Annona muricata leaves induced apoptosis in A549 cells through mitochondrial-mediated pathway and involvement of NF-κB

BMC Complementary and Alternative Medicine

Volumn 14, Issue 1, 2014, Pages

  Moghadamtousi, Soheil Z ^a   Kadir, Habsah A ^a   Paydar, Mohammadjavad ^b   Rouhollahi, Elham ^b   Karimian, Hamed ^b  

^a UNIVERSITY OF MALAYA   (Malaysia)

^b UNIVERSITY OF MALAYA   (Malaysia)

Author keywords

Annona muricata; Apoptosis; Caspase; Lung cancer; Mitochondria; NF B

Indexed keywords

ACETIC ACID ETHYL ESTER; ANNONA MURICATA EXTRACT; ANNONA MURICATA LEAVES ETHYL ACETATE EXTRACT; CASPASE 3; CASPASE 7; CASPASE 8; CASPASE 9; CURCUMIN; CYTOCHROME C; HEXANE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LACTATE DEHYDROGENASE; METHANOL; PHOSPHATIDYLSERINE; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANNONA MURICATA; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CELL MEMBRANE PERMEABILITY; CELL NUCLEUS; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; CYTOPLASM; CYTOSOL; CYTOTOXICITY; DRUG MECHANISM; ENZYME ACTIVATION; G1 PHASE CELL CYCLE CHECKPOINT; GENE EXPRESSION; HUMAN; HUMAN CELL; IC50; LUNG CANCER CELL LINE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; PLANT LEAF; PROTEIN EXPRESSION; UPREGULATION;

EID: 84946186731     PISSN: None     EISSN: 14726882     Source Type: Journal    
DOI: 10.1186/1472-6882-14-299     Document Type: Article

References (43)

1. Ramezanpour M, da Silva KB, Sanderson BJ. Venom present in sea anemone (heteractis magnifica) induces apoptosis in non-small-cell lung cancer A549 cells through activation of mitochondria-mediated pathway. Biotechnol Lett 2012, 36(3):1-7.
2. Siegel R, DeSantis C, Virgo K, Stein K, Mariotto A, Smith T, Cooper D, Gansler T, Lerro C, Fedewa S, Lin C, Leach C, Cannady RS, Cho H, Scoopa S, Hachey M, Kirch R, Jemal A, Ward E. Cancer treatment and survivorship statistics, 2012. CA-Cancer J Clin 2012, 62(4):220-241.
3. Mitsudomi T, Morita S, Yatabe Y, Negoro S, Okamoto I, Tsurutani J, Seto T, Satouchi M, Tada H, Hirashima T, Asami K, Katakami N, Takada M, Yoshioka H, Shibata K, Kudoh S, Shimizu E, Saito H, Toyooka S, Nakagawa K, Fukuoka M. Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial. Lancet Oncol 2010, 11(2):121-128. 10.1016/S1470-2045(09)70364-X, 20022809.
4. Kim SS, Cho HJ, Kang JY, Kang HK, Yoo TK. Inhibition of androgen receptor expression with small interfering RNA enhances cancer cell apoptosis by suppressing survival factors in androgen insensitive, late stage LNCaP cells. Sci World J 2013, 2013. doi:10.1155/2013/519397.
5. Ocker M, Höpfner M. Apoptosis-modulating drugs for improved cancer therapy. Eur Surg Res 2012, 48(3):111-120. 10.1159/000336875, 22538523.
6. Schumacker PT. Reactive oxygen species in cancer cells: live by the sword, die by the sword. Cancer Cell 2006, 10(3):175-176. 10.1016/j.ccr.2006.08.015, 16959608.
7. Moghadamtousi SZ, Goh BH, Chan CK, Shabab T, Kadir HA. Biological activities and phytochemicals of swietenia macrophylla king. Molecules 2013, 18(9):10465-10483. 10.3390/molecules180910465, 23999722.
8. Simon H-U, Haj-Yehia A, Levi-Schaffer F. Role of reactive oxygen species (ROS) in apoptosis induction. Apoptosis 2000, 5(5):415-418. 10.1023/A:1009616228304, 11256882.
9. Martinou J-C, Youle RJ. Mitochondria in apoptosis: Bcl-2 family members and mitochondrial dynamics. Dev Cell 2011, 21(1):92-101. 10.1016/j.devcel.2011.06.017, 3156409, 21763611.
10. Yang F, Jove V, Chang S, Hedvat M, Liu L, Buettner R, Tian Y, Scuto A, Wen W, Yip MLR, Meter TV, Yen Y, Jove R. Bortezomib induces apoptosis and growth suppression in human medulloblastoma cells, associated with inhibition of AKT and NF-kB signaling, and synergizes with an ERK inhibitor. Cancer Biol Ther 2012, 13(6):349-357. 10.4161/cbt.19239, 3341212, 22313636.
11. Van Waes C. Nuclear factor-κB in development, prevention, and therapy of cancer. Clin Cancer Res 2007, 13(4):1076-1082. 10.1158/1078-0432.CCR-06-2221, 17317814.
12. Adewole SO, Caxton-Martins EA. Morphological changes and hypoglycemic effects of annona muricata Linn.(annonaceae) leaf aqueous extract on pancreatic β-cells of streptozotocin-treated diabetic rats. Afr J Biomed Res 2006, 9(3):173-187.
13. Adewole SO, Ojewole JA. Protective effects of annona muricata Linn. (annonaceae) leaf aqueous extract on serum lipid profiles and oxidative stress in hepatocytes of streptozotocin-treated diabetic rats. Afr J Tra Compl Alter Med 2009, 6(1):30.
14. George VC, Kumar DN, Rajkumar V, Suresh P, Ashok R. Quantitative assessment of the relative antineoplastic potential of the n-butanolic leaf extract of annona muricata Linn. In normal and immortalized human cell lines. Asian Pac J Cancer P 2012, 13(2):699-704.
15. Mishra S, Ahmad S, Kumar N, Sharma BK. Annona muricata (the cancer killer): a review. Glob J Pharma Res 2013, 2(1):1613-1618.
16. Ezirim AU, Okachi VI, James AB, Adebeshi OA, Ogunnowo S, Odeghe OB. Induction of apoptosis in myelogenous leukemic K562 cells by ethanolic leaf extract of annona muricata. Indian J Drugs Dis 2013, 2(3):142-151.
17. Zeng L, Wu F-E, Oberlies NH, McLaughlin JL, Sastrodihadjo S. Five new monotetrahydrofuran ring acetogenins from the leaves of annona muricata. J Nat Prod 1996, 59(11):1035-1042. 10.1021/np960447e, 8946744.
18. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 1983, 65(1):55-63.
19. Liew SY, Looi CY, Paydar M, Cheah FK, Leong KH, Wong WF, Mustafa MR, Litaudon M, Awang K. Subditine, a new monoterpenoid indole alkaloid from bark of nauclea subdita (korth.) steud. Induces apoptosis in human prostate cancer cells. PLoS One 2014, 9(2):e87286. 10.1371/journal.pone.0087286, 3925085, 24551054.
20. Looi CY, Moharram B, Paydar M, Wong YL, Leong KH, Mohamad K, Arya A, Wong WF, Mustafa MR. Induction of apoptosis in melanoma A375 cells by a chloroform fraction of centratherum anthelminticum (L.) seeds involves NF-kappaB, p53 and Bcl-2-controlled mitochondrial signaling pathways. BMC Complem Altern M 2013, 13(1):166.
21. Chan FK-M, Moriwaki K, De Rosa MJ. Detection of Necrosis by Release of Lactate Dehydrogenase Activity. Immune Homeostasis 2013, 65-70. New York: Humana Press, Snow AL, Lenardo MJ.
22. Häcker G. The morphology of apoptosis. Cell Tissue Res 2000, 301(1):5-17. 10.1007/s004410000193, 10928277.
23. Ovadje P, Chatterjee S, Griffin C, Tran C, Hamm C, Pandey S. Selective induction of apoptosis through activation of caspase-8 in human leukemia cells (Jurkat) by dandelion root extract. J Ethnopharmacol 2011, 133(1):86-91. 10.1016/j.jep.2010.09.005, 20849941.
24. Rajagopalan V, Hannun YA. Sphingolipid Metabolism and Signaling as a Target for Cancer Treatment. Cell Death Signaling in Cancer Biology and Treatment 2013, 205-229. New York: Springer press, Johnson DE.
25. Ding X, Zhu F-S, Li M, Gao S-G. Induction of apoptosis in human hepatoma SMMC-7721 cells by solamargine from solanum nigrum L. J Ethnopharmacol 2012, 139(2):599-604. 10.1016/j.jep.2011.11.058, 22172325.
26. Elmore S. Apoptosis: a review of programmed cell death. Toxicol Pathol 2007, 35(4):495-516. 10.1080/01926230701320337, 2117903, 17562483.
27. Arur S, Uche UE, Rezaul K, Fong M, Scranton V, Cowan AE, Mohler W, Han DK. Annexin I is an endogenous ligand that mediates apoptotic cell engulfment. Dev Cell 2003, 4(4):587-598. 10.1016/S1534-5807(03)00090-X, 12689596.
28. Park M-T, Lee S-J. Cell cycle and cancer. J Biochem Mol Biol 2003, 36(1):60-65. 10.5483/BMBRep.2003.36.1.060, 12542976.
29. Pucci B, Kasten M, Giordano A. Cell cycle and apoptosis. Neoplasia 2000, 2(4):291-299. 10.1038/sj.neo.7900101, 1550296, 11005563.
30. Zorofchian Moghadamtousi S, Karimian H, Khanabdali R, Razavi M, Firoozinia M, Zandi K, Kadir HA. Anticancer and antitumor potential of fucoidan and fucoxanthin. Two main metabolites isolated from brown algae. Sci World J 2014, 2014. doi:10.1155/2014/768323.
31. Li T, Kon N, Jiang L, Tan M, Ludwig T, Zhao Y, Baer R, Gu W. Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence. Cell 2012, 149(6):1269-1283. 10.1016/j.cell.2012.04.026, 3688046, 22682249.
32. Adams DJ, Boskovic ZV, Theriault JR, Wang AJ, Stern AM, Wagner BK, Shamji AF, Schreiber SL. High-throughput screening identifies small-molecule enhancers of reactive oxygen species that are nontoxic or cause genotype-selective cell death. ACS Chem Biol 2013, 8(5):923-929. 10.1021/cb300653v, 3658551, 23477340.
33. Circu ML, Aw TY. Reactive oxygen species, cellular redox systems, and apoptosis. Free Radic Biol Med 2010, 48(6):749-762. 10.1016/j.freeradbiomed.2009.12.022, 2823977, 20045723.
34. Kushnareva Y, Andreyev AY, Kuwana T, Newmeyer DD. Bax activation initiates the assembly of a multimeric catalyst that facilitates Bax pore formation in mitochondrial outer membranes. PLoS Biol 2012, 10(9):e1001394. 10.1371/journal.pbio.1001394, 3457932, 23049480.
35. Saelens X, Festjens N, Walle LV, Grup MV, Loo GV, Vandenabeele P. Toxic proteins released from mitochondria in cell death. Oncogene 2012, 23(16):2861-2874. 2012.
36. Hill MM, Adrain C, Duriez PJ, Creagh EM, Martin SJ. Analysis of the composition, assembly kinetics and activity of native Apaf-1 apoptosomes. EMBO J 2004, 23(10):2134-2145. 10.1038/sj.emboj.7600210, 424369, 15103327.
37. Mondragón L, Orzáez M, Gortat A, Sancho M, Messeguer A, Vicent MJ, Perez-Paya E. Molecules That Bind a Central Protein Component of the Apoptosome, Apaf-1, and Modulate Its Activity. Apoptosome 2010, 75-94. Netherlands: Springer press, Cecconi F, D'Amelio M.
38. Callus B, Vaux D. Caspase inhibitors: viral, cellular and chemical. Cell Death Differ 2006, 14(1):73-78.
39. Delgado ME, Olsson M, Lincoln FA, Zhivotovsky B, Rehm M. Determining the contributions of caspase-2, caspase-8 and effector caspases to intracellular VDVADase activities during apoptosis initiation and execution. BBA-Mol Cell Res 2013, 1833(10):2279-2292.
40. Cory S, Adams JM. The Bcl2 family: regulators of the cellular life-or-death switch. Nat Rev Cancer 2002, 2(9):647-656. 10.1038/nrc883, 12209154.
41. Zamzami N, Kroemer G. The mitochondrion in apoptosis: how Pandora's box opens. Nat Rev Mol Cell Bio 2001, 2(1):67-71.
42. Bhardwaj A, Sethi G, Vadhan-Raj S, Bueso-Ramos C, Takada Y, Gaur Y, Nair AS, Shishodia S, Aggarwal BB. Resveratrol inhibits proliferation, induces apoptosis, and overcomes chemoresistance through down-regulation of STAT3 and nuclear factor-κB-regulated antiapoptotic and cell survival gene products in human multiple myeloma cells. Blood 2007, 109(6):2293-2302. 10.1182/blood-2006-02-003988, 17164350.
43. Baldwin AS. Control of oncogenesis and cancer therapy resistance by the transcription factor NF-κB. J Clin Invest 2001, 107(3):241-246. 10.1172/JCI11991, 199203, 11160144.