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Volumn 152, Issue SUPPL. 1, 1997, Pages

The use of transgenic mouse models of amyotrophic lateral sclerosis in preclinical drug studies

Author keywords

Amyotrophic lateral sclerosis; Riluzole; Superoxide dismutase; Transgenic mice

Indexed keywords

COPPER ZINC SUPEROXIDE DISMUTASE; GLUTAMIC ACID; OXYGEN RADICAL; RILUZOLE;

EID: 0030690490     PISSN: 0022510X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-510X(97)00247-5     Document Type: Conference Paper
Times cited : (159)

References (42)
  • 2
    • 0031014470 scopus 로고    scopus 로고
    • Progressive motor neuron impairment in an animal model of familial amyotrophic lateral sclerosis
    • Azzouz M., Leclerc N., Gurney M., Warter J.-M., Poindron P., Borg J. Progressive motor neuron impairment in an animal model of familial amyotrophic lateral sclerosis. Muscle Nerve. 20:1997;45-51.
    • (1997) Muscle Nerve , vol.20 , pp. 45-51
    • Azzouz, M.1    Leclerc, N.2    Gurney, M.3    Warter, J.-M.4    Poindron, P.5    Borg, J.6
  • 4
    • 0028097839 scopus 로고
    • A controlled trial of riluzole in amyotrophic lateral sclerosis (in collaboration the ALS/Riluzole Study Group)
    • Bensimon G., Lacomblez L., Meininger V. A controlled trial of riluzole in amyotrophic lateral sclerosis (in collaboration the ALS/Riluzole Study Group). New Engl. J. Med. 330:1994;585-591.
    • (1994) New Engl. J. Med. , vol.330 , pp. 585-591
    • Bensimon, G.1    Lacomblez, L.2    Meininger, V.3
  • 6
    • 0027359334 scopus 로고
    • Superoxide dismutase activity, oxidative damage, and mitochondrial energy metabolism in familial and sporadic amyotrophic lateral sclerosis
    • Bowling A.C., Schulz J.B., Brown R.H. Jr., Beal M.F. Superoxide dismutase activity, oxidative damage, and mitochondrial energy metabolism in familial and sporadic amyotrophic lateral sclerosis. J. Neurochem. 61:1993;2322-2325.
    • (1993) J. Neurochem. , vol.61 , pp. 2322-2325
    • Bowling, A.C.1    Schulz, J.B.2    Brown R.H., Jr.3    Beal, M.F.4
  • 8
    • 0029004898 scopus 로고
    • Defective axonal transport in a transgenic mouse model of amyotrophic lateral sclerosis
    • Collard J.F., Cote F., Julien J.P. Defective axonal transport in a transgenic mouse model of amyotrophic lateral sclerosis. Nature. 375:1995;61-64.
    • (1995) Nature , vol.375 , pp. 61-64
    • Collard, J.F.1    Cote, F.2    Julien, J.P.3
  • 9
    • 0027465098 scopus 로고
    • Progressive neuronopathy in transgenic mice expressing the human neurofilament heavy gene: A mouse model of amyotrophic lateral sclerosis
    • Cote F., Collard J.F., Julien J.P. Progressive neuronopathy in transgenic mice expressing the human neurofilament heavy gene: a mouse model of amyotrophic lateral sclerosis. Cell. 73:1993;35-46.
    • (1993) Cell , vol.73 , pp. 35-46
    • Cote, F.1    Collard, J.F.2    Julien, J.P.3
  • 10
    • 0027946294 scopus 로고
    • The development of CNS pathology in a murine transgenic model of human ALS
    • Dal Canto M.C., Gurney M.E. The development of CNS pathology in a murine transgenic model of human ALS. Am. J. Pathol. 145:1994;1271-1279.
    • (1994) Am. J. Pathol. , vol.145 , pp. 1271-1279
    • Dal Canto, M.C.1    Gurney, M.E.2
  • 11
    • 0028933344 scopus 로고
    • Neuropathological changes in two lines of mice carrying a transgene for mutant human Cu,Zn SOD, and in mice overexpressing wild type human SOD: A model of familial amyotrophic lateral sclerosis (FALS)
    • Dal Canto M.C., Gurney M.E. Neuropathological changes in two lines of mice carrying a transgene for mutant human Cu,Zn SOD, and in mice overexpressing wild type human SOD: a model of familial amyotrophic lateral sclerosis (FALS). Brain Res. 676:1995;25-40.
    • (1995) Brain Res. , vol.676 , pp. 25-40
    • Dal Canto, M.C.1    Gurney, M.E.2
  • 12
    • 0030916609 scopus 로고    scopus 로고
    • A low expressor line of transgneic mice carrying a mutant human Cu,Zn superoxide dismutase (SOD1) gene develops pathological changes which most closely resemble those in human ALS
    • Dal Canto M.C., Gurney M.E. A low expressor line of transgneic mice carrying a mutant human Cu,Zn superoxide dismutase (SOD1) gene develops pathological changes which most closely resemble those in human ALS. Acta Neuropathol. 93:1997;537-550.
    • (1997) Acta Neuropathol. , vol.93 , pp. 537-550
    • Dal Canto, M.C.1    Gurney, M.E.2
  • 14
    • 0014368955 scopus 로고
    • An hereditary motor neuron disease with progressive denervation of muscle in the mouse: The mutant 'wobbler'
    • Duchen L.W., Strich S.J. An hereditary motor neuron disease with progressive denervation of muscle in the mouse: The mutant 'wobbler'. J. Neurol. Neurosurg. Psychiatry. 31:1968;535-547.
    • (1968) J. Neurol. Neurosurg. Psychiatry , vol.31 , pp. 535-547
    • Duchen, L.W.1    Strich, S.J.2
  • 17
    • 0030050727 scopus 로고    scopus 로고
    • Benefit of Vitamin E, Riluzole, and Gabapentin in a transgenic model of familial amyotrophic lateral sclerosis
    • Gurney M.E., Cutting F.B., Zhai P., Doble A., Taylor C.P., Andrus P.K., Hall E.D. Benefit of Vitamin E, Riluzole, and Gabapentin in a transgenic model of familial amyotrophic lateral sclerosis. Ann. Neurol. 39:1996;147-157.
    • (1996) Ann. Neurol. , vol.39 , pp. 147-157
    • Gurney, M.E.1    Cutting, F.B.2    Zhai, P.3    Doble, A.4    Taylor, C.P.5    Andrus, P.K.6    Hall, E.D.7
  • 18
    • 0014063240 scopus 로고
    • Familial amyotrophic lateral sclerosis. A subgroup characterized by posterior and spinocerebellar tract involvement and hyaline inclusions in the anterior horn cells
    • Hirano A., Kurland L.T., Sayre G.P. Familial amyotrophic lateral sclerosis. A subgroup characterized by posterior and spinocerebellar tract involvement and hyaline inclusions in the anterior horn cells. Arch. Neurol. 16:1967;232-243.
    • (1967) Arch. Neurol. , vol.16 , pp. 232-243
    • Hirano, A.1    Kurland, L.T.2    Sayre, G.P.3
  • 19
    • 0016816804 scopus 로고
    • The interaction of bovine erythrocyte superoxide dismutase with hydrogen peroxide: Inactivation of the enzyme
    • Hodgson E.K., Fridovich I. The interaction of bovine erythrocyte superoxide dismutase with hydrogen peroxide: Inactivation of the enzyme. Biochemistry. 14:1975;5294-5299.
    • (1975) Biochemistry , vol.14 , pp. 5294-5299
    • Hodgson, E.K.1    Fridovich, I.2
  • 20
    • 0030887622 scopus 로고    scopus 로고
    • Midbrain dopaminergic neuronal degeneration in a transgenic model of familial amyotrophic lateral sclerosis
    • Kostic V., Gurney M.E., Deng H.-X., Siddique T., Epstein C.J., Przedborski S. Midbrain dopaminergic neuronal degeneration in a transgenic model of familial amyotrophic lateral sclerosis. Ann. Neurol. 41:1997;497-504.
    • (1997) Ann. Neurol. , vol.41 , pp. 497-504
    • Kostic, V.1    Gurney, M.E.2    Deng, H.-X.3    Siddique, T.4    Epstein, C.J.5    Przedborski, S.6
  • 22
    • 0023212297 scopus 로고
    • Histopathology of the late-onset motor neuron degeneration (Mnd) mutant in the mouse
    • Messer A., Strominger N.L., Mazurkiewicz J.E. Histopathology of the late-onset motor neuron degeneration (Mnd) mutant in the mouse. J. Neurogenet. 4:1987;201-213.
    • (1987) J. Neurogenet. , vol.4 , pp. 201-213
    • Messer, A.1    Strominger, N.L.2    Mazurkiewicz, J.E.3
  • 23
  • 24
    • 0029890685 scopus 로고    scopus 로고
    • The Golgi apparatus of spinal cord motor neurons in transgenic mice expressing mutant Cu,Zn superoxide dismutase becomes fragmented in early, preclinical stages of the disease
    • Mourelatos Z., Gonatas N.K., Stieber A., Gurney M.E., Dal Canto M.C. The Golgi apparatus of spinal cord motor neurons in transgenic mice expressing mutant Cu,Zn superoxide dismutase becomes fragmented in early, preclinical stages of the disease. Proc. Natl. Acad. Sci. USA. 93:1996;5472-5477.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 5472-5477
    • Mourelatos, Z.1    Gonatas, N.K.2    Stieber, A.3    Gurney, M.E.4    Dal Canto, M.C.5
  • 25
    • 0025260736 scopus 로고
    • Excitatory amino acid release and free radical formation may cooperate in the genesis of ischemia-induced neuronal damage
    • Pelligrini-Giampietro D.E., Cherici G., Alesiani M., Carla V., Moroni F. Excitatory amino acid release and free radical formation may cooperate in the genesis of ischemia-induced neuronal damage. J. Neurosci. 10:1990;1035-1041.
    • (1990) J. Neurosci. , vol.10 , pp. 1035-1041
    • Pelligrini-Giampietro, D.E.1    Cherici, G.2    Alesiani, M.3    Carla, V.4    Moroni, F.5
  • 27
    • 0028888945 scopus 로고
    • Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis
    • Ripps M.E., Huntley G.W., Hof P.R., Morrison J.H., Gordon J.W. Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis. Proc. Natl. Acad. Sci. U.S.A. 92:1995;689-693.
    • (1995) Proc. Natl. Acad. Sci. U.S.A. , vol.92 , pp. 689-693
    • Ripps, M.E.1    Huntley, G.W.2    Hof, P.R.3    Morrison, J.H.4    Gordon, J.W.5
  • 29
    • 0029950147 scopus 로고    scopus 로고
    • GDNF slows loss of motoneurons but not axonal degeneration or premature death of pmn/pmn mice
    • Sagot Y., Tan S.A., Hammang J.P., Aebischer P., Kato A.C. GDNF slows loss of motoneurons but not axonal degeneration or premature death of pmn/pmn mice. J. Neurosci. 16:1996;2335-2341.
    • (1996) J. Neurosci. , vol.16 , pp. 2335-2341
    • Sagot, Y.1    Tan, S.A.2    Hammang, J.P.3    Aebischer, P.4    Kato, A.C.5
  • 31
    • 0026749255 scopus 로고
    • Ciliary neurotrophic factor prevents degeneration of motor neurons in mouse-mutant progressive motor neuronopathy
    • Sendtner M., Schmalbruch H., Stockli K.A., Carroll P., Kreutzberg G.W., Thoenen H. Ciliary neurotrophic factor prevents degeneration of motor neurons in mouse-mutant progressive motor neuronopathy. Nature. 358:1992;502-504.
    • (1992) Nature , vol.358 , pp. 502-504
    • Sendtner, M.1    Schmalbruch, H.2    Stockli, K.A.3    Carroll, P.4    Kreutzberg, G.W.5    Thoenen, H.6
  • 32
    • 0029810307 scopus 로고    scopus 로고
    • Genetics of amyotrophic lateral sclerosis
    • Siddique T., Deng H.-X. Genetics of amyotrophic lateral sclerosis. Hum. Mol. Genet. 5:1996;1465-1470.
    • (1996) Hum. Mol. Genet. , vol.5 , pp. 1465-1470
    • Siddique, T.1    Deng, H.-X.2
  • 34
    • 0029966363 scopus 로고    scopus 로고
    • Transgenic mice carrying a human mutant superoxide dismutase transgene develop neuronal cytoskeletal pathology resembling human amyotrophic lateral sclerosis
    • Tu P.H., Raju P., Robinson K.A., Gurney M.E., Trojanowski J.Q., Lee V.M.Y. Transgenic mice carrying a human mutant superoxide dismutase transgene develop neuronal cytoskeletal pathology resembling human amyotrophic lateral sclerosis. Proc. Natl. Acad. Sci. USA. 93:1996;3155-3160.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 3155-3160
    • Tu, P.H.1    Raju, P.2    Robinson, K.A.3    Gurney, M.E.4    Trojanowski, J.Q.5    Lee, V.M.Y.6
  • 35
    • 0030910404 scopus 로고    scopus 로고
    • Oxidative stress, mutant SOD1, and neurofilament pathology in transgenic mouse models of human motor neuron disease
    • Tu P.H., Gurney M.E., Julien J.P., Lee V.M.Y., Trojanowski J.Q. Oxidative stress, mutant SOD1, and neurofilament pathology in transgenic mouse models of human motor neuron disease. Lab. Invest. 76:1997;441-456.
    • (1997) Lab. Invest. , vol.76 , pp. 441-456
    • Tu, P.H.1    Gurney, M.E.2    Julien, J.P.3    Lee, V.M.Y.4    Trojanowski, J.Q.5
  • 37
    • 0030596899 scopus 로고    scopus 로고
    • Riluzole
    • Wokke J. Riluzole. Lancet. 348:1996;795-799.
    • (1996) Lancet , vol.348 , pp. 795-799
    • Wokke, J.1
  • 38
    • 0029053881 scopus 로고
    • An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration og mitochondria
    • Wong P.C., Pardo C.A., Borchelt D.R., Lee M.K., Copeland N.G., Jenkins N.A., Sisodia S.S., Cleveland D.W., Price D.L. An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration og mitochondria. Neuron. 14:1995;1105-1116.
    • (1995) Neuron , vol.14 , pp. 1105-1116
    • Wong, P.C.1    Pardo, C.A.2    Borchelt, D.R.3    Lee, M.K.4    Copeland, N.G.5    Jenkins, N.A.6    Sisodia, S.S.7    Cleveland, D.W.8    Price, D.L.9
  • 39
    • 0025285382 scopus 로고
    • Copper,zinc superoxide dismutase catalyzes hydroxyl radical production from hydrogen peroxide
    • Yim M.B., Chock P.B., Stadtman E.R. Copper,zinc superoxide dismutase catalyzes hydroxyl radical production from hydrogen peroxide. Proc. Natl. Acad. Sci. USA. 87:1990;5006-5010.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 5006-5010
    • Yim, M.B.1    Chock, P.B.2    Stadtman, E.R.3
  • 40
    • 0027456505 scopus 로고
    • Enzyme function of copper, zinc superoxide dismutase as a free radical generator
    • Yim M.B., Chock P.B., Stadtman E.R. Enzyme function of copper, zinc superoxide dismutase as a free radical generator. J. Biol. Chem. 268:1993;4099-4105.
    • (1993) J. Biol. Chem. , vol.268 , pp. 4099-4105
    • Yim, M.B.1    Chock, P.B.2    Stadtman, E.R.3
  • 42
    • 0027410516 scopus 로고
    • Increased expression of neurofilament subunit NF-L produces morphological alterations that resemble the pathology of human motor neuron disease
    • Xu Z., Cork L.C., Griffin J.W., Cleveland D.W. Increased expression of neurofilament subunit NF-L produces morphological alterations that resemble the pathology of human motor neuron disease. Cell. 73:1993;23-33.
    • (1993) Cell , vol.73 , pp. 23-33
    • Xu, Z.1    Cork, L.C.2    Griffin, J.W.3    Cleveland, D.W.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.