Mitochondrial delivery of Coenzyme Q10 via systemic administration using a MITO-Porter prevents ischemia/reperfusion injury in the mouse liver

Journal of Controlled Release

Volumn 213, Issue , 2015, Pages 86-95

  Yamada, Yuma ^a   Nakamura, Kohei ^a   Abe, Jiro ^a,b   Hyodo, Mamoru ^c   Haga, Sanae ^a   Ozaki, Michitaka ^a   Harashima, Hideyoshi ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b HOKKAIDO UNIVERSITY HOSPITAL   (Japan)

^c AICHI INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

Antioxidant chemicals; Coenzyme Q10 Ischemia reperfusion injury; In vivo delivery; MITO Porter; Mitochondria; Mitochondrial delivery

Indexed keywords

AMINO ACIDS; BODY FLUIDS; CELL MEMBRANES; COENZYMES; MAMMALS;

ALANINE AMINOTRANSFERASE; CONFOCAL LASER SCANNING MICROSCOPY; HISTOLOGICAL OBSERVATIONS; IN-VIVO; ISCHEMIA/REPERFUSION; MITO-PORTER; MITOCHONDRIAL DELIVERY; REACTIVE OXYGEN SPECIES;

MITOCHONDRIA;

ALANINE AMINOTRANSFERASE; ANTIOXIDANT; CYTOCHROME C OXIDASE; DRUG CARRIER; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; HISTONE H3; MITO PORTER; RADIOISOTOPE; REACTIVE OXYGEN METABOLITE; RHODAMINE; UBIDECARENONE; UNCLASSIFIED DRUG; LIPOSOME; UBIQUINONE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BINDING AFFINITY; BINDING ASSAY; CELL LYSATE; CELL SIZE; CELL TRANSPORT; CELLULAR DISTRIBUTION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOSOLIC FRACTION; DRUG ACCUMULATION; DRUG DELIVERY SYSTEM; DRUG EFFECT; DRUG TARGETING; GENE OVEREXPRESSION; IN VITRO STUDY; IN VIVO STUDY; LIPID COMPOSITION; LIVER CELL; LIVER HOMOGENATE; LIVER ISCHEMIA; LIVER MITOCHONDRION; LIVER PROTECTION; MALE; MEMBRANE FUSION; MICROENCAPSULATION; MITOCHONDRIAL DRUG DELIVERY SYSTEM; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; MOUSE; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; RESPIRATORY CHAIN; SURFACE PROPERTY; ANALOGS AND DERIVATIVES; ANIMAL; C57BL MOUSE; DRUG EFFECTS; LIVER; METABOLISM; PATHOLOGY; REPERFUSION INJURY;

ANIMALS; ANTIOXIDANTS; DRUG DELIVERY SYSTEMS; LIPOSOMES; LIVER; MALE; MICE; MICE, INBRED C57BL; MITOCHONDRIA; REPERFUSION INJURY; UBIQUINONE;

EID: 84946715979     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2015.06.037     Document Type: Article

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