A novel mechanism of autophagic cell death in dystrophic muscle regulated by P2RX7 receptor large-pore formation and HSP90

Autophagy

Volumn 11, Issue 1, 2015, Pages 113-130

  Young, Christopher N J ^a   Sinadinos, Anthony ^a   Lefebvre, Alexis ^b   Chan, Philippe ^b   Arkle, Stephen ^a   Vaudry, David ^b   Gorecki, Dariusz C ^a  

^a UNIVERSITY OF PORTSMOUTH   (United Kingdom)

^b UNIVERSITY OF ROUEN   (France)

Author keywords

ATP; Autophagy; Cell death; DMD; HSP70; HSP90; LC3; P2RX7; Purinoceptors

Indexed keywords

ADENOSINE TRIPHOSPHATE; CASPASE 3; CASPASE 7; HEAT SHOCK PROTEIN 90; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; P2RX7 RECEPTOR; PURINERGIC P2 RECEPTOR; UNCLASSIFIED DRUG; CALCIUM CHANNEL; HEAT SHOCK PROTEIN 70; HSPA2 PROTEIN, MOUSE; MAP1LC3 PROTEIN, MOUSE; MICROTUBULE ASSOCIATED PROTEIN; P2RX7 PROTEIN, MOUSE; PHOSPHOPROTEIN; PROTEOME; PURINERGIC P2X7 RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOPHAGY; CALCIUM TRANSPORT; CELL DEATH; CHANNEL GATING; CONTROLLED STUDY; MALE; MOUSE; MUSCULAR DYSTROPHY; MYOBLAST; MYOTUBE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEOMICS; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; ANIMAL; ANIMAL MUSCULAR DYSTROPHY; APOPTOSIS; BIOLOGICAL MODEL; C57BL MOUSE; DRUG EFFECTS; ENZYME ACTIVATION; FEMALE; MACROPHAGE; METABOLISM; PATHOLOGY; SKELETAL MUSCLE; X CHROMOSOME LINKED MUSCULAR DYSTROPHIC MOUSE;

ADENOSINE TRIPHOSPHATE; ANIMALS; APOPTOSIS; AUTOPHAGY; CALCIUM CHANNELS; ENZYME ACTIVATION; FEMALE; HSP70 HEAT-SHOCK PROTEINS; HSP90 HEAT-SHOCK PROTEINS; MACROPHAGES; MALE; MICE, INBRED C57BL; MICE, INBRED MDX; MICROTUBULE-ASSOCIATED PROTEINS; MODELS, BIOLOGICAL; MUSCLE, SKELETAL; MUSCULAR DYSTROPHY, ANIMAL; MYOBLASTS; PHOSPHOPROTEINS; PROTEOME; RECEPTORS, PURINERGIC P2X7; SIGNAL TRANSDUCTION;

EID: 84923335301     PISSN: 15548627     EISSN: 15548635     Source Type: Journal    
DOI: 10.4161/15548627.2014.994402     Document Type: Article

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