ApoE4-specific Misfolded Intermediate Identified by Molecular Dynamics Simulations

PLoS Computational Biology

Volumn 11, Issue 10, 2015, Pages

  Williams II, Benfeard ^a   Convertino, Marino ^a   Das, Jhuma ^a   Dokholyan, Nikolay V ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MOLECULAR DYNAMICS; PHYSIOLOGY;

ALZHEIMER; AMINO-ACIDS; APOLIPOPROTEIN E; DOMAIN-DOMAIN INTERACTIONS; DYNAMICS SIMULATION; HOMOEOSTASIS; INTERMEDIATE STATE; ISOFORMS; RISK FACTORS; SEQUENCE SIMILARITY;

PROTEINS;

APOLIPOPROTEIN E4; ISOPROTEIN; PROTEIN VARIANT;

ALZHEIMER DISEASE; ARTICLE; CONTROLLED STUDY; LIPID HOMEOSTASIS; LIPID TRANSPORT; MOLECULAR DYNAMICS; MOLECULAR MODEL; PATHOGENESIS; PROTEIN AGGREGATION; PROTEIN DETERMINATION; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN MISFOLDING; PROTEIN PROTEIN INTERACTION; SEQUENCE HOMOLOGY; STRUCTURE ANALYSIS; THERMOSTABILITY; CHEMICAL MODEL; CHEMISTRY; PROTEIN CONFORMATION; PROTEIN DENATURATION; THERMODYNAMICS; ULTRASTRUCTURE;

APOLIPOPROTEIN E4; MODELS, CHEMICAL; MOLECULAR DYNAMICS SIMULATION; PROTEIN CONFORMATION; PROTEIN DENATURATION; PROTEIN FOLDING; THERMODYNAMICS;

EID: 84946036229     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1004359     Document Type: Article

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