Gene therapy for mitochondrial disease by delivering restriction endonuclease SmaI into mitochondria

Journal of Biomedical Science

Volumn 9, Issue 5-6, 2002, Pages 534-541

  Tanaka, Masashi ^a,b   Borgeld, Harm Jan ^a,b   Zhang, Jin ^a,b   Muramatsu, Shin ichi ^c   Gong, Jian Sheng ^a,b   Yoneda, Makoto ^d   Maruyama, Wakako ^e   Naoi, Makoto ^b   Ibi, Tohru ^f   Sahashi, Ko ^f   Shamoto, Masayo ^e   Fuku, Noriyuki ^a,g   Kurata, Miyuki ^a   Yamada, Yoshiji ^a,b   Nishizawa, Kumi ^a   Akao, Yukihiro ^a,b   Ohishi, Nobuko ^b   Miyabayashi, Shigeaki ^h   Umemoto, Hiraku ⁱ   Muramatsu, Tatsuo ⁱ   Furukawa, Koichi ^j   Kikuchi, Akihiko ^j   Nakano, Imaharu ^c   Ozawa, Keiya ^c   Yagi, Kunio ^a,b   more..

^a GIFU INTERNATIONAL INSTITUTE OF BIOTECHNOLOGY   (Japan)

^b Institute of Applied Biochemistry   (Japan)

^c JICHI MEDICAL UNIVERSITY   (Japan)

^d UNIVERSITY OF FUKUI   (Japan)

^e NATIONAL CENTER FOR GERIATRICS AND GERONTOLOGY   (Japan)

^f AICHI MEDICAL UNIVERSITY   (Japan)

^g JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^h SENDAI CITY MEDICAL CENTER   (Japan)

ⁱ NAGOYA UNIVERSITY   (Japan)

^j NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

more..

Author keywords

Gene therapy; Leigh's disease; Mitochondrial disease; Neurogenic muscle weakness, ataxia and retinitis pigmentosa; Restriction endonuclease

Indexed keywords

MITOCHONDRIAL DNA; RESTRICTION ENDONUCLEASE;

ARTICLE; ATAXIA; CELL LINE; CHROMOSOME LOSS; CONTROLLED STUDY; CYBRID; ELECTROPORATION; ENZYME ACTIVITY; ENZYME RELEASE; GENE; GENE EXPRESSION; GENE TARGETING; GENE THERAPY; HETEROPLASMY; HUMAN; HUMAN CELL; LEIGH DISEASE; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; MUTANT; MUTATION; PLASMID; POPULATION DYNAMICS; PRIORITY JOURNAL; RETINITIS PIGMENTOSA; WILD TYPE;

APOPTOSIS; CELL LINE; DEOXYRIBONUCLEASE ECORI; DEOXYRIBONUCLEASES, TYPE II SITE-SPECIFIC; DNA, MITOCHONDRIAL; FIBROBLASTS; GENE THERAPY; HUMANS; LEIGH DISEASE; MITOCHONDRIAL DISEASES; MUTATION; PLASMIDS;

CRICETINAE;

EID: 0036420547     PISSN: 10217770     EISSN: 14230127     Source Type: Journal    
DOI: 10.1007/BF02254980     Document Type: Article

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