Palmitate-activated astrocytes via serine palmitoyltransferase increase BACE1 in primary neurons by sphingomyelinases

Neurobiology of Aging

Volumn 34, Issue 2, 2013, Pages 540-550

  Liu, Li ^a   Martin, Rebecca ^b   Chan, Christina ^b,c  

^a Michigan State University ^*  (United States)

^b Michigan State University   (United States)

^c Michigan State University   (United States)

Author keywords

Alzheimer's disease; Ceramide; TNF ; Fatty acid; IL 1 ; Serine palmitoyltransferase; Sphingomyelinase

Indexed keywords

BETA SECRETASE 1; CERAMIDE; INTERLEUKIN 1BETA; PALMITIC ACID; SERINE PALMITOYLTRANSFERASE; SPHINGOMYELIN PHOSPHODIESTERASE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; ASTROCYTE; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME ACTIVITY; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; UPREGULATION;

AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ACID ENDOPEPTIDASES; ASTROCYTES; CELLS, CULTURED; CERAMIDES; NEURONS; PALMITIC ACID; RATS; RATS, SPRAGUE-DAWLEY; SERINE C-PALMITOYLTRANSFERASE; SPHINGOMYELIN PHOSPHODIESTERASE;

EID: 84869090965     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2012.05.017     Document Type: Article

References (50)

1. Adibhatla R.M., Dempsy R., Hatcher J.F. Integration of cytokine biology and lipid metabolism in stroke. Front. Biosci 2008, 13:1250-1270.
2. Blázquez C., Galve-Roperh I., Guzmán M. De novo-synthesized ceramide signals apoptosis in astrocytes via extracellular signal-regulated kinase. FASEB J 2000, 14:2315-2322.
3. Bourne K.Z., Ferrari D.C., Lange-Dohna C., Rossner S., Wood T.G., Perez-Polo J.R. Differential regulation of BACE1 promoter activity by nuclear factor-kappaB in neurons and glia upon exposure to beta-amyloid peptides. J. Neurosci. Res 2007, 85:1194-1204.
4. Busik J.V., Reid G.E., Lydic T.A. Global analysis of retina lipids by complementary precursor ion and neutral loss mode tandem mass spectrometry. Methods Mol. Biol 2009, 579:33-70.
5. Cole S.L., Vassar R. The Alzheimer's disease beta-secretase enzyme, BACE1. Mol. Neurodegener 2007, 2:22.
6. 42. J. Alzheimers Dis 2011, 24:335-347.
7. Geekiyanage H., Chan C. MicroRNA-137/181c regulates serine palmitoyltransferase and in turn amyloid β, novel targets in sporadic Alzheimer's disease. J. Neurosci 2011, 31:14820-14830.
8. Gil J., Alcamí J., Esteban M. Activation of NF-kappa B by the dsRNA-dependent protein kinase, PKR involves the I kappa B kinase complex. Oncogene 2000, 19:1369-1378.
9. Golde T.E., Dickson D., Hutton M. Filling the gaps in the abeta cascade hypothesis of Alzheimer's disease. Curr. Alzheimer Res 2006, 3:421-430.
10. Han X., M Holtzman D., McKeel D.W., Kelley J., Morris J.C. Substantial sulfatide deficiency and ceramide elevation in very early Alzheimer's disease: potential role in disease pathogenesis. J. Neurochem 2002, 82:809-818.
11. Haughey N.J., Bandaru V.V., Bae M., Mattson M.P. Roles for dysfunctional sphingolipid metabolism in Alzheimer's disease neuropathogenesis. Biochim. Biophys. Acta 2010, 1801:878-886.
12. Håversen L., Danielsson K.N., Fogelstrand L., Wiklund O. Induction of proinflammatory cytokines by long-chain saturated fatty acids in human macrophages. Atherosclerosis 2009, 202:382-393.
13. He X., Huang Y., Li B., Gong C.X., Schuchman E.H. Deregulation of sphingolipid metabolism in Alzheimer's disease. Neurobiol. Aging 2010, 31:398-408.
14. Huang C., Ma W.Y., Ding M., Li J., Shi X., Castranova V., Vallyathan V., Bode A.M., Dong Z. Involvement of sphingomyelinase in insulin-induced phosphatidylinositol 3-kinase activation. FASEB J 2001, 15:1113-1114.
15. Jana A., Pahan K. Fibrillar amyloid-beta peptides kill human primary neurons via NADPH oxidase-mediated activation of neutral sphingomyelinase. Implications for Alzheimer's disease. J. Biol. Chem 2004, 279:51451-51459.
16. Jana A., Pahan K. Fibrillar amyloid-beta-activated human astroglia kill primary human neurons via neutral sphingomyelinase: implications for Alzheimer's disease. J. Neurosci 2010, 30:12676-12689.
17. Ju T.C., Chen S.D., Liu C.C., Yang D.I. Protective effects of S-nitrosoglutathione against amyloid beta-peptide neurotoxicity. Free Radic. Biol. Med 2005, 38:938-949.
18. Katsel P., Li C., Haroutunian V. Gene expression alterations in the sphingolipid metabolism pathways during progression of dementia and Alzheimer's disease: a shift toward ceramide accumulation at the earliest recognizable stages of Alzheimer's disease?. Neurochem. Res 2007, 32:845-856.
19. Ko M.H., Puglielli L. Two endoplasmic reticulum (ER)/ER Golgi intermediate compartment-based lysine acetyltransferases post-translationally regulate BACE1 levels. J. Biol. Chem 2009, 284:2482-2492.
20. Krasowska-Zoladek A., Banaszewska M., Kraszpulski M., Konat G.W. Kinetics of inflammatory response of astrocytes induced by TLR 3 and TLR4 ligation. J. Neurosci. Res 2007, 85:205-212.
21. Levin-Allerhand J.A., Lominska C.E., Smith J.D. Increased amyloid- levels in APPSWE transgenic mice treated chronically with a physiological high-fat high-cholesterol diet. J. Nutr. Health Aging 2002, 6:315-319.
22. Li R., Rohatgi T., Hanck T., Reiser G. Alpha A-crystallin and alpha B-crystallin, newly identified interaction proteins of protease-activated receptor-2, rescue astrocytes from C2-ceramide- and staurosporine-induced cell death. J. Neurochem 2009, 110:1433-1444.
23. Malaplate-Armand C., Florent-Béchard S., Youssef I., Koziel V., Sponne I., Kriem B., Leininger-Muller B., Olivier J.L., Oster T., Pillot T. Soluble oligomers of amyloid-beta peptide induce neuronal apoptosis by activating a cPLA2-dependent sphingomyelinase-ceramide pathway. Neurobiol. Dis 2006, 23:178-189.
24. Molteni R., Wu A., Vaynman S., Ying Z., Barnard R.J., Gómez-Pinilla F. Exercise reverses the harmful effects of consumption of a high-fat diet on synaptic and behavioral plasticity associated to the action of brain-derived neurotrophic factor. Neuroscience 2004, 123:429-440.
25. Mori T., Koyama N., Arendash G.W., Horikoshi-Sakuraba Y., Tan J., Town T. Overexpression of human S100B exacerbates cerebral amyloidosis and gliosis in the Tg2576 mouse model of Alzheimer's disease. Glia 2010, 58:300-314.
26. Morris M.C., Tangney C.C. Diet and prevention of Alzheimer disease. JAMA 2010, 303:2519-2520.
27. O'Connor T., Sadleir K.R., Maus E., Velliquette R.A., Zhao J., Cole S.L., Eimer W.A., Hitt B., Bembinster L.A., Lammich S., Lichtenthaler S.F., Hébert S.S., De Strooper B., Haass C., Bennett D.A., Vassar R. Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis. Neuron 2008, 60:988-1009.
28. Oksman M., Iivonen H., Hogyes E., Amtul Z., Penke B., Leenders I., Broersen L., Lütjohann D., Hartmann T., Tanila H. Impact of different saturated fatty acid, polyunsaturated fatty acid and cholesterol containing diets on beta-amyloid accumulation in APP/PS1 transgenic mice. Neurobiol. Dis 2006, 23:563-572.
29. Pappolla M.A., Smith M.A., Bryant-Thomas T., Bazan N., Petanceska S., Perry G., Thal L.J., Sano M., Refolo L.M. Cholesterol, oxidative stress, and Alzheimer's disease: expanding the horizons of pathogenesis. Free Radic. Biol. Med 2002, 33:173-181.
30. Patil S. Involvement of saturated fatty acids in causing pathophysiological and metabolic changes associated with Alzheimer's disease [dissertation] 2007, Michigan State University.
31. Patil S., Chan C. Palmitic and stearic fatty acids induce Alzheimer-like hyperphosphorylation of tau in primary rat cortical neurons. Neurosci. Lett 2005, 384:288-293.
32. Patil S., Melrose J., Chan C. Involvement of astroglial ceramide in palmitic acid-induced Alzheimer-like changes in primary neurons. Eur. J. Neurosci 2007, 26:2131-2141.
33. Patil S., Sheng L., Masserang A., Chan C. Palmitic acid-treated astrocytes induce BACE1 upregulation and accumulation of C-terminal fragment of APP in primary cortical neurons. Neurosci. Lett 2006, 406:55-59.
34. Puglielli L., Ellis B.C., Saunders A.J., Kovacs D.M. Ceramide stabilizes beta-site amyloid precursor protein-cleaving enzyme 1 and promotes amyloid beta-peptide biogenesis. J. Biol. Chem 2003, 278:19777-19783.
35. Qin J., Berdyshev E., Goya J., Natarajan V., Dawson G. Neurons and oligodendrocytes recycle sphingosine 1-phosphate to ceramide: significance for apoptosis and multiple sclerosis. J. Biol. Chem 2010, 285:14134-14143.
36. Querfurth H.W., LaFerla F.M. Alzheimer's disease. N Engl J. Med 2010, 362:329-344.
37. Roher A.E., Weiss N., Kokjohn T.A., Kuo Y.M., Kalback W., Anthony J., Watson D., Luehrs D.C., Sue L., Walker D., Emmerling M., Goux W., Beach T. Increased A beta peptides and reduced cholesterol and myelin proteins characterize white matter degeneration in Alzheimer's disease. Biochemistry 2002, 41:11080-11090.
38. Ruvolo P.P., Gao F., Blalock W.L., Deng X., May W.S. Ceramide regulates protein synthesis by a novel mechanism involving the cellular PKR activator RAX. J. Biol. Chem 2001, 276:11754-11758.
39. Shi Y., Pestka J.J. Mechanisms for suppression of interleukin-6 expression in peritoneal macrophages from docosahexaenoic acid-fed mice. J. Nutr. Biochem 2009, 20:358-368.
40. Sidoryk-Wegrzynowicz M., Wegrzynowicz M., Lee E., Bowman A.B., Aschner M. Role of astrocytes in brain function and disease. Toxicol. Pathol 2011, 39:115-123.
41. Sortino M.A., Condorelli F., Vancheri C., Canonico P.L. Tumor necrosis factor-alpha induces apoptosis in immortalized hypothalamic neurons: involvement of ceramide-generating pathways. Endocrinology 1999, 140:4841-4849.
42. Takechi R., Galloway S., Pallebage-Gamarallage M.M., Lam V., Mamo J.C. Dietary fats, cerebrovasculature integrity and Alzheimer's disease risk. Prog. Lipid Res 2010, 49:159-170.
43. Tamboli I.Y., Prager K., Barth E., Heneka M., Sandhoff K., Walter J. Inhibition of glycosphingolipid biosynthesis reduces secretion of the beta-amyloid precursor protein and amyloid beta-peptide. J. Biol. Chem 2005, 280:28110-28117.
44. Vlad S.C., Miller D.R., Kowall N.W., Felson D.T. Protective effects of NSAIDs on the development of Alzheimer disease. Neurology 2008, 70:1672-1677.
45. Wen Y., Yu W.H., Maloney B., Bailey J., Ma J., Marié I., Maurin T., Wang L., Figueroa H., Herman M., Krishnamurthy P., Liu L., Planel E., Lau L.F., Lahiri D.K., Duff K. Transcriptional regulation of beta-secretase by p25/cdk5 leads to enhanced amyloidogenic processing. Neuron 2008, 57:680-690.
46. Wimo A., Prince M. World Alzheimer report 2010: the global economic impact of dementia http://www.alz.co.uk/research/files/WorldAlzheimerReport2010.pdf.
47. Wyss-Coray T., Mucke L. Inflammation in neurodegenerative disease-a double-edged sword. Neuron 2002, 35:419-432.
48. Yamamoto M., Kiyota T., Horiba M., Buescher J.L., Walsh S.M., Gendelman H.E., Ikezu T. Interferon-gamma and tumor necrosis factor-alpha regulate amyloid-beta plaque deposition and beta-secretase expression in Swedish mutant APP transgenic mice. Am. J. Pathol 2007, 170:680-692.
49. Yang D.I., Yeh C.H., Chen S., Xu J., Hsu C.Y. Neutral sphingomyelinase activation in endothelial and glial cell death induced by amyloid beta-peptide. Neurobiol. Dis 2004, 17:99-107.
50. Zhou X., Lin D.S., Zheng F., Sutton M.A., Wang H. Intracellular calcium and calmodulin link brain-derived neurotrophic factor to p70S6 kinase phosphorylation and dendritic protein synthesis. J. Neurosci. Res 2010, 88:1420-1432.