메뉴 건너뛰기




Volumn 12, Issue 1, 2015, Pages

IL-4/10 prevents stress vulnerability following imipramine discontinuation

Author keywords

Depression; IL 10; IL 4; Microglia; Stress vulnerability

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; IMIPRAMINE; INTERLEUKIN 10; INTERLEUKIN 4; KYNURENINE; RECOMBINANT INTERLEUKIN 10; RECOMBINANT INTERLEUKIN 4; SEROTONIN RECEPTOR; RECOMBINANT PROTEIN; TRICYCLIC ANTIDEPRESSANT AGENT;

EID: 84946490672     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/s12974-015-0416-3     Document Type: Article
Times cited : (53)

References (68)
  • 1
    • 38049081662 scopus 로고    scopus 로고
    • Major depressive disorder
    • Belmaker RH, Agam G. Major depressive disorder. N Engl J Med. 2008;358:55-68.
    • (2008) N Engl J Med , vol.358 , pp. 55-68
    • Belmaker, R.H.1    Agam, G.2
  • 2
    • 0031737512 scopus 로고    scopus 로고
    • The effects of adherence to antidepressant treatment guidelines on relapse and recurrence of depression
    • Melfi CA, Chawla AJ, Croghan TW, Hanna MP, Kennedy S, Sredl K. The effects of adherence to antidepressant treatment guidelines on relapse and recurrence of depression. Arch Gen Psychiatry. 1998;55:1128-32.
    • (1998) Arch Gen Psychiatry , vol.55 , pp. 1128-1132
    • Melfi, C.A.1    Chawla, A.J.2    Croghan, T.W.3    Hanna, M.P.4    Kennedy, S.5    Sredl, K.6
  • 4
    • 78651417057 scopus 로고    scopus 로고
    • Immune suppression and immune activation in depression
    • Blume J, Douglas SD, Evans DL. Immune suppression and immune activation in depression. Brain Behav Immun. 2011;25:221-9.
    • (2011) Brain Behav Immun , vol.25 , pp. 221-229
    • Blume, J.1    Douglas, S.D.2    Evans, D.L.3
  • 6
    • 63449122724 scopus 로고    scopus 로고
    • Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression
    • Miller AH, Maletic V, Raison CL. Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression. Biol Psychiatry. 2009;65:732-41.
    • (2009) Biol Psychiatry , vol.65 , pp. 732-741
    • Miller, A.H.1    Maletic, V.2    Raison, C.L.3
  • 7
    • 34547794475 scopus 로고    scopus 로고
    • The immune-mediated alteration of serotonin and glutamate: towards an integrated view of depression
    • Müller N, Schwarz MJ. The immune-mediated alteration of serotonin and glutamate: towards an integrated view of depression. Mol Psychiatry. 2007;12:988-1000.
    • (2007) Mol Psychiatry , vol.12 , pp. 988-1000
    • Müller, N.1    Schwarz, M.J.2
  • 8
    • 0242720163 scopus 로고    scopus 로고
    • Cytokine-serotonin interaction through IDO: a neurodegeneration hypothesis of depression
    • Myint AM, Kim YK. Cytokine-serotonin interaction through IDO: a neurodegeneration hypothesis of depression. Med Hypotheses. 2003;61:519-25.
    • (2003) Med Hypotheses , vol.61 , pp. 519-525
    • Myint, A.M.1    Kim, Y.K.2
  • 9
    • 0028803021 scopus 로고
    • The effect of chronic treatment with imipramine on the immunoreactivity of animals subjected to a chronic mild stress model of depression
    • Kubera M, Basta-Kaim A, Papp M. The effect of chronic treatment with imipramine on the immunoreactivity of animals subjected to a chronic mild stress model of depression. Immunopharmacology. 1995;30:225-30.
    • (1995) Immunopharmacology , vol.30 , pp. 225-230
    • Kubera, M.1    Basta-Kaim, A.2    Papp, M.3
  • 10
    • 84901253775 scopus 로고    scopus 로고
    • Dynamic microglial alterations underlie stress-induced depressive-like behavior and suppressed neurogenesis
    • Kreisel T, Frank MG, Licht T, Reshef R, Ben-Menachem-Zidon O, Baratta MV, et al. Dynamic microglial alterations underlie stress-induced depressive-like behavior and suppressed neurogenesis. Mol Psychiatry. 2013;19:699-709.
    • (2013) Mol Psychiatry , vol.19 , pp. 699-709
    • Kreisel, T.1    Frank, M.G.2    Licht, T.3    Reshef, R.4    Ben-Menachem-Zidon, O.5    Baratta, M.V.6
  • 11
    • 34047190418 scopus 로고    scopus 로고
    • Depressive disorders and immunity: 20years of progress and discovery
    • Irwin MR, Miller AH. Depressive disorders and immunity: 20years of progress and discovery. Brain Behav Immun. 2007;21:374-83.
    • (2007) Brain Behav Immun , vol.21 , pp. 374-383
    • Irwin, M.R.1    Miller, A.H.2
  • 12
    • 0036803832 scopus 로고    scopus 로고
    • Depression and immune function: central pathways to morbidity and mortality
    • Kiecolt-Glaser JK, Glaser R. Depression and immune function: central pathways to morbidity and mortality. J Psychosom Res. 2002;53:873-6.
    • (2002) J Psychosom Res , vol.53 , pp. 873-876
    • Kiecolt-Glaser, J.K.1    Glaser, R.2
  • 14
    • 0035107338 scopus 로고    scopus 로고
    • Anti-inflammatory effects of antidepressants through suppression of the interferon-[gamma]/interleukin-10 production ratio
    • Kubera M, Lin A-H, Kenis G, Bosmans E, van Bockstaele D, Maes M. Anti-inflammatory effects of antidepressants through suppression of the interferon-[gamma]/interleukin-10 production ratio. J Clin Psychopharmacol. 2001;21:199-206.
    • (2001) J Clin Psychopharmacol , vol.21 , pp. 199-206
    • Kubera, M.1    Lin, A.-H.2    Kenis, G.3    Bosmans, E.4    Bockstaele, D.5    Maes, M.6
  • 15
    • 0033057940 scopus 로고    scopus 로고
    • Negative immunoregulatory effects of antidepressants: inhibition of interferon-gamma and stimulation of interleukin-10 secretion
    • Maes M, Song C, Lin AH, Bonaccorso S, Kenis G, De Jongh R, et al. Negative immunoregulatory effects of antidepressants: inhibition of interferon-gamma and stimulation of interleukin-10 secretion. Neuropsychopharmacology. 1999;20:370-9.
    • (1999) Neuropsychopharmacology , vol.20 , pp. 370-379
    • Maes, M.1    Song, C.2    Lin, A.H.3    Bonaccorso, S.4    Kenis, G.5    Jongh, R.6
  • 16
    • 71749092663 scopus 로고    scopus 로고
    • Depression and immunity: a role for T cells?
    • Miller AH. Depression and immunity: a role for T cells? Brain Behav Immun. 2010;24:1-8.
    • (2010) Brain Behav Immun , vol.24 , pp. 1-8
    • Miller, A.H.1
  • 17
    • 84887962377 scopus 로고    scopus 로고
    • Acute and chronic stress-induced disturbances of microglial plasticity, phenotype and function
    • Walker FR, Nilsson M, Jones K. Acute and chronic stress-induced disturbances of microglial plasticity, phenotype and function. Curr Drug Targets. 2013;14:1262-76.
    • (2013) Curr Drug Targets , vol.14 , pp. 1262-1276
    • Walker, F.R.1    Nilsson, M.2    Jones, K.3
  • 19
    • 80355143546 scopus 로고    scopus 로고
    • Microglial cell origin and phenotypes in health and disease
    • Saijo K, Glass CK. Microglial cell origin and phenotypes in health and disease. Nat Rev Immunol. 2011;11:775-87.
    • (2011) Nat Rev Immunol , vol.11 , pp. 775-787
    • Saijo, K.1    Glass, C.K.2
  • 21
    • 29244481976 scopus 로고    scopus 로고
    • Stress-induced elevation of glucocorticoids increases microglia proliferation through NMDA receptor activation
    • Nair A, Bonneau RH. Stress-induced elevation of glucocorticoids increases microglia proliferation through NMDA receptor activation. J Neuroendocrinol. 2006;171:72-85.
    • (2006) J Neuroendocrinol , vol.171 , pp. 72-85
    • Nair, A.1    Bonneau, R.H.2
  • 22
    • 80054830690 scopus 로고    scopus 로고
    • Chronic stress alters the density and morphology of microglia in a subset of stress-responsive brain regions
    • Tynan RJ, Naicker S, Hinwood M, Nalivaiko E, Buller KM, Pow DV, et al. Chronic stress alters the density and morphology of microglia in a subset of stress-responsive brain regions. Brain Behav Immun. 2010;24:1058-68.
    • (2010) Brain Behav Immun , vol.24 , pp. 1058-1068
    • Tynan, R.J.1    Naicker, S.2    Hinwood, M.3    Nalivaiko, E.4    Buller, K.M.5    Pow, D.V.6
  • 23
    • 34247880267 scopus 로고    scopus 로고
    • Stress induced morphological microglial activation in the rodent brain: involvement of interleukin-18
    • Sugama S, Fujita M, Hashimoto M, Conti B. Stress induced morphological microglial activation in the rodent brain: involvement of interleukin-18. Neuroscience. 2007;146:1388-99.
    • (2007) Neuroscience , vol.146 , pp. 1388-1399
    • Sugama, S.1    Fujita, M.2    Hashimoto, M.3    Conti, B.4
  • 24
    • 78651167060 scopus 로고
    • Species differences in the metabolism of imipramine and desmethylimipramine (DMI)
    • Dingell JV, Sulser F, Gillette JR. Species differences in the metabolism of imipramine and desmethylimipramine (DMI). J Pharmacol Exp Ther. 1964;143:14-22.
    • (1964) J Pharmacol Exp Ther , vol.143 , pp. 14-22
    • Dingell, J.V.1    Sulser, F.2    Gillette, J.R.3
  • 25
    • 37549043206 scopus 로고    scopus 로고
    • The differential effects of emotional or physical stress on pain behaviors or on c-Fos immunoreactivity in paraventricular nucleus or arcuate nucleus
    • Kwon MS, Seo YJ, Shim EJ, Lee JK, Jang JE, Park SH, et al. The differential effects of emotional or physical stress on pain behaviors or on c-Fos immunoreactivity in paraventricular nucleus or arcuate nucleus. Brain Res. 2008;1190:122-31.
    • (2008) Brain Res , vol.1190 , pp. 122-131
    • Kwon, M.S.1    Seo, Y.J.2    Shim, E.J.3    Lee, J.K.4    Jang, J.E.5    Park, S.H.6
  • 26
    • 0023636527 scopus 로고
    • Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant
    • Willner P, Towell A, Sampson D, Sophokleous S, Muscat R. Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant. Psychopharmacology (Berl). 1987;93:358-64.
    • (1987) Psychopharmacology (Berl) , vol.93 , pp. 358-364
    • Willner, P.1    Towell, A.2    Sampson, D.3    Sophokleous, S.4    Muscat, R.5
  • 27
    • 0019199013 scopus 로고
    • Preliminary report of a simple animal behavior model for the anxiolytic effects of benzodiazepines
    • Crawley J, Goodwin FK. Preliminary report of a simple animal behavior model for the anxiolytic effects of benzodiazepines. Pharmacol Biochem Behav. 1980;13:167-70.
    • (1980) Pharmacol Biochem Behav , vol.13 , pp. 167-170
    • Crawley, J.1    Goodwin, F.K.2
  • 28
    • 0022620470 scopus 로고
    • Anxiolytic and anxiogenic drug effects on exploratory activity in an elevated plus-maze: a novel test of anxiety in the rat
    • Pellow S, File SE. Anxiolytic and anxiogenic drug effects on exploratory activity in an elevated plus-maze: a novel test of anxiety in the rat. Pharmacol Biochem Behav. 1986;24:525-9.
    • (1986) Pharmacol Biochem Behav , vol.24 , pp. 525-529
    • Pellow, S.1    File, S.E.2
  • 29
    • 0021990491 scopus 로고
    • The tail suspension test: a new method for screening antidepressants in mice
    • Steru L, Chermat R, Thierry B, Simon P. The tail suspension test: a new method for screening antidepressants in mice. Psychopharmacology (Berl). 1985;85:367-70.
    • (1985) Psychopharmacology (Berl) , vol.85 , pp. 367-370
    • Steru, L.1    Chermat, R.2    Thierry, B.3    Simon, P.4
  • 30
    • 0017618768 scopus 로고
    • Depression: a new animal model sensitive to antidepressant treatments
    • Porsolt RD, Le Pichon M, Jalfre M. Depression: a new animal model sensitive to antidepressant treatments. Nature. 1977;266:730-2.
    • (1977) Nature , vol.266 , pp. 730-732
    • Porsolt, R.D.1    Pichon, M.2    Jalfre, M.3
  • 31
    • 31844447417 scopus 로고    scopus 로고
    • Optimization of chronic stress paradigms using anxiety- and depression-like behavioral parameters
    • Kim K-S, Han P-L. Optimization of chronic stress paradigms using anxiety- and depression-like behavioral parameters. J Neurosci Res. 2006;83:497-507.
    • (2006) J Neurosci Res , vol.83 , pp. 497-507
    • Kim, K.-S.1    Han, P.-L.2
  • 32
    • 84896529057 scopus 로고    scopus 로고
    • Possible additional antidepressant-like mechanism of sodium butyrate: targeting the hippocampus
    • Han A, Sung YB, Chung SY, Kwon MS. Possible additional antidepressant-like mechanism of sodium butyrate: targeting the hippocampus. Neuropharmacology. 2014;81:292-302.
    • (2014) Neuropharmacology , vol.81 , pp. 292-302
    • Han, A.1    Sung, Y.B.2    Chung, S.Y.3    Kwon, M.S.4
  • 33
    • 84908617290 scopus 로고    scopus 로고
    • Evidence for increased microglial priming and macrophage recruitment in the dorsal anterior cingulate white matter of depressed suicides
    • Torres-Platas SG, Cruceanu C, Chen GG, Turecki G, Mechawar N. Evidence for increased microglial priming and macrophage recruitment in the dorsal anterior cingulate white matter of depressed suicides. Brain Behav Immun. 2014;42:50-9. doi: 10.1016/j.bbi.2014.05.007.
    • (2014) Brain Behav Immun , vol.42 , pp. 50-59
    • Torres-Platas, S.G.1    Cruceanu, C.2    Chen, G.G.3    Turecki, G.4    Mechawar, N.5
  • 34
    • 84898543914 scopus 로고    scopus 로고
    • Immune status influences fear and anxiety responses in mice after acute stress exposure
    • Clark SM, Sand J, Francis TC, Nagaraju A, Michael KC, Keegan AD, et al. Immune status influences fear and anxiety responses in mice after acute stress exposure. Brain Behav Immun. 2014;38:192-201. doi: 10.1016/j.bbi.2014.02.001.
    • (2014) Brain Behav Immun , vol.38 , pp. 192-201
    • Clark, S.M.1    Sand, J.2    Francis, T.C.3    Nagaraju, A.4    Michael, K.C.5    Keegan, A.D.6
  • 35
    • 0041880262 scopus 로고    scopus 로고
    • Untreated depression and hippocampal volume loss
    • Sheline YI, Gado MH, Kraemer HC. Untreated depression and hippocampal volume loss. Am J Psychiatry. 2003;160:1516-8.
    • (2003) Am J Psychiatry , vol.160 , pp. 1516-1518
    • Sheline, Y.I.1    Gado, M.H.2    Kraemer, H.C.3
  • 36
    • 3242745166 scopus 로고    scopus 로고
    • Depression: a case of neuronal life and death?
    • Duman RS. Depression: a case of neuronal life and death? Biol Psychiatry. 2004;56:140-5.
    • (2004) Biol Psychiatry , vol.56 , pp. 140-145
    • Duman, R.S.1
  • 37
    • 84879554454 scopus 로고    scopus 로고
    • The changing phenotype of microglia from homeostasis to disease
    • Luo XG, Chen SD. The changing phenotype of microglia from homeostasis to disease. Transl Neurodegener. 2012;1:9.
    • (2012) Transl Neurodegener , vol.1 , pp. 9
    • Luo, X.G.1    Chen, S.D.2
  • 39
    • 0035101129 scopus 로고    scopus 로고
    • The immunoregulatory effects of antidepressants
    • Maes M. The immunoregulatory effects of antidepressants. Hum Psychopharmacol Clin Exp. 2001;16:95-103.
    • (2001) Hum Psychopharmacol Clin Exp , vol.16 , pp. 95-103
    • Maes, M.1
  • 40
    • 0036901920 scopus 로고    scopus 로고
    • Effects of antidepressants on the production of cytokines
    • Kenis G, Maes M. Effects of antidepressants on the production of cytokines. Int J Neuropsychopharmacol. 2002;5:401-12.
    • (2002) Int J Neuropsychopharmacol , vol.5 , pp. 401-412
    • Kenis, G.1    Maes, M.2
  • 43
    • 84898540196 scopus 로고    scopus 로고
    • Mesenchymal stem cells prevent restraint stress-induced lymphocyte depletion via interleukin-4
    • Cao G, Yang Q, Zhang S, Xu C, Roberts AI, Wang Y, et al. Mesenchymal stem cells prevent restraint stress-induced lymphocyte depletion via interleukin-4. Brain Behav Immun. 2014;38:125-32.
    • (2014) Brain Behav Immun , vol.38 , pp. 125-132
    • Cao, G.1    Yang, Q.2    Zhang, S.3    Xu, C.4    Roberts, A.I.5    Wang, Y.6
  • 44
    • 35648932799 scopus 로고    scopus 로고
    • Maladaptation to mental stress mitigated by the adaptive immune system via depletion of naturally occurring regulatory CD4 + CD25+ cells
    • Cohen H, Ziv Y, Cardon M, Kaplan Z, Matar MA, Gidron Y, et al. Maladaptation to mental stress mitigated by the adaptive immune system via depletion of naturally occurring regulatory CD4 + CD25+ cells. J Neurobiol. 2006;66:552-63.
    • (2006) J Neurobiol , vol.66 , pp. 552-563
    • Cohen, H.1    Ziv, Y.2    Cardon, M.3    Kaplan, Z.4    Matar, M.A.5    Gidron, Y.6
  • 45
    • 84874777901 scopus 로고    scopus 로고
    • Prolonged restraint stress increases IL-6, reduces IL-10, and causes persistent depressive-like behavior that is reversed by recombinant IL-10
    • Voorhees JL, Tarr AJ, Wohleb ES, Godbout JP, Mo X, Sheridan JF, et al. Prolonged restraint stress increases IL-6, reduces IL-10, and causes persistent depressive-like behavior that is reversed by recombinant IL-10. PLoS ONE. 2013;8, e58488.
    • (2013) PLoS ONE , vol.8
    • Voorhees, J.L.1    Tarr, A.J.2    Wohleb, E.S.3    Godbout, J.P.4    Mo, X.5    Sheridan, J.F.6
  • 47
    • 0036165085 scopus 로고    scopus 로고
    • Connecting cytokines and brain: a review of current issues
    • Quan N, Herkenham M. Connecting cytokines and brain: a review of current issues. Histol Histopathol. 2002;17:273-88.
    • (2002) Histol Histopathol , vol.17 , pp. 273-288
    • Quan, N.1    Herkenham, M.2
  • 48
    • 77649225653 scopus 로고    scopus 로고
    • The blood brain barrier and the role of cytokines in neuropsychiatry
    • Yarlagadda A, Alfson E, Clayton AH. The blood brain barrier and the role of cytokines in neuropsychiatry. Psychiatry (Edgmont). 2009;6:18-22.
    • (2009) Psychiatry (Edgmont) , vol.6 , pp. 18-22
    • Yarlagadda, A.1    Alfson, E.2    Clayton, A.H.3
  • 49
    • 14744289048 scopus 로고    scopus 로고
    • Blood-brain barrier transport of cytokines: a mechanism for neuropathology
    • Banks WA. Blood-brain barrier transport of cytokines: a mechanism for neuropathology. Curr Pharm Des. 2005;11:973-84.
    • (2005) Curr Pharm Des , vol.11 , pp. 973-984
    • Banks, W.A.1
  • 50
    • 84896690774 scopus 로고    scopus 로고
    • Bone marrow-derived microglia infiltrate into the paraventricular nucleus of chronic psychological stress-loaded mice
    • Ataka K, Asakawa A, Nagaishi K, Kaimoto K, Sawada A, Hayakawa Y, et al. Bone marrow-derived microglia infiltrate into the paraventricular nucleus of chronic psychological stress-loaded mice. PLoS One. 2013;8, e81744.
    • (2013) PLoS One , vol.8
    • Ataka, K.1    Asakawa, A.2    Nagaishi, K.3    Kaimoto, K.4    Sawada, A.5    Hayakawa, Y.6
  • 51
    • 84922343846 scopus 로고    scopus 로고
    • Peripheral and central effects of repeated social defeat stress: monocyte trafficking, microglial activation, and anxiety
    • Reader BF, Jarrett BL, McKim DB, Wohleb ES, Godbout JP, Sheridan JF. Peripheral and central effects of repeated social defeat stress: monocyte trafficking, microglial activation, and anxiety. NSC. 2015;289:429-42.
    • (2015) NSC , vol.289 , pp. 429-442
    • Reader, B.F.1    Jarrett, B.L.2    McKim, D.B.3    Wohleb, E.S.4    Godbout, J.P.5    Sheridan, J.F.6
  • 52
    • 0034062158 scopus 로고    scopus 로고
    • Cytokines and the brain: implications for clinical psychiatry
    • Kronfol Z, Remick DG. Cytokines and the brain: implications for clinical psychiatry. Am J Psychiatry. 2000;157:683-94.
    • (2000) Am J Psychiatry , vol.157 , pp. 683-694
    • Kronfol, Z.1    Remick, D.G.2
  • 53
    • 35148835215 scopus 로고    scopus 로고
    • CNS-derived interleukin-4 is essential for the regulation of autoimmune inflammation and induces a state of alternative activation in microglial cells
    • Ponomarev ED, Maresz K, Tan Y, Dittel BN. CNS-derived interleukin-4 is essential for the regulation of autoimmune inflammation and induces a state of alternative activation in microglial cells. J Neurosci. 2007;27:10714-21.
    • (2007) J Neurosci , vol.27 , pp. 10714-10721
    • Ponomarev, E.D.1    Maresz, K.2    Tan, Y.3    Dittel, B.N.4
  • 54
    • 84865331656 scopus 로고    scopus 로고
    • Phenotyping primary human microglia: tight regulation of LPS responsiveness
    • Melief J, Koning N, Schuurman KG, Van De Garde MD, Smolders J, Hoek RM, et al. Phenotyping primary human microglia: tight regulation of LPS responsiveness. Glia. 2012;60:1506-17.
    • (2012) Glia , vol.60 , pp. 1506-1517
    • Melief, J.1    Koning, N.2    Schuurman, K.G.3    Garde, M.D.4    Smolders, J.5    Hoek, R.M.6
  • 55
    • 34250877066 scopus 로고    scopus 로고
    • Microglia can be induced by IFN-α or IL-4 to express neural or dendritic-like markers
    • Butovsky O, Bukshpan S, Kunis G, Jung S, Schwartz M. Microglia can be induced by IFN-α or IL-4 to express neural or dendritic-like markers. Mol Cell Neurosci. 2007;35:490-500.
    • (2007) Mol Cell Neurosci , vol.35 , pp. 490-500
    • Butovsky, O.1    Bukshpan, S.2    Kunis, G.3    Jung, S.4    Schwartz, M.5
  • 56
    • 84875414225 scopus 로고    scopus 로고
    • Orchestrated leukocyte recruitment to immune-privileged sites: absolute barriers versus educational gates
    • Shechter R, London A, Schwartz M. Orchestrated leukocyte recruitment to immune-privileged sites: absolute barriers versus educational gates. Nat Rev Immunol. 2013;13:206-18.
    • (2013) Nat Rev Immunol , vol.13 , pp. 206-218
    • Shechter, R.1    London, A.2    Schwartz, M.3
  • 57
    • 23744475685 scopus 로고    scopus 로고
    • The ins and outs of T-lymphocyte trafficking to the CNS: anatomical sites and molecular mechanisms
    • Engelhardt B, Ransohoff RM. The ins and outs of T-lymphocyte trafficking to the CNS: anatomical sites and molecular mechanisms. Trends Immunol. 2005;26:485-95.
    • (2005) Trends Immunol , vol.26 , pp. 485-495
    • Engelhardt, B.1    Ransohoff, R.M.2
  • 58
    • 0142259710 scopus 로고    scopus 로고
    • Three or more routes for leukocyte migration into the central nervous system
    • Ransohoff RM, Kivisakk P, Kidd G. Three or more routes for leukocyte migration into the central nervous system. Nat Rev Immunol. 2003;3:569-81.
    • (2003) Nat Rev Immunol , vol.3 , pp. 569-581
    • Ransohoff, R.M.1    Kivisakk, P.2    Kidd, G.3
  • 59
    • 84902549638 scopus 로고    scopus 로고
    • Neuroinflammation and M2 microglia: the good, the bad, and the inflamed
    • Cherry JD, Olschowka JA, O'Banion MK. Neuroinflammation and M2 microglia: the good, the bad, and the inflamed. J Neuroinflammation. 2014;11:98.
    • (2014) J Neuroinflammation , vol.11 , pp. 98
    • Cherry, J.D.1    Olschowka, J.A.2    O'Banion, M.K.3
  • 60
    • 84928828181 scopus 로고    scopus 로고
    • Imipramine attenuates neuroinflammatory signaling and reverses stress-induced social avoidance
    • Ramirez K, Shea DT, McKim DB, Reader BF, Sheridan JF. Imipramine attenuates neuroinflammatory signaling and reverses stress-induced social avoidance. Brain Behav Immun. 2015;46:212-20.
    • (2015) Brain Behav Immun , vol.46 , pp. 212-220
    • Ramirez, K.1    Shea, D.T.2    McKim, D.B.3    Reader, B.F.4    Sheridan, J.F.5
  • 63
    • 78650161998 scopus 로고    scopus 로고
    • Fractalkine receptor (CX3CR1) deficiency sensitizes mice to the behavioral changes induced by lipopolysaccharide
    • Corona AW, Huang Y, O'Connor JC, Dantzer R, Kelley KW, Popovich PG, et al. Fractalkine receptor (CX3CR1) deficiency sensitizes mice to the behavioral changes induced by lipopolysaccharide. J Neuroinflammation. 2010;7:93.
    • (2010) J Neuroinflammation , vol.7 , pp. 93
    • Corona, A.W.1    Huang, Y.2    O'Connor, J.C.3    Dantzer, R.4    Kelley, K.W.5    Popovich, P.G.6
  • 64
    • 78650994912 scopus 로고    scopus 로고
    • Protracted downregulation of CX3CR1 on microglia of aged mice after lipopolysaccharide challenge
    • Wynne AM, Henry CJ, Huang Y, Cleland A, Godbout JP. Protracted downregulation of CX3CR1 on microglia of aged mice after lipopolysaccharide challenge. Brain Behav Immun. 2010;24:1190-201.
    • (2010) Brain Behav Immun , vol.24 , pp. 1190-1201
    • Wynne, A.M.1    Henry, C.J.2    Huang, Y.3    Cleland, A.4    Godbout, J.P.5
  • 65
    • 0036429079 scopus 로고    scopus 로고
    • Cytokines, stress, and depressive illness
    • Anisman H, Merali Z. Cytokines, stress, and depressive illness. Brain Behav Immun. 2002;16:513-24.
    • (2002) Brain Behav Immun , vol.16 , pp. 513-524
    • Anisman, H.1    Merali, Z.2
  • 66
    • 0037855767 scopus 로고    scopus 로고
    • Lack of association between depressive symptoms and markers of immune and vascular inflammation in middle-aged men and women
    • Steptoe A, Kunz-Ebrecht SR, Owen N. Lack of association between depressive symptoms and markers of immune and vascular inflammation in middle-aged men and women. Psychol Med. 2003;33:667-74.
    • (2003) Psychol Med , vol.33 , pp. 667-674
    • Steptoe, A.1    Kunz-Ebrecht, S.R.2    Owen, N.3
  • 67
    • 0036430515 scopus 로고    scopus 로고
    • Questions raised by the cytokine hypothesis of depression
    • de Beaurepaire R. Questions raised by the cytokine hypothesis of depression. Brain Behav Immun. 2002;16:610-7.
    • (2002) Brain Behav Immun , vol.16 , pp. 610-617
    • Beaurepaire, R.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.