Engineered mtZFNs for manipulation of human mitochondrial DNA heteroplasmy

Methods in Molecular Biology

Volumn 1351, Issue , 2016, Pages 145-162

  Gammage, Payam A ^a   Van Haute, Lindsey ^a   Minczuk, Michal ^a  

^a NONE

Author keywords

Gene therapy; Genetic engineering; Heteroplasmy; Mitochondrial disease; Zinc finger; Zinc finger nuclease

Indexed keywords

MITOCHONDRIAL DNA; MITOCHONDRIALLY TARGETED ZINC FINGER NUCLEASE; UNCLASSIFIED DRUG; ZINC FINGER NUCLEASE; ENDODEOXYRIBONUCLEASE FOKI; TYPE II SITE SPECIFIC DEOXYRIBONUCLEASE; ZINC FINGER PROTEIN;

AGAR GEL ELECTROPHORESIS; CLONING VECTOR; CONTROLLED STUDY; FLUORESCENCE ACTIVATED CELL SORTING; GENE AMPLIFICATION; GENETIC ENGINEERING; HAPLOTYPE; HETEROPLASMY; HUMAN; HUMAN CELL; OSTEOSARCOMA; POINT MUTATION; PROTEIN EXPRESSION; PROTEIN PURIFICATION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; RESTRICTION SITE; CELL CULTURE; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DOUBLE STRANDED DNA BREAK; GENE DOSAGE; GENETIC VARIATION; GENETICS; METABOLISM; MITOCHONDRION;

CELLS, CULTURED; DEOXYRIBONUCLEASES, TYPE II SITE-SPECIFIC; DNA BREAKS, DOUBLE-STRANDED; DNA, MITOCHONDRIAL; GENE DOSAGE; GENETIC VARIATION; HAPLOTYPES; HUMANS; MITOCHONDRIA; MITOCHONDRIAL DISEASES; ZINC FINGERS;

EID: 84946430545     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4939-3040-1_11     Document Type: Chapter

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