Regulation of HMGB1 release by inflammasomes

Protein and Cell

Volumn 4, Issue 3, 2013, Pages 163-167

  Lu, Ben ^a,b   Wang, Haichao ^c   Andersson, Ulf ^d   Tracey, Kevin J ^a  

^a FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH   (United States)

^b Elmezzi Graduate School of Molecular Medicine   (United States)

^c NORTH SHORE UNIVERSITY HOSPITAL   (United States)

^d KAROLINSKA INSTITUTE   (Sweden)

Author keywords

HMGB1; inflammasome; PKR

Indexed keywords

ADVANCED GLYCATION END PRODUCT RECEPTOR; CASPASE 11; CRYOPYRIN; HIGH MOBILITY GROUP B1 PROTEIN; INFLAMMASOME; INTERLEUKIN 18; INTERLEUKIN 1BETA CONVERTING ENZYME; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR; PROTEIN KINASE R; STROMAL CELL DERIVED FACTOR 1; TOLL LIKE RECEPTOR 4;

CELL DEATH; CELL STRESS; CHROMATIN STRUCTURE; COMPLEX FORMATION; DNA FRAGMENTATION; ENDOTOXEMIA; ENVIRONMENTAL STRESS; ENZYME ACTIVATION; HUMAN; IMMUNOCOMPETENT CELL; INFLAMMATION; INFLAMMATORY DISEASE; NUCLEAR LOCALIZATION SIGNAL; OLIGOMERIZATION; PATTERN RECOGNITION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION; REVIEW; SEPSIS; SIGNAL TRANSDUCTION;

EID: 84874919170     PISSN: 1674800X     EISSN: 16748018     Source Type: Journal    
DOI: 10.1007/s13238-012-2118-2     Document Type: Review

References (32)

1. Andersson, U., and Tracey, K. J. (2011). HMGB1 is a therapeutic target for sterile inflammation and infection. Annu Rev Immunol 29, 139-162.
2. Bonaldi, T., Talamo, F., Scaffidi, P., Ferrera, D., Porto, A., Bachi, A., Rubartelli, A., Agresti, A., and Bianchi, M. E. (2003). Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion. EMBO J 22, 5551-5560.
3. Bustin, M., and Neihart, N. K. (1979). Antibodies against chromosomal HMG proteins stain the cytoplasm of mammalian cells. Cell 16, 181-189.
4. Dey, M., Cao, C., Dar, A. C., Tamura, T., Ozato, K., Sicheri, F., and Dever, T. E. (2005). Mechanistic link between PKR dimerization, autophosphorylation, and eIF2alpha substrate recognition. Cell 122, 901-913.
5. Evankovich, J., Cho, SW., Zhang, R., Cardinal, J., Dhupar, R., Zhang, L., Klune, J. R., Zlotnicki, J., Billiar, T., and Tsung, A. (2010). High mobility group box 1 release from hepatocytes during ischemia and reperfusion injury is mediated by decreased histone deacetylase activity. J Biol Chem. 285, 39888-39897.
6. Franchi, L., Muñoz-Planillo, R., and Núñez, G. (2012) Sensing and reacting to microbes through the inflammasomes. Nat Immunol 13, 325-332.
7. Gardella, S., Andrei, C., Ferrera, D., Lotti, L. V., Torrisi, M. R., Bianchi, M. E., and Rubartelli, A. (2002). The nuclear protein HMGB1 is secreted by monocytes via a non-classical, vesicle-mediated secretory pathway. EMBO Rep 3, 995-1001.
8. Hsu, L. C., Park, J. M., Zhang, K., Luo, J. L., Maeda, S., Kaufman, R. J., Eckmann, L., Guiney, D. G., and Karin, M. (2004). The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4. Nature 428, 341-345.
9. Javaherian, K., Liu, J. F., and Wang, J. C. (1978). Nonhistone proteins HMG1 and HMG2 change the DNA helical structure. Science 199, 1345-1346.
10. Jin, T., Perry, A., Jiang, J., Smith, P., Curry, J. A., Unterholzner, L., Jiang, Z., Horvath, G., Rathinam, V. A., and Johnstone, R. W., et al. (2012). Structures of the HIN domain: DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor. Immunity 36, 561-571.
11. Kayagaki, N., Warming, S., Lamkanfi, M., Vande Walle, L., Louie, S., Dong, J., Newton, K., Qu, Y., Liu, J., Heldens, S., et al. (2011). Noncanonical inflammasome activation targets caspase-11. Nature 479, 117-121.
12. Kofoed, E. M., and Vance, R. E. (2011). Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity. Nature 477, 592-595.
13. Lamkanfi, M., Sarkar, A., Vande Walle, L., Vitari, A. C., Amer, A. O., Wewers, M. D., Tracey, K. J., Kanneganti, T. D., and Dixit, V. M. (2010). Inflammasome-dependent release of the alarmin HMGB1 in endotoxemia. J Immunol 185, 4385-4392.
14. Lu, B., Nakamura, T., Inouye, K., Li, J., Tang, Y., Lundbäck, P., Valdes-Ferrer, S. I., Olofsson, P. S., Kalb, T., and Roth, J., et al. (2012). Novel role of PKR in inflammasome activation and HMGB1 release. Nature 488, 670-674.
15. Manfredi, A. A., Capobianco, A., Esposito, A., De Cobelli, F., Canu, T., Monno, A., Raucci, A., Sanvito, F., Doglioni, C., Nawroth, P. P., et al. (2008). Maturing dendritic cells depend on RAGE for in vivo homing to lymph nodes. J Immunol 180, 2270-2275.
16. Maroso, M., Balosso, S., Ravizza, T., Liu, J., Aronica, E., Iyer, A. M., Rossetti, C., Molteni, M., Casalgrandi, M., Manfredi, A. A., et al. (2010). Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures. Nat Med 16, 413-419.
17. Medzhitov, R. (2010). Inflammation 2010: new adventures of an old flame. Cell 140, 771-776.
18. Miao, E. A., Rajan, J. V., and Aderem, A. (2011). Caspase-1-induced pyroptotic cell death. Immunol Rev 243, 206-214.
19. Müller, S., Scaffidi, P., Degryse, B., Bonaldi, T., Ronfani, L., Agresti, A., Beltrame, M., and Bianchi, M. E. (2001). New EMBO members' review: the double life of HMGB1 chromatin protein: architectural factor and extracellular signal. EMBO J 20, 4337-4340.
20. Nakamura, T., Furuhashi, M., Li, P., Cao, H., Tuncman, G., Sonenberg, N., Gorgun, C. Z., and Hotamisligil, G. S. (2010). Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis. Cell 140, 338-348.
21. Qin, S., Wang, H., Yuan, R., Li, H., Ochani, M., Ochani, K., Rosas-Ballina, M., Czura, C. J., Huston, J. M., Miller, E., et al. (2006). Role of HMGB1 in apoptosis-mediated sepsis lethality. J Exp Med 203, 1637-1642.
22. Rathinam, V. A., Vanaja, S. K., and Fitzgerald, K. A. (2012). Regulation of inflammasome signaling. Nat Immunol 13, 333-332.
23. Scaffidi, P., Misteli, T., and Bianchi, M. E. (2002). Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Nature 418, 191-195.
24. Schiraldi, M., Raucci, A., Muñoz, L. M., Livoti, E., Celona, B., Venereau, E., Apuzzo, T., De Marchis, F., Pedotti, M., Bachi, A., et al. (2012). HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4. J Exp Med 209, 551-563.
25. Strowig, T., Henao-Mejia, J., Elinav, E., and Flavell, R. (2012). Inflammasomes in health and disease. Nature 481, 278-286.
26. Wang, H., Bloom, O., Zhang, M., Vishnubhakat, J. M., Ombrellino, M., Che, J., Frazier, A., Yang, H., Ivanova, S., Borovikova, L., et al. (1999). HMG-1 as a late mediator of endotoxin lethality in mice. Science 285, 248-251.
27. Wen, H., Ting, J. P., and O'Neill, L. A. (2012). A role for the NLRP3 inflammasome in metabolic diseases-did Warburg miss inflammation. Nat Immunol 13, 352-357.
28. Willingham, S. B., Allen, I. C., Bergstralh, D. T., Brickey, W. J., Huang, M. T., Taxman, D. J., Duncan, J. A., and Ting, J. P. (2009). NLRP3 (NALP3, Cryopyrin) facilitates in vivo caspase-1 activation, necrosis, and HMGB1 release via inflammasome-dependent and -independent pathways. J Immunol 182, 6460-6469.
29. Topalova, D., Ugrinova, I., Pashev, I. G., and Pasheva, E. A. (2008). HMGB1 protein inhibits DNA replication in vitro: a role of the acetylation and the acidic tail. Int J Biochem Cell Biol 40, 1536-1542.
30. Venereau, E., Casalgrandi, M., Schiraldi, M., Antoine, D. J., Cattaneo, A., De Marchis, F., Liu, J., Antonelli, A., Preti, A., Raeli, L., et al. (2012). Mutually exclusive redox forms of HMGB1 promote cell recruitment or proinflammatory cytokine release. J Exp Med 209, 1519-1528.
31. Yang, H., Hreggvidsdottir, H. S., Palmblad, K., Wang, H., Ochani, M., Li, J., Lu, B., Chavan, S., Rosas-Ballina, M., Al-Abed, Y., et al. (2010). A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release. Proc Natl Acad Sci U S A 107, 11942-11947.
32. Zhao, Y., Yang, J., Shi, J., Gong, Y. N., Lu, Q., Xu, H., Liu, L., and Shao, F. (2011). The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus. Nature 477, 596-600.