A strategy for the improvement of the bioavailability and antiosteoporosis activity of BCS IV flavonoid glycosides through the formulation of their lipophilic aglycone into nanocrystals

Molecular Pharmaceutics

Volumn 10, Issue 7, 2013, Pages 2534-2542

  Li, Yan ^a,b   Sun, Shaoping ^c   Chang, Qi ^d   Zhang, Lei ^d   Wang, Gengnan ^d   Chen, Weixing ^b   Miao, Xiaoqing ^a   Zheng, Ying ^a  

^a University of Macau   (Macao)

^b PATENT EXAMINATION COOPERATION CENTER OF THE PATENT OFFICE   (China)

^c HEILONGJIANG UNIVERSITY   (China)

^d INSTITUTE OF MEDICINAL PLANT DEVELOPMENT   (China)

Author keywords

antisolvent precipitation; glycoside; icaritin (ICT); nanocrystal; oral bioavailability; osteoporosis

Indexed keywords

AGLYCONE; FLAVONOID GLYCOSIDE; HYDROXYPROPYLMETHYLCELLULOSE; ICARITIN; NANOCRYSTAL; UNCLASSIFIED DRUG;

ANIMAL CELL; AREA UNDER THE CURVE; ARTICLE; ATOMIC FORCE MICROSCOPY; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG ADSORPTION; DRUG BIOAVAILABILITY; DRUG SOLUBILITY; IN VITRO STUDY; LIPOPHILICITY; MAXIMUM PLASMA CONCENTRATION; MOUSE; NONHUMAN; OSTEOBLAST; PRIORITY JOURNAL; RAT; TIME TO MAXIMUM PLASMA CONCENTRATION;

ANIMALS; BIOLOGICAL AVAILABILITY; CALORIMETRY, DIFFERENTIAL SCANNING; CELL DIFFERENTIATION; CELL LINE; CELL PROLIFERATION; GLYCOSIDES; METHYLCELLULOSE; MICROSCOPY, ELECTRON, SCANNING; NANOPARTICLES; OSTEOPOROSIS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84879720593     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp300688t     Document Type: Article

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