallate shows a pronounced growth inhibitory effect on cancerous cells but not on their normal counterparts. Cancer Letters, 129, 173-179.
17. Lu, J., Ho, C. T., Ghai, G., & Chen, K. Y. (2000). Differential effects of theaflavin monogallates on cell growth, apoptosis, and Cox-2 gene expression in cancerous versus normal cells. Cancer Research, 60, 6465-6471.
18. Ahmad, M. S., Fazal, F., Rahman, A., Hadi, S. M., & Parish, J. H. (1992). Activities of flavonoids for the cleavage of DNA in the presence of Cu(II): Correlation with the generation of active oxygen species. Carcinogenesis, 13, 605-608.
19. Gali, H. U., Perchellet, E. M., Klish, D. S., Johnson, J. M., & Perchellet, J. P. (1992). Hydrolyzable tannins; potent inhibitors of hydroperoxide production and tumor promotion in the mouse skin treated with 12-O-tetradecanoyl phorbol-13-acetate in vivo. International Journal of Cancer, 51, 425-432.
20. Hadi, S. M., Asad, S. F., Singh, S., & Ahmad, A. (2000). A putative mechanism for anticancer and apoptosis inducing properties of plant-derived polyphenolic compounds. IUBMB Life, 50, 1-5.
21. Hadi, S. M., Bhat, S. H., Azmi, A. S., Hanif, S., et al. (2007). Oxidative breakage of cellular DNA by plant polyphenols: A putative mechanism for anticancer properties. Seminars in Cancer Biology, 17, 370-376.
22. Bhat, S. H., Azmi, A. S., Hanif, S., & Hadi, S. M. (2006). Ascorbic acid mobilizes endogenous copper in human peripheral lymphocytes leading to oxidative DNA breakage: A putative mechanism for anticancer properties. IJBCB, 38, 2074-2081.
23. 2. Journal of Biological Chemistry, 226, 20175-20184.
24. Ebadi, M., & Swanson, S. (1998). The status of zinc, copper and metallothionien in cancer patients. Progress in Clinical and Biological Research, 259, 61-67.
25. Margalioth, E. J., Udassin, R., Cohen, C., & Maor, J. (1987). Serum copper level in gynaecologic malignancies. American Journal of Obstetrics, 157, 93-96.
26. Yoshida, D., Ikeda, Y., & Nakazawa, S. (1993). Quantitative analysis of copper, zinc and copper/zinc ratio in selective human brain tumors. Journal of Neuro-oncology, 16, 109-115.
27. Ebara, M., Fukuda, H., Hanato, R., Saisho, H., et al. (2000). Relationship between zinc, copper and metallothionein in hepatocellular carcinoma and its surrounding liver parenchyma. Journal of Hepatology, 33, 415-422.
28. Zheng, L. F., Wei, Q. Y., Cai, Y. J., Fang, J. G., et al. (2006). DNA damage induced by resveratrol and its synthetic analogs in the presence of Cu(II) ions: Mechanism and structure-activity relationship. Free Radical Biology and Medicine, 41, 1807-1816.
29. Pool-Zoble, B. L., Guigas, C., Klein, R. G., Neudecker, C. H., Renner, H. W., & Schmezer, P. (1993). Assesment of genotoxic effects of lindane. Food and Chemical Toxicology, 31, 271-283.
30. Szeto, Y. T., Collins, A. R., & Benzie, I. F. F. (2002). Effects of dietary antioxidants on DNA damage in lysed cells using a modified comet assay procedure. Mutation Research, 500, 31-38.
31. Kasamatsu, T., Kohda, K., & Kawazoe, Y. (1996). Comparison of chemically induced DNA breakage in cellular and subcellular systems using the comet assay. Mutation Research, 369, 1-6.
32. Azmi, A. S., Bhat, S. H., & Hadi, S. M. (2005). Resveratrol-Cu(II) induced DNA breakage in human peripheral lymphocytes: Implications for anticancer properties. FEBS Letters, 579, 3131-3135.
33. Ramanathan, R., Das, N. P., & Tan, C. H. (1994). Effect of γ-linolenic acid, flavonoids and vitamins on cytotoxicity and lipid peroxidation. Free Radical Biology and Medicine, 16, 43-48.
34. Tice, R. R., Agurell, E., Anderson, D., Burlinson, B., Hartmann, A., Kobayashi, H., et al. (2000). Single cell gel electrophoresis/comet assay: Guidelines for invitro and invivo genetic toxicology testing. Environmental and Molecular Mutagenesis, 35, 206-221.
35. Quinlan, G. J., & Gutteridge, M. C. (1987). Oxygen radical damage to DNA by Rifamycin SV and copper ions. Biochemical Pharmacology, 36, 3629-3633.
36. Rahman, A., Shahabuddin, S., Hadi, S. M., Parish, J. H., & Ainley, K. (1989). Strand scissions in DNA induced by quercetin and Cu(II): Role of Cu(I) and oxygen free radicals in the reaction. Carcinogenesis, 10, 1833-1839.
37. Ullah, M. F., Shamim, U., Hanif, S., Azmi, A. S., & Hadi, S. M. (2009). Cellular DNA breakage by soy isoflavone genistein and its methylated structural analogue biochanin A. Molecular Nutrition & Food Research, 53, 1376-1385.
38. Badwey, A., & Karnovsky, M. L. (1980). Active oxygen species and the functions of phagocytic leukocytes. Annual Review of Biochemistry, 49, 695-726.
39. Czene, S., Tiback, M., & Harms-Ringdahl, M. (1997). pH-dependent DNA cleavage in permeabilized human fibroblasts. Biochemical Journal, 323, 337-341.
40. Oberly, T. D., & Oberly, L. W. (1997). Antioxidant enzyme levels in cancer. Histology and Histopathology, 12, 525-535.
41. Kong, Q., Beel, J. A., & Lilleihei, K. O. (2000). A threshold concept for cancer therapy. Medical Hypotheses, 55, 29-35.
42. Ahmad, N., Feyes, D. K., Nieminen, A. L., Agarwal, R., & Mukhtar, H. (1997). Green tea constituent epigallocatechin-3-gallate, and induction of cell cycle arrest in human carcinoma cells. Journal of the National Cancer Institute, 89, 1881-1886.
43. Chevion, M. (1988). Site-specific mechanism for free radical induced biological damage. The essential role of redox-active transition metals. Free Radical Biology and Medicine, 5, 27-37.
44. Zimmer, C., Luck, G., Fritzsche, H., & Triebel, H. (1971). DNA-copper (II) complex and the DNA conformation. Biopolymers, 10, 441-463.
45. Gupte, A., & Mumper, R. J. (2008). Elevated copper and oxidative stress in cancer cells as a target for cancer treatment. Cancer Treatment Reviews, 35, 32-46.
46. Devi, G. S., Prasad, M. H., Saraswathi, I., Rao, D. N., & Reddy, P. P. (2000). Free radicals antioxidant enzymes and lipid peroxidation in different types of leukemia. Clinica Chimica Acta, 293, 53-62.