Sequence-specific modification of mitochondrial DNA using a chimeric zinc finger methylase

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 52, 2006, Pages 19689-19694

  Minczuk, Michal ^a,b   Papworth, Monika A ^a   Kolasinska, Paulina ^a   Murphy, Michael P ^b   Klug, Aaron ^a  

^a MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^b MEDICAL RESEARCH COUNCIL   (United Kingdom)

Author keywords

Gene therapy; Mitochondria; Mitochondrial diseases; Nuclear export signal; Synthetic zinc finger peptides

Indexed keywords

METHYLTRANSFERASE; MITOCHONDRIAL DNA; ZINC FINGER PROTEIN;

ANIMAL CELL; ARTICLE; CHIMERA; CONTROLLED STUDY; DNA METHYLATION; DNA MODIFICATION; DNA SEQUENCE; GENE THERAPY; LEIGH DISEASE; MITOCHONDRION; MUTATION; NARP SYNDROME; NONHUMAN; NUCLEAR EXPORT SIGNAL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DNA BINDING; PROTEIN EXPRESSION;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CELL LINE; CERCOPITHECUS AETHIOPS; DNA METHYLATION; DNA MODIFICATION METHYLASES; DNA, MITOCHONDRIAL; MITOCHONDRIA; MODELS, MOLECULAR; MUTATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY; ZINC FINGERS;

ATAXIA;

EID: 33845916259     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0609502103     Document Type: Article

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