-
1
-
-
77649216536
-
Membrane transporters in drug development
-
Giacomini, K. M. et al. Membrane transporters in drug development. Nat. Rev. Drug Discov. 9, 215-236 (2010).
-
(2010)
Nat. Rev. Drug Discov.
, vol.9
, pp. 215-236
-
-
Giacomini, K.M.1
-
2
-
-
84862966547
-
Drug transporters in drug efficacy and toxicity
-
DeGorter, M. K., Xia, C. Q., Yang, J. J. & Kim, R. B. Drug transporters in drug efficacy and toxicity. Annu. Rev. Pharmacol. Toxicol. 52, 249-273 (2012).
-
(2012)
Annu. Rev. Pharmacol. Toxicol.
, vol.52
, pp. 249-273
-
-
DeGorter, M.K.1
Xia, C.Q.2
Yang, J.J.3
Kim, R.B.4
-
3
-
-
84879327902
-
Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus
-
Yan, H. et al. Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus. eLife 1, e00049 (2012).
-
(2012)
ELife
, vol.1
, pp. e00049
-
-
Yan, H.1
-
4
-
-
24344439264
-
Transporters and drug therapy: Implications for drug disposition and disease
-
Ho, R. H. & Kim, R. B. Transporters and drug therapy: implications for drug disposition and disease. Clin. Pharmacol. Ther. 78, 260-277 (2005).
-
(2005)
Clin. Pharmacol. Ther.
, vol.78
, pp. 260-277
-
-
Ho, R.H.1
Kim, R.B.2
-
5
-
-
49949090275
-
The role of ethnicity in variability in response to drugs: Focus on clinical pharmacology studies
-
Yasuda, S. U., Zhang, L. & Huang, S. M. The role of ethnicity in variability in response to drugs: focus on clinical pharmacology studies. Clin. Pharmacol. Ther. 84, 417-423 (2008).
-
(2008)
Clin. Pharmacol. Ther.
, vol.84
, pp. 417-423
-
-
Yasuda, S.U.1
Zhang, L.2
Huang, S.M.3
-
6
-
-
72849141790
-
Transporter pharmacogenetics and statin toxicity
-
Niemi, M. Transporter pharmacogenetics and statin toxicity. Clin. Pharmacol. Ther. 87, 130-133 (2010).
-
(2010)
Clin. Pharmacol. Ther.
, vol.87
, pp. 130-133
-
-
Niemi, M.1
-
7
-
-
84862600938
-
The clinical pharmacogenomics implementation consortium: CPIC guideline for SLCO1B1 and simvastatin-induced myopathy
-
Wilke, R. A. et al. The clinical pharmacogenomics implementation consortium: CPIC guideline for SLCO1B1 and simvastatin-induced myopathy. Clin. Pharmacol. Ther. 92, 112-117 (2012).
-
(2012)
Clin. Pharmacol. Ther.
, vol.92
, pp. 112-117
-
-
Wilke, R.A.1
-
8
-
-
84873590053
-
Genome-wide study of methotrexate clearance replicates SLCO1B1
-
Ramsey, L. B. et al. Genome-wide study of methotrexate clearance replicates SLCO1B1. Blood 121, 898-904 (2013).
-
(2013)
Blood
, vol.121
, pp. 898-904
-
-
Ramsey, L.B.1
-
9
-
-
84899105668
-
Association of ABCC2-24C>T polymorphism with highdose methotrexate plasma concentrations and toxicities in childhood acute lymphoblastic leukemia
-
Liu, Y. et al. Association of ABCC2-24C>T polymorphism with highdose methotrexate plasma concentrations and toxicities in childhood acute lymphoblastic leukemia. PLoS One 9, e82681 (2014).
-
(2014)
PLoS One
, vol.9
, pp. e82681
-
-
Liu, Y.1
-
10
-
-
33750958330
-
High-dose methotrexate in pediatric acute lymphoblastic leukemia: Impact of ABCC2 polymorphisms on plasma concentrations
-
Rau, T., Erney, B., Gores, R., Eschenhagen, T., Beck, J. & Langer, T. High-dose methotrexate in pediatric acute lymphoblastic leukemia: impact of ABCC2 polymorphisms on plasma concentrations. Clin. Pharmacol. Ther. 80, 468-476 (2006).
-
(2006)
Clin. Pharmacol. Ther.
, vol.80
, pp. 468-476
-
-
Rau, T.1
Erney, B.2
Gores, R.3
Eschenhagen, T.4
Beck, J.5
Langer, T.6
-
11
-
-
84870060943
-
UGT1A9, UGT2B7, and MRP2 genotypes can predict mycophenolic acid pharmacokinetic variability in pediatric kidney transplant recipients
-
Fukuda, T. et al. UGT1A9, UGT2B7, and MRP2 genotypes can predict mycophenolic acid pharmacokinetic variability in pediatric kidney transplant recipients. Ther. Drug Monit. 34, 671-679 (2012).
-
(2012)
Ther. Drug Monit.
, vol.34
, pp. 671-679
-
-
Fukuda, T.1
-
12
-
-
84906733842
-
ABCC3 and OCT1 genotypes influence pharmacokinetics of morphine in children
-
Venkatasubramanian, R. et al. ABCC3 and OCT1 genotypes influence pharmacokinetics of morphine in children. Pharmacogenomics 15, 1297-1309 (2014).
-
(2014)
Pharmacogenomics
, vol.15
, pp. 1297-1309
-
-
Venkatasubramanian, R.1
-
13
-
-
84867780513
-
Highlights from the International Transporter Consortium second workshop
-
Zamek-Gliszczynski, M. J., Hoffmaster, K. A., Tweedie, D. J., Giacomini, K. M. & Hillgren, K. M. Highlights from the International Transporter Consortium second workshop. Clin. Pharmacol. Ther. 92, 553-556 (2012).
-
(2012)
Clin. Pharmacol. Ther.
, vol.92
, pp. 553-556
-
-
Zamek-Gliszczynski, M.J.1
Hoffmaster, K.A.2
Tweedie, D.J.3
Giacomini, K.M.4
Hillgren, K.M.5
-
14
-
-
84899066256
-
Developmental trajectory of intestinal MDR1/ABCB1 mRNA expression in children
-
Mizuno, T. et al. Developmental trajectory of intestinal MDR1/ABCB1 mRNA expression in children. Br. J. Clin. Pharmacol. 77, 910-912 (2014).
-
(2014)
Br. J. Clin. Pharmacol.
, vol.77
, pp. 910-912
-
-
Mizuno, T.1
-
15
-
-
33747439382
-
Impact of inflammation on the duodenal mRNA expression of CYP3A and P-glycoprotein in children with Crohn's disease
-
Fakhoury, M., Lecordier, J., Medard, Y., Peuchmaur, M. & Jacqz-Agrain, E. Impact of inflammation on the duodenal mRNA expression of CYP3A and P-glycoprotein in children with Crohn's disease. Inflamm. Bowel Dis. 12, 745-749 (2006).
-
(2006)
Inflamm. Bowel Dis.
, vol.12
, pp. 745-749
-
-
Fakhoury, M.1
Lecordier, J.2
Medard, Y.3
Peuchmaur, M.4
Jacqz-Agrain, E.5
-
16
-
-
73349093447
-
mRNA expression of MDR1 and major metabolising enzymes in human fetal tissues
-
Fakhoury, M. et al. mRNA expression of MDR1 and major metabolising enzymes in human fetal tissues. Drug Metab. Pharmacokinet. 24, 529-536 (2009).
-
(2009)
Drug Metab. Pharmacokinet.
, vol.24
, pp. 529-536
-
-
Fakhoury, M.1
-
17
-
-
13844271333
-
Steroid and xenobiotic receptor (SXR), cytochrome P450 3A4 and multidrug resistance gene 1 in human adult and fetal tissues
-
Miki, Y., Suzuki, T., Tazawa, C., Blumberg, B. & Sasano, H. Steroid and xenobiotic receptor (SXR), cytochrome P450 3A4 and multidrug resistance gene 1 in human adult and fetal tissues. Mol. Cell Endocrinol. 231, 75-85 (2005).
-
(2005)
Mol. Cell Endocrinol.
, vol.231
, pp. 75-85
-
-
Miki, Y.1
Suzuki, T.2
Tazawa, C.3
Blumberg, B.4
Sasano, H.5
-
18
-
-
0026440586
-
Multidrug resistance gene (P-glycoprotein) expression in the human fetus
-
van Kalken, C. K. et al. Multidrug resistance gene (P-glycoprotein) expression in the human fetus. Am. J. Pathol. 141, 1063-1072 (1992).
-
(1992)
Am. J. Pathol.
, vol.141
, pp. 1063-1072
-
-
Van Kalken, C.K.1
-
19
-
-
27544454323
-
Localization and mRNA expression of CYP3A and P-glycoprotein in human duodenum as a function of age
-
Fakhoury, M. et al. Localization and mRNA expression of CYP3A and P-glycoprotein in human duodenum as a function of age. Drug Metab. Dispos. 33, 1603-1607 (2005).
-
(2005)
Drug Metab. Dispos.
, vol.33
, pp. 1603-1607
-
-
Fakhoury, M.1
-
20
-
-
84904196927
-
Ontogeny of human hepatic and intestinal transporter gene expression during childhood: Age matters
-
Mooij, M. G. et al. Ontogeny of human hepatic and intestinal transporter gene expression during childhood: Age matters. Drug Metab. Dispos. 42, 1268-1274 (2014).
-
(2014)
Drug Metab. Dispos.
, vol.42
, pp. 1268-1274
-
-
Mooij, M.G.1
-
21
-
-
81155137892
-
Differential expression of ABC transporters ( MDR1, MRP1, BCRP) in developing human embryos
-
Konieczna, A., Erdosova, B., Lichnovska, R., Jandl, M., Cizkova, K. & Ehrmann, J. Differential expression of ABC transporters (MDR1, MRP1, BCRP) in developing human embryos. J. Mol. Histol. 42, 567-574 (2011).
-
(2011)
J. Mol. Histol.
, vol.42
, pp. 567-574
-
-
Konieczna, A.1
Erdosova, B.2
Lichnovska, R.3
Jandl, M.4
Cizkova, K.5
Ehrmann, J.6
-
22
-
-
33644973924
-
Weanling, but not adult, rabbit colon absorbs bile acids: Flux is linked to expression of putative bile acid transporters
-
Weihrauch, D., Kanchanapoo, J., Ao, M., Prasad, R., Piyachaturawat, P. & Rao, M. C. Weanling, but not adult, rabbit colon absorbs bile acids: flux is linked to expression of putative bile acid transporters. Am. J. Physiol. Gastrointest. Liver Physiol. 290, G439-450 (2006).
-
(2006)
Am. J. Physiol. Gastrointest. Liver Physiol.
, vol.290
, pp. G439-450
-
-
Weihrauch, D.1
Kanchanapoo, J.2
Ao, M.3
Prasad, R.4
Piyachaturawat, P.5
Rao, M.C.6
-
23
-
-
0036135878
-
Expression and cellular distribution during development of the peptide transporter (PepT1) in the small intestinal epithelium of the rat
-
Hussain, I., Kellett, L., Affleck, J., Shepherd, J. & Boyd, R. Expression and cellular distribution during development of the peptide transporter (PepT1) in the small intestinal epithelium of the rat. Cell Tissue Res. 307, 139-142 (2002).
-
(2002)
Cell Tissue Res.
, vol.307
, pp. 139-142
-
-
Hussain, I.1
Kellett, L.2
Affleck, J.3
Shepherd, J.4
Boyd, R.5
-
24
-
-
0034983708
-
Developmental expression of PEPT1 and PEPT2 in rat small intestine, colon, and kidney
-
Shen, H., Smith, D. E. & Brosius, F. C. 3rd. Developmental expression of PEPT1 and PEPT2 in rat small intestine, colon, and kidney. Pediatr. Res. 49, 789-795 (2001).
-
(2001)
Pediatr. Res.
, vol.49
, pp. 789-795
-
-
Shen, H.1
Smith, D.E.2
Brosius, F.C.3
-
25
-
-
0030057395
-
Sequence, tissue distribution and developmental changes in rat intestinal oligopeptide transporter
-
Miyamoto, K. et al. Sequence, tissue distribution and developmental changes in rat intestinal oligopeptide transporter. Biochim. Biophys. Acta 1305, 34-38 (1996).
-
(1996)
Biochim. Biophys. Acta
, vol.1305
, pp. 34-38
-
-
Miyamoto, K.1
-
26
-
-
12344292818
-
Developmental regulation of a Turkey intestinal peptide transporter (PepT1)
-
Van, L., Pan, Y. X., Bloomquist, J. R., Webb, K. E., Jr. & Wong, E. A. Developmental regulation of a turkey intestinal peptide transporter (PepT1). Poult. Sci. 84, 75-82 (2005).
-
(2005)
Poult. Sci.
, vol.84
, pp. 75-82
-
-
Van, L.1
Pan, Y.X.2
Bloomquist, J.R.3
Webb, K.E.4
Wong, E.A.5
-
27
-
-
24044541995
-
Expression of MRP2 and MDR1 transporters and other hepatic markers in rat and human liver and in WRL 68 cell line
-
Cizkova, D., Morky, J., Micuda, S., Osterreicher, J. & Martinkova, J. Expression of MRP2 and MDR1 transporters and other hepatic markers in rat and human liver and in WRL 68 cell line. Physiol. Res. 54, 419-428 (2005).
-
(2005)
Physiol. Res.
, vol.54
, pp. 419-428
-
-
Cizkova, D.1
Morky, J.2
Micuda, S.3
Osterreicher, J.4
Martinkova, J.5
-
28
-
-
77949398878
-
Xenobiotic, bile acid, and cholesterol transporters: Function and regulation
-
Klaassen, C. D. & Aleksunes, L. M. Xenobiotic, bile acid, and cholesterol transporters: function and regulation. Pharmacol. Rev. 62, 1-96 (2010).
-
(2010)
Pharmacol. Rev.
, vol.62
, pp. 1-96
-
-
Klaassen, C.D.1
Aleksunes, L.M.2
-
29
-
-
0029616617
-
Interindividual variation in expression of P-glycoprotein in normal human liver and secondary hepatic neoplasms
-
Schuetz, E. G., Furuya, K. N. & Schuetz, J. D. Interindividual variation in expression of P-glycoprotein in normal human liver and secondary hepatic neoplasms. J. Pharmacol. Exp. Ther. 275, 1011-1018 (1995).
-
(1995)
J. Pharmacol. Exp. Ther.
, vol.275
, pp. 1011-1018
-
-
Schuetz, E.G.1
Furuya, K.N.2
Schuetz, J.D.3
-
30
-
-
84975099361
-
Age-associated protein expression of P-glycoprotein (MDR1/P-gp) and MRP2 in human pediatric liver
-
Tang, L., Hines, R. N., Schuetz, E. G. & Meibohm, B. Age-associated protein expression of P-glycoprotein (MDR1/P-gp) and MRP2 in human pediatric liver. Clin. Pharmacol. Ther. 81, S101 (2007).
-
(2007)
Clin. Pharmacol. Ther.
, vol.81
, pp. S101
-
-
Tang, L.1
Hines, R.N.2
Schuetz, E.G.3
Meibohm, B.4
-
31
-
-
84874190918
-
Impact of OATP1B1, MDR1, and CYP3A4 expression in liver and intestine on interpatient pharmacokinetic variability of atorvastatin in obese subjects
-
Ulvestad, M. et al. Impact of OATP1B1, MDR1, and CYP3A4 expression in liver and intestine on interpatient pharmacokinetic variability of atorvastatin in obese subjects. Clin. Pharmacol. Ther. 93, 275-282 (2013).
-
(2013)
Clin. Pharmacol. Ther.
, vol.93
, pp. 275-282
-
-
Ulvestad, M.1
-
32
-
-
84890663852
-
Interindividual variability in hepatic organic aniontransporting polypeptides and P-glycoprotein (ABCB1) protein expression: Quantification by liquid chromatography tandem mass spectroscopy and influence of genotype, age, and sex
-
Prasad, B. et al. Interindividual variability in hepatic organic aniontransporting polypeptides and P-glycoprotein (ABCB1) protein expression: quantification by liquid chromatography tandem mass spectroscopy and influence of genotype, age, and sex. Drug Metab. Dispos. 42, 78-88 (2014).
-
(2014)
Drug Metab. Dispos.
, vol.42
, pp. 78-88
-
-
Prasad, B.1
-
33
-
-
84872745588
-
Hepatobiliary disposition of 17-OHPC and taurocholate in fetal human hepatocytes: A comparison with adult human hepatocytes
-
Sharma, S. et al. Hepatobiliary disposition of 17-OHPC and taurocholate in fetal human hepatocytes: A comparison with adult human hepatocytes. Drug Metab. Dispos. 41, 296-304 (2013).
-
(2013)
Drug Metab. Dispos.
, vol.41
, pp. 296-304
-
-
Sharma, S.1
-
34
-
-
79955074075
-
Higher clearance of micafungin in neonates compared with adults: Role of age-dependent micafungin serum binding
-
Yanni, S. B. et al. Higher clearance of micafungin in neonates compared with adults: role of age-dependent micafungin serum binding. Biopharm. Drug Dispos. 32, 222-232 (2011).
-
(2011)
Biopharm. Drug Dispos.
, vol.32
, pp. 222-232
-
-
Yanni, S.B.1
-
35
-
-
84878129920
-
Interindividual variability in the hepatic expression of the human breast cancer resistance protein (BCRP/ABCG2): Effect of age, sex, and genotype
-
Prasad, B., Lai, Y., Lin, Y. & Unadkat, J. D. Interindividual variability in the hepatic expression of the human breast cancer resistance protein (BCRP/ABCG2): effect of age, sex, and genotype. J. Pharm. Sci. 102, 787-793 (2013).
-
(2013)
J. Pharm. Sci.
, vol.102
, pp. 787-793
-
-
Prasad, B.1
Lai, Y.2
Lin, Y.3
Unadkat, J.D.4
-
36
-
-
23444456468
-
Developmental expression of canalicular transporter genes in human liver
-
Chen, H. L. et al. Developmental expression of canalicular transporter genes in human liver. J. Hepatol. 43, 472-477 (2005).
-
(2005)
J. Hepatol.
, vol.43
, pp. 472-477
-
-
Chen, H.L.1
-
37
-
-
84859899906
-
Interindividual variability in hepatic expression of the multidrug resistance-associated protein 2 (MRP2/ABCC2): Quantification by liquid chromatography/tandem mass spectrometry
-
Deo, A. K., Prasad, B., Balogh, L., Lai, Y. & Unadkat, J. D. Interindividual variability in hepatic expression of the multidrug resistance-associated protein 2 (MRP2/ABCC2): quantification by liquid chromatography/tandem mass spectrometry. Drug Metab. Dispos. 40, 852-855 (2012).
-
(2012)
Drug Metab. Dispos.
, vol.40
, pp. 852-855
-
-
Deo, A.K.1
Prasad, B.2
Balogh, L.3
Lai, Y.4
Unadkat, J.D.5
-
38
-
-
0029099818
-
Differential ontogenic regulation of basolateral and canalicular bile acid transport proteins in rat liver
-
Hardikar, W., Ananthanarayanan, M. & Suchy, F. J. Differential ontogenic regulation of basolateral and canalicular bile acid transport proteins in rat liver. J. Biol. Chem. 270, 20841-20846 (1995).
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 20841-20846
-
-
Hardikar, W.1
Ananthanarayanan, M.2
Suchy, F.J.3
-
39
-
-
84966315072
-
Ageassociated expression of OATP1B1 and OATP1B3 in human pediatric liver
-
Thomson, M. M., Hines, R. N., Schuetz, E. G. & Meibohm, B. Ageassociated expression of OATP1B1 and OATP1B3 in human pediatric liver. AAPS J. 14(Suppl 2), W4301 (2012).
-
(2012)
AAPS J.
, vol.14
, pp. W4301
-
-
Thomson, M.M.1
Hines, R.N.2
Schuetz, E.G.3
Meibohm, B.4
-
40
-
-
84966419971
-
Evaluation of uptake transporters in human adult and pediatric hepatocytes. Abstracts of the 17th North American Regional ISSX International Society for the Study of Xenobiotics
-
Hayashi, M., Hui, A., DeKeyser, J., Louie, S., Shou, M. & Xu, L. Evaluation of uptake transporters in human adult and pediatric hepatocytes. Abstracts of the 17th North American Regional ISSX International Society for the Study of Xenobiotics. Drug Metab. Rev. 43, 37-211 (2011).
-
(2011)
Drug Metab. Rev.
, vol.43
, pp. 37-211
-
-
Hayashi, M.1
Hui, A.2
DeKeyser, J.3
Louie, S.4
Shou, M.5
Xu, L.6
-
41
-
-
8844240624
-
Temporal expression profiles of organic anion transport proteins in placenta and fetal liver of the rat
-
St-Pierre, M. V. et al. Temporal expression profiles of organic anion transport proteins in placenta and fetal liver of the rat. Am. J. Physiol. Regul. Integr. Comp. Physiol. 287, R1505-1516 (2004).
-
(2004)
Am. J. Physiol. Regul. Integr. Comp. Physiol.
, vol.287
, pp. R1505-1516
-
-
St-Pierre, M.V.1
-
42
-
-
84860539477
-
Bile acids via FXR initiate the expression of major transporters involved in the enterohepatic circulation of bile acids in newborn mice
-
Cui, J. Y. et al. Bile acids via FXR initiate the expression of major transporters involved in the enterohepatic circulation of bile acids in newborn mice. Am. J. Physiol. Gastrointest. Liver Physiol. 302, G979-996 (2012).
-
(2012)
Am. J. Physiol. Gastrointest. Liver Physiol.
, vol.302
, pp. G979-996
-
-
Cui, J.Y.1
-
43
-
-
22344432207
-
Tissue distribution and hepatic and renal ontogeny of the multidrug resistance-associated protein (Mrp) family in mice
-
Maher, J. M., Slitt, A. L., Cherrington, N. J., Cheng, X. & Klaassen, C. D. Tissue distribution and hepatic and renal ontogeny of the multidrug resistance-associated protein (Mrp) family in mice. Drug Metab. Dispos. 33, 947-955 (2005).
-
(2005)
Drug Metab. Dispos.
, vol.33
, pp. 947-955
-
-
Maher, J.M.1
Slitt, A.L.2
Cherrington, N.J.3
Cheng, X.4
Klaassen, C.D.5
-
44
-
-
4444266366
-
Differential expression of bile salt and organic anion transporters in developing rat liver
-
Gao, B., St Pierre, M. V., Stieger, B. & Meier, P. J. Differential expression of bile salt and organic anion transporters in developing rat liver. J Hepatol 41, 201-208 (2004).
-
(2004)
J Hepatol
, vol.41
, pp. 201-208
-
-
Gao, B.1
St Pierre, M.V.2
Stieger, B.3
Meier, P.J.4
-
45
-
-
84892464073
-
Lack of metformin effect on mouse embryo AMPK activity: Implications for metformin treatment during pregnancy
-
Lee, H. Y., Wei, D. & Loeken, M. R. Lack of metformin effect on mouse embryo AMPK activity: implications for metformin treatment during pregnancy. Diabetes Metab. Res. Rev. 30, 23-30 (2014).
-
(2014)
Diabetes Metab. Res. Rev.
, vol.30
, pp. 23-30
-
-
Lee, H.Y.1
Wei, D.2
Loeken, M.R.3
-
46
-
-
45849103909
-
Expression of hepatocyte transporters and nuclear receptors in children with early and late-stage biliary atresia
-
Chen, H. L. et al. Expression of hepatocyte transporters and nuclear receptors in children with early and late-stage biliary atresia. Pediatr. Res. 63, 667-673 (2008).
-
(2008)
Pediatr. Res.
, vol.63
, pp. 667-673
-
-
Chen, H.L.1
-
47
-
-
84861467587
-
RNA-Seq reveals different mRNA abundance of transporters and their alternative transcript isoforms during liver development
-
Cui, J. Y. et al. RNA-Seq reveals different mRNA abundance of transporters and their alternative transcript isoforms during liver development. Toxicol. Sci. 127, 592-608 (2012).
-
(2012)
Toxicol. Sci.
, vol.127
, pp. 592-608
-
-
Cui, J.Y.1
-
48
-
-
0034004157
-
Developmentally regulated expression of organic ion transporters NKT (OAT1) OCT1, NLT (OAT2), and Roct
-
Pavlova, A., Sakurai, H., Leclercq, B., Beier, D. R., Yu, A. S. & Nigam, S. K. Developmentally regulated expression of organic ion transporters NKT (OAT1), OCT1, NLT (OAT2), and Roct. Am. J. Physiol. Renal Physiol. 278, F635-643 (2000).
-
(2000)
Am. J. Physiol. Renal Physiol.
, vol.278
, pp. F635-643
-
-
Pavlova, A.1
Sakurai, H.2
Leclercq, B.3
Beier, D.R.4
Yu, A.S.5
Nigam, S.K.6
-
49
-
-
55949104608
-
The ontogeny of drug metabolizing enzymes and transporters in the rat
-
de Zwart, L. et al. The ontogeny of drug metabolizing enzymes and transporters in the rat. Reprod. Toxicol. 26, 220-230 (2008).
-
(2008)
Reprod. Toxicol.
, vol.26
, pp. 220-230
-
-
De Zwart, L.1
-
50
-
-
33644499212
-
Organic anion and cation transporter expression and function during embryonic kidney development and in organ culture models
-
Sweet, D. H., Eraly, S. A., Vaughn, D. A., Bush, K. T. & Nigam, S. K. Organic anion and cation transporter expression and function during embryonic kidney development and in organ culture models. Kidney Int. 69, 837-845 (2006).
-
(2006)
Kidney Int.
, vol.69
, pp. 837-845
-
-
Sweet, D.H.1
Eraly, S.A.2
Vaughn, D.A.3
Bush, K.T.4
Nigam, S.K.5
-
52
-
-
79959313678
-
Functional maturation of drug transporters in the developing, neonatal, and postnatal kidney
-
Sweeney, D. E., Vallon, V., Rieg, T., Wu, W., Gallegos, T. F. & Nigam, S. K. Functional maturation of drug transporters in the developing, neonatal, and postnatal kidney. Mol. Pharmacol. 80, 147-154 (2011).
-
(2011)
Mol. Pharmacol.
, vol.80
, pp. 147-154
-
-
Sweeney, D.E.1
Vallon, V.2
Rieg, T.3
Wu, W.4
Gallegos, T.F.5
Nigam, S.K.6
-
53
-
-
0033779852
-
Development of intestinal transport function in mammals
-
Pacha, J. Development of intestinal transport function in mammals. Physiol. Rev. 80, 1633-1667 (2000).
-
(2000)
Physiol. Rev.
, vol.80
, pp. 1633-1667
-
-
Pacha, J.1
-
54
-
-
0036265618
-
Development of the intestinal mucosal barrier
-
Walker, W. A. Development of the intestinal mucosal barrier. J. Pediatr. Gastroenterol. Nutr. 34(suppl. 1), S33-S39 (2002).
-
(2002)
J. Pediatr. Gastroenterol. Nutr.
, vol.34
, pp. S33-S39
-
-
Walker, W.A.1
-
55
-
-
0141919897
-
Species comparison of anatomical and functional renal development
-
Zoetis, T. & Hurtt, M. E. Species comparison of anatomical and functional renal development. Birth Defects Res. B Dev. Reprod. Toxicol. 68, 111-120 (2003).
-
(2003)
Birth Defects Res. B Dev. Reprod. Toxicol.
, vol.68
, pp. 111-120
-
-
Zoetis, T.1
Hurtt, M.E.2
-
56
-
-
77249119389
-
Validation of suitable internal control genes for expression studies in aging
-
Zampieri, M. et al. Validation of suitable internal control genes for expression studies in aging. Mech. Ageing Dev. 131, 89-95 (2010).
-
(2010)
Mech. Ageing Dev.
, vol.131
, pp. 89-95
-
-
Zampieri, M.1
-
57
-
-
84875720543
-
An old method facing a new challenge: Re-visiting housekeeping proteins as internal reference control for neuroscience research
-
Li, R. & Shen, Y. An old method facing a new challenge: re-visiting housekeeping proteins as internal reference control for neuroscience research. Life Sci. 92, 747-751 (2013).
-
(2013)
Life Sci.
, vol.92
, pp. 747-751
-
-
Li, R.1
Shen, Y.2
-
58
-
-
84884903479
-
Drug metabolizing enzyme and transporter protein profiles of hepatocytes derived from human embryonic and induced pluripotent stem cells
-
Ulvestad, M. et al. Drug metabolizing enzyme and transporter protein profiles of hepatocytes derived from human embryonic and induced pluripotent stem cells. Biochem. Pharmacol. 86, 691-702 (2013).
-
(2013)
Biochem. Pharmacol.
, vol.86
, pp. 691-702
-
-
Ulvestad, M.1
-
59
-
-
0035898287
-
Translating developmental time across mammalian species
-
Clancy, B., Darlington, R. B. & Finlay, B. L. Translating developmental time across mammalian species. Neuroscience 105, 7-17 (2001).
-
(2001)
Neuroscience
, vol.105
, pp. 7-17
-
-
Clancy, B.1
Darlington, R.B.2
Finlay, B.L.3
-
60
-
-
78049239044
-
Ttime: An R package for translating the timing of brain development across mammalian species
-
Nagarajan, R., Darlington, R. B., Finlay, B. L. & Clancy, B. Ttime: An R package for translating the timing of brain development across mammalian species. Neuroinformatics 8, 201-205 (2010).
-
(2010)
Neuroinformatics
, vol.8
, pp. 201-205
-
-
Nagarajan, R.1
Darlington, R.B.2
Finlay, B.L.3
Clancy, B.4
-
61
-
-
79951615778
-
Resurgence in the use of physiologically based pharmacokinetic models in pediatric clinical pharmacology: Parallel shift in incorporating the knowledge of biological elements and increased applicability to drug development and clinical practice
-
Johnson, T. N. & Rostami-Hodjegan, A. Resurgence in the use of physiologically based pharmacokinetic models in pediatric clinical pharmacology: parallel shift in incorporating the knowledge of biological elements and increased applicability to drug development and clinical practice. Paediatr. Anaesth. 21, 291-301 (2011).
-
(2011)
Paediatr. Anaesth.
, vol.21
, pp. 291-301
-
-
Johnson, T.N.1
Rostami-Hodjegan, A.2
-
62
-
-
84884159539
-
Drug disposition and clinical practice in neonates: Cross talk between developmental physiology and pharmacology
-
Smits, A., Annaert, P. & Allegaert, K. Drug disposition and clinical practice in neonates: cross talk between developmental physiology and pharmacology. Int. J. Pharm. 452, 8-13 (2013).
-
(2013)
Int. J. Pharm.
, vol.452
, pp. 8-13
-
-
Smits, A.1
Annaert, P.2
Allegaert, K.3
-
63
-
-
85027919555
-
Genetic and epigenetic regulation of gene expression in fetal and adult human livers
-
Bonder, M. J. et al. Genetic and epigenetic regulation of gene expression in fetal and adult human livers. BMC Genomics 15, 860 (2014).
-
(2014)
BMC Genomics
, vol.15
, pp. 860
-
-
Bonder, M.J.1
-
64
-
-
84883156126
-
Ontogeny, distribution and potential roles of 5-hydroxymethylcytosine in human liver function
-
Ivanov, M. et al. Ontogeny, distribution and potential roles of 5-hydroxymethylcytosine in human liver function. Genome Biol. 14, R83 (2013).
-
(2013)
Genome Biol.
, vol.14
, pp. R83
-
-
Ivanov, M.1
-
65
-
-
33646065989
-
Hormonal regulation of renal multidrug resistance-associated proteins 3 and 4 (Mrp3 and Mrp4) in mice
-
Maher, J. M., Cheng, X., Tanaka, Y., Scheffer, G. L. & Klaassen, C. D. Hormonal regulation of renal multidrug resistance-associated proteins 3 and 4 (Mrp3 and Mrp4) in mice. Biochem. Pharmacol. 71, 1470-1478 (2006).
-
(2006)
Biochem. Pharmacol.
, vol.71
, pp. 1470-1478
-
-
Maher, J.M.1
Cheng, X.2
Tanaka, Y.3
Scheffer, G.L.4
Klaassen, C.D.5
-
66
-
-
33748919292
-
Endocrine regulation of gender-divergent mouse organic anion-transporting polypeptide (Oatp) expression
-
Cheng, X., Maher, J., Lu, H. & Klaassen, C. D. Endocrine regulation of gender-divergent mouse organic anion-transporting polypeptide (Oatp) expression. Mol. Pharmacol. 70, 1291-1297 (2006).
-
(2006)
Mol. Pharmacol.
, vol.70
, pp. 1291-1297
-
-
Cheng, X.1
Maher, J.2
Lu, H.3
Klaassen, C.D.4
-
67
-
-
80655147017
-
Age and CYP3A5 genotype affect tacrolimus dosing requirements after transplant in pediatric heart recipients
-
Gijsen, V. et al. Age and CYP3A5 genotype affect tacrolimus dosing requirements after transplant in pediatric heart recipients. J. Heart Lung Transplant. 30, 1352-1359 (2011).
-
(2011)
J. Heart Lung Transplant.
, vol.30
, pp. 1352-1359
-
-
Gijsen, V.1
-
68
-
-
84866599789
-
Interpreting pharmacogenetic data in the developing neonate: The challenge of hitting a moving target
-
Leeder, J. S. & Kearns, G. L. Interpreting pharmacogenetic data in the developing neonate: The challenge of hitting a moving target. Clin. Pharmacol. Ther. 92, 434-436 (2012).
-
(2012)
Clin. Pharmacol. Ther.
, vol.92
, pp. 434-436
-
-
Leeder, J.S.1
Kearns, G.L.2
-
69
-
-
81855206575
-
Variations in ATP-binding cassette transporter regulation during the progression of human nonalcoholic fatty liver disease
-
Hardwick, R. N., Fisher, C. D., Canet, M. J., Scheffer, G. L. & Cherrington, N. J. Variations in ATP-binding cassette transporter regulation during the progression of human nonalcoholic fatty liver disease. Drug Metab. Dispos. 39, 2395-2402 (2011).
-
(2011)
Drug Metab. Dispos.
, vol.39
, pp. 2395-2402
-
-
Hardwick, R.N.1
Fisher, C.D.2
Canet, M.J.3
Scheffer, G.L.4
Cherrington, N.J.5
-
70
-
-
80053162318
-
Analysis of global and absorption, distribution, metabolism, and elimination gene expression in the progressive stages of human nonalcoholic fatty liver disease
-
Lake, A. D. et al. Analysis of global and absorption, distribution, metabolism, and elimination gene expression in the progressive stages of human nonalcoholic fatty liver disease. Drug Metab. Dispos. 39, 1954-1960 (2011).
-
(2011)
Drug Metab. Dispos.
, vol.39
, pp. 1954-1960
-
-
Lake, A.D.1
-
71
-
-
84885032015
-
Age related changes in fractional elimination pathways for drugs: Assessing the impact of variable ontogeny on metabolic drug-drug interactions
-
Salem, F., Johnson, T. N., Barter, Z. E., Leeder, J. S. & Rostami-Hodjegan, A. Age related changes in fractional elimination pathways for drugs: Assessing the impact of variable ontogeny on metabolic drug-drug interactions. J. Clin. Pharmacol. 53, 857-865 (2013).
-
(2013)
J. Clin. Pharmacol.
, vol.53
, pp. 857-865
-
-
Salem, F.1
Johnson, T.N.2
Barter, Z.E.3
Leeder, J.S.4
Rostami-Hodjegan, A.5
-
72
-
-
84875803011
-
Predicting pharmacokinetic profiles using in silico derived parameters
-
Hosea, N. A. & Jones, H. M. Predicting pharmacokinetic profiles using in silico derived parameters. Mol. Pharm. 10, 1207-1215 (2013).
-
(2013)
Mol. Pharm.
, vol.10
, pp. 1207-1215
-
-
Hosea, N.A.1
Jones, H.M.2
-
73
-
-
33646124969
-
A novel strategy for physiologically based predictions of human pharmacokinetics
-
Jones, H. M., Parrott, N., Jorga, K. & Lave, T. A novel strategy for physiologically based predictions of human pharmacokinetics. Clin. Pharmacokinet. 45, 511-542 (2006).
-
(2006)
Clin. Pharmacokinet.
, vol.45
, pp. 511-542
-
-
Jones, H.M.1
Parrott, N.2
Jorga, K.3
Lave, T.4
-
74
-
-
52649085416
-
Physiology-based simulations of a pathological condition: Prediction of pharmacokinetics in patients with liver cirrhosis
-
Edginton, A. N. & Willmann, S. Physiology-based simulations of a pathological condition: prediction of pharmacokinetics in patients with liver cirrhosis. Clin. Pharmacokinet. 47, 743-752 (2008).
-
(2008)
Clin. Pharmacokinet.
, vol.47
, pp. 743-752
-
-
Edginton, A.N.1
Willmann, S.2
-
75
-
-
77249090840
-
A semi-mechanistic model to predict the effects of liver cirrhosis on drug clearance
-
Johnson, T. N., Boussery, K., Rowland-Yeo, K., Tucker, G. T. & Rostami-Hodjegan, A. A semi-mechanistic model to predict the effects of liver cirrhosis on drug clearance. Clin. Pharmacokinet. 49, 189-206 (2010).
-
(2010)
Clin. Pharmacokinet.
, vol.49
, pp. 189-206
-
-
Johnson, T.N.1
Boussery, K.2
Rowland-Yeo, K.3
Tucker, G.T.4
Rostami-Hodjegan, A.5
-
76
-
-
33746803672
-
Prediction of the clearance of eleven drugs and associated variability in neonates, infants and children
-
Johnson, T. N., Rostami-Hodjegan, A. & Tucker, G. T. Prediction of the clearance of eleven drugs and associated variability in neonates, infants and children. Clin. Pharmacokinet. 45, 931-956 (2006).
-
(2006)
Clin. Pharmacokinet.
, vol.45
, pp. 931-956
-
-
Johnson, T.N.1
Rostami-Hodjegan, A.2
Tucker, G.T.3
-
77
-
-
80051499168
-
Development of a physiologically based model for oseltamivir and simulation of pharmacokinetics in neonates and infants
-
Parrott, N. et al. Development of a physiologically based model for oseltamivir and simulation of pharmacokinetics in neonates and infants. Clin. Pharmacokinet. 50, 613-623 (2011).
-
(2011)
Clin. Pharmacokinet.
, vol.50
, pp. 613-623
-
-
Parrott, N.1
-
78
-
-
84966319738
-
-
Minutes for the March 14, 2012 meeting of the Advisory Committee for Pharmaceutical Science and Clinical Pharmacology (PDF-44KB)
-
Minutes for the March 14, 2012 meeting of the Advisory Committee for Pharmaceutical Science and Clinical Pharmacology (PDF-44KB). .
-
-
-
-
79
-
-
84863344719
-
PBPK as a tool in regulatory review
-
Huang, S. M. PBPK as a tool in regulatory review. Biopharm. Drug Dispos. 33, 51-52 (2012).
-
(2012)
Biopharm. Drug Dispos.
, vol.33
, pp. 51-52
-
-
Huang, S.M.1
-
80
-
-
84881613954
-
The utility of modeling and simulation in drug development and regulatory review
-
Huang, S. M., Abernethy, D. R., Wang, Y., Zhao, P. & Zineh, I. The utility of modeling and simulation in drug development and regulatory review. J. Pharm. Sci. 102, 2912-2923 (2013).
-
(2013)
J. Pharm. Sci.
, vol.102
, pp. 2912-2923
-
-
Huang, S.M.1
Abernethy, D.R.2
Wang, Y.3
Zhao, P.4
Zineh, I.5
-
81
-
-
84859994663
-
Regulatory experience with physiologically based pharmacokinetic modeling for pediatric drug trials
-
Leong, R. et al. Regulatory experience with physiologically based pharmacokinetic modeling for pediatric drug trials. Clin. Pharmacol. Ther. 91, 926-931 (2012).
-
(2012)
Clin. Pharmacol. Ther.
, vol.91
, pp. 926-931
-
-
Leong, R.1
-
82
-
-
84879810923
-
From pediatric covariate model to semiphysiological function for maturation: Part I. Extrapolation of a covariate model from morphine to Zidovudine
-
Krekels, E. H. et al. From pediatric covariate model to semiphysiological function for maturation: part I. Extrapolation of a covariate model from morphine to Zidovudine. CPT Pharmacometrics Syst. Pharmacol. 1, e9 (2012).
-
(2012)
CPT Pharmacometrics Syst. Pharmacol.
, vol.1
, pp. e9
-
-
Krekels, E.H.1
-
83
-
-
84925285641
-
What do drug transporters really do Nat
-
Nigam, S. K. What do drug transporters really do Nat. Rev. Drug Discov. 14, 29-44 (2015).
-
(2015)
Rev. Drug Discov.
, vol.14
, pp. 29-44
-
-
Nigam, S.K.1
-
84
-
-
84921842817
-
Ethics of drug research in the pediatric intensive care unit
-
Kleiber, N., Tromp, K., Mooij, M. G., van de Vathorst, S., Tibboel, D. & de Wildt, S. N. Ethics of drug research in the pediatric intensive care unit. Paediatr. Drugs 17, 43-53 (2015).
-
(2015)
Paediatr. Drugs
, vol.17
, pp. 43-53
-
-
Kleiber, N.1
Tromp, K.2
Mooij, M.G.3
Van De Vathorst, S.4
Tibboel, D.5
De Wildt, S.N.6
-
85
-
-
84865743377
-
Applications of accelerator MS in pediatric drug evaluation
-
Vuong, L. T., Blood, A. B., Vogel, J. S., Anderson, M. E. & Goldstein, B. Applications of accelerator MS in pediatric drug evaluation. Bioanalysis 4, 1871-1882 (2012).
-
(2012)
Bioanalysis
, vol.4
, pp. 1871-1882
-
-
Vuong, L.T.1
Blood, A.B.2
Vogel, J.S.3
Anderson, M.E.4
Goldstein, B.5
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