메뉴 건너뛰기




Volumn 12, Issue 8, 2006, Pages 745-749

Impact of inflammation on the duodenal mRNA expression of CYP3A and P-glycoprotein in children with Crohn's disease

Author keywords

Crohn's disease; CYP3A; mRNA expression; P glycoprotein

Indexed keywords

CORTICOSTEROID; CYTOCHROME P450 3A; CYTOCHROME P450 3A4; CYTOCHROME P450 3A5; CYTOCHROME P450 3A7; CYTOKINE; GAMMA INTERFERON; GLYCOPROTEIN P; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 6; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA;

EID: 33747439382     PISSN: 10780998     EISSN: 15364844     Source Type: Journal    
DOI: 10.1097/00054725-200608000-00011     Document Type: Article
Times cited : (52)

References (28)
  • 1
    • 0037022008 scopus 로고    scopus 로고
    • Crohn's disease
    • Shanahan F. Crohn's disease. Lancet. 2002;359:62-69.
    • (2002) Lancet , vol.359 , pp. 62-69
    • Shanahan, F.1
  • 2
    • 11244261399 scopus 로고    scopus 로고
    • Inflammatory bowel disease. II. Crohn's disease: Pathophysiology and conventional and alternative treatment options
    • Head K, Jurenka J. Inflammatory bowel disease. II. Crohn's disease: pathophysiology and conventional and alternative treatment options. Altern Med Rev. 2004;9:360-401.
    • (2004) Altern Med Rev , vol.9 , pp. 360-401
    • Head, K.1    Jurenka, J.2
  • 3
    • 27444443972 scopus 로고    scopus 로고
    • Influence of the proinflammatory cytokines on P-glycoprotein expression and functionality
    • Fernandez C, Buyse M, German-Fattel M, et al. Influence of the proinflammatory cytokines on P-glycoprotein expression and functionality. J Pharm Pharmaceut Sci. 2004;7:359-371.
    • (2004) J Pharm Pharmaceut Sci , vol.7 , pp. 359-371
    • Fernandez, C.1    Buyse, M.2    German-Fattel, M.3
  • 4
    • 0037378891 scopus 로고    scopus 로고
    • Genetic polymorphisms in biotransformation enzymes in Crohn's disease: Association with microsomal epoxide hydrolase
    • De Jong DJ, van der Logt EMJ, van Schaik A, et al. Genetic polymorphisms in biotransformation enzymes in Crohn's disease: association with microsomal epoxide hydrolase. Gut. 2003;52:547-551.
    • (2003) Gut , vol.52 , pp. 547-551
    • De Jong, D.J.1    Van Der Logt, E.M.J.2    Van Schaik, A.3
  • 5
    • 0043208313 scopus 로고    scopus 로고
    • In Vitro Prediction of Gastrointestinal Absorption and Bioavailability
    • Paper presented, Berlin, Germany, May 5-6
    • Pelkonen O, Boobis AR, Gundert-Remy U. In Vitro Prediction of Gastrointestinal Absorption and Bioavailability. Paper presented at the COST B15 Meeting, Berlin, Germany, May 5-6, 2000.
    • (2000) COST B15 Meeting
    • Pelkonen, O.1    Boobis, A.R.2    Gundert-Remy, U.3
  • 6
    • 0031765907 scopus 로고    scopus 로고
    • Role of P-glycoprotein and cytochrome P450 3A in limiting oral absorption of peptides and peptidomimetics
    • Wacher VJ, Silverman JA, Zhang YC, et al. Role of P-glycoprotein and cytochrome P450 3A in limiting oral absorption of peptides and peptidomimetics. J Pharm Sci. 1998;87:1322-1330.
    • (1998) J Pharm Sci , vol.87 , pp. 1322-1330
    • Wacher, V.J.1    Silverman, J.A.2    Zhang, Y.C.3
  • 7
    • 0036786382 scopus 로고    scopus 로고
    • Interindividual variability and tissue-specificity in the expression of cytochrome P450 3A mRNA
    • Koch I, Weil R, Wolbold R, et al. Interindividual variability and tissue-specificity in the expression of cytochrome P450 3A mRNA. Drug Metab Disp. 2002;30:1108-1114.
    • (2002) Drug Metab Disp , vol.30 , pp. 1108-1114
    • Koch, I.1    Weil, R.2    Wolbold, R.3
  • 8
    • 0035882515 scopus 로고    scopus 로고
    • Pharmacogenetics of the human drug-transporter gene MDR1: Impact of polymorphisms on pharmacotherapy
    • Brinkmann U, Roots I, Eichelbaum M. Pharmacogenetics of the human drug-transporter gene MDR1: impact of polymorphisms on pharmacotherapy. Drug Discov Today. 2001;6:835-839.
    • (2001) Drug Discov Today , vol.6 , pp. 835-839
    • Brinkmann, U.1    Roots, I.2    Eichelbaum, M.3
  • 9
    • 0033975157 scopus 로고    scopus 로고
    • Role of P-glycoprotein in drug disposition
    • Tanigawara Y. Role of P-glycoprotein in drug disposition. Ther Drug Monit. 2000;22:137-140.
    • (2000) Ther Drug Monit , vol.22 , pp. 137-140
    • Tanigawara, Y.1
  • 10
    • 0035478419 scopus 로고    scopus 로고
    • The drug efflux-metabolism alliance: Biochemical aspects
    • Benet LZ, Cummins CL. The drug efflux-metabolism alliance: biochemical aspects. Adv Drug Deliv Rev. 2001;50(Suppl 1):S3-S11.
    • (2001) Adv Drug Deliv Rev , vol.50 , Issue.1 SUPPL.
    • Benet, L.Z.1    Cummins, C.L.2
  • 11
    • 0034637122 scopus 로고    scopus 로고
    • Interleukin-6 negatively regulates the expression of pregnane X receptor and constitutively activated receptor in primary human hepatocytes
    • Pascussi J-M, Gerbal-Chaloin S, Pichard-Garcia L, et al. Interleukin-6 negatively regulates the expression of pregnane X receptor and constitutively activated receptor in primary human hepatocytes. Biochem Biophys Res Commun. 2000;274:707-713.
    • (2000) Biochem Biophys Res Commun , vol.274 , pp. 707-713
    • Pascussi, J.-M.1    Gerbal-Chaloin, S.2    Pichard-Garcia, L.3
  • 12
    • 1642579697 scopus 로고    scopus 로고
    • Suppression of drug-metabolizing enzymes and efflux transporters in the intestine of endotoxin-treated rats
    • Kalitsky-Szirtes J, Shayeganpour A, Broks DR, et al. Suppression of drug-metabolizing enzymes and efflux transporters in the intestine of endotoxin-treated rats. Drug Metab Dispos. 2004;32:20-27.
    • (2004) Drug Metab Dispos , vol.32 , pp. 20-27
    • Kalitsky-Szirtes, J.1    Shayeganpour, A.2    Broks, D.R.3
  • 13
    • 0035994885 scopus 로고    scopus 로고
    • Effect of hr-IL2 treatment on intestinal P-glycoprotein expression and activity in Caco-2 cells
    • Belliard AM, Tardivel S, Farinotti R, et al. Effect of hr-IL2 treatment on intestinal P-glycoprotein expression and activity in Caco-2 cells. J Pharm Pharmacol. 2002;54:1103-1109.
    • (2002) J Pharm Pharmacol , vol.54 , pp. 1103-1109
    • Belliard, A.M.1    Tardivel, S.2    Farinotti, R.3
  • 14
    • 0035038677 scopus 로고    scopus 로고
    • Cytokines influence mRNA expression of Cytochrome P450 3A and MDR1 in intestinal cells
    • Bertilsson PM, Olsson P, Magnusson KE. Cytokines influence mRNA expression of Cytochrome P450 3A and MDR1 in intestinal cells. J Pharm Sci. 2001;90:638-646.
    • (2001) J Pharm Sci , vol.90 , pp. 638-646
    • Bertilsson, P.M.1    Olsson, P.2    Magnusson, K.E.3
  • 15
    • 0026736026 scopus 로고
    • Soluble interleukine-2 receptor, interleukin-6 and interleukin-1 beta in patients with Crohn's disease and ulcerative colitis: Preoperative levels and postoperative changes in serum concentrations
    • Schurmann G, Betzler M, Post S, et al. Soluble interleukine-2 receptor, interleukin-6 and interleukin-1 beta in patients with Crohn's disease and ulcerative colitis: preoperative levels and postoperative changes in serum concentrations. Digestion. 1992;51:51-59.
    • (1992) Digestion , vol.51 , pp. 51-59
    • Schurmann, G.1    Betzler, M.2    Post, S.3
  • 16
    • 20144383986 scopus 로고    scopus 로고
    • Profile of soluble cytokine receptors in Crohn's disease
    • Gustot T, Lemmers A, Louis E, et al. Profile of soluble cytokine receptors in Crohn's disease. Gut. 2005;54:488-495.
    • (2005) Gut , vol.54 , pp. 488-495
    • Gustot, T.1    Lemmers, A.2    Louis, E.3
  • 17
    • 0031876486 scopus 로고    scopus 로고
    • Differential alterations in levels of hepatic microsomal Cytochrome P450 isozymes following intracerebroventricular injection of bacterial lipopolysaccharide in rats
    • Shimamoto Y, Kitamura H, Hoshi H, et al. Differential alterations in levels of hepatic microsomal Cytochrome P450 isozymes following intracerebroventricular injection of bacterial lipopolysaccharide in rats. Arch Toxicol. 1998;72:492-498.
    • (1998) Arch Toxicol , vol.72 , pp. 492-498
    • Shimamoto, Y.1    Kitamura, H.2    Hoshi, H.3
  • 18
    • 0037716531 scopus 로고    scopus 로고
    • Downregulation of mdr1a expression in the brain and liver during CNS inflammation alters the in vivo disposition of digoxin
    • Goralski KB, Hartmann G, Piquette-Miller M, et al. Downregulation of mdr1a expression in the brain and liver during CNS inflammation alters the in vivo disposition of digoxin. Br J Pharmacol. 2003;39:35-48.
    • (2003) Br J Pharmacol , vol.39 , pp. 35-48
    • Goralski, K.B.1    Hartmann, G.2    Piquette-Miller, M.3
  • 19
    • 0036296149 scopus 로고    scopus 로고
    • Reduction in cytochrome P-450 enzyme expression is associated with repression of CAR (constitutive androstane receptor) and PXR (pregnane X receptor) in mouse liver during the acute phase response
    • Beigneux AP, Moser AH, Shigenaga JK, et al. Reduction in cytochrome P-450 enzyme expression is associated with repression of CAR (constitutive androstane receptor) and PXR (pregnane X receptor) in mouse liver during the acute phase response. Biochem Biophys Res Commun. 2002;293:145-149.
    • (2002) Biochem Biophys Res Commun , vol.293 , pp. 145-149
    • Beigneux, A.P.1    Moser, A.H.2    Shigenaga, J.K.3
  • 20
    • 0027443904 scopus 로고
    • Cytokines down-regulate expression of major cytochrome P-450 enzymes in adult human hepatocytes in primary culture
    • Abdel-Razzak Z, Loyer P, Fautrel A, et al. Cytokines down-regulate expression of major cytochrome P-450 enzymes in adult human hepatocytes in primary culture. Mol Pharmacol. 1993;44:707-715.
    • (1993) Mol Pharmacol , vol.44 , pp. 707-715
    • Abdel-Razzak, Z.1    Loyer, P.2    Fautrel, A.3
  • 21
    • 0842304217 scopus 로고    scopus 로고
    • Effect of recombinant interleukin-2 pretreatment on oral and intravenous digoxin pharmacokinetics and P-glycoprotein activity in mice
    • Bonhome-Faivre L, Castagne V, Urien S, et al. Effect of recombinant interleukin-2 pretreatment on oral and intravenous digoxin pharmacokinetics and P-glycoprotein activity in mice. Drug Metab Dispos. 2004;32:168-171.
    • (2004) Drug Metab Dispos , vol.32 , pp. 168-171
    • Bonhome-Faivre, L.1    Castagne, V.2    Urien, S.3
  • 22
    • 2642537787 scopus 로고    scopus 로고
    • Effect of tumor necrosis factor-α and interferon-γ on intestinal P-glycoprotein expression, activity and localization in Caco-2 cells
    • Belliard AM, Lacour B, Farinotti R, et al. Effect of tumor necrosis factor-α and interferon-γ on intestinal P-glycoprotein expression, activity and localization in Caco-2 cells. J Pharm Sci. 2004;93:1524-1536.
    • (2004) J Pharm Sci , vol.93 , pp. 1524-1536
    • Belliard, A.M.1    Lacour, B.2    Farinotti, R.3
  • 23
    • 0141676887 scopus 로고    scopus 로고
    • Cytokine tissue levels as markers of disease activity in pediatric Crohn disease
    • Silva MA, Menezes J, Wizman S, et al. Cytokine tissue levels as markers of disease activity in pediatric Crohn disease. Pediatr Res. 2003;54:456-461.
    • (2003) Pediatr Res , vol.54 , pp. 456-461
    • Silva, M.A.1    Menezes, J.2    Wizman, S.3
  • 24
    • 0026645868 scopus 로고
    • Variable expression of P-glycoprotein in normal, inflamed and dysplastic areas in ulcerative colitis
    • Saclarides TJ, Jakate SM, Coon JS, et al. Variable expression of P-glycoprotein in normal, inflamed and dysplastic areas in ulcerative colitis. Dis Colon Rectum. 1992;35:747-752.
    • (1992) Dis Colon Rectum , vol.35 , pp. 747-752
    • Saclarides, T.J.1    Jakate, S.M.2    Coon, J.S.3
  • 25
    • 3242735503 scopus 로고    scopus 로고
    • Loss of detoxification in inflammatory bowel disease: Dysregulation of pregnane X receptor target genes
    • Langmann T, Moehle C, Mauerer R, et al. Loss of detoxification in inflammatory bowel disease: dysregulation of pregnane X receptor target genes. Gastroenterology. 2004;127:26-40.
    • (2004) Gastroenterology , vol.127 , pp. 26-40
    • Langmann, T.1    Moehle, C.2    Mauerer, R.3
  • 26
    • 0035071598 scopus 로고    scopus 로고
    • Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression
    • Kuehl P, Zhang J, Lin Y, et al. Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression. Nat Genet. 2001;27:383-391.
    • (2001) Nat Genet , vol.27 , pp. 383-391
    • Kuehl, P.1    Zhang, J.2    Lin, Y.3
  • 27
    • 0033932053 scopus 로고    scopus 로고
    • Two linked mutations in transcriptional regulatory elements of the CYP3A5 gene constitute the major genetic determinant of polymorphic activity in humans
    • Paulussen A, Lavrijsen K, Bohets H. Two linked mutations in transcriptional regulatory elements of the CYP3A5 gene constitute the major genetic determinant of polymorphic activity in humans. Pharmacogenetics. 2000;10:415-424.
    • (2000) Pharmacogenetics , vol.10 , pp. 415-424
    • Paulussen, A.1    Lavrijsen, K.2    Bohets, H.3
  • 28
    • 27544454323 scopus 로고    scopus 로고
    • Localization and mRNA expression of CYP3A and P-glycoprotein in human duodenum as a function of age
    • Fakhoury M, Litalien C, Medard Y, et al. Localization and mRNA expression of CYP3A and P-glycoprotein in human duodenum as a function of age. Drug Metab Dispos. 2005;33:1603-1607.
    • (2005) Drug Metab Dispos , vol.33 , pp. 1603-1607
    • Fakhoury, M.1    Litalien, C.2    Medard, Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.