메뉴 건너뛰기




Volumn 72, Issue 11, 2015, Pages 1346-1353

Naturally occurringmonoclonal antibodies and their therapeutic potential for neurologic diseases

Author keywords

[No Author keywords available]

Indexed keywords

ADUCANUMAB; ALZHEIMER DISEASE VACCINE; BAPINEUZUMAB; CALCIUM; MONOCLONAL ANTIBODY; NATALIZUMAB; PONEZUMAB; RECOMBINANT HUMAN MONOCLONAL IMMUNOGLOBULIN M 22; RILUZOLE; SOLANEZUMAB; UNCLASSIFIED DRUG; IMMUNOGLOBULIN CLASS; RECOMBINANT PROTEIN;

EID: 84946743031     PISSN: 21686149     EISSN: 21686157     Source Type: Journal    
DOI: 10.1001/jamaneurol.2015.2188     Document Type: Review
Times cited : (15)

References (67)
  • 1
    • 84924561292 scopus 로고    scopus 로고
    • Cleanup crew
    • 1061
    • Leslie M. Cleanup crew. Science. 2015;347(6226):1058-1059, 1061.
    • (2015) Science , vol.347 , Issue.6226 , pp. 1058-1059
    • Leslie, M.1
  • 3
    • 84946794492 scopus 로고    scopus 로고
    • Safety and tolerability of the remyelinating therapeutic antibody rHIgM22 in patients with stable multiple sclerosis [poster P4.339/ACO P5130]
    • April 18-25, Washington, DC
    • Greenberg BM, Rodriguez M, Kantarci OH, et al. Safety and tolerability of the remyelinating therapeutic antibody rHIgM22 in patients with stable multiple sclerosis [poster P4.339/ACO P5130]. Poster presented at: 67th American Academy of Neurology Annual Meeting; April 18-25, 2015; Washington, DC.
    • (2015) 67th American Academy of Neurology Annual Meeting
    • Greenberg, B.M.1    Rodriguez, M.2    Kantarci, O.H.3
  • 4
    • 0013986472 scopus 로고
    • Natural antibodies and the immune response
    • Boyden SV. Natural antibodies and the immune response. Adv Immunol. 1966;5:1-28.
    • (1966) Adv Immunol. , vol.5 , pp. 1-28
    • Boyden, S.V.1
  • 5
    • 0025905663 scopus 로고
    • Natural autoantibodies: From "horror autotoxicus" to "gnothi seauton"
    • Avrameas S. Natural autoantibodies: from "horror autotoxicus" to "gnothi seauton. " Immunol Today. 1991;12(5):154-159.
    • (1991) Immunol Today , vol.12 , Issue.5 , pp. 154-159
    • Avrameas, S.1
  • 6
    • 84922572798 scopus 로고    scopus 로고
    • Natural IgM prevents autoimmunity by enforcing B cell central tolerance induction
    • Nguyen TT, Elsner RA, Baumgarth N. Natural IgM prevents autoimmunity by enforcing B cell central tolerance induction. J Immunol. 2015;194(4):1489-1502.
    • (2015) J Immunol. , vol.194 , Issue.4 , pp. 1489-1502
    • Nguyen, T.T.1    Elsner, R.A.2    Baumgarth, N.3
  • 7
    • 59749101668 scopus 로고    scopus 로고
    • The effects of blood-brain barrier disruption on glial cell function in multiple sclerosis
    • McQuaid S, Cunnea P, McMahon J, Fitzgerald U. The effects of blood-brain barrier disruption on glial cell function in multiple sclerosis. Biochem Soc Trans. 2009;37(pt 1):n329-331.
    • (2009) Biochem Soc Trans. , vol.37 , pp. 329-331
    • McQuaid, S.1    Cunnea, P.2    McMahon, J.3    Fitzgerald, U.4
  • 8
    • 0026013693 scopus 로고
    • Blood-brain barrier damage in acute multiple sclerosis plaques: An immunocytological study
    • Gay D, Esiri M. Blood-brain barrier damage in acute multiple sclerosis plaques: an immunocytological study. Brain. 1991;114(Pt 1B):557-572.
    • (1991) Brain , vol.114 , pp. 557-572
    • Gay, D.1    Esiri, M.2
  • 9
    • 0028089844 scopus 로고
    • Blood-brain barrier abnormalities in longstanding multiple sclerosis lesions: An immunohistochemical study
    • Kwon EE, Prineas JW. Blood-brain barrier abnormalities in longstanding multiple sclerosis lesions: an immunohistochemical study. J Neuropathol Exp Neurol. 1994;53(6):625-636.
    • (1994) J Neuropathol Exp Neurol. , vol.53 , Issue.6 , pp. 625-636
    • Kwon, E.E.1    Prineas, J.W.2
  • 10
    • 0036953160 scopus 로고    scopus 로고
    • Passage of amyloid β protein antibody across the blood-brain barrier in a mouse model of Alzheimer's disease
    • Banks WA, Terrell B, Farr SA, Robinson SM, Nonaka N, Morley JE. Passage of amyloid β protein antibody across the blood-brain barrier in a mouse model of Alzheimer's disease. Peptides. 2002;23(12):2223-2226.
    • (2002) Peptides , vol.23 , Issue.12 , pp. 2223-2226
    • Banks, W.A.1    Terrell, B.2    Farr, S.A.3    Robinson, S.M.4    Nonaka, N.5    Morley, J.E.6
  • 11
    • 80054787044 scopus 로고    scopus 로고
    • Exposure levels of anti-LINGO-1 Li81 antibody in the central nervous system and dose-efficacy relationships in rat spinal cord remyelination models after systemic administration
    • Pepinsky RB, Shao Z, Ji B, et al. Exposure levels of anti-LINGO-1 Li81 antibody in the central nervous system and dose-efficacy relationships in rat spinal cord remyelination models after systemic administration. J Pharmacol Exp Ther. 2011;339(2):519-529.
    • (2011) J Pharmacol Exp Ther. , vol.339 , Issue.2 , pp. 519-529
    • Pepinsky, R.B.1    Shao, Z.2    Ji, B.3
  • 12
    • 84875544291 scopus 로고    scopus 로고
    • Pharmacokinetics and brain uptake in the rhesus monkey of a fusion protein of arylsulfatase a and a monoclonal antibody against the human insulin receptor
    • Boado RJ, Lu JZ, Hui EK, Sumbria RK, Pardridge WM. Pharmacokinetics and brain uptake in the rhesus monkey of a fusion protein of arylsulfatase a and a monoclonal antibody against the human insulin receptor. Biotechnol Bioeng. 2013;110(5):1456-1465.
    • (2013) Biotechnol Bioeng , vol.110 , Issue.5 , pp. 1456-1465
    • Boado, R.J.1    Lu, J.Z.2    Hui, E.K.3    Sumbria, R.K.4    Pardridge, W.M.5
  • 13
    • 84878856619 scopus 로고    scopus 로고
    • Bispecific antibodies for delivery into the brain
    • Watts RJ, Dennis MS. Bispecific antibodies for delivery into the brain. Curr Opin Chem Biol. 2013;17(3):393-399.
    • (2013) Curr Opin Chem Biol. , vol.17 , Issue.3 , pp. 393-399
    • Watts, R.J.1    Dennis, M.S.2
  • 14
    • 84878276906 scopus 로고    scopus 로고
    • Addressing safety liabilities of TfR bispecific antibodies that cross the blood-brain barrier
    • 1-12
    • Couch JA, Yu YJ, Zhang Y, et al. Addressing safety liabilities of TfR bispecific antibodies that cross the blood-brain barrier. Sci Transl Med. 2013;5(183):183ra57; 1-12.
    • (2013) Sci Transl Med. , vol.5 , Issue.183 , pp. 183ra57
    • Couch, J.A.1    Yu, Y.J.2    Zhang, Y.3
  • 15
    • 0033835996 scopus 로고    scopus 로고
    • Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease
    • Bard F, Cannon C, Barbour R, et al. Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease. Nat Med. 2000;6(8):916-919.
    • (2000) Nat Med. , vol.6 , Issue.8 , pp. 916-919
    • Bard, F.1    Cannon, C.2    Barbour, R.3
  • 16
    • 0035902619 scopus 로고    scopus 로고
    • Peripheral anti-Aβ antibody alters CNS and plasma Aβ clearance and decreases brain Aβ burden in a mouse model of Alzheimer's disease
    • De Mattos RB, Bales KR, Cummins DJ, Dodart JC, Paul SM, Holtzman DM. Peripheral anti-Aβ antibody alters CNS and plasma Aβ clearance and decreases brain Aβ burden in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A. 2001;98(15):8850-8855.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , Issue.15 , pp. 8850-8855
    • De Mattos, R.B.1    Bales, K.R.2    Cummins, D.J.3    Dodart, J.C.4    Paul, S.M.5    Holtzman, D.M.6
  • 17
    • 0036240395 scopus 로고    scopus 로고
    • Immunization reverses memory deficits without reducing brain Aβ burden in Alzheimer's disease model
    • Dodart JC, Bales KR, Gannon KS, et al. Immunization reverses memory deficits without reducing brain Aβ burden in Alzheimer's disease model. Nat Neurosci. 2002;5(5):452-457.
    • (2002) Nat Neurosci. , vol.5 , Issue.5 , pp. 452-457
    • Dodart, J.C.1    Bales, K.R.2    Gannon, K.S.3
  • 18
    • 0037107177 scopus 로고    scopus 로고
    • Non-Fc-mediated mechanisms are involved in clearance of amyloid-β in vivo by immunotherapy
    • Bacskai BJ, Kajdasz ST, McLellan ME, et al. Non-Fc-mediated mechanisms are involved in clearance of amyloid-β in vivo by immunotherapy. J Neurosci. 2002;22(18):7873-7878.
    • (2002) J Neurosci. , vol.22 , Issue.18 , pp. 7873-7878
    • Bacskai, B.J.1    Kajdasz, S.T.2    McLellan, M.E.3
  • 19
    • 84880189986 scopus 로고    scopus 로고
    • Immunotherapy for Alzheimer's disease
    • Morgan D. Immunotherapy for Alzheimer's disease. J Alzheimers Dis. 2006;9(3)(suppl):425-432.
    • (2006) J Alzheimers Dis. , vol.9 , Issue.3 , pp. 425-432
    • Morgan, D.1
  • 20
    • 10744230547 scopus 로고    scopus 로고
    • Subacute meningoencephalitis in a subset of patients with AD after Aβ42 immunization
    • Orgogozo JM, Gilman S, Dartigues JF, et al. Subacute meningoencephalitis in a subset of patients with AD after Aβ42 immunization. Neurology. 2003;61(1):46-54.
    • (2003) Neurology , vol.61 , Issue.1 , pp. 46-54
    • Orgogozo, J.M.1    Gilman, S.2    Dartigues, J.F.3
  • 21
    • 77951893095 scopus 로고    scopus 로고
    • Beneficial effect of human anti-amyloid-β active immunization on neurite morphology and tau pathology
    • Serrano-Pozo A, William CM, Ferrer I, et al. Beneficial effect of human anti-amyloid-β active immunization on neurite morphology and tau pathology. Brain. 2010;133(pt 5):1312-1327.
    • (2010) Brain , vol.133 , pp. 1312-1327
    • Serrano-Pozo, A.1    William, C.M.2    Ferrer, I.3
  • 22
    • 77953872812 scopus 로고    scopus 로고
    • Reduction of aggregated tau in neuronal processes but not in the cell bodies after Aβ42 immunisation in Alzheimer's disease
    • Boche D, Donald J, Love S, et al. Reduction of aggregated tau in neuronal processes but not in the cell bodies after Aβ42 immunisation in Alzheimer's disease. Acta Neuropathol. 2010;120(1):13-20.
    • (2010) Acta Neuropathol. , vol.120 , Issue.1 , pp. 13-20
    • Boche, D.1    Donald, J.2    Love, S.3
  • 23
    • 84863750982 scopus 로고    scopus 로고
    • Effect of immunotherapy with bapineuzumab on cerebrospinal fluid biomarker levels in patients with mild to moderate Alzheimer disease
    • Blennow K, Zetterberg H, Rinne JO, et al; AAB-001 201/202 Investigators. Effect of immunotherapy with bapineuzumab on cerebrospinal fluid biomarker levels in patients with mild to moderate Alzheimer disease. Arch Neurol. 2012;69(8):1002-1010.
    • (2012) Arch Neurol. , vol.69 , Issue.8 , pp. 1002-1010
    • Blennow, K.1    Zetterberg, H.2    Rinne, J.O.3
  • 26
    • 84872970450 scopus 로고    scopus 로고
    • Safety and pharmacology of ponezumab (PF-04360365) after a single 10-minute intravenous infusion in subjects with mild to moderate Alzheimer disease
    • Burstein AH, Zhao Q, Ross J, et al. Safety and pharmacology of ponezumab (PF-04360365) after a single 10-minute intravenous infusion in subjects with mild to moderate Alzheimer disease. Clin Neuropharmacol. 2013;36(1):8-13.
    • (2013) Clin Neuropharmacol. , vol.36 , Issue.1 , pp. 8-13
    • Burstein, A.H.1    Zhao, Q.2    Ross, J.3
  • 27
    • 0035845614 scopus 로고    scopus 로고
    • Reduced levels of amyloid β-peptide antibody in Alzheimer disease
    • Du Y, Dodel R, Hampel H, et al. Reduced levels of amyloid β-peptide antibody in Alzheimer disease. Neurology. 2001;57(5):801-805.
    • (2001) Neurology , vol.57 , Issue.5 , pp. 801-805
    • Du, Y.1    Dodel, R.2    Hampel, H.3
  • 28
    • 51749103554 scopus 로고    scopus 로고
    • Natural human antibodies to amyloid beta peptide
    • Szabo P, Relkin N, Weksler ME. Natural human antibodies to amyloid beta peptide. Autoimmun Rev. 2008;7(6):415-420.
    • (2008) Autoimmun Rev. , vol.7 , Issue.6 , pp. 415-420
    • Szabo, P.1    Relkin, N.2    Weksler, M.E.3
  • 29
    • 33646865770 scopus 로고    scopus 로고
    • Diagnostic and therapeutic potential of amyloid-reactive IgG antibodies contained in human sera
    • O'Nuallain B, Hrncic R, Wall JS, Weiss DT, Solomon A. Diagnostic and therapeutic potential of amyloid-reactive IgG antibodies contained in human sera. J Immunol. 2006;176(11):7071-7078.
    • (2006) J Immunol. , vol.176 , Issue.11 , pp. 7071-7078
    • O'Nuallain, B.1    Hrncic, R.2    Wall, J.S.3    Weiss, D.T.4    Solomon, A.5
  • 30
    • 41949107347 scopus 로고    scopus 로고
    • Autoantibody-catalyzed hydrolysis of amyloid β peptide
    • Taguchi H, Planque S, Nishiyama Y, et al. Autoantibody-catalyzed hydrolysis of amyloid β peptide. J Biol Chem. 2008;283(8):4714-4722.
    • (2008) J Biol Chem. , vol.283 , Issue.8 , pp. 4714-4722
    • Taguchi, H.1    Planque, S.2    Nishiyama, Y.3
  • 33
    • 18844481916 scopus 로고    scopus 로고
    • Prospective validation of consensus criteria for the diagnosis of dementia with Lewy bodies
    • McKeith IG, Ballard CG, Perry RH, et al. Prospective validation of consensus criteria for the diagnosis of dementia with Lewy bodies. Neurology. 2000;54(5):1050-1058.
    • (2000) Neurology , vol.54 , Issue.5 , pp. 1050-1058
    • McKeith, I.G.1    Ballard, C.G.2    Perry, R.H.3
  • 34
    • 34247402084 scopus 로고    scopus 로고
    • Autoantibodies to alpha-synuclein in inherited Parkinson's disease
    • Papachroni KK, Ninkina N, Papapanagiotou A, et al. Autoantibodies to alpha-synuclein in inherited Parkinson's disease. J Neurochem. 2007;101(3):749-756.
    • (2007) J Neurochem. , vol.101 , Issue.3 , pp. 749-756
    • Papachroni, K.K.1    Ninkina, N.2    Papapanagiotou, A.3
  • 35
    • 51749097108 scopus 로고    scopus 로고
    • Immunotherapy and naturally occurring autoantibodies in neurodegenerative disorders
    • Neff F, Wei X, Nolker C, Bacher M, Du Y, Dodel R. Immunotherapy and naturally occurring autoantibodies in neurodegenerative disorders. Autoimmun Rev. 2008;7(6):501-507.
    • (2008) Autoimmun Rev. , vol.7 , Issue.6 , pp. 501-507
    • Neff, F.1    Wei, X.2    Nolker, C.3    Bacher, M.4    Du, Y.5    Dodel, R.6
  • 36
    • 84873641251 scopus 로고    scopus 로고
    • Naturally occurring α-synuclein autoantibody levels are lower in patients with Parkinson disease
    • Besong-Agbo D, Wolf E, Jessen F, et al. Naturally occurring α-synuclein autoantibody levels are lower in patients with Parkinson disease. Neurology. 2013;80(2):169-175.
    • (2013) Neurology , vol.80 , Issue.2 , pp. 169-175
    • Besong-Agbo, D.1    Wolf, E.2    Jessen, F.3
  • 37
    • 84890911043 scopus 로고    scopus 로고
    • Novel immunomodulatory approaches for the management of multiple sclerosis
    • Kantarci OH, Pirko I, Rodriguez M. Novel immunomodulatory approaches for the management of multiple sclerosis. Clin Pharmacol Ther. 2014;95(1):32-44.
    • (2014) Clin Pharmacol Ther. , vol.95 , Issue.1 , pp. 32-44
    • Kantarci, O.H.1    Pirko, I.2    Rodriguez, M.3
  • 38
    • 84861022041 scopus 로고    scopus 로고
    • Risk of natalizumab-associated progressive multifocal leukoencephalopathy
    • Bloomgren G, Richman S, Hotermans C, et al. Risk of natalizumab-associated progressive multifocal leukoencephalopathy. N Engl J Med. 2012;366(20):1870-1880.
    • (2012) N Engl J Med. , vol.366 , Issue.20 , pp. 1870-1880
    • Bloomgren, G.1    Richman, S.2    Hotermans, C.3
  • 39
    • 84946750437 scopus 로고    scopus 로고
    • Published January 30, 2015, Accessed June 1, 2015
    • ClinicSpeak: natalizumab PML update. Q4 2014. BartsMS blog. http://bitly.com/nat-pml. Published January 30, 2015. Accessed June 1, 2015.
    • (2014) ClinicSpeak: Natalizumab PML Update. Q4
  • 40
    • 84940050223 scopus 로고    scopus 로고
    • Poor early relapse recovery affects onset of progressive disease course in multiple sclerosis [published online July 24, 2015]
    • Novotna M, Paz Soldan MM, Abou Zeid N, et al. Poor early relapse recovery affects onset of progressive disease course in multiple sclerosis [published online July 24, 2015]. Neurology. doi:10.1212/WNL.0000000000001856.
    • Neurology
    • Novotna, M.1    Paz Soldan, M.M.2    Abou Zeid, N.3
  • 41
    • 0021647198 scopus 로고
    • Demyelination and remyelination in murine viral encephalomyelitis
    • Lang W, Rodriguez M, Lennon VA, Lampert PW. Demyelination and remyelination in murine viral encephalomyelitis. Ann N Y Acad Sci. 1984;436:98-102.
    • (1984) Ann N Y Acad Sci. , vol.436 , pp. 98-102
    • Lang, W.1    Rodriguez, M.2    Lennon, V.A.3    Lampert, P.W.4
  • 43
    • 0036674424 scopus 로고    scopus 로고
    • Direct evidence that a human antibody derived from patient serum can promotemyelin repair in a mouse model of chronic-progressive demyelinating disease
    • Mitsunaga Y, Ciric B, Van Keulen V, et al. Direct evidence that a human antibody derived from patient serum can promotemyelin repair in a mouse model of chronic-progressive demyelinating disease. FASEB J. 2002;16(10):1325-1327.
    • (2002) FASEB J. , vol.16 , Issue.10 , pp. 1325-1327
    • Mitsunaga, Y.1    Ciric, B.2    Van Keulen, V.3
  • 45
    • 84863892585 scopus 로고    scopus 로고
    • High-affinity binding of remyelinating natural autoantibodies to myelin-mimicking lipid bilayers revealed by nanohole surface plasmon resonance
    • Wittenberg NJ, Im H, Xu X, et al. High-affinity binding of remyelinating natural autoantibodies to myelin-mimicking lipid bilayers revealed by nanohole surface plasmon resonance. Anal Chem. 2012;84(14):6031-6039.
    • (2012) Anal Chem. , vol.84 , Issue.14 , pp. 6031-6039
    • Wittenberg, N.J.1    Im, H.2    Xu, X.3
  • 46
    • 0037285507 scopus 로고    scopus 로고
    • Remyelination-promoting antibodies activate distinct Ca2+ influx pathways in astrocytes and oligodendrocytes: Relationship to the mechanism of myelin repair
    • Paz Soldan MM, Warrington AE, Bieber AJ, et al. Remyelination-promoting antibodies activate distinct Ca2+ influx pathways in astrocytes and oligodendrocytes: relationship to the mechanism of myelin repair. Mol Cell Neurosci. 2003;22(1):14-24.
    • (2003) Mol Cell Neurosci. , vol.22 , Issue.1 , pp. 14-24
    • Paz Soldan, M.M.1    Warrington, A.E.2    Bieber, A.J.3
  • 47
    • 78649338732 scopus 로고    scopus 로고
    • Human remyelination promoting antibody inhibits apoptotic signaling and differentiation through Lyn kinase in primary rat oligodendrocytes
    • Watzlawik J, Holicky E, Edberg DD, et al. Human remyelination promoting antibody inhibits apoptotic signaling and differentiation through Lyn kinase in primary rat oligodendrocytes. Glia. 2010;58(15):1782-1793.
    • (2010) Glia , vol.58 , Issue.15 , pp. 1782-1793
    • Watzlawik, J.1    Holicky, E.2    Edberg, D.D.3
  • 48
    • 84873248664 scopus 로고    scopus 로고
    • PDGF is required for remyelination-promoting IgM stimulation of oligodendrocyte progenitor cell proliferation
    • Watzlawik JO, Warrington AE, Rodriguez M. PDGF is required for remyelination-promoting IgM stimulation of oligodendrocyte progenitor cell proliferation. PLoS One. 2013;8(2):e55149.
    • (2013) PLoS One , vol.8 , Issue.2 , pp. e55149
    • Watzlawik, J.O.1    Warrington, A.E.2    Rodriguez, M.3
  • 49
    • 9444237918 scopus 로고    scopus 로고
    • A human antibody that promotes remyelination enters the CNS and decreases lesion load as detected by T2-weighted spinal cord MRI in a virus-induced murine model of MS
    • Pirko I, Ciric B, Gamez J, et al. A human antibody that promotes remyelination enters the CNS and decreases lesion load as detected by T2-weighted spinal cord MRI in a virus-induced murine model of MS. FASEB J. 2004;18(13):1577-1579.
    • (2004) FASEB J. , vol.18 , Issue.13 , pp. 1577-1579
    • Pirko, I.1    Ciric, B.2    Gamez, J.3
  • 50
    • 0031839220 scopus 로고    scopus 로고
    • Magnetization transfer changes in the normal appearing white matter precede the appearance of enhancing lesions in patients with multiple sclerosis
    • Filippi M, Rocca MA, Martino G, Horsfield MA, Comi G. Magnetization transfer changes in the normal appearing white matter precede the appearance of enhancing lesions in patients with multiple sclerosis. Ann Neurol. 1998;43(6):809-814.
    • (1998) Ann Neurol. , vol.43 , Issue.6 , pp. 809-814
    • Filippi, M.1    Rocca, M.A.2    Martino, G.3    Horsfield, M.A.4    Comi, G.5
  • 51
    • 0024990661 scopus 로고
    • Breakdown of the blood-brain barrier precedes symptoms and other MRI signs of new lesions in multiple sclerosis: Pathogenetic and clinical implications
    • Kermode AG, Thompson AJ, Tofts P, et al. Breakdown of the blood-brain barrier precedes symptoms and other MRI signs of new lesions in multiple sclerosis: pathogenetic and clinical implications. Brain. 1990;113(pt 5):1477-1489.
    • (1990) Brain , vol.113 , pp. 1477-1489
    • Kermode, A.G.1    Thompson, A.J.2    Tofts, P.3
  • 52
    • 84936871460 scopus 로고    scopus 로고
    • Structural and functional features of central nervous system lymphatic vessels
    • Louveau A, Smirnov I, Keyes TJ, et al. Structural and functional features of central nervous system lymphatic vessels. Nature. 2015;523(7560):337-341.
    • (2015) Nature , vol.523 , Issue.7560 , pp. 337-341
    • Louveau, A.1    Smirnov, I.2    Keyes, T.J.3
  • 53
    • 84942469639 scopus 로고    scopus 로고
    • A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules
    • Aspelund A, Antila S, Proulx ST, et al. A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules. J Exp Med. 2015;212(7):991-999.
    • (2015) J Exp Med. , vol.212 , Issue.7 , pp. 991-999
    • Aspelund, A.1    Antila, S.2    Proulx, S.T.3
  • 56
    • 33644853625 scopus 로고    scopus 로고
    • Immunomodulation using the recombinant monoclonal human B7-DC cross-linking antibody rHIgM12
    • Van Keulen VP, Ciric B, Radhakrishnan S, et al. Immunomodulation using the recombinant monoclonal human B7-DC cross-linking antibody rHIgM12. Clin Exp Immunol. 2006;143(2):314-321.
    • (2006) Clin Exp Immunol. , vol.143 , Issue.2 , pp. 314-321
    • Van Keulen, V.P.1    Ciric, B.2    Radhakrishnan, S.3
  • 57
    • 80052678265 scopus 로고    scopus 로고
    • A human IgMsignals axon outgrowth: Coupling lipid raft to microtubules
    • Xu X, Warrington AE, Wright BR, et al. A human IgMsignals axon outgrowth: coupling lipid raft to microtubules. J Neurochem. 2011;119(1):100-112.
    • (2011) J Neurochem. , vol.119 , Issue.1 , pp. 100-112
    • Xu, X.1    Warrington, A.E.2    Wright, B.R.3
  • 58
    • 84894477501 scopus 로고    scopus 로고
    • A patterned recombinant human IgMguides neurite outgrowth of CNS neurons
    • Xu X, Wittenberg NJ, Jordan LR, et al. A patterned recombinant human IgMguides neurite outgrowth of CNS neurons. Sci Rep. 2013;3:2267.
    • (2013) Sci Rep. , vol.3 , pp. 2267
    • Xu, X.1    Wittenberg, N.J.2    Jordan, L.R.3
  • 59
    • 80053944104 scopus 로고    scopus 로고
    • A single dose of neuron-binding human monoclonal antibody improves spontaneous activity in a murine model of demyelination
    • Denic A, Macura SI, Warrington AE, et al. A single dose of neuron-binding human monoclonal antibody improves spontaneous activity in a murine model of demyelination. PLoS One. 2011;6(10):e26001. doi:10.1371/journal.pone.0026001.
    • (2011) PLoS One , vol.6 , Issue.10 , pp. e26001
    • Denic, A.1    Macura, S.I.2    Warrington, A.E.3
  • 60
    • 84929314650 scopus 로고    scopus 로고
    • A single dose of a neuron-binding human monoclonal antibody improves brainstem NAA concentrations, a biomarker for density of spinal cord axons, in a model of progressive multiple sclerosis
    • Wootla B, Denic A, Watzlawik JO, Warrington AE, Rodriguez M. A single dose of a neuron-binding human monoclonal antibody improves brainstem NAA concentrations, a biomarker for density of spinal cord axons, in a model of progressive multiple sclerosis. J Neuroinflammation. 2015;12(1):83.
    • (2015) J Neuroinflammation , vol.12 , Issue.1 , pp. 83
    • Wootla, B.1    Denic, A.2    Watzlawik, J.O.3    Warrington, A.E.4    Rodriguez, M.5
  • 61
    • 84939584249 scopus 로고    scopus 로고
    • Polysialic acid as an antigen for monoclonal antibody HIgM12 to treat multiple sclerosis and other neurodegenerative disorders
    • Watzlawik JO, Kahoud RJ, Ng S, et al. Polysialic acid as an antigen for monoclonal antibody HIgM12 to treat multiple sclerosis and other neurodegenerative disorders. J Neurochem. 2015;134(5):865-878.
    • (2015) J Neurochem. , vol.134 , Issue.5 , pp. 865-878
    • Watzlawik, J.O.1    Kahoud, R.J.2    Ng, S.3
  • 62
    • 0030690490 scopus 로고    scopus 로고
    • The use of transgenic mouse models of amyotrophic lateral sclerosis in preclinical drug studies
    • Gurney ME. The use of transgenic mouse models of amyotrophic lateral sclerosis in preclinical drug studies. J Neurol Sci. 1997;152(suppl 1):S67-S73.
    • (1997) J Neurol Sci. , vol.152 , pp. S67-S73
    • Gurney, M.E.1
  • 63
    • 77952190999 scopus 로고    scopus 로고
    • Toward more efficient clinical trials for amyotrophic lateral sclerosis
    • Cudkowicz ME, Katz J, Moore DH, et al. Toward more efficient clinical trials for amyotrophic lateral sclerosis. Amyotroph Lateral Scler. 2010;11(3):259-265.
    • (2010) Amyotroph Lateral Scler. , vol.11 , Issue.3 , pp. 259-265
    • Cudkowicz, M.E.1    Katz, J.2    Moore, D.H.3
  • 64
    • 34250208597 scopus 로고    scopus 로고
    • Riluzole for amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND)
    • Miller RG, Mitchell JD, Lyon M, Moore DH. Riluzole for amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND). Cochrane Database Syst Rev. 2007;(1): CD001447.
    • (2007) Cochrane Database Syst Rev. , Issue.1 , pp. CD001447
    • Miller, R.G.1    Mitchell, J.D.2    Lyon, M.3    Moore, D.H.4
  • 65
    • 77951924183 scopus 로고    scopus 로고
    • Intracerebroventricular infusion of monoclonal antibody or its derived Fab fragment against misfolded forms of SOD1 mutant delays mortality in a mouse model of ALS
    • Gros-Louis F, Soucy G, Lariviere R, Julien JP. Intracerebroventricular infusion of monoclonal antibody or its derived Fab fragment against misfolded forms of SOD1 mutant delays mortality in a mouse model of ALS. J Neurochem. 2010;113(5):1188-1199.
    • (2010) J Neurochem. , vol.113 , Issue.5 , pp. 1188-1199
    • Gros-Louis, F.1    Soucy, G.2    Lariviere, R.3    Julien, J.P.4
  • 66
    • 84939552007 scopus 로고    scopus 로고
    • A natural human IgMthat binds to gangliosides is therapeutic in murine models of amyotrophic lateral sclerosis
    • Xu X, Denic A, Jordan LR, et al. A natural human IgMthat binds to gangliosides is therapeutic in murine models of amyotrophic lateral sclerosis. Dis Model Mech. 2015;8(8):831-842.
    • (2015) Dis Model Mech. , vol.8 , Issue.8 , pp. 831-842
    • Xu, X.1    Denic, A.2    Jordan, L.R.3
  • 67
    • 84890796734 scopus 로고    scopus 로고
    • Seven-tesla phase imaging of acute multiple sclerosis lesions: A new window into the inflammatory process
    • Absinta M, Sati P, Gaitan MI, et al. Seven-tesla phase imaging of acute multiple sclerosis lesions: a new window into the inflammatory process. Ann Neurol. 2013;74(5):669-678.
    • (2013) Ann Neurol. , vol.74 , Issue.5 , pp. 669-678
    • Absinta, M.1    Sati, P.2    Gaitan, M.I.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.