Modulation of P2X4/P2X7/Pannexin-1 sensitivity to extracellular ATP via Ivermectin induces a non-apoptotic and inflammatory form of cancer cell death

Scientific Reports

Volumn 5, Issue , 2015, Pages

  Draganov, Dobrin ^a   Gopalakrishna Pillai, Sailesh ^a   Chen, Yun Ru ^b   Zuckerman, Neta ^a   Moeller, Sara ^a   Wang, Carrie ^a   Ann, David ^b   Lee, Peter P ^a  

^a Hope ^*  (United States)

^b Diabetes and Metabolism Research Institute   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CARRIER PROTEIN; GAP JUNCTION PROTEIN; INTERLEUKIN 1BETA CONVERTING ENZYME; IVERMECTIN; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; NERVE PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PANX1 PROTEIN, HUMAN; PURINERGIC P2X4 RECEPTOR; PURINERGIC P2X7 RECEPTOR; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

ALLOSTERISM; ANIMAL; ANTAGONISTS AND INHIBITORS; APOPTOSIS; AUTOPHAGY; BAGG ALBINO MOUSE; CHEMISTRY; DRUG EFFECTS; GENETICS; HUMAN; METABOLISM; MOUSE; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ADENOSINE TRIPHOSPHATE; ALLOSTERIC REGULATION; ANIMALS; APOPTOSIS; AUTOPHAGY; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; CASPASE 1; CELL LINE, TUMOR; CONNEXINS; HUMANS; IVERMECTIN; MICE; MICE, INBRED BALB C; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; NADPH OXIDASE; NERVE TISSUE PROTEINS; POLY(ADP-RIBOSE) POLYMERASES; REACTIVE OXYGEN SPECIES; RECEPTORS, PURINERGIC P2X4; RECEPTORS, PURINERGIC P2X7; RNA INTERFERENCE; SIGNAL TRANSDUCTION;

EID: 84946839391     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep16222     Document Type: Article

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