The importin α/β-specific inhibitor Ivermectin affects HIF-dependent hypoxia response pathways

Biological Chemistry

Volumn 396, Issue 12, 2015, Pages 1357-1367

  Kosyna, Friederike K ^a   Nagel, Marie ^a,b   Kluxen, Larissa ^a   Kraushaar, Kim ^a   Depping, Reinhard ^a  

^a UNIVERSITY OF LÜBECK   (Germany)

^b UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

Author keywords

HIF; hypoxia; importin ; Ivermectin; nuclear transport

Indexed keywords

HETERODIMER; HYPOXIA INDUCIBLE FACTOR 1ALPHA; IVERMECTIN; KARYOPHERIN ALPHA; KARYOPHERIN BETA; PROTEIN BINDING;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CYTOPLASM; DRUG EFFECT; DRUG SCREENING; GENE EXPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; NUCLEAR LOCALIZATION SIGNAL; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; U2OS CELL LINE; ANOXIA; ANTAGONISTS AND INHIBITORS; CELL NUCLEUS; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; FLUORESCENCE MICROSCOPY; GENETICS; METABOLISM; REAL TIME POLYMERASE CHAIN REACTION; TUMOR CELL LINE;

ANOXIA; BETA KARYOPHERINS; CELL LINE, TUMOR; CELL NUCLEUS; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IVERMECTIN; MICROSCOPY, FLUORESCENCE; PROTEIN BINDING; REAL-TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

EID: 84946771299     PISSN: 14316730     EISSN: 14374315     Source Type: Journal    
DOI: 10.1515/hsz-2015-0171     Document Type: Article

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