Suppression of antigen presentation by IL-10

Current Opinion in Immunology

Volumn 34, Issue , 2015, Pages 22-27

  Mittal, Sharad K ^a   Roche, Paul A ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD68 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 10; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PEPTIDES AND PROTEINS; PROTEIN MARCH I; TOLL LIKE RECEPTOR; UNCLASSIFIED DRUG;

ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DENDRITIC CELL; HUMAN; IMMUNOREGULATION; MACROPHAGE ACTIVATION; MONOCYTE; NONHUMAN; REVIEW; SIGNAL TRANSDUCTION; ANIMAL; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; PHAGOCYTE;

ANIMALS; ANTIGEN PRESENTATION; DENDRITIC CELLS; HUMANS; IMMUNE TOLERANCE; INTERLEUKIN-10; PHAGOCYTES; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTORS;

EID: 84921291171     PISSN: 09527915     EISSN: 18790372     Source Type: Journal    
DOI: 10.1016/j.coi.2014.12.009     Document Type: Review

References (48)

1. Banchereau J., Briere F., Caux C., Davoust J., Lebecque S., Liu Y.J., Pulendran B., Palucka K. Immunobiology of dendritic cells. Annu Rev Immunol 2000, 18:767-811.
2. Murray P.J., Wynn T.A. Protective and pathogenic functions of macrophage subsets. Nat Rev Immunol 2011, 11:723-737.
3. Hume D.A. Macrophages as APC and the dendritic cell myth. J Immunol 2008, 181:5829-5835.
4. Sun Z., Zhang R., Wang H., Jiang P., Zhang J., Zhang M., Gu L., Yang X., Ji X. Serum IL-10 from systemic lupus erythematosus patients suppresses the differentiation and function of monocyte-derived dendritic cells. J Biomed Res 2012, 26:456-466. [edn 2013/04/05].
5. Grutz G. New insights into the molecular mechanism of interleukin-10-mediated immunosuppression. J Leukoc Biol 2005, 77:3-15.
6. Hutchins A.P., Diez D., Miranda-Saavedra D. The IL-10/STAT3-mediated anti-inflammatory response: recent developments and future challenges. Brief Funct Genom 2013, 12:489-498.
7. Wu H.Y., Quintana F.J., da Cunha A.P., Dake B.T., Koeglsperger T., Starossom S.C., Weiner H.L. In vivo induction of Tr1 cells via mucosal dendritic cells and AHR signaling. PLoS ONE 2011, 6:e23618.
8. Parcina M., Miranda-Garcia M.A., Durlanik S., Ziegler S., Over B., Georg P., Foermer S., Ammann S., Hilmi D., Weber K.J., et al. Pathogen-triggered activation of plasmacytoid dendritic cells induces IL-10-producing B cells in response to Staphylococcus aureus. J Immunol 2013, 190:1591-1602.
9. Doz E., Lombard R., Carreras F., Buzoni-Gatel D., Winter N. Mycobacteria-infected dendritic cells attract neutrophils that produce IL-10 and specifically shut down Th17 CD4 T cells through their IL-10 receptor. J Immunol 2013, 191:3818-3826.
10. Ng S.S., Li A., Pavlakis G.N., Ozato K., Kino T. Viral infection increases glucocorticoid-induced interleukin-10 production through ERK-mediated phosphorylation of the glucocorticoid receptor in dendritic cells: potential clinical implications. PLOS ONE 2013, 8:e63587.
11. Liu B.S., Cao Y., Huizinga T.W., Hafler D.A., Toes R.E. TLR-mediated STAT3 and ERK activation controls IL-10 secretion by human B cells. Eur J Immunol 2014, 44:2121-2129.
12. Carey A.J., Tan C.K., Ulett G.C. Infection-induced IL-10 and JAK-STAT. A review of the molecular circuitry controlling immune hyperactivity in response to pathogenic microbes. JAKSTAT 2012, 1:159-167.
13. Liu W.H., Liu J.J., Wu J., Zhang L.L., Liu F., Yin L., Zhang M.M., Yu B. Novel mechanism of inhibition of dendritic cells maturation by mesenchymal stem cells via interleukin-10 and the JAK1/STAT3 signaling pathway. PLOS ONE 2013, 8:e55487.
14. Wang Y., Li T., Wu B., Liu H., Luo J., Feng D., Shi Y. STAT1 regulates MD-2 expression in monocytes of sepsis via miR-30a. Inflammation 2014, 37:1903-1911.
15. Redford P.S., Murray P.J., O'Garra A. The role of IL-10 in immune regulation during M. tuberculosis infection. Mucosal Immunol 2011, 4:261-270.
16. Antoniv T.T., Ivashkiv L.B. Interleukin-10-induced gene expression and suppressive function are selectively modulated by the PI3K-Akt-GSK3 pathway. Immunology 2011, 132:567-577.
17. Brooks D.G., Walsh K.B., Elsaesser H., Oldstone M.B. IL-10 directly suppresses CD4 but not CD8 T cell effector and memory responses following acute viral infection. Proc Natl Acad Sci U S A 2010, 107:3018-3023.
18. Akdis C.A., Joss A., Akdis M., Faith A., Blaser K. A molecular basis for T cell suppression by IL-10: CD28-associated IL-10 receptor inhibits CD28 tyrosine phosphorylation and phosphatidylinositol 3-kinase binding. FASEB J 2000, 14:1666-1668.
19. Kawai T., Akira S. TLR signaling. Cell Death Differ 2006, 13:816-825.
20. Curtale G., Mirolo M., Renzi T.A., Rossato M., Bazzoni F., Locati M. Negative regulation of Toll-like receptor 4 signaling by IL-10-dependent microRNA-146b. Proc Natl Acad Sci U S A 2013, 110:11499-11504.
21. McCoy C.E., Sheedy F.J., Qualls J.E., Doyle S.L., Quinn S.R., Murray P.J., O'Neill L.A. IL-10 inhibits miR-155 induction by toll-like receptors. J Biol Chem 2010, 285:20492-20498.
22. An H., Xu H., Zhang M., Zhou J., Feng T., Qian C., Qi R., Cao X. Src homology 2 domain-containing inositol-5-phosphatase 1 (SHIP1) negatively regulates TLR4-mediated LPS response primarily through a phosphatase activity- and PI-3K-independent mechanism. Blood 2005, 105:4685-4692.
23. Gabhann J.N., Higgs R., Brennan K., Thomas W., Damen J.E., Ben Larbi N., Krystal G., Jefferies C.A. Absence of SHIP-1 results in constitutive phosphorylation of tank-binding kinase 1 and enhanced TLR3-dependent IFN-beta production. J Immunol 2010, 184:2314-2320.
24. Quinn S.R., Mangan N.E., Caffrey B.E., Gantier M.P., Williams B.R., Hertzog P.J., McCoy C.E., O'Neill L.A. The role of Ets2 transcription factor in the induction of microRNA-155 (miR-155) by lipopolysaccharide and its targeting by interleukin-10. J Biol Chem 2014, 289:4316-4325.
25. Bhattacharyya S., Sen P., Wallet M., Long B., Baldwin A.S., Tisch R. Immunoregulation of dendritic cells by IL-10 is mediated through suppression of the PI3K/Akt pathway and of IkappaB kinase activity. Blood 2004, 104:1100-1109.
26. Sabat R. IL-10 family of cytokines. Cytokine Growth Factor Rev 2010, 21:315-324.
27. Sag D., Carling D., Stout R.D., Suttles J. Adenosine 5'-monophosphate-activated protein kinase promotes macrophage polarization to an anti-inflammatory functional phenotype. J Immunol 2008, 181:8633-8641.
28. Carroll K.C., Viollet B., Suttles J. AMPKalpha1 deficiency amplifies proinflammatory myeloid APC activity and CD40 signaling. J Leukoc Biol 2013, 94:1113-1121.
29. Chang J., Kunkel S.L., Chang C.H. Negative regulation of MyD88-dependent signaling by IL-10 in dendritic cells. Proc Natl Acad Sci U S A 2009, 106:18327-18332.
30. Rossato M., Curtale G., Tamassia N., Castellucci M., Mori L., Gasperini S., Mariotti B., De Luca M., Mirolo M., Cassatella M.A., et al. IL-10-induced microRNA-187 negatively regulates TNF-alpha, IL-6, and IL-12p40 production in TLR4-stimulated monocytes. Proc Natl Acad Sci U S A 2012, 109:E3101-E3110.
31. Schaljo B., Kratochvill F., Gratz N., Sadzak I., Sauer I., Hammer M., Vogl C., Strobl B., Muller M., Blackshear P.J., et al. Tristetraprolin is required for full anti-inflammatory response of murine macrophages to IL-10. J Immunol 2009, 183:1197-1206.
32. Hammer M., Mages J., Dietrich H., Servatius A., Howells N., Cato A.C., Lang R. Dual specificity phosphatase 1 (DUSP1) regulates a subset of LPS-induced genes and protects mice from lethal endotoxin shock. J Exp Med 2006, 203:15-20.
33. Avdic S., Cao J.Z., McSharry B.P., Clancy L.E., Brown R., Steain M., Gottlieb D.J., Abendroth A., Slobedman B. Human cytomegalovirus interleukin-10 polarizes monocytes toward a deactivated M2c phenotype to repress host immune responses. J Virol 2013, 87:10273-10282.
34. Ito S., Ansari P., Sakatsume M., Dickensheets H., Vazquez N., Donnelly R.P., Larner A.C., Finbloom D.S. Interleukin-10 inhibits expression of both interferon alpha- and interferon gamma-induced genes by suppressing tyrosine phosphorylation of STAT1. Blood 1999, 93:1456-1463.
35. Chan L.L., Cheung B.K., Li J.C., Lau A.S. A role for STAT3 and cathepsin S in IL-10 down-regulation of IFN-gamma-induced MHC class II molecule on primary human blood macrophages. J Leukoc Biol 2010, 88:303-311.
36. Bobadilla K., Sada E., Jaime M.E., Gonzalez Y., Ramachandra L., Rojas R.E., Pedraza-Sanchez S., Michalak C., Gonzalez-Noriega A., Torres M. Human phagosome processing of Mycobacterium tuberculosis antigens is modulated by interferon-gamma and interleukin-10. Immunology 2013, 138:34-46.
37. Blander J.M., Medzhitov R. Toll-dependent selection of microbial antigens for presentation by dendritic cells. Nature 2006, 440:808-812.
38. Kalinski P., Schuitemaker J.H., Hilkens C.M., Kapsenberg M.L. Prostaglandin E2 induces the final maturation of IL-12-deficient CD1a+CD83+ dendritic cells: the levels of IL-12 are determined during the final dendritic cell maturation and are resistant to further modulation. J Immunol 1998, 161:2804-2809.
39. Pajkrt D., Camoglio L., Tiel-van Buul M.C., de Bruin K., Cutler D.L., Affrime M.B., Rikken G., van der Poll T., ten Cate J.W., van Deventer S.J. Attenuation of proinflammatory response by recombinant human IL-10 in human endotoxemia: effect of timing of recombinant human IL-10 administration. J Immunol 1997, 158:3971-3977.
40. Herrero C., Hu X., Li W.P., Samuels S., Sharif M.N., Kotenko S., Ivashkiv L.B. Reprogramming of IL-10 activity and signaling by IFN-gamma. J Immunol 2003, 171:5034-5041.
41. Koppelman B., Neefjes J.J., de Vries J.E., de Waal Malefyt R. Interleukin-10 down-regulates MHC class II alphabeta peptide complexes at the plasma membrane of monocytes by affecting arrival and recycling. Immunity 1997, 7:861-871.
42. Thibodeau J., Bourgeois-Daigneault M.C., Huppe G., Tremblay J., Aumont A., Houde M., Bartee E., Brunet A., Gauvreau M.E., de Gassart A., et al. Interleukin-10-induced MARCH1 mediates intracellular sequestration of MHC class II in monocytes. Eur J Immunol 2008, 38:1225-1230.
43. Ishido S., Goto E., Matsuki Y., Ohmura-Hoshino M. E3 ubiquitin ligases for MHC molecules. Curr Opin Immunol 2009, 21:78-83.
44. Furuta K., Walseng E., Roche P.A. Internalizing MHC class II-peptide complexes are ubiquitinated in early endosomes and targeted for lysosomal degradation. Proc Natl Acad Sci U S A 2013, 110:20188-20193.
45. Walseng E., Furuta K., Goldszmid R.S., Weih K.A., Sher A., Roche P.A. Dendritic cell activation prevents MHC class II ubiquitination and promotes MHC class II survival regardless of the activation stimulus. J Biol Chem 2010, 285:41749-41754.
46. Hunt D., Wilson J.E., Weih K.A., Ishido S., Harton J.A., Roche P.A., Drake J.R. Francisella tularensis elicits IL-10 via a PGE(2)-inducible factor, to drive macrophage MARCH1 expression and class II down-regulation. PLOS ONE 2012, 7:e37330.
47. Tze L.E., Horikawa K., Domaschenz H., Howard D.R., Roots C.M., Rigby R.J., Way D.A., Ohmura-Hoshino M., Ishido S., Andoniou C.E., et al. CD83 increases MHC II and CD86 on dendritic cells by opposing IL-10-driven MARCH1-mediated ubiquitination and degradation. J Exp Med 2011, 208:149-165.
48. Chattopadhyay G., Shevach E.M. Antigen-specific induced T regulatory cells impair dendritic cell function via an IL-10/MARCH1-dependent mechanism. J Immunol 2013, 191:5875-5884.