Ontogeny of human hepatic and intestinal transporter gene expression during childhood: Age matters

Drug Metabolism and Disposition

Volumn 42, Issue 8, 2014, Pages 1268-1274

  Mooij, Miriam G ^a   Schwarz, Ute I ^a   De Koning, Barbara A E ^a   Leeder, J Steven ^c   Gaedigk, Roger ^c   Samsom, Janneke N ^a   Spaans, Edwin ^a   Van Goudoever, Johannes B ^d,e   Tibboel, Dick ^a   Kim, Richard B ^a,b   De Wildt, Saskia N ^a  

^a SOPHIA CHILDREN S HOSPITAL   (Netherlands)

^b UNIVERSITY OF WESTERN ONTARIO   (Canada)

^c CHILDREN S MERCY HOSPITAL   (United States)

^d EMMA CHILDREN S HOSPITAL   (Netherlands)

^e VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CAFFEINE; COMPLEMENTARY DNA; DEXTROMETHORPHAN; GENOMIC DNA; HEPATIC DRUG TRANSPORTER; INTESTINAL DRUG TRANSPORTER; MEMBRANE PROTEIN; MESSENGER RNA; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 2; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 2; ORGANIC ANION TRANSPORTER F; RNA 18S; SOLUTE CARRIER ORGANIC ANION TRANSPORTER 1B1; SOLUTE CARRIER ORGANIC ANION TRANSPORTER 1B3; UNCLASSIFIED DRUG; VILLIN; CARRIER PROTEIN; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 2; ORGANIC ANION TRANSPORTER; SLCO1B1 PROTEIN, HUMAN; SLCO1B3 PROTEIN, HUMAN;

ADULT; ARTICLE; CHILD; CONTROLLED STUDY; DNA SYNTHESIS; DRUG ABSORPTION; DRUG ELIMINATION; FEMALE; GENE EXPRESSION; GROUPS BY AGE; HUMAN; HUMAN TISSUE; INTESTINE CELL; LIVER; LIVER CELL; MALE; ONTOGENY; PEDIATRICS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SMALL INTESTINE; ADOLESCENT; GENE ONTOLOGY; GENETICS; INFANT; INTESTINE; METABOLISM; NEWBORN; PRESCHOOL CHILD; TRANSPORT AT THE CELLULAR LEVEL;

ADOLESCENT; ADULT; BIOLOGICAL TRANSPORT; CHILD; CHILD, PRESCHOOL; FEMALE; GENE EXPRESSION; GENE ONTOLOGY; HUMANS; INFANT; INFANT, NEWBORN; INTESTINES; LIVER; MALE; MEMBRANE TRANSPORT PROTEINS; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; ORGANIC ANION TRANSPORTERS; ORGANIC ANION TRANSPORTERS, SODIUM-INDEPENDENT;

EID: 84904196927     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.114.056929     Document Type: Article

References (37)

1. Albermann N, Schmitz-Winnenthal FH, Z'graggen K, Volk C, Hoffmann MM, Haefeli WE, and Weiss J (2005) Expression of the drug transporters MDR1/ABCB1, MRP1/ABCC1, MRP2/ABCC2, BCRP/ABCG2, and PXR in peripheral blood mononuclear cells and their relationship with the expression in intestine and liver. Biochem Pharmacol 70:949-958. (Pubitemid 41138860)
2. Bebawy M, Rasmussen C, Sambasivam S, and Bao S (2009) Dietary nucleotide supplements in infant formula modify the expression of P-glycoprotein in the intestinal epithelium in vitro. Int J Vitam Nutr Res 79:381-387.
3. Blake MJ, Abdel-Rahman SM, Pearce RE, Leeder JS, and Kearns GL (2006) Effect of diet on the development of drug metabolism by cytochrome P-450 enzymes in healthy infants. Pediatr Res 60:717-723. (Pubitemid 44789515)
4. Chen HL, Chen HL, Liu YJ, Feng CH, Wu CY, Shyu MK, Yuan RH, and Chang MH (2005) Developmental expression of canalicular transporter genes in human liver. J Hepatol 43:472-477. (Pubitemid 41111429)
5. Chen HL, Liu YJ, Chen HL, Wu SH, Ni YH, Ho MC, Lai HS, Hsu WM, Hsu HY, and Tseng HC, et al. (2008) Expression of hepatocyte transporters and nuclear receptors in children with early and late-stage biliary atresia. Pediatr Res 63:667-673.
6. Cízková D, Morký J, Micuda S, Osterreicher J, and Martínková J (2005) Expression of MRP2 and MDR1 transporters and other hepatic markers in rat and human liver and in WRL 68 cell line. Physiol Res 54:419-428.
7. de Wildt SN (2011) Profound changes in drug metabolism enzymes and possible effects on drug therapy in neonates and children. Expert Opin Drug Metab Toxicol 7:935-948.
8. de Wildt SN, Kearns GL, Hop WC, Murry DJ, Abdel-Rahman SM, and van den Anker JN (2002) Pharmacokinetics and metabolism of oral midazolam in preterm infants. Br J Clin Pharmacol 53:390-392. (Pubitemid 34415590)
9. DeGorter MK, Xia CQ, Yang JJ, and Kim RB (2012) Drug transporters in drug efficacy and toxicity. Annu Rev Pharmacol Toxicol 52:249-273.
10. Fakhoury M, de Beaumais T, Guimiot F, Azougagh S, Elie V, Medard Y, Delezoide AL, and Jacqz-Aigrain E (2009) mRNA expression of MDR1 and major metabolising enzymes in human fetal tissues. Drug Metab Pharmacokinet 24:529-536.
11. Fakhoury M, Lecordier J, Medard Y, Peuchmaur M, and Jacqz-Agrain E (2006) Impact of inflammation on the duodenal mRNA expression of CYP3A and P-glycoprotein in children with Crohn's disease. Inflamm Bowel Dis 12:745-749. (Pubitemid 44253759)
12. Fakhoury M, Litalien C, Medard Y, Cavé H, Ezzahir N, Peuchmaur M, and Jacqz-Aigrain E (2005) Localization and mRNA expression of CYP3A and P-glycoprotein in human duodenum as a function of age. Drug Metab Dispos 33:1603-1607. (Pubitemid 41539956)
13. Fernandez C, Buyse M, German-Fattal M, and Gimenez F (2004) Influence of the proinflammatory cytokines on P-glycoprotein expression and functionality. J Pharm Pharm Sci 7:359-371. (Pubitemid 41528888)
14. Fukudo M, Yano I, Masuda S, Goto M, Uesugi M, Katsura T, Ogura Y, Oike F, Takada Y, and Egawa H, et al. (2006) Population pharmacokinetic and pharmacogenomic analysis of tacrolimus in pediatric living-donor liver transplant recipients. Clin Pharmacol Ther 80:331-345. (Pubitemid 44479749)
15. Glaeser H, Bailey DG, Dresser GK, Gregor JC, Schwarz UI, McGrath JS, Jolicoeur E, Lee W, Leake BF, and Tirona RG, et al. (2007) Intestinal drug transporter expression and the impact of grapefruit juice in humans. Clin Pharmacol Ther 81:362-370. (Pubitemid 46364477)
16. Johnson TN, Tanner MS, Taylor CJ, and Tucker GT (2001) Enterocytic CYP3A4 in a paediatric population: developmental changes and the effect of coeliac disease and cystic fibrosis. Br J Clin Pharmacol 51:451-460. (Pubitemid 32852983)
17. Kacevska M, Ivanov M, Wyss A, Kasela S, Milani L, Rane A, and Ingelman-Sundberg M (2012) DNA methylation dynamics in the hepatic CYP3A4 gene promoter. Biochimie 94:2338-2344.
18. Kearns GL, Abdel-Rahman SM, Alander SW, Blowey DL, Leeder JS, and Kauffman RE (2003) Developmental pharmacology - drug disposition, action, and therapy in infants and children. N Engl J Med 349:1157-1167. (Pubitemid 37122329)
19. Klaassen CD and Aleksunes LM (2010) Xenobiotic, bile acid, and cholesterol transporters: function and regulation. Pharmacol Rev 62:1-96.
20. Le Vee M, Jouan E, Moreau A, and Fardel O (2011) Regulation of drug transporter mRNA expression by interferon-γ in primary human hepatocytes. Fundam Clin Pharmacol 25:99-103.
21. Leeder JS, Gaedigk R, Marcucci KA, Gaedigk A, Vyhlidal CA, Schindel BP, and Pearce RE (2005) Variability of CYP3A7 expression in human fetal liver. J Pharmacol Exp Ther 314:626-635. (Pubitemid 41043843)
22. Miki Y, Suzuki T, Tazawa C, Blumberg B, and Sasano H (2005) Steroid and xenobiotic receptor (SXR), cytochrome P450 3A4 and multidrug resistance gene 1 in human adult and fetal tissues. Mol Cell Endocrinol 231:75-85. (Pubitemid 40248818)
23. Mizuno T, Fukuda T, Masuda S, Uemoto S, Matsubara K, Inui KI, and Vinks AA (2014) Developmental trajectory of intestinal MDR1/ABCB1 mRNA expression in children. Br J Clin Pharmacol 77:910-912.
24. Nies AT, Niemi M, Burk O, Winter S, Zanger UM, Stieger B, Schwab M, and Schaeffeler E (2013) Genetics is a major determinant of expression of the human hepatic uptake transporter OATP1B1, but not of OATP1B3 and OATP2B1. Genome Med 5:1.
25. Prasad B, Evers R, Gupta A, Hop CE, Salphati L, Shukla S, Ambudkar SV, and Unadkat JD (2014) Interindividual variability in hepatic organic anion-transporting polypeptides and P-glycoprotein (ABCB1) protein expression: quantification by liquid chromatography tandem mass spectroscopy and influence of genotype, age, and sex. Drug Metab Dispos 42:78-88.
26. Prasad B, Lai Y, Lin Y, and Unadkat JD (2013) Interindividual variability in the hepatic expression of the human breast cancer resistance protein (BCRP/ABCG2): effect of age, sex, and genotype. J Pharm Sci 102:787-793.
27. Schaeffeler E, Hellerbrand C, Nies AT, Winter S, Kruck S, Hofmann U, van der Kuip H, Zanger UM, Koepsell H, and Schwab M (2011) DNA methylation is associated with downregulation of the organic cation transporter OCT1 (SLC22A1) in human hepatocellular carcinoma. Genome Med 3:82.
28. Schmittgen TD and Livak KJ (2008) Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc 3:1101-1108. (Pubitemid 351818697)
29. Schwarz UI, Hanso H, Oertel R, Miehlke S, Kuhlisch E, Glaeser H, Hitzl M, Dresser GK, Kim RB, and Kirch W (2007) Induction of intestinal P-glycoprotein by St John's wort reduces the oral bioavailability of talinolol. Clin Pharmacol Ther 81:669-678. (Pubitemid 46625125)
30. Schwarz UI, Seemann D, Oertel R, Miehlke S, Kuhlisch E, Fromm MF, Kim RB, Bailey DG, and Kirch W (2005) Grapefruit juice ingestion significantly reduces talinolol bioavailability. Clin Pharmacol Ther 77:291-301. (Pubitemid 40470385)
31. Sharma S, Ellis EC, Gramignoli R, Dorko K, Tahan V, Hansel M, Mattison DR, Caritis SN, Hines RN, and Venkataramanan R, et al. (2013) Hepatobiliary disposition of 17-OHPC and taurocholate in fetal human hepatocytes: a comparison with adult human hepatocytes. Drug Metab Dispos 41:296-304.
32. Synold TW, Dussault I, and Forman BM (2001) The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux. Nat Med 7:584-590. (Pubitemid 32448326)
33. Thomson MMS, Krauel S, Hines RN, Scheutz EG, and Meibohm B (2013) Lack of effect of genetic variants on the age-associated prtoein expression of OATP1B1 and OATP1B3 in human pediatric liver. Abstract LB111-6. 114th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics; 2013 Mar 5-9; Indianapolis, IN. American Society for Clinical Pharmacology and Therapeutics, Alexandria, VA.
34. Ulvestad M, Skottheim IB, Jakobsen GS, Bremer S, Molden E, Asberg A, Hjelmesæth J, Andersson TB, Sandbu R, and Christensen H (2013) Impact of OATP1B1, MDR1, and CYP3A4 expression in liver and intestine on interpatient pharmacokinetic variability of atorvastatin in obese subjects. Clin Pharmacol Ther 93:275-282.
35. van Kalken CK, Giaccone G, van der Valk P, Kuiper CM, Hadisaputro MM, Bosma SA, Scheper RJ, Meijer CJ, and Pinedo HM (1992) Multidrug resistance gene (P-glycoprotein) expression in the human fetus. Am J Pathol 141:1063-1072.
36. Vet NJ, de Hoog M, Tibboel D, and de Wildt SN (2012) The effect of critical illness and inflammation on midazolam therapy in children. Pediatr Crit Care Med 13:e48-e50.
37. Yanni SB, Smith PB, Benjamin DK, Jr, Augustijns PF, Thakker DR, and Annaert PP (2011) Higher clearance of micafungin in neonates compared with adults: role of age-dependent micafungin serum binding. Biopharm Drug Dispos 32:222-232.