Apogossypolone, derivative of gossypol, mobilizes endogenous copper in human peripheral lymphocytes leading to oxidative DNA breakage

European Journal of Pharmaceutical Sciences

Volumn 47, Issue 1, 2012, Pages 280-286

  Zubair, Haseeb ^a   Khan, Husain Y ^a   Ullah, M F ^a,b   Ahmad, Aamir ^a,c   Wu, Daocheng ^d   Hadi, S M ^a  

^a ALIGARH MUSLIM UNIVERSITY   (India)

^b UNIVERSITY OF TENNESSEE   (United States)

^c WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d XI'AN JIAOTONG UNIVERSITY   (China)

Author keywords

Anticancer mechanism; Apogossypolone; Endogenous copper; Gossypol; Oxidative DNA breakage

Indexed keywords

ANTINEOPLASTIC AGENT; APOGOSSYPOLONE; COPPER ION; GOSSYPOL DERIVATIVE; IRON; UNCLASSIFIED DRUG; ZINC;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DNA STRAND BREAKAGE; DRUG PENETRATION; DRUG SCREENING; HUMAN; HUMAN CELL; ION TRANSPORT; OXIDATIVE STRESS; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS; CELL NUCLEUS; CHELATING AGENTS; CHROMATIN; COPPER; DNA BREAKS; DNA DAMAGE; GOSSYPOL; HUMANS; HYDROGEN PEROXIDE; IRON; LYMPHOCYTES; OXIDATIVE STRESS; PERMEABILITY; REACTIVE OXYGEN SPECIES; ZINC;

EID: 84864288611     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2012.04.014     Document Type: Article

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