Mesenchymal stem cells prevent restraint stress-induced lymphocyte depletion via interleukin-4

Brain, Behavior, and Immunity

Volumn 38, Issue , 2014, Pages 125-132

  Cao, Gang ^a   Yang, Qian ^a   Zhang, Siyu ^a   Xu, Chunliang ^a   Roberts, Arthur I ^b   Wang, Ying ^a   Shi, Yufang ^a,b  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b CHILD HEALTH INSTITUTE OF NEW JERSEY   (United States)

Author keywords

Apoptosis; Interleukin 4; Lymphocyte; Mesenchymal stem cell; Restraint stress

Indexed keywords

DEXAMETHASONE; GLUCOCORTICOID; INTERLEUKIN 4; NEUTRALIZING ANTIBODY; STAT6 PROTEIN; INTERLEUKIN 4 ANTIBODY; INTERLEUKIN 4 RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CORTICOSTEROID BLOOD LEVEL; CYTOKINE PRODUCTION; IMMOBILIZATION STRESS; IN VIVO STUDY; LYMPHOCYTE DEPLETION; MALE; MESENCHYMAL STEM CELL; MODULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; REST; SIGNAL TRANSDUCTION; SPLEEN CELL; ANIMAL; BAGG ALBINO MOUSE; EXERCISE; IMMUNOLOGY; LYMPHOCYTE; MENTAL STRESS; MESENCHYMAL STEM CELL TRANSPLANTATION; METABOLISM; SPLEEN; ANIMAL MODEL; ANIMAL TISSUE; CELL ACTIVITY; CELL STRESS; IMMUNOMODULATION; PHYSICAL STRESS; PROTEIN DEPLETION; TREATMENT RESPONSE;

ANIMALS; APOPTOSIS; INTERLEUKIN-4; LYMPHOCYTES; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MICE; MICE, INBRED BALB C; RESTRAINT, PHYSICAL; SPLEEN; STRESS, PSYCHOLOGICAL;

EID: 84898540196     PISSN: 08891591     EISSN: 10902139     Source Type: Journal    
DOI: 10.1016/j.bbi.2014.01.013     Document Type: Article

References (19)

1. Chrousos G.P. Stress and disorders of the stress system. Nat. Rev. Endocrinol. 2009, 5:374-381.
2. Dallos T., Krivosikova M., Luszczyna L., Chorazy-Massalska M., Warnawin E., Rudnicka W., Maslinski W. Mesenchymal stem cells from bone marrow of rheumatoid arthritis patients provide survival signals to T- and B- cells in vitro. Joint Bone Spine 2007, 74. 217-217.
3. Feng Z., Liu L., Zhang C., Zheng T., Wang J., Lin M., Zhao Y., Wang X., Levine A.J., Hu W. Chronic restraint stress attenuates p53 function and promotes tumorigenesis. Proc. Natl. Acad. Sci. USA 2012, 109:7013-7018.
4. Glaser R., Kiecolt-Glaser J.K. Science and society - stress-induced immune dysfunction: implications for health. Nat. Rev. Immunol. 2005, 5:243-251.
5. Kemp K., Hares K., Mallam E., Heesom K.J., Scolding N., Wilkins A. Mesenchymal stem cell-secreted superoxide dismutase promotes cerebellar neuronal survival. J. Neurochem. 2010, 114:1569-1580.
6. Koh S.H., Choi H.S., Park E.S., Kang H.J., Ahn H.S., Shin H.Y. Co-culture of human CD34+ cells with mesenchymal stem cells increases the survival of CD34+ cells against the 5-aza-deoxycytidine- or trichostatin A-induced cell death. Biochem. Biophys. Res. Commun. 2005, 329:1039-1045.
7. Li W., Ren G., Huang Y., Su J., Han Y., Li J., Chen X., Cao K., Chen Q., Shou P., Zhang L., Yuan Z.R., Roberts A.I., Shi S., Le A.D., Shi Y. Mesenchymal stem cells: a double-edged sword in regulating immune responses. Cell Death Differ. 2012, 19:1505-1513.
8. Morale C., Brouwer J., Testa N., Tirolo C., Barden N., Dijkstra C.D., Amor S., Marchetti B. Stress, glucocorticoids and the susceptibility to develop autoimmune disorders of the central nervous system. Neurol. Sci. 2001, 22:159-162.
9. Mourcin F., Breton C., Tellier J., Narang P., Chasson L., Jorquera A., Coles M., Schiff C., Mancini S.J. Galectin-1-expressing stromal cells constitute a specific niche for pre-BII cell development in mouse bone marrow. Blood 2011, 117:6552-6561.
10. Padgett D.A., Glaser R. How stress influences the immune response. Trends Immunol. 2003, 24:444-448.
11. Ren G., Zhang L., Zhao X., Xu G., Zhang Y., Roberts A.I., Zhao R.C., Shi Y. Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxide. Cell Stem Cell 2008, 2:141-150.
12. Ren G., Zhao X., Wang Y., Zhang X., Chen X., Xu C., Yuan Z.R., Roberts A.I., Zhang L., Zheng B., Wen T., Han Y., Rabson A.B., Tischfield J.A., Shao C., Shi Y. CCR2-dependent recruitment of macrophages by tumor-educated mesenchymal stromal cells promotes tumor development and is mimicked by TNFalpha. Cell Stem Cell 2012, 11:812-824.
13. Riccardi C., Nicoletti I. Analysis of apoptosis by propidium iodide staining and flow cytometry. Nat. Protoc. 2006, 1:1458-1461.
14. Segerstrom S.C., Miller G.E. Psychological stress and the human immune system: a meta-analytic study of 30years of inquiry. Psychol. Bull. 2004, 130:601-630.
15. Shi Y.F., Su J.J., Roberts A.I., Shou P.S., Rabson A.B., Ren G.W. How mesenchymal stem cells interact with tissue immune responses. Trends Immunol. 2012, 33:136-143.
16. Uccelli A., Moretta L., Pistoia V. Mesenchymal stem cells in health and disease. Nat. Rev. Immunol. 2008, 8:726-736.
17. Wang K.X., Shi Y., Denhardt D.T. Osteopontin regulates hindlimb-unloading-induced lymphoid organ atrophy and weight loss by modulating corticosteroid production. Proc. Natl. Acad. Sci. USA 2007, 104:14777-14782.
18. Xu G., Zhang Y., Zhang L., Ren G., Shi Y. The role of IL-6 in inhibition of lymphocyte apoptosis by mesenchymal stem cells. Biochem. Biophys. Res. Commun. 2007, 361:745-750.
19. Yin D., Tuthill D., Mufson R.A., Shi Y. Chronic restraint stress promotes lymphocyte apoptosis by modulating CD95 expression. J. Exp. Med. 2000, 191:1423-1428.