Induction of apoptosis in melanoma A375 cells by a chloroform fraction of Centratherum anthelminticum (L.) seeds involves NF-kappaB, p53 and Bcl-2-controlled mitochondrial signaling pathways

BMC Complementary and Alternative Medicine

Volumn 13, Issue , 2013, Pages

  Looi, Chung Y ^a   Moharram, Bushra ^a   Paydar, Mohammadjavad ^a   Wong, Yi L ^a   Leong, Kok H ^a   Mohamad, Khalit ^a   Arya, Aditya ^a   Wong, Won F ^a   Mustafa, Mohd R ^a  

^a UNIVERSITY OF MALAYA   (Malaysia)

Author keywords

Apoptosis; Bcl 2; Caspase cascade; Centratherum anthelminticum; Melanoma; NF B; P53

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 7; CASPASE 9; CENTRATHERUM ANTHELMINTICUM EXTRACT; CHLOROFORM; CYTOCHROME C; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOCORTIN 5; PLANT EXTRACT; PROTEIN BCL 2; PROTEIN P53; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BLACK CUMIN; CANCER INHIBITION; CELL NUCLEUS; CELL STRESS; CELL STRUCTURE; CELL SURVIVAL; CENTRATHERUM ANTHELMINTICUM; CONTROLLED STUDY; DNA FRAGMENTATION; DRUG EFFECT; DRUG SCREENING; ENZYME ACTIVATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VITRO STUDY; LIQUID CHROMATOGRAPHY; MELANOCYTE; MELANOMA; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; PLANT SEED; PROTEIN SECRETION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; TANDEM MASS SPECTROMETRY; UPREGULATION; WESTERN BLOTTING;

APOPTOSIS; ASTERACEAE; CASPASES; CELL PROLIFERATION; CYTOCHROMES C; FEMALE; HUMANS; MELANOMA; MIDDLE AGED; MITOCHONDRIA; NF-KAPPA B; PLANT EXTRACTS; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; SEEDS; SIGNAL TRANSDUCTION; SKIN NEOPLASMS; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84880033897     PISSN: None     EISSN: 14726882     Source Type: Journal    
DOI: 10.1186/1472-6882-13-166     Document Type: Article

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