Protein C system defects inflicted by the malaria parasite protein PfEMP1 can be overcome by a soluble EPCR variant

Thrombosis and Haemostasis

Volumn 114, Issue 5, 2015, Pages 1038-1048

  Petersen, Jens E V ^a   Bouwens, Eveline A M ^b   Tamayo, Ibai ^c   Turner, Louise ^a   Wang, Christian W ^a   Stins, Monique ^d   Theander, Thor G ^a   Hermida, José ^c   Mosnier, Laurent O ^b   Lavstsen, Thomas ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF NAVARRA   (Spain)

^d JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Endothelial cells; Endothelial protein C receptor; Malaria; PfEMP1

Indexed keywords

ENDOTHELIAL PROTEIN C RECEPTOR; ERYTHROCYTE MEMBRANE PROTEIN 1; PROTEIN C; PROTEINASE ACTIVATED RECEPTOR 1; THROMBOMODULIN; CELL SURFACE RECEPTOR; ERYTHROCYTE MEMBRANE PROTEIN 1, PLASMODIUM FALCIPARUM; LEUKOCYTE ANTIGEN; MUTANT PROTEIN; PROCR PROTEIN, HUMAN; PROTEIN BINDING; PROTOZOAL PROTEIN;

ARTICLE; BLOOD CLOTTING; CAPILLARY ENDOTHELIAL CELL; CELL ADHESION; CELL ADHESION ASSAY; CONTROLLED STUDY; HUMAN; HUMAN CELL; MALARIA; PHENOTYPE; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN DEFECT; PROTEIN EXPRESSION; BRAIN; CELL CULTURE; CELL PROTECTION; CLINICAL TRIAL; DRUG EFFECTS; ENDOTHELIUM CELL; GENETICS; METABOLISM; PARASITOLOGY; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE; SIGNAL TRANSDUCTION;

ANTIGENS, CD; BRAIN; CELLS, CULTURED; CYTOPROTECTION; ENDOTHELIAL CELLS; HUMANS; MALARIA; MUTANT PROTEINS; PLASMODIUM FALCIPARUM; PROTEIN BINDING; PROTEIN C; PROTEIN STRUCTURE, TERTIARY; PROTOZOAN PROTEINS; RECEPTOR, PAR-1; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION;

EID: 84946615500     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH15-01-0018     Document Type: Article

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