A single dose of neuron-binding human monoclonal antibody improves spontaneous activity in a murine model of demyelination

PLoS ONE

Volumn 6, Issue 10, 2011, Pages

  Denic, Aleksandar ^a   Macura, Slobodan I ^a   Warrington, Arthur E ^a   Pirko, Istvan ^a   Grossardt, Brandon R ^a   Pease, Larry R ^b   Rodriguez, Moses ^a,b  

^a MAYO CLINIC   (United States)

^b MAYO GRADUATE SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HUMAN MONOCLONAL ANTIBODY; IMMUNOGLOBULIN M; RECOMBINANT ANTIBODY; RECOMBINANT SERUM DERIVED HUMAN MONOCLONAL ANTIBODY; RHIGM12; SODIUM CHLORIDE; UNCLASSIFIED DRUG; MONOCLONAL ANTIBODY;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DEMYELINATING DISEASE; DEMYELINATION; DISEASE COURSE; FEMALE; HYPOTHESIS; IN VITRO STUDY; MATHEMATICAL ANALYSIS; MONITORING; MOTOR PERFORMANCE; MOUSE; MOUSE STRAIN; MURINE ENCEPHALOMYELITIS VIRUS; NERVE CELL; NERVE FIBER GROWTH; NEUROLOGIC DISEASE; NEUROPROTECTION; NONHUMAN; OBSERVATIONAL METHOD; PHYSICAL ACTIVITY; PROTEIN BINDING; RECORDING; REMYELINIZATION; SINGLE DRUG DOSE; VIRUS INFECTION; ANIMAL; CARDIOVIRUS INFECTION; DARKNESS; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECT; HUMAN; INTRAPERITONEAL DRUG ADMINISTRATION; METABOLISM; MOTOR ACTIVITY; PATHOPHYSIOLOGY; VIROLOGY;

MURINAE; MUS; RODENTIA; THEILER'S ENCEPHALOMYELITIS VIRUS;

ANIMALS; ANTIBODIES, MONOCLONAL; CARDIOVIRUS INFECTIONS; DARKNESS; DEMYELINATING DISEASES; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; INJECTIONS, INTRAPERITONEAL; MICE; MOTOR ACTIVITY; NEURONS; PROTEIN BINDING; THEILOVIRUS;

EID: 80053944104     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0026001     Document Type: Article

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