-
1
-
-
0026591793
-
The protein C anticoagulant pathway
-
Esmon CT (1992) The protein C anticoagulant pathway. Arterioscler Thromb 12, 135-145.
-
(1992)
Arterioscler Thromb
, vol.12
, pp. 135-145
-
-
Esmon, C.T.1
-
2
-
-
0002971870
-
Regulation of Coagulation
-
(Loscalzo J & Schafer AI, eds). Williams and Watkins, Baltimore
-
Simmonds RE & Lane DA (1998) Regulation of Coagulation. In Thrombosis and Hemorrhage (Loscalzo J & Schafer AI, eds). Williams and Watkins, Baltimore.
-
(1998)
Thrombosis and Hemorrhage
-
-
Simmonds, R.E.1
Lane, D.A.2
-
3
-
-
0029790055
-
The endothelial cell protein C receptor augments protein C activation by the thrombin-thrombomodulin complex
-
Stearns-Kurosawa DJ, Kurosawa S, Mollica JS, Ferrell GL & Esmon CT (1996) The endothelial cell protein C receptor augments protein C activation by the thrombin-thrombomodulin complex. Proc Natl Acad Sci USA 93, 10212-10216.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 10212-10216
-
-
Stearns-Kurosawa, D.J.1
Kurosawa, S.2
Mollica, J.S.3
Ferrell, G.L.4
Esmon, C.T.5
-
4
-
-
0032489916
-
Activation mechanism of anticoagulant protein C in large blood vessels involving the endothelial cell protein C receptor
-
Fukudome K, Ye X, Tsuneyoshi N, Tokunaga O, Sugawara K, Mizokami H & Kimoto M (1998) Activation mechanism of anticoagulant protein C in large blood vessels involving the endothelial cell protein C receptor. J Exp Med 187, 1029-1035.
-
(1998)
J Exp Med
, vol.187
, pp. 1029-1035
-
-
Fukudome, K.1
Ye, X.2
Tsuneyoshi, N.3
Tokunaga, O.4
Sugawara, K.5
Mizokami, H.6
Kimoto, M.7
-
5
-
-
0033525831
-
Reconstitution of the human endothelial cell protein C receptor with thrombomodulin in phosphatidylcholine vesicles enhances protein C activation
-
Xu J, Esmon NL & Esmon CT (1999) Reconstitution of the human endothelial cell protein C receptor with thrombomodulin in phosphatidylcholine vesicles enhances protein C activation. J Biol Chem 274, 6704-6710.
-
(1999)
J Biol Chem
, vol.274
, pp. 6704-6710
-
-
Xu, J.1
Esmon, N.L.2
Esmon, C.T.3
-
6
-
-
0030756899
-
The protein C pathway: New insights
-
Esmon CT, Ding W, Yasuhiro K, Gu JM, Ferrell G, Regan LM, Stearns-Kurosawa DJ, Kurosawa S, Mather T, Laszik Z & Esmon NL (1997) The protein C pathway: new insights. Thromb Haemost 78, 70-74.
-
(1997)
Thromb Haemost
, vol.78
, pp. 70-74
-
-
Esmon, C.T.1
Ding, W.2
Yasuhiro, K.3
Gu, J.M.4
Ferrell, G.5
Regan, L.M.6
Stearns-Kurosawa, D.J.7
Kurosawa, S.8
Mather, T.9
Laszik, Z.10
Esmon, N.L.11
-
7
-
-
0025888388
-
Activated protein C-catalyzed inactivation of human factor VIII and factor VIIIa. Identification of cleavage sites and correlation of proteolysis with cofactor activity
-
Fay PJ, Smudzin TM & Walker FJ (1991) Activated protein C-catalyzed inactivation of human factor VIII and factor VIIIa. Identification of cleavage sites and correlation of proteolysis with cofactor activity. J Biol Chem 266, 20139-20145.
-
(1991)
J Biol Chem
, vol.266
, pp. 20139-20145
-
-
Fay, P.J.1
Smudzin, T.M.2
Walker, F.J.3
-
8
-
-
0017567792
-
Anticoagulant properties of bovine plasma protein C following activation by thrombin
-
Kisiel W, Canfield WM, Ericsson LH & Davie EW (1977) Anticoagulant properties of bovine plasma protein C following activation by thrombin. Biochemistry 16, 5824-5831.
-
(1977)
Biochemistry
, vol.16
, pp. 5824-5831
-
-
Kisiel, W.1
Canfield, W.M.2
Ericsson, L.H.3
Davie, E.W.4
-
9
-
-
0018715761
-
The inhibition of blood coagulation by activated protein C through the selective inactivation of activated factor V
-
Walker FJ, Sexton PW & Esmon CT (1979) The inhibition of blood coagulation by activated Protein C through the selective inactivation of activated Factor V. Biochim Biophys Acta 571, 333-342.
-
(1979)
Biochim Biophys Acta
, vol.571
, pp. 333-342
-
-
Walker, F.J.1
Sexton, P.W.2
Esmon, C.T.3
-
10
-
-
0028110027
-
The mechanism of inactivation of human factor V and human factor Va by activated protein C
-
Kalafatis M, Rand MD & Mann KG (1994) The mechanism of inactivation of human factor V and human factor Va by activated protein C. J Biol Chem 269, 31869-31880.
-
(1994)
J Biol Chem
, vol.269
, pp. 31869-31880
-
-
Kalafatis, M.1
Rand, M.D.2
Mann, K.G.3
-
12
-
-
0029133654
-
Peptide bond cleavages and loss of functional activity during inactivation of factor Va and factor VaR506Q by activated protein C
-
Nicolaes GA, Tans G, Thomassen MC, Hemker HC, Pabinger I, Varadi K, Schwarz HP & Rosing J (1995) Peptide bond cleavages and loss of functional activity during inactivation of factor Va and factor VaR506Q by activated protein C. J Biol Chem 270, 21158-21166.
-
(1995)
J Biol Chem
, vol.270
, pp. 21158-21166
-
-
Nicolaes, G.A.1
Tans, G.2
Thomassen, M.C.3
Hemker, H.C.4
Pabinger, I.5
Varadi, K.6
Schwarz, H.P.7
Rosing, J.8
-
13
-
-
0027744465
-
Role of the membrane in the inactivation of factor Va by activated protein C
-
Kalafatis M & Mann KG (1993) Role of the membrane in the inactivation of factor Va by activated protein C. J Biol Chem 268, 27246-27257.
-
(1993)
J Biol Chem
, vol.268
, pp. 27246-27257
-
-
Kalafatis, M.1
Mann, K.G.2
-
14
-
-
0037100417
-
Functional characterization of recombinant FV Hong Kong and FV Cambridge
-
Norstrom E, Thorelli E & Dahlback B (2002) Functional characterization of recombinant FV Hong Kong and FV Cambridge. Blood 100, 524-530.
-
(2002)
Blood
, vol.100
, pp. 524-530
-
-
Norstrom, E.1
Thorelli, E.2
Dahlback, B.3
-
15
-
-
0037036069
-
Activation of endothelial cell protease activated receptor 1 by the protein C pathway
-
Riewald M, Petrovan RJ, Donner A, Mueller BM & Ruf W (2002) Activation of endothelial cell protease activated receptor 1 by the protein C pathway. Science 296, 1880-1882.
-
(2002)
Science
, vol.296
, pp. 1880-1882
-
-
Riewald, M.1
Petrovan, R.J.2
Donner, A.3
Mueller, B.M.4
Ruf, W.5
-
16
-
-
0037352279
-
Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective
-
Cheng T, Liu D, Griffin JH, Fernandez JA, Castellino F, Rosen ED, Fukudome K & Zlokovic BV (2003) Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective. Nat Med 9, 338-342.
-
(2003)
Nat Med
, vol.9
, pp. 338-342
-
-
Cheng, T.1
Liu, D.2
Griffin, J.H.3
Fernandez, J.A.4
Castellino, F.5
Rosen, E.D.6
Fukudome, K.7
Zlokovic, B.V.8
-
17
-
-
0028109316
-
High affinity binding sites for activated protein C and protein C on cultured human umbilical vein endothelial cells. Independent of protein S and distinct from known ligands
-
Bangalore N, Drohan WN & Orthner CL (1994) High affinity binding sites for activated protein C and protein C on cultured human umbilical vein endothelial cells. Independent of protein S and distinct from known ligands. Thromb Haemost 72, 465-474.
-
(1994)
Thromb Haemost
, vol.72
, pp. 465-474
-
-
Bangalore, N.1
Drohan, W.N.2
Orthner, C.L.3
-
18
-
-
0027943163
-
Identification, cloning, and regulation of a novel endothelial cell protein C/activated protein C receptor
-
Fukudome K & Esmon CT (1994) Identification, cloning, and regulation of a novel endothelial cell protein C/activated protein C receptor. J Biol Chem 269, 26486-26491.
-
(1994)
J Biol Chem
, vol.269
, pp. 26486-26491
-
-
Fukudome, K.1
Esmon, C.T.2
-
19
-
-
0030016347
-
The endothelial cell protein C receptor. Cell surface expression and direct ligand binding by the soluble receptor
-
Fukudome K, Kurosawa S, Stearns-Kurosawa DJ, He X, Rezaie AR & Esmon CT (1996) The endothelial cell protein C receptor. Cell surface expression and direct ligand binding by the soluble receptor. J Biol Chem 271, 17491-17498.
-
(1996)
J Biol Chem
, vol.271
, pp. 17491-17498
-
-
Fukudome, K.1
Kurosawa, S.2
Stearns-Kurosawa, D.J.3
He, X.4
Rezaie, A.R.5
Esmon, C.T.6
-
20
-
-
0030666197
-
The interaction between the endothelial cell protein C receptor and protein C is dictated by the gamma-carboxyglutamic acid domain of protein C
-
Regan LM, Mollica JS, Rezaie AR & Esmon CT (1997) The interaction between the endothelial cell protein C receptor and protein C is dictated by the gamma-carboxyglutamic acid domain of protein C. J Biol Chem 272, 26279-26284.
-
(1997)
J Biol Chem
, vol.272
, pp. 26279-26284
-
-
Regan, L.M.1
Mollica, J.S.2
Rezaie, A.R.3
Esmon, C.T.4
-
21
-
-
0030056114
-
Identification of the phospholipid binding site in the vitamin K-dependent blood coagulation protein factor IX
-
Freedman SJ, Blostein MD, Baleja JD, Jacobs M, Furie BC & Furie B (1996) Identification of the phospholipid binding site in the vitamin K-dependent blood coagulation protein factor IX. J Biol Chem 271, 16227-16236.
-
(1996)
J Biol Chem
, vol.271
, pp. 16227-16236
-
-
Freedman, S.J.1
Blostein, M.D.2
Baleja, J.D.3
Jacobs, M.4
Furie, B.C.5
Furie, B.6
-
22
-
-
0029083550
-
Structure of the calcium ion-bound gamma-carboxyglutamic acid-rich domain of factor IX
-
Freedman SJ, Furie BC, Furie B & Baleja JD (1995) Structure of the calcium ion-bound gamma-carboxyglutamic acid-rich domain of factor IX. Biochemistry 34, 12126-12137.
-
(1995)
Biochemistry
, vol.34
, pp. 12126-12137
-
-
Freedman, S.J.1
Furie, B.C.2
Furie, B.3
Baleja, J.D.4
-
23
-
-
0024472048
-
Structure of Ca2+ prothrombin fragment 1 including the conformation of the Gla domain
-
Soriano-Garcia M, Park CH, Tulinsky A, Ravichandran KG & Skrzypczak-Jankun E (1989) Structure of Ca2+ prothrombin fragment 1 including the conformation of the Gla domain. Biochemistry 28, 6805-6810.
-
(1989)
Biochemistry
, vol.28
, pp. 6805-6810
-
-
Soriano-Garcia, M.1
Park, C.H.2
Tulinsky, A.3
Ravichandran, K.G.4
Skrzypczak-Jankun, E.5
-
24
-
-
0026610682
-
The Ca2+ ion and membrane binding structure of the Gla domain of Ca-prothrombin fragment 1
-
Soriano-Garcia M, Padmanabhan K, de Vos AM & Tulinsky A (1992) The Ca2+ ion and membrane binding structure of the Gla domain of Ca-prothrombin fragment 1. Biochemistry 31, 2554-2566.
-
(1992)
Biochemistry
, vol.31
, pp. 2554-2566
-
-
Soriano-Garcia, M.1
Padmanabhan, K.2
De Vos, A.M.3
Tulinsky, A.4
-
25
-
-
0037067752
-
The crystal structure of the endothelial protein C receptor and a bound phospholipid
-
Oganesyan V, Oganesyan N, Terzyan S, Qu D, Dauter Z, Esmon NL & Esmon CT (2002) The crystal structure of the endothelial protein C receptor and a bound phospholipid. J Biol Chem 277, 24851-24854.
-
(2002)
J Biol Chem
, vol.277
, pp. 24851-24854
-
-
Oganesyan, V.1
Oganesyan, N.2
Terzyan, S.3
Qu, D.4
Dauter, Z.5
Esmon, N.L.6
Esmon, C.T.7
-
26
-
-
0035968172
-
The omega-loop region of the human pro thrombin gamma-carboxyglutamic acid domain penetrates anionic phospholipid membranes
-
Falls LA, Furie BC, Jacobs M, Furie B & Rigby AC (2001) The omega-loop region of the human pro thrombin gamma-carboxyglutamic acid domain penetrates anionic phospholipid membranes. J Biol Chem 276, 23895-23902.
-
(2001)
J Biol Chem
, vol.276
, pp. 23895-23902
-
-
Falls, L.A.1
Furie, B.C.2
Jacobs, M.3
Furie, B.4
Rigby, A.C.5
-
27
-
-
0041819513
-
Structural basis of membrane binding by Gla domains of vitamin K-dependent proteins
-
Huang M, Rigby AC, Morelli X, Grant MA, Huang G, Furie B, Seaton B & Furie BC (2003) Structural basis of membrane binding by Gla domains of vitamin K-dependent proteins. Nat Struct Biol 10, 751-756.
-
(2003)
Nat Struct Biol
, vol.10
, pp. 751-756
-
-
Huang, M.1
Rigby, A.C.2
Morelli, X.3
Grant, M.A.4
Huang, G.5
Furie, B.6
Seaton, B.7
Furie, B.C.8
-
28
-
-
0033566326
-
Structural and functional implications of the intron/exon organization of the human endothelial cell protein C/activated protein C receptor (EPCR) gene: Comparison with the structure of CD1/major histocompatibility complex alpha1 and alpha2 domains
-
Simmonds RE & Lane DA (1999) Structural and functional implications of the intron/exon organization of the human endothelial cell protein C/activated protein C receptor (EPCR) gene: comparison with the structure of CD1/major histocompatibility complex alpha1 and alpha2 domains. Blood 94, 632-641.
-
(1999)
Blood
, vol.94
, pp. 632-641
-
-
Simmonds, R.E.1
Lane, D.A.2
-
29
-
-
0032716327
-
Structural prediction and analysis of endothelial cell protein C/activated protein C receptor
-
Villoutreix BO, Blom AM & Dahlback B (1999) Structural prediction and analysis of endothelial cell protein C/activated protein C receptor. Protein Eng 12, 833-840.
-
(1999)
Protein Eng
, vol.12
, pp. 833-840
-
-
Villoutreix, B.O.1
Blom, A.M.2
Dahlback, B.3
-
30
-
-
0028925756
-
Molecular cloning and expression of murine and bovine endothelial cell protein C/activated protein C receptor (EPCR). The structural and functional conservation in human, bovine, and murine EPCR
-
Fukudome K & Esmon CT (1995) Molecular cloning and expression of murine and bovine endothelial cell protein C/activated protein C receptor (EPCR). The structural and functional conservation in human, bovine, and murine EPCR. J Biol Chem 270, 5571-5577.
-
(1995)
J Biol Chem
, vol.270
, pp. 5571-5577
-
-
Fukudome, K.1
Esmon, C.T.2
-
31
-
-
0035896608
-
Identification of the protein C/activated protein C binding sites on the endothelial cell protein C receptor. Implications for a novel mode of ligand recognition by a major histocompatibility complex class 1-type receptor
-
Liaw PC, Mather T, Oganesyan N, Ferrell GL & Esmon CT (2001) Identification of the protein C/activated protein C binding sites on the endothelial cell protein C receptor. Implications for a novel mode of ligand recognition by a major histocompatibility complex class 1-type receptor. J Biol Chem 276, 8364-8370.
-
(2001)
J Biol Chem
, vol.276
, pp. 8364-8370
-
-
Liaw, P.C.1
Mather, T.2
Oganesyan, N.3
Ferrell, G.L.4
Esmon, C.T.5
-
32
-
-
0029043736
-
Protein C deficiency: A database of mutations, 1995 update
-
On behalf of the Subcommittee on Plasma Coagulation Inhibitors of the Scientific and Standardization Committee of the ISTH
-
Reitsma PH, Bernardi F, Doig RG, Gandrille S, Greengard JS, Ireland H, Krawczak M, Lind B, Long GL, Poort SR et al. (1995) Protein C deficiency: a database of mutations, 1995 update. On behalf of the Subcommittee on Plasma Coagulation Inhibitors of the Scientific and Standardization Committee of the ISTH. Thromb Haemost 73, 876-889.
-
(1995)
Thromb Haemost
, vol.73
, pp. 876-889
-
-
Reitsma, P.H.1
Bernardi, F.2
Doig, R.G.3
Gandrille, S.4
Greengard, J.S.5
Ireland, H.6
Krawczak, M.7
Lind, B.8
Long, G.L.9
Poort, S.R.10
-
33
-
-
0029148317
-
Hydrophobie amino acid residues of human anticoagulation protein C that contribute to its functional binding to phospholipid vesicles
-
Christiansen WT, Jalbert LR, Robertson RM, Jhingan A, Prorok M & Castellino FJ (1995) Hydrophobie amino acid residues of human anticoagulation protein C that contribute to its functional binding to phospholipid vesicles. Biochemistry 34, 10376-10382.
-
(1995)
Biochemistry
, vol.34
, pp. 10376-10382
-
-
Christiansen, W.T.1
Jalbert, L.R.2
Robertson, R.M.3
Jhingan, A.4
Prorok, M.5
Castellino, F.J.6
-
34
-
-
0028670884
-
Functions of individual gamma-carboxyglutamic acid (Gla) residues of human protein C. Determination of functionally nonessential Gla residues and correlations with their mode of binding to calcium
-
Christiansen WT, Tulinsky A & Castellino FJ (1994) Functions of individual gamma-carboxyglutamic acid (Gla) residues of human protein C. Determination of functionally nonessential Gla residues and correlations with their mode of binding to calcium. Biochemistry 33, 14993-15000.
-
(1994)
Biochemistry
, vol.33
, pp. 14993-15000
-
-
Christiansen, W.T.1
Tulinsky, A.2
Castellino, F.J.3
-
35
-
-
0029945107
-
The hydrophobic nature of residue-5 of human protein C is a major determinant of its functional interactions with acidic phospholipid vesicles
-
Jalbert LR, Chan JC, Christiansen WT & Castellino FJ (1996) The hydrophobic nature of residue-5 of human protein C is a major determinant of its functional interactions with acidic phospholipid vesicles. Biochemistry 35, 7093-7099.
-
(1996)
Biochemistry
, vol.35
, pp. 7093-7099
-
-
Jalbert, L.R.1
Chan, J.C.2
Christiansen, W.T.3
Castellino, F.J.4
-
36
-
-
0031424043
-
Enhancing the activity of protein C by mutagenesis to improve the membrane-binding site: Studies related to proline-10
-
Shen L, Shah AM, Dahlback B & Nelsestuen GL (1997) Enhancing the activity of protein C by mutagenesis to improve the membrane-binding site: studies related to proline-10. Biochemistry 36, 16025-16031.
-
(1997)
Biochemistry
, vol.36
, pp. 16025-16031
-
-
Shen, L.1
Shah, A.M.2
Dahlback, B.3
Nelsestuen, G.L.4
-
37
-
-
0037443444
-
Gla domain-mutated human protein C exhibiting enhanced anticoagulant activity and increased phospholipid binding
-
Sun YH, Shen L & Dahlback B (2003) Gla domain-mutated human protein C exhibiting enhanced anticoagulant activity and increased phospholipid binding. Blood 101, 2277-2284.
-
(2003)
Blood
, vol.101
, pp. 2277-2284
-
-
Sun, Y.H.1
Shen, L.2
Dahlback, B.3
-
38
-
-
0027155692
-
The contributions of individual gamma-carboxyglutamic acid residues in the calcium-dependent binding of recombinant human protein C to acidic phospholipid vesicles
-
Zhang L & Castellino FJ (1993) The contributions of individual gamma-carboxyglutamic acid residues in the calcium-dependent binding of recombinant human protein C to acidic phospholipid vesicles. J Biol Chem 268, 12040-12045.
-
(1993)
J Biol Chem
, vol.268
, pp. 12040-12045
-
-
Zhang, L.1
Castellino, F.J.2
-
39
-
-
0032762628
-
Enhancement of vitamin-K-dependent protein function by modification of the gamma-carboxyglutamic acid domain: Studies of protein C and factor VII
-
Nelsestuen GL (1999) Enhancement of vitamin-K-dependent protein function by modification of the gamma-carboxyglutamic acid domain: studies of protein C and factor VII. Trends Cardiovasc Med 9, 162-167.
-
(1999)
Trends Cardiovasc Med
, vol.9
, pp. 162-167
-
-
Nelsestuen, G.L.1
-
40
-
-
0030036189
-
The endothelial cell protein C receptor. Inhibition of activated protein C anticoagulant function without modulation of reaction with proteinase inhibitors
-
Regan LM, Stearns-Kurosawa DJ, Kurosawa S, Mollica J, Fukudome K & Esmon CT (1996) The endothelial cell protein C receptor. Inhibition of activated protein C anticoagulant function without modulation of reaction with proteinase inhibitors. J Biol Chem 271, 17499-17503.
-
(1996)
J Biol Chem
, vol.271
, pp. 17499-17503
-
-
Regan, L.M.1
Stearns-Kurosawa, D.J.2
Kurosawa, S.3
Mollica, J.4
Fukudome, K.5
Esmon, C.T.6
-
41
-
-
0032773568
-
Involvement of Lys 62 (217) and Lys 63 (218) of human anticoagulant protein C in heparin stimulation of inhibition by the protein C inhibitor
-
Shen L, Villoutreix BO & Dahlback B (1999) Involvement of Lys 62 (217) and Lys 63 (218) of human anticoagulant protein C in heparin stimulation of inhibition by the protein C inhibitor. Thromb Haemost 82, 72-79.
-
(1999)
Thromb Haemost
, vol.82
, pp. 72-79
-
-
Shen, L.1
Villoutreix, B.O.2
Dahlback, B.3
-
42
-
-
0032862393
-
Interspecies loop grafting in the protease domain of human protein C yielding enhanced catalytic and anticoagulant activity
-
Shen L, Villoutreix BO & Dahlback B (1999) Interspecies loop grafting in the protease domain of human protein C yielding enhanced catalytic and anticoagulant activity. Thromb Haemost 82, 1078-1087.
-
(1999)
Thromb Haemost
, vol.82
, pp. 1078-1087
-
-
Shen, L.1
Villoutreix, B.O.2
Dahlback, B.3
-
43
-
-
0021318997
-
A functional assay of protein C in human plasma
-
Sala N, Owen WG & Collen D (1984) A functional assay of protein C in human plasma. Blood 63, 671-675.
-
(1984)
Blood
, vol.63
, pp. 671-675
-
-
Sala, N.1
Owen, W.G.2
Collen, D.3
-
44
-
-
0043092166
-
Importance of protein S and phospholipid for activated protein C-mediated cleavages in factor Va
-
Norstrom EA, Steen M, Tran S & Dahlback B (2003) Importance of protein S and phospholipid for activated protein C-mediated cleavages in factor Va. J Biol Chem 278, 24904-24911.
-
(2003)
J Biol Chem
, vol.278
, pp. 24904-24911
-
-
Norstrom, E.A.1
Steen, M.2
Tran, S.3
Dahlback, B.4
-
45
-
-
0030034473
-
Mutations which introduce free cysteine residues in the Gla-domain of vitamin K dependent proteins result in the formation of complexes with alpha 1-microglobulin
-
Wojcik EG, Simioni P, de Berg M, Girolami A & Bertina RM (1996) Mutations which introduce free cysteine residues in the Gla-domain of vitamin K dependent proteins result in the formation of complexes with alpha 1-microglobulin. Thromb Haemost 75, 70-75.
-
(1996)
Thromb Haemost
, vol.75
, pp. 70-75
-
-
Wojcik, E.G.1
Simioni, P.2
De Berg, M.3
Girolami, A.4
Bertina, R.M.5
-
46
-
-
0027364901
-
A compound heterozygous protein C deficiency with a single nucleotide G deletion encoding Gly-381 and an amino acid substitution of Lys for Gla-26
-
Ido M, Ohiwa M, Hayashi T, Nishioka J, Hatada T, Watanabe Y, Wada H, Shirakawa S & Suzuki K (1993) A compound heterozygous protein C deficiency with a single nucleotide G deletion encoding Gly-381 and an amino acid substitution of Lys for Gla-26. Thromb Haemost 70, 636-641.
-
(1993)
Thromb Haemost
, vol.70
, pp. 636-641
-
-
Ido, M.1
Ohiwa, M.2
Hayashi, T.3
Nishioka, J.4
Hatada, T.5
Watanabe, Y.6
Wada, H.7
Shirakawa, S.8
Suzuki, K.9
-
47
-
-
0029670444
-
The Gla26 residue of protein C is required for the binding of protein C to thrombomodulin and endothelial cell protein C receptor, but not to protein S and factor Va
-
Nishioka J, Ido M, Hayashi T & Suzuki K (1996) The Gla26 residue of protein C is required for the binding of protein C to thrombomodulin and endothelial cell protein C receptor, but not to protein S and factor Va. Thromb Haemost 75, 275-282.
-
(1996)
Thromb Haemost
, vol.75
, pp. 275-282
-
-
Nishioka, J.1
Ido, M.2
Hayashi, T.3
Suzuki, K.4
-
48
-
-
11444265684
-
The binding site on protein C for the endothelial cell protein C receptor
-
Stearns-Kurosawa DJ, Mather T, Kurosawa S & Esmon CT (1999) The binding site on protein C for the endothelial cell protein C receptor. Blood 94, 2878.
-
(1999)
Blood
, vol.94
, pp. 2878
-
-
Stearns-Kurosawa, D.J.1
Mather, T.2
Kurosawa, S.3
Esmon, C.T.4
-
49
-
-
0030967015
-
Comparison of naturally occurring vitamin K-dependent proteins: Correlation of amino acid sequences and membrane binding properties suggests a membrane contact site
-
McDonald JF, Shah AM, Schwalbe RA, Kisiel W, Dahlback B & Nelsestuen GL (1997) Comparison of naturally occurring vitamin K-dependent proteins: correlation of amino acid sequences and membrane binding properties suggests a membrane contact site. Biochemistry 36, 5120-5127.
-
(1997)
Biochemistry
, vol.36
, pp. 5120-5127
-
-
McDonald, J.F.1
Shah, A.M.2
Schwalbe, R.A.3
Kisiel, W.4
Dahlback, B.5
Nelsestuen, G.L.6
-
50
-
-
0009284026
-
Type II protein C deficiency: Identification and molecular modelling of two natural mutants with low anticoagulant and normal amidolytic activity
-
Faioni EM, Hermida J, Rovida E, Razzari C, Asti D, Zeinali S & Mannucci PM (2000) Type II protein C deficiency: identification and molecular modelling of two natural mutants with low anticoagulant and normal amidolytic activity. Br J Haematol 108, 265-271.
-
(2000)
Br J Haematol
, vol.108
, pp. 265-271
-
-
Faioni, E.M.1
Hermida, J.2
Rovida, E.3
Razzari, C.4
Asti, D.5
Zeinali, S.6
Mannucci, P.M.7
-
51
-
-
0038482456
-
Such stuff as dreams are made on: Mediator-directed therapy in sepsis
-
Marshall JC (2003) Such stuff as dreams are made on: mediator-directed therapy in sepsis. Nat Rev Drug Discov 2, 391-405.
-
(2003)
Nat Rev Drug Discov
, vol.2
, pp. 391-405
-
-
Marshall, J.C.1
-
52
-
-
0038115229
-
Activated protein C alters cytosolic calcium flux in human brain endothelium via binding to endothelial protein C receptor and activation of protease activated receptor-1
-
Domotor E, Benzakour O, Griffin JH, Yule D, Fukudome K & Zlokovic BV (2003) Activated protein C alters cytosolic calcium flux in human brain endothelium via binding to endothelial protein C receptor and activation of protease activated receptor-1. Blood 101, 4797-4801.
-
(2003)
Blood
, vol.101
, pp. 4797-4801
-
-
Domotor, E.1
Benzakour, O.2
Griffin, J.H.3
Yule, D.4
Fukudome, K.5
Zlokovic, B.V.6
-
53
-
-
2142827026
-
Identification and characterization of a natural R96C EPCR variant
-
Hermida J, Hurtado V, Villegas-Mendez A, Catto AJ & Philippou H (2003) Identification and characterization of a natural R96C EPCR variant. J Thromb Haemost 1, 1850-1852.
-
(2003)
J Thromb Haemost
, vol.1
, pp. 1850-1852
-
-
Hermida, J.1
Hurtado, V.2
Villegas-Mendez, A.3
Catto, A.J.4
Philippou, H.5
-
54
-
-
0034768673
-
Abnormal propeptide processing resulting in the presence of two abnormal species of protein C in plasma: Characterization of the dysfunctional protein C Padua3 (protein C (R-1L/propeptide)
-
Simioni P, Kalafatis M, Tormene D, Luni S, Zerbinati P, Barzon L, Palu G & Girolami A (2001) Abnormal propeptide processing resulting in the presence of two abnormal species of protein C in plasma: characterization of the dysfunctional protein C Padua3 (protein C (R-1L/propeptide). Thromb Haemost 86, 1017-1022.
-
(2001)
Thromb Haemost
, vol.86
, pp. 1017-1022
-
-
Simioni, P.1
Kalafatis, M.2
Tormene, D.3
Luni, S.4
Zerbinati, P.5
Barzon, L.6
Palu, G.7
Girolami, A.8
-
55
-
-
0036166536
-
Genetic and phenotypic variability between families with hereditary protein S deficiency
-
Rezende SM, Lane DA, Zoller B, Mille-Baker B, Laffan M, Dahlback B & Simmonds RE (2002) Genetic and phenotypic variability between families with hereditary protein S deficiency. Thromb Haemost 87, 258-265.
-
(2002)
Thromb Haemost
, vol.87
, pp. 258-265
-
-
Rezende, S.M.1
Lane, D.A.2
Zoller, B.3
Mille-Baker, B.4
Laffan, M.5
Dahlback, B.6
Simmonds, R.E.7
-
56
-
-
0025598301
-
A gamma-carboxyglutamic acid (gamma) variant (gamma 6D, gamma 7D) of human activated protein C displays greatly reduced activity as an anticoagulant
-
Zhang L & Castellino FJ (1990) A gamma-carboxyglutamic acid (gamma) variant (gamma 6D, gamma 7D) of human activated protein C displays greatly reduced activity as an anticoagulant. Biochemistry 29, 10828-10834.
-
(1990)
Biochemistry
, vol.29
, pp. 10828-10834
-
-
Zhang, L.1
Castellino, F.J.2
-
57
-
-
0037076527
-
Contribution of basic residues of the 70-80-loop to heparin binding and anticoagulant function of activated protein C
-
Yang L, Manithody C & Rezaie AR (2002) Contribution of basic residues of the 70-80-loop to heparin binding and anticoagulant function of activated protein C. Biochemistry 41, 6149-6157.
-
(2002)
Biochemistry
, vol.41
, pp. 6149-6157
-
-
Yang, L.1
Manithody, C.2
Rezaie, A.R.3
-
58
-
-
0001637870
-
Permanent cell line expressing human factor VIII-related antigen established by hybridization
-
Edgell CJ, McDonald CC & Graham JB (1983) Permanent cell line expressing human factor VIII-related antigen established by hybridization. Proc Natl Acad Sci USA 80, 3734-3737.
-
(1983)
Proc Natl Acad Sci USA
, vol.80
, pp. 3734-3737
-
-
Edgell, C.J.1
McDonald, C.C.2
Graham, J.B.3
-
59
-
-
0023374585
-
Structure and expression of human thrombomodulin, a thrombin receptor on endothelium acting as a cofactor for protein C activation
-
Suzuki K, Kusumoto H, Deyashiki Y, Nishioka J, Maruyama I, Zushi M, Kawahara S, Honda G, Yamamoto S & Horiguchi S (1987) Structure and expression of human thrombomodulin, a thrombin receptor on endothelium acting as a cofactor for protein C activation. EMBO J 6, 1891-1897.
-
(1987)
EMBO J
, vol.6
, pp. 1891-1897
-
-
Suzuki, K.1
Kusumoto, H.2
Deyashiki, Y.3
Nishioka, J.4
Maruyama, I.5
Zushi, M.6
Kawahara, S.7
Honda, G.8
Yamamoto, S.9
Horiguchi, S.10
|