Rapid fine conformational epitope mapping using comprehensive mutagenesis and deep sequencing

Journal of Biological Chemistry

Volumn 290, Issue 44, 2015, Pages 26457-26470

  Kowalsky, Caitlin A ^a   Faber, Matthew S ^b   Nath, Aritro ^c   Dann, Hailey E ^a   Kelly, Vince W ^a   Liu, Li ^d   Shanker, Purva ^a   Wagner, Ellen K ^f   Maynard, Jennifer A ^f   Chan, Christina ^a,b,c   Whitehead, Timothy A ^a,e  

^a Michigan State University   (United States)

^b Michigan State University   (United States)

^c MICHIGAN STATE UNIVERSITY   (United States)

^d NONE   (United States)

^e Michigan State University   (United States)

^f The University of Texas at Austin   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODIES; ANTIGEN-ANTIBODY REACTIONS; CELL MEMBRANES; GENE ENCODING; MAPPING; MUTAGENESIS;

ANALYTICAL EQUATIONS; ANTIBODY-ANTIGEN INTERACTIONS; CELL SURFACE DISPLAYS; CONFORMATIONAL EPITOPES; NEUTRALIZING EPITOPE; PERTUSSIS TOXIN; STRUCTURAL BASIS; WEALTH OF INFORMATION;

EPITOPES;

EPITOPE; MEMBRANE PROTEIN; PERTUSSIS TOXIN; PROTEIN TROP2; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; ANTIBODY; CELL ADHESION MOLECULE; TACSTD2 PROTEIN, HUMAN; TNF PROTEIN, HUMAN; TUMOR ANTIGEN;

ANTIGEN ANTIBODY REACTION; ARTICLE; CELL SURFACE DISPLAY; CONTROLLED STUDY; DNA SEQUENCE; EPITOPE MAPPING; HUMAN; HUMAN CELL; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; CHEMISTRY; GENETICS; HIGH THROUGHPUT SEQUENCING; PROCEDURES;

ANTIBODIES; ANTIGENS, NEOPLASM; CELL ADHESION MOLECULES; EPITOPE MAPPING; EPITOPES; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; MUTAGENESIS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84946098489     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.676635     Document Type: Article

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