메뉴 건너뛰기




Volumn 15, Issue 6, 2015, Pages 581-587

Effect of allergen-specific immunotherapy on CD4+ T cells

Author keywords

Allergen immunotherapy; Allergy; Apoptosis; CD4+ T cells; Desensitization; Interleukin 10; Tolerance

Indexed keywords

ALLERGEN; CD4 ANTIGEN; INTERLEUKIN 10;

EID: 84946565124     PISSN: 15284050     EISSN: 14736322     Source Type: Journal    
DOI: 10.1097/ACI.0000000000000216     Document Type: Review
Times cited : (61)

References (48)
  • 1
    • 84877045546 scopus 로고    scopus 로고
    • Update on immune mechanisms associated with sublingual immunotherapy: Practical implications for the clinician
    • Moingeon P. Update on immune mechanisms associated with sublingual immunotherapy: practical implications for the clinician. J Allergy Clin Immunol Pract 2013;1:228-241.
    • (2013) J Allergy Clin Immunol Pract , vol.1 , pp. 228-241
    • Moingeon, P.1
  • 2
    • 77949901839 scopus 로고    scopus 로고
    • Birch pollen immunotherapy leads to differential induction of regulatory T cells and delayed helper T cell immune deviation
    • Mobs C, Slotosch C, Loffler H, et al. Birch pollen immunotherapy leads to differential induction of regulatory T cells and delayed helper T cell immune deviation. J Immunol 2010;184:2194-2203.
    • (2010) J Immunol , vol.184 , pp. 2194-2203
    • Mobs, C.1    Slotosch, C.2    Loffler, H.3
  • 3
    • 84907371316 scopus 로고    scopus 로고
    • Sequential transcriptional changes dictate safe and effective antigen-specific immunotherapy
    • Burton BR, Britton GJ, Fang H, et al. Sequential transcriptional changes dictate safe and effective antigen-specific immunotherapy. Nat Commun 2014;5:1-13.
    • (2014) Nat Commun , vol.5 , pp. 1-13
    • Burton, B.R.1    Britton, G.J.2    Fang, H.3
  • 4
    • 84891735552 scopus 로고    scopus 로고
    • Grass tablet sublingual immunotherapy downregulates the TH2 cytokine response followed by regulatory T-cell generation
    • Suarez-Fueyo A, Ramos T, Galan A, et al. Grass tablet sublingual immunotherapy downregulates the TH2 cytokine response followed by regulatory T-cell generation. J Allergy Clin Immunol 2014;133:130-138; e1-2.
    • (2014) J Allergy Clin Immunol , vol.133 , pp. 130e1-138e2
    • Suarez-Fueyo, A.1    Ramos, T.2    Galan, A.3
  • 5
    • 77953246494 scopus 로고    scopus 로고
    • T-cell responses induced by allergen-specific immunotherapy
    • Maggi E. T-cell responses induced by allergen-specific immunotherapy. Clin Exp Immunol 2010;161:10-18.
    • (2010) Clin Exp Immunol , vol.161 , pp. 10-18
    • Maggi, E.1
  • 6
    • 84938991407 scopus 로고    scopus 로고
    • Mechanisms of allergen-specific immunotherapy and immune tolerance to allergens
    • Akdis CA, Akdis M. Mechanisms of allergen-specific immunotherapy and immune tolerance to allergens. World Allergy Org J 2015;8:1-12.
    • (2015) World Allergy Org J , vol.8 , pp. 1-12
    • Akdis, C.A.1    Akdis, M.2
  • 7
    • 43649090380 scopus 로고    scopus 로고
    • Single cell assessment of allergen-specific T cell responses with MHC class II peptide tetramers: Methodological aspects
    • Wambre E, Van Overtvelt L, Maillere B, et al. Single cell assessment of allergen-specific T cell responses with MHC class II peptide tetramers: methodological aspects. Int Arch Allergy Immunol 2008;146:99-112.
    • (2008) Int Arch Allergy Immunol , vol.146 , pp. 99-112
    • Wambre, E.1    Van Overtvelt, L.2    Maillere, B.3
  • 9
    • 58149306013 scopus 로고    scopus 로고
    • In vivo switch to IL-10-secreting T regulatory cells in high dose allergen exposure
    • Meiler F, Zumkehr J, Klunker S, et al. In vivo switch to IL-10-secreting T regulatory cells in high dose allergen exposure. J Exp Med 2008;205:2887-2898.
    • (2008) J Exp Med , vol.205 , pp. 2887-2898
    • Meiler, F.1    Zumkehr, J.2    Klunker, S.3
  • 12
    • 1342308180 scopus 로고    scopus 로고
    • + regulatory T-cell suppression of allergen-driven T-cell activation to atopic status and expression of allergic disease
    • + regulatory T-cell suppression of allergen-driven T-cell activation to atopic status and expression of allergic disease. Lancet (London, England) 2004;363:608-615.
    • (2004) Lancet (London, England) , vol.363 , pp. 608-615
    • Ling, E.M.1    Smith, T.2    Nguyen, X.D.3
  • 13
    • 84901421855 scopus 로고    scopus 로고
    • Regulatory T cells and their roles in immune dysregulation and allergy
    • Pellerin L, Jenks JA, Begin P, et al. Regulatory T cells and their roles in immune dysregulation and allergy. Immunol Res 2014;58(2-3):358-368.
    • (2014) Immunol Res , vol.58 , Issue.2-3 , pp. 358-368
    • Pellerin, L.1    Jenks, J.A.2    Begin, P.3
  • 14
    • 84875427488 scopus 로고    scopus 로고
    • Regulatory T cells: Recommendations to simplify the nomenclature
    • Abbas AK, Benoist C, Bluestone JA, et al. Regulatory T cells: recommendations to simplify the nomenclature. Nat Immunol 2013;14:307-308.
    • (2013) Nat Immunol , vol.14 , pp. 307-308
    • Abbas, A.K.1    Benoist, C.2    Bluestone, J.A.3
  • 15
    • 84869111251 scopus 로고    scopus 로고
    • Birch pollen immunotherapy results in longterm loss of Bet v 1-specific TH2 responses, transient TR1 activation, and synthesis of IgE-blocking antibodies
    • Mobs C, Ipsen H, Mayer L, et al. Birch pollen immunotherapy results in longterm loss of Bet v 1-specific TH2 responses, transient TR1 activation, and synthesis of IgE-blocking antibodies. J Allergy Clin Immunol 2012;130:1108-1116; e6.
    • (2012) J Allergy Clin Immunol , vol.130 , pp. 1108-1116e6
    • Mobs, C.1    Ipsen, H.2    Mayer, L.3
  • 16
    • 84921476622 scopus 로고    scopus 로고
    • IL-10 and regulatory T cells cooperate in allergen-specific immunotherapy to ameliorate allergic asthma
    • Bohm L, Maxeiner J, Meyer-Martin H, et al. IL-10 and regulatory T cells cooperate in allergen-specific immunotherapy to ameliorate allergic asthma. J Immunol 2015;194:887-897.
    • (2015) J Immunol , vol.194 , pp. 887-897
    • Bohm, L.1    Maxeiner, J.2    Meyer-Martin, H.3
  • 17
    • 84908631984 scopus 로고    scopus 로고
    • Mechanisms of immune tolerance to allergens: Role of IL-10 and Tregs
    • Akdis CA, Akdis M. Mechanisms of immune tolerance to allergens: role of IL-10 and Tregs. J Clin Invest 2014;124:4678-4680.
    • (2014) J Clin Invest , vol.124 , pp. 4678-4680
    • Akdis, C.A.1    Akdis, M.2
  • 18
    • 17144405680 scopus 로고    scopus 로고
    • Potential role of interleukin-10-secreting regulatory T cells in allergy and asthma
    • Hawrylowicz CM, O'Garra A. Potential role of interleukin-10-secreting regulatory T cells in allergy and asthma. Nat Rev Immunol 2005;5:271-283.
    • (2005) Nat Rev Immunol , vol.5 , pp. 271-283
    • Hawrylowicz, C.M.1    O'Garra, A.2
  • 19
    • 84866600066 scopus 로고    scopus 로고
    • Contribution of regulatory T cells to alleviation of experimental allergic asthma after specific immunotherapy
    • Maazi H, Shirinbak S, Willart M, et al. Contribution of regulatory T cells to alleviation of experimental allergic asthma after specific immunotherapy. Clin Exp Allergy 2012;42:1519-1528.
    • (2012) Clin Exp Allergy , vol.42 , pp. 1519-1528
    • Maazi, H.1    Shirinbak, S.2    Willart, M.3
  • 20
    • 2942685507 scopus 로고    scopus 로고
    • Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells
    • Akdis M, Verhagen J, Taylor A, et al. Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells. J Exp Med 2004;199:1567-1575.
    • (2004) J Exp Med , vol.199 , pp. 1567-1575
    • Akdis, M.1    Verhagen, J.2    Taylor, A.3
  • 21
    • 4544256262 scopus 로고    scopus 로고
    • Defective suppression of Th2 cytokines by CD4CD25 regulatory T cells in birch allergics during birch pollen season
    • Grindebacke H, Wing K, Andersson AC, et al. Defective suppression of Th2 cytokines by CD4CD25 regulatory T cells in birch allergics during birch pollen season. Clin Exp Allergy 2004;34:1364-1372.
    • (2004) Clin Exp Allergy , vol.34 , pp. 1364-1372
    • Grindebacke, H.1    Wing, K.2    Andersson, A.C.3
  • 22
    • 84893405498 scopus 로고    scopus 로고
    • Peanut oral immunotherapy results in increased antigen-induced regulatory T-cell function and hypomethylation of forkhead box protein 3 (FOXP3)
    • Syed A, Garcia MA, Lyu SC, et al. Peanut oral immunotherapy results in increased antigen-induced regulatory T-cell function and hypomethylation of forkhead box protein 3 (FOXP3). J Allergy Clin Immunol 2014;133:500-510.
    • (2014) J Allergy Clin Immunol , vol.133 , pp. 500-510
    • Syed, A.1    Garcia, M.A.2    Lyu, S.C.3
  • 23
    • 84862865711 scopus 로고    scopus 로고
    • Epigenetic modifications and improved regulatory T-cell function in subjects undergoing dual sublingual immunotherapy
    • Swamy RS, Reshamwala N, Hunter T, et al. Epigenetic modifications and improved regulatory T-cell function in subjects undergoing dual sublingual immunotherapy. J Allergy Clin Immunol 2012;130:215-224; e7.
    • (2012) J Allergy Clin Immunol , vol.130 , pp. 215-224e7
    • Swamy, R.S.1    Reshamwala, N.2    Hunter, T.3
  • 24
    • 38549166301 scopus 로고    scopus 로고
    • GATA3-driven Th2 responses inhibit TGF-beta1-induced FOXP3 expression and the formation of regulatory T cells
    • Mantel PY, Kuipers H, Boyman O, et al. GATA3-driven Th2 responses inhibit TGF-beta1-induced FOXP3 expression and the formation of regulatory T cells. PLoS Biol 2007;5:2847-2861.
    • (2007) PLoS Biol , vol.5 , pp. 2847-2861
    • Mantel, P.Y.1    Kuipers, H.2    Boyman, O.3
  • 25
    • 59649105182 scopus 로고    scopus 로고
    • IL4 blockade of inducible regulatory T cell differentiation: The role of Th2 cells, Gata3 and PU.1
    • Hadjur S, Bruno L, Hertweck A, et al. IL4 blockade of inducible regulatory T cell differentiation: the role of Th2 cells, Gata3 and PU.1. Immunol Letters 2009;122:37-43.
    • (2009) Immunol Letters , vol.122 , pp. 37-43
    • Hadjur, S.1    Bruno, L.2    Hertweck, A.3
  • 27
    • 1642306579 scopus 로고    scopus 로고
    • IL-4-dependent Th2 collateral priming to inhaled antigens independent of Toll-like receptor 4 and myeloid differentiation factor 88
    • Eisenbarth SC, Zhadkevich A, Ranney P, et al. IL-4-dependent Th2 collateral priming to inhaled antigens independent of Toll-like receptor 4 and myeloid differentiation factor 88. J Immunol 2004;172:4527-4534.
    • (2004) J Immunol , vol.172 , pp. 4527-4534
    • Eisenbarth, S.C.1    Zhadkevich, A.2    Ranney, P.3
  • 28
    • 68949103932 scopus 로고    scopus 로고
    • STAT6 activation confers upon T helper cells resistance to suppression by regulatory T cells
    • Pillemer BB, Qi Z, Melgert B, et al. STAT6 activation confers upon T helper cells resistance to suppression by regulatory T cells. J Immunol 2009;183:155-163.
    • (2009) J Immunol , vol.183 , pp. 155-163
    • Pillemer, B.B.1    Qi, Z.2    Melgert, B.3
  • 30
    • 84896729297 scopus 로고    scopus 로고
    • Specific immunotherapy modifies allergen-specific CD4 (+) T-cell responses in an epitope-dependent manner
    • Wambre E, DeLong JH, James EA, et al. Specific immunotherapy modifies allergen-specific CD4 (+) T-cell responses in an epitope-dependent manner. J Allergy Clin Immunol 2014;133:872-879; e7.
    • (2014) J Allergy Clin Immunol , vol.133 , pp. 872-879e7
    • Wambre, E.1    De Long, J.H.2    James, E.A.3
  • 31
    • 74049131014 scopus 로고    scopus 로고
    • Different routes of bacterial infection induce long-lived TH1 memory cells and short-lived TH17 cells
    • Pepper M, Linehan JL, Pagan AJ, et al. Different routes of bacterial infection induce long-lived TH1 memory cells and short-lived TH17 cells. Nat Immunol 2010;11:83-89.
    • (2010) Nat Immunol , vol.11 , pp. 83-89
    • Pepper, M.1    Linehan, J.L.2    Pagan, A.J.3
  • 32
    • 84897001539 scopus 로고    scopus 로고
    • Sublingual immunotherapy for asthma: Affects T-cells but does not impact basophil activation
    • Ciepiela O, Zawadzka-Krajewska A, Kotula I, et al. Sublingual Immunotherapy for asthma: affects T-cells but does not impact basophil activation. Pediatr Allergy Immunol Pulmonol 2014;27:17-23.
    • (2014) Pediatr Allergy Immunol Pulmonol , vol.27 , pp. 17-23
    • Ciepiela, O.1    Zawadzka-Krajewska, A.2    Kotula, I.3
  • 33
    • 68649116551 scopus 로고    scopus 로고
    • Interleukin-10 production by Th1 cells requires interleukin-12-induced STAT4 transcription factor and ERK MAP kinase activation by high antigen dose
    • Saraiva M, Christensen JR, Veldhoen M, et al. Interleukin-10 production by Th1 cells requires interleukin-12-induced STAT4 transcription factor and ERK MAP kinase activation by high antigen dose. Immunity 2009;31:209-219.
    • (2009) Immunity , vol.31 , pp. 209-219
    • Saraiva, M.1    Christensen, J.R.2    Veldhoen, M.3
  • 34
    • 77952711172 scopus 로고    scopus 로고
    • + regulatory T cells suppressing Th2-mediated allergic asthma
    • + regulatory T cells suppressing Th2-mediated allergic asthma. Proc Natl Acad Sci U S A 2010;107:8742-8747.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 8742-8747
    • Kim, B.S.1    Kim, I.K.2    Park, Y.J.3
  • 35
    • 84902544789 scopus 로고    scopus 로고
    • Epigenetic regulation of asthma and allergic disease
    • Begin P, Nadeau KC. Epigenetic regulation of asthma and allergic disease. Allergy Asthma Clin Immuno 2014;10:1-12.
    • (2014) Allergy Asthma Clin Immuno , vol.10 , pp. 1-12
    • Begin, P.1    Nadeau, K.C.2
  • 36
    • 84938934234 scopus 로고    scopus 로고
    • Specific epicutaneous immunotherapy prevents sensitization to new allergens in a murine model
    • Mondoulet L, Dioszeghy V, Puteaux E, et al. Specific epicutaneous immunotherapy prevents sensitization to new allergens in a murine model. J Allergy Clin Immunol 2015;135:1546-1557; e4.
    • (2015) J Allergy Clin Immunol , vol.135 , pp. 1546-1557e4
    • Mondoulet, L.1    Dioszeghy, V.2    Puteaux, E.3
  • 38
    • 79551504195 scopus 로고    scopus 로고
    • Long-term tolerance after allergen immunotherapy is accompanied by selective persistence of blocking antibodies
    • James LK, Shamji MH, Walker SM, et al. Long-term tolerance after allergen immunotherapy is accompanied by selective persistence of blocking antibodies. J Allergy Clin Immunol 2011;127:509-516; e1-5.
    • (2011) J Allergy Clin Immunol , vol.127 , pp. 509e1-516e5
    • James, L.K.1    Shamji, M.H.2    Walker, S.M.3
  • 39
    • 84862075886 scopus 로고    scopus 로고
    • + Th2 inhibitory cells form in a Foxp3-independent, IL-2-dependent manner from Th2 effectors during chronic inflammation
    • + Th2 inhibitory cells form in a Foxp3-independent, IL-2-dependent manner from Th2 effectors during chronic inflammation. J Immunol 2012;188:5478-5488.
    • (2012) J Immunol , vol.188 , pp. 5478-5488
    • Altin, J.A.1    Goodnow, C.C.2    Cook, M.C.3
  • 40
    • 84855264803 scopus 로고    scopus 로고
    • Th2 and regulatory immune reactions contribute to IgG4 production and the initiation of Mikulicz disease
    • Tanaka A, Moriyama M, Nakashima H, et al. Th2 and regulatory immune reactions contribute to IgG4 production and the initiation of Mikulicz disease. Arthritis Rheum 2012;64:254-263.
    • (2012) Arthritis Rheum , vol.64 , pp. 254-263
    • Tanaka, A.1    Moriyama, M.2    Nakashima, H.3
  • 41
    • 84952638825 scopus 로고    scopus 로고
    • Chronic cat-allergen exposure induces a TH2 cell-dependent IgG4 response related to low-sensitization
    • Renand A, Archila LD, McGinty J, Wambre E, Robinson D, Hales BJ, et al. Chronic cat-allergen exposure induces a TH2 cell-dependent IgG4 response related to low-sensitization. J Allergy Clin Immunol 2015; pii: S0091-6749 (15) 01091-X. doi:10.1016/j.jaci.2015.07.031. [Epub ahead of print]
    • (2015) J Allergy Clin Immunol
    • Renand, A.1    Archila, L.D.2    McGinty, J.3    Wambre, E.4    Robinson, D.5    Hales, B.J.6
  • 42
    • 0033846514 scopus 로고    scopus 로고
    • Changes in cytokine production in vitro during the early phase of birch-pollen immunotherapy
    • Moverare R, Elfman L, Bjornsson E, Stalenheim G. Changes in cytokine production in vitro during the early phase of birch-pollen immunotherapy. Scand J Immunol 2000;52:200-206.
    • (2000) Scand J Immunol , vol.52 , pp. 200-206
    • Moverare, R.1    Elfman, L.2    Bjornsson, E.3    Stalenheim, G.4
  • 44
    • 33750499311 scopus 로고    scopus 로고
    • Interleukin-10 determines viral clearance or persistence in vivo
    • Brooks DG, Trifilo MJ, Edelmann KH, et al. Interleukin-10 determines viral clearance or persistence in vivo. Nat Med 2006;12:1301-1309.
    • (2006) Nat Med , vol.12 , pp. 1301-1309
    • Brooks, D.G.1    Trifilo, M.J.2    Edelmann, K.H.3
  • 45
    • 77949357362 scopus 로고    scopus 로고
    • T-cell exhaustion: Characteristics, causes and conversion
    • Yi JS, Cox MA, Zajac AJ. T-cell exhaustion: characteristics, causes and conversion. Immunology 2010;129:474-481.
    • (2010) Immunology , vol.129 , pp. 474-481
    • Yi, J.S.1    Cox, M.A.2    Zajac, A.J.3
  • 46
    • 84921291171 scopus 로고    scopus 로고
    • Suppression of antigen presentation by IL-10
    • Mittal SK, Roche PA. Suppression of antigen presentation by IL-10. CurrOpin Immunol 2015;34:22-27.
    • (2015) CurrOpin Immunol , vol.34 , pp. 22-27
    • Mittal, S.K.1    Roche, P.A.2
  • 47
    • 84893692443 scopus 로고    scopus 로고
    • Pathogenic memory type Th2 cells in allergic inflammation
    • Endo Y, Hirahara K, Yagi R, et al. Pathogenic memory type Th2 cells in allergic inflammation. Trend Immunol 2014;35:69-78.
    • (2014) Trend Immunol , vol.35 , pp. 69-78
    • Endo, Y.1    Hirahara, K.2    Yagi, R.3
  • 48
    • 85019298841 scopus 로고    scopus 로고
    • TH2A cells as a unique TH2 cell subset in allergic individuals: Steps toward a T cell biomarker for allergy
    • Wambre E, Delong EA, James EA, et al. TH2A cells as a unique TH2 cell subset in allergic individuals: steps toward a T cell biomarker for allergy. J Allergy Clin Immunol 2012;129(2 Supplemental): AB129.
    • (2012) J Allergy Clin Immunol , vol.129 , Issue.2 , pp. AB129
    • Wambre, E.1    Delong, E.A.2    James, E.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.