The antiparasitic agent ivermectin induces chloride-dependent membrane hyperpolarization and cell death in leukemia cells

Blood

Volumn 116, Issue 18, 2010, Pages 3593-3603

  Sharmeen, Sumaiya ^a   Skrtic, Marko ^a   Sukhai, Mahadeo A ^a   Hurren, Rose ^a   Gronda, Marcela ^a   Wang, Xiaoming ^a   Fonseca, Sonali B ^b   Sun, Hong ^a   Wood, Tabitha E ^a,b   Ward, Richard ^a   Minden, Mark D ^a   Batey, Robert A ^b   Datti, Alessandro ^c,d   Wrana, Jeff ^c   Kelley, Shana O ^b   Schimmer, Aaron D ^a  

^a PRINCESS MARGARET HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c MOUNT SINAI HOSPITAL   (Canada)

^d UNIVERSITY OF PERUGIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORIDE CHANNEL; CHLORIDE ION; CYTARABINE; DAUNORUBICIN; IVERMECTIN; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DEATH; CELL MEMBRANE; CELL SIZE; CHLORIDE TRANSPORT; CONTROLLED STUDY; DRUG DOSE ESCALATION; DRUG DOSE INCREASE; DRUG POTENTIATION; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; HYPERPOLARIZATION; LEUKEMIA; LEUKEMIA CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NONHUMAN; PRIORITY JOURNAL; TUMOR GROWTH;

EID: 78149296388     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2010-01-262675     Document Type: Article

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