Sublingual immunotherapy for asthma: Affects T-cells but does not impact basophil activation

Pediatric, Allergy, Immunology, and Pulmonology

Volumn 27, Issue 1, 2014, Pages 17-23

  Ciepiela, Olga ^a   Zawadzka Krajewska, Anna ^a   Kotuła, Iwona ^a   Van Overveld, Frans ^b   Kulus, Marek ^a   Demkow, Urszula ^a  

^a MEDICAL UNIVERSITY OF WARSAW   (Poland)

^b Roosevelt Academy   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGEN; CD203C ANTIGEN; GRASS POLLEN ALLERGEN; HOUSE DUST ALLERGEN; LYMPHOCYTE ANTIGEN; PROTEIN BCL 2; UNCLASSIFIED DRUG; VACCINE;

ADOLESCENT; ALLERGIC ASTHMA; ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; BASOPHIL; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; HOUSE DUST ALLERGY; HUMAN; IMMUNE RESPONSE; LEUKOCYTE ACTIVATION; MALE; PILOT STUDY; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; SUBLINGUAL IMMUNOTHERAPY; TH1 CELL; TH2 CELL; VACCINATION;

EID: 84897001539     PISSN: 2151321X     EISSN: 21513228     Source Type: Journal    
DOI: 10.1089/ped.2014.0328     Document Type: Article

References (40)

1. Majak P, Kaczmarek-Woźniak J, Brzozowska A, Bobrowska-Korzeniowska M, Jerzynska J, Stelmach I. One-year follow-up of clinical and inflammatory parameters in children allergic to grass pollen receiving high-dose ultrarush sublingual immunotherapy. J Investig Allergol Clin Immunol 2010; 20:602-606.
2. Okubo K, Gotoh M, Fujieda S, et al. A randomized double-blind comparative study of sublingual immunotherapy for cedar pollinosis. Allergol Int 2008; 57: 265-275.
3. Pfaar O, Kleine-Tebbe J, Hörmann K, Klimek L. Allergenspecific immunotherapy: which outcome measures are useful in monitoring clinical trials? Immunol Allergy Clin N Am 2011; 31:289-309.
4. Matsuoka T, Shamji MH, Durham SR. Allergen immunotherapy and tolerance. Allergol Int 2013; 62:403-413.
5. Aryan Z, Comapalati E, Canonica GW, Rezaei N. Allergenspecific immunotherapy in asthmatic children: from basis to clinical applications. Expert Rev Vaccines 2013; 12:639-659.
6. Calderón MA, Simons FER, Malling H-J, Lockey RF, Moingeon P, Demoly P. Sublingual allergen immunotherapy: mode of action and its relationship with the safety profile. Allergy 2011; 67:302-311.
7. Cox L. Sublingual immunotherapy in pediatric allergic rhinitis and asthma: efficacy, safety, and practical considerations. Curr Allergy Asthma Rep 2007; 7:410-420.
8. Akdis CA, Akdis M, Mechanisms of allergen-specific immunotherapy. J Allergy Clin Immunol 2011; 127:18-27.
9. Ciprandi G, Tosca MA, Marseglia GL. Sublingual immunotherapy mechanisms of action: the role of Th1 response. Int J Immunopathol Pharmacol 2009; 22:S9-12.
10. Angelini F, Pacciani V, Corrente S, et al. Dendritic cells modification during sublingual immunotherapy in children with allergic symptoms to house dust mites. World J Pediatr 2011; 7:24-30.
11. Moingeon P, Mascarell L. Induction of tolerance via the sublingual route: mechanisms and application. Clin Dev Immunol 2012; Article ID 623474, doi:10.1155/2012/623474.
12. Calderon MA, Simons FER, Malling M-J, Lockey RF, Moingeon P, Demoly P. Sublingual allergen immunotherapy: mode of action and its relationship with the safety profile. Allergy 2012; 67:302-311.
13. Ciprandi G, De Amici M, Tosca MA, Pistorio A, Marseglia GL. Sublingual immunotherapy affects specific antibody and TGF-beta serum levels in patients with allergic rhinitis. Int J Immunopathol Pharmacol 2009; 22:1089-1096.
14. Shamji MH, Durham SR. Mechanisms of immunotherapy to aeroallergens. Clin Exp Allergy 2011; 41:1235-1246.
15. Fujita H, Soyka MB, Akdis M, Akdis CA. Mechanisms of allergen-specific immunotherapy. Clin Transl Allergy 2012; 2:2.
16. Bahceciler NN, Arikan C, Taylor A, et al. Impact of sublingual immunotherapy on specific antibody levels in asthmatic children allergic to house dust mites. Int Arch Allergy Immunol 2005; 136:287-294.
17. Bohle B, Kinciyan T, Gerstmayr M, Radakovics A, Jahn-Schmid B, Ebner C. Sublingual immunotherapy induces IL-10-producing T regulatory cells, allergen specific T-cell tolerance, and immune deviation. J Allergy Clin Immunol 2007; 120:707-713.
18. Burastero SE, Mistrello G, Falagiani P, et al. Effect of sublingual immunotherapy with grass monomeric allergoid on allergen-specific T-cell proliferation and interleukin 10 production. Ann Allergy Asthma Immunol 2008; 100: 343-350.
19. Cosmi L, Santarlasci V, Angeli R, et al. Sublingual immunotherapy with Dermatophagoides monomeric allergoid down-regulates allergen-specific immunoglobulin E and increases both interferon gamma and interleukin-10- production. Clin Exp Allergy 2006; 36:261-272.
20. Leatherman BD, Owen S, Parker M, et al. Sublingual Immunotherapy: past, present, paradigm for the future? A review of the literature. Otolaryngol Head Neck Surg 2007; 136:S1-20.
21. Abdulamir AS, Kadhim HS, Hafidh RR, et al. Severity of asthma: the role of CD25 +, CD30 +, NF-κB and apoptotic markers. J Invest Allergol Clin Immunol 2009; 19:218-224.
22. Abdulamir AS, Hafidh RR, Abubakar F, Abbas KS. Changing survival, memory cell compartment, and Thelper balance of lymphocytes between severe and mild asthma. BMC Immunol 2008; 9:73-82.
23. Expert Panel Report 3: Guidelines for the diagnosis and management of asthma. National Heart, Lung, and Blood Institute. U.S. Department of Health and Human Services, National Institutes of Health; 2007.
24. McGowan EC, Saini S. Update on the performance and application of basophil activation tests. Curr Allergy Asthma Rep 2013; 13:101-109.
25. Potapinska O, Gorska E, Demkow U, Zawadzka-Krajewska A, Kulus M, Wasik M. The usefulness of CD203c expression measurement on basophils after activation with grass pollen and Dermatophagoides pteronyssinus antigens. Preliminary study. Pneumonol Alergol Pol 2009; 77: 138-144.
26. Eifan AO, Akkoc T, Yildiz A, et al. Clinical efficacy and immunological mechanisms of sublingual and subcutaneous immunotherapy in asthmatic/rhinitis children sensitized to house dust mite: an open randomized controlled trial. Clin Exp Allergy 2010; 40:922-932.
27. O'Hehir RE, Gardner LM, de Leon MP, et al. House dust mite sublingual immunotherapy: the role for transforming growth factor-beta and functional regulatory T-cells. Am J Respir Crit Care Med 2009; 180:936-947.
28. Savolainen J, Jacobsen L, Valovirta E. Sublingual immunotherapy in children modulates allergen-induced in vitro expression of cytokine mRNA in PBMC. Allergy 2006; 61:1184-1190.
29. Kamiński M, Kloda K, Pawlik A. The role of interleukin-18 in the pathogenesis of bronchial asthma and other allergic diseases and in activation of basophils and mastocytes. Pneumonol Alergol Pol 2008; 76:432-436.
30. Cosmi L, Santarlasci V, Angeli R, et al. Sublingual immunotherapy with Dermatophagoides monomeric allergoid down-regulate allergen-specific immunoglobulin E and increases both interferon gamma and interleukin-10- production. Clin Exp Allergy 2006; 36:261-272.
31. Kim EH, Bird JA, Kulis M, et al. Sublingual immunotherapy for peanut allergy: clinical and immunologic evidence of desensitization. J Allergy Clin Immunol 2011; 127:640-646.
32. Romagnani S. Cytokines and chemoattractants in allergic inflammation. Mol Immunol 2002; 38:881-885.
33. Horak F, Zieglmayer P, Zieglmayer R, et al. Early onset of action of a 5-grass-pollen 300-IR sublingual immunotherapy tablet evaluated in an allergen challenge chamber. J Allergy Clin Immunol 2009; 124:471-477.
34. Van Overtvelt L, Baron-Bodo V, Horiot S, et al. Changes in basophil activation during grass-pollen sublingual immunotherapy do not correlate with clinical efficacy. Allergy 2011; 66:1530-1537.
35. Fujisawa T, Nagao M, Hiraguchi Y, et al. Biomarkers for allergen immunotherapy in cedar pollinosis. Allergol Int 2009; 58:163-170.
36. Swamy RS, Reshamwala N, Hunter T, et al. Epigenetic modifications and improved regulatory T-cell function in subjects undergoing dual sublingual immunotherapy. J Allergy Clin Immunol 2012; 130:215-224.
37. Shim JY, Kim BS, Cho SH, Min KU, Hong SJ. Allergenspecific conventional immunotherapy decreases immunoglobulin E-mediated basophil histamine releasability. Clin Exp Allergy 2003; 33:52-57.
38. Frisella PD, Silverberg J, Joks R, Frieri M. Transforming growth factor beta: a role in the upper airway and rhino-sinusitis-Dermatophagoides pteronyssinus-induced apoptosis with pulmonary alveolar cells. Am J Rhinol Allergy 2011; 25:231-235.
39. Tsai YG, Chien JW, Chen WL, Shieh JJ, Lin CY. Induced apoptosis of TH2 lymphocytes in asthmatic children treated with Dermatophagoides pteronyssinus immunotherapy. Pediatr Allergy Immunol 2005; 16:602-608.
40. Maggi E, Vultaggio A, Matucci A. T-cell responses during allergen-specific immunotherapy. Curr Opin Allergy Clin Immunol 2012; 12:1-6.