The river blindness drug Ivermectin and related macrocyclic lactones inhibit WNT-TCF pathway responses in human cancer

EMBO Molecular Medicine

Volumn 6, Issue 10, 2014, Pages 1263-1278

  Melotti, Alice ^a   Mas, Christophe ^a   Kuciak, Monika ^a   Lorente Trigos, Aiala ^a   Borges, Isabel ^a   Ruiz i Altaba, Ariel ^a  

^a UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

Cancer; Ivermectin; TCF; WNT; Xenograft

Indexed keywords

BETA CATENIN; CYCLIN D1; IVERMECTIN; LACTONE DERIVATIVE; MACROCYCLIC COMPOUND; OKADAIC ACID; PHOSPHOPROTEIN PHOSPHATASE; SELAMECTIN; T CELL FACTOR PROTEIN; WNT PROTEIN; INSECTICIDE; LACTONE;

APOPTOSIS; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; GENE EXPRESSION PROFILING; HUMAN; HUMAN CELL; IN VIVO STUDY; LOW DRUG DOSE; ONCHOCERCIASIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; STABLE EXPRESSION; TUMOR XENOGRAFT; ANIMAL; CELL PROLIFERATION; DRUG EFFECTS; DRUG SCREENING; FEMALE; GENETICS; HEK293 CELL LINE; HT 29 CELL LINE; IMMUNOHISTOCHEMISTRY; INBRED MOUSE STRAIN; METABOLISM; MUTATION; NEOPLASMS; NUDE MOUSE; ONCHOCERCIASIS, OCULAR; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR CELL LINE; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; BETA CATENIN; BLOTTING, WESTERN; CELL LINE, TUMOR; CELL PROLIFERATION; FEMALE; HEK293 CELLS; HT29 CELLS; HUMANS; IMMUNOHISTOCHEMISTRY; INSECTICIDES; IVERMECTIN; LACTONES; MACROCYCLIC COMPOUNDS; MICE, INBRED STRAINS; MICE, NUDE; MUTATION; NEOPLASMS; ONCHOCERCIASIS, OCULAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TCF TRANSCRIPTION FACTORS; WNT PROTEINS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84908113555     PISSN: 17574676     EISSN: 17574684     Source Type: Journal    
DOI: 10.15252/emmm.201404084     Document Type: Article

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