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Volumn 9, Issue 3, 2014, Pages

Extracellular proteolysis of apolipoprotein e (apoE) by secreted serine neuronal protease

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E; APOLIPOPROTEIN E3; CHYMOTRYPSIN A; NEURITE PROMOTING FACTOR; NEUROSERPIN; SERINE PROTEINASE; ALPHA 1 ANTICHYMOTRYPSIN; APOLIPOPROTEIN E4; CHYMOTRYPSIN; CONDITIONED MEDIUM; NEUROPEPTIDE; SERINE PROTEINASE INHIBITOR;

EID: 84899796613     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0093120     Document Type: Article
Times cited : (28)

References (77)
  • 1
    • 84855558632 scopus 로고    scopus 로고
    • Alzheimer's disease
    • doi:10.1101/cshperspect.a004457
    • Selkoe DJ (2011) Alzheimer's disease. Cold Spring Harb Perspect Biol 3. doi:10.1101/cshperspect.a004457
    • (2011) Cold Spring Harb Perspect Biol , vol.3
    • Selkoe, D.J.1
  • 2
    • 85007768150 scopus 로고    scopus 로고
    • Alzheimer's disease
    • Masters CL, Beyreuther K (1998) Alzheimer's disease. BMJ 316: 446-448.
    • (1998) BMJ , vol.316 , pp. 446-448
    • Masters, C.L.1    Beyreuther, K.2
  • 4
    • 76849086405 scopus 로고    scopus 로고
    • The secretases: Enzymes with therapeutic potential in Alzheimer disease
    • doi:10.1038/nrneurol.2009.218
    • De Strooper B, Vassar R, Golde T (2010) The secretases: enzymes with therapeutic potential in Alzheimer disease. Nat Rev Neurol 6: 99-107. doi:10.1038/nrneurol.2009.218
    • (2010) Nat Rev Neurol , vol.6 , pp. 99-107
    • De Strooper, B.1    Vassar, R.2    Golde, T.3
  • 5
    • 0029844205 scopus 로고    scopus 로고
    • Human apolipoprotein E: The Alzheimer's disease connection
    • Weisgraber KH, Mahley RW (1996) Human apolipoprotein E: the Alzheimer's disease connection. FASEB J 10: 1485-1494. (Pubitemid 26384445)
    • (1996) FASEB Journal , vol.10 , Issue.13 , pp. 1485-1494
    • Weisgraber, K.H.1    Mahley, R.W.2
  • 6
    • 0029914688 scopus 로고    scopus 로고
    • Apolipoprotein E and Alzheimer's disease
    • Strittmatter WJ, Roses AD (1996) Apolipoprotein E and Alzheimer's disease. Annu Rev Neurosci 19: 53-77. doi:10.1146/annurev.ne.19.030196.000413 (Pubitemid 26080822)
    • (1996) Annual Review of Neuroscience , vol.19 , pp. 53-77
    • Strittmatter, W.J.1    Roses, A.D.2
  • 7
    • 79951713725 scopus 로고    scopus 로고
    • Apolipoprotein E in Alzheimer's disease and other neurological disorders
    • doi:10.1016/S1474-4422(10)70325-2
    • Verghese PB, Castellano JM, Holtzman DM (2011) Apolipoprotein E in Alzheimer's disease and other neurological disorders. Lancet Neurol 10: 241-252. doi:10.1016/S1474-4422(10)70325-2
    • (2011) Lancet Neurol , vol.10 , pp. 241-252
    • Verghese, P.B.1    Castellano, J.M.2    Holtzman, D.M.3
  • 8
    • 84867608942 scopus 로고    scopus 로고
    • The genetics of Alzheimer disease
    • doi:10.1101/cshperspect.a006296
    • Tanzi RE (2012) The genetics of Alzheimer disease. Cold Spring Harb Perspect Med 2. doi:10.1101/cshperspect.a006296
    • (2012) Cold Spring Harb Perspect Med , vol.2
    • Tanzi, R.E.1
  • 9
    • 0027374047 scopus 로고
    • Apolipoprotein E in sporadic Alzheimer's disease: Allelic variation and receptor interactions
    • DOI 10.1016/0896-6273(93)90070-8
    • Rebeck GW, Reiter JS, Strickland DK, Hyman BT (1993) Apolipoprotein E in sporadic Alzheimer's disease: allelic variation and receptor interactions. Neuron 11: 575-580. (Pubitemid 23321768)
    • (1993) Neuron , vol.11 , Issue.4 , pp. 575-580
    • Rebeck, G.W.1    Reiter, J.S.2    Strickland, D.K.3    Hyman, B.T.4
  • 10
    • 4143091289 scopus 로고    scopus 로고
    • Apolipoprotein E: Diversity of cellular origins, structural and biophysical properties, and effects in Alzheimer's disease
    • DOI 10.1385/JMN:23:3:189
    • Huang Y, Weisgraber KH, Mucke L, Mahley RW (2004) Apolipoprotein E: diversity of cellular origins, structural and biophysical properties, and effects in Alzheimer's disease. J Mol Neurosci 23: 189-204. doi:10.1385/JMN:23: 3:189 (Pubitemid 41389385)
    • (2004) Journal of Molecular Neuroscience , vol.23 , Issue.3 , pp. 189-204
    • Huang, Y.1    Weisgraber, K.H.2    Mucke, L.3    Mahley, R.W.4
  • 11
    • 79959252555 scopus 로고    scopus 로고
    • Function and comorbidities of apolipoprotein e in Alzheimer's disease
    • doi:10.4061/2011/974361
    • Leduc V, Domenger D, De Beaumont L, Lalonde D, Bélanger-Jasmin S, et al. (2011) Function and comorbidities of apolipoprotein e in Alzheimer's disease. Int J Alzheimers Dis 2011: 974361. doi:10.4061/2011/974361
    • (2011) Int J Alzheimers Dis , vol.2011 , pp. 974361
    • Leduc, V.1    Domenger, D.2    De Beaumont, L.3    Lalonde, D.4    Bélanger-Jasmin, S.5
  • 12
    • 84855263811 scopus 로고    scopus 로고
    • Introducing Human APOE into Ab Transgenic Mouse Models
    • doi:10.4061/2011/810981
    • Tai LM, Youmans KL, Jungbauer L, Yu C, Ladu MJ (2011) Introducing Human APOE into Ab Transgenic Mouse Models. Int J Alzheimers Dis 2011: 810981. doi:10.4061/2011/810981
    • (2011) Int J Alzheimers Dis , vol.2011 , pp. 810981
    • Tai, L.M.1    Youmans, K.L.2    Jungbauer, L.3    Yu, C.4    Ladu, M.J.5
  • 13
    • 0033827557 scopus 로고    scopus 로고
    • Apolipoprotein E affects the amount, form, and anatomical distribution of amyloid beta-peptide deposition in homozygous APP(V717F) transgenic mice
    • Irizarry MC, Cheung BS, Rebeck GW, Paul SM, Bales KR, et al. (2000) Apolipoprotein E affects the amount, form, and anatomical distribution of amyloid beta-peptide deposition in homozygous APP(V717F) transgenic mice. Acta Neuropathol 100: 451-458.
    • (2000) Acta Neuropathol , vol.100 , pp. 451-458
    • Irizarry, M.C.1    Cheung, B.S.2    Rebeck, G.W.3    Paul, S.M.4    Bales, K.R.5
  • 14
    • 84867797446 scopus 로고    scopus 로고
    • Apolipoprotein E, especially apolipoprotein E4, increases the oligomerization of amyloid β peptide
    • doi:10.1523/JNEUROSCI.1542-12.2012
    • Hashimoto T, Serrano-Pozo A, Hori Y, Adams KW, Takeda S, et al. (2012) Apolipoprotein E, especially apolipoprotein E4, increases the oligomerization of amyloid β peptide. J Neurosci 32: 15181-15192. doi:10.1523/JNEUROSCI.1542- 12.2012
    • (2012) J Neurosci , vol.32 , pp. 15181-15192
    • Hashimoto, T.1    Serrano-Pozo, A.2    Hori, Y.3    Adams, K.W.4    Takeda, S.5
  • 15
    • 68249134074 scopus 로고    scopus 로고
    • The role of apolipoprotein E in Alzheimer's disease
    • doi:10.1016/j.neuron.2009.06.026
    • Kim J, Basak JM, Holtzman DM (2009) The role of apolipoprotein E in Alzheimer's disease. Neuron 63: 287-303. doi:10.1016/j.neuron.2009.06.026
    • (2009) Neuron , vol.63 , pp. 287-303
    • Kim, J.1    Basak, J.M.2    Holtzman, D.M.3
  • 16
    • 84876136764 scopus 로고    scopus 로고
    • Cerebrovascular Effects of Apolipoprotein E: Implications for Alzheimer Disease
    • doi:10.1001/jamaneurol.2013.2152
    • Zlokovic B V (2013) Cerebrovascular Effects of Apolipoprotein E: Implications for Alzheimer Disease. JAMA Neurol 70: 1-5. doi:10.1001/jamaneurol. 2013.2152
    • (2013) JAMA Neurol , vol.70 , pp. 1-5
    • Zlokovic, B.V.1
  • 18
    • 0034122869 scopus 로고    scopus 로고
    • Role of the low-density lipoprotein receptor-related protein in beta- amyloid metabolism and Alzheimer disease
    • Hyman BT, Strickland D, Rebeck GW (2000) Role of the low-density lipoprotein receptor-related protein in beta-amyloid metabolism and Alzheimer disease. Arch Neurol 57: 646-650. (Pubitemid 30252798)
    • (2000) Archives of Neurology , vol.57 , Issue.5 , pp. 646-650
    • Hyman, B.T.1    Strickland, D.2    Rebeck, G.W.3
  • 19
    • 52649157170 scopus 로고    scopus 로고
    • Cerebral small vessel disease-induced apolipoprotein E leakage is associated with Alzheimer disease and the accumulation of amyloid beta-protein in perivascular astrocytes
    • doi:10.1097/NEN.0b013e3181836a71
    • Utter S, Tamboli IY, Walter J, Upadhaya AR, Birkenmeier G, et al. (2008) Cerebral small vessel disease-induced apolipoprotein E leakage is associated with Alzheimer disease and the accumulation of amyloid beta-protein in perivascular astrocytes. J Neuropathol Exp Neurol 67: 842-856. doi:10.1097/NEN.0b013e3181836a71
    • (2008) J Neuropathol Exp Neurol , vol.67 , pp. 842-856
    • Utter, S.1    Tamboli, I.Y.2    Walter, J.3    Upadhaya, A.R.4    Birkenmeier, G.5
  • 20
    • 84864691664 scopus 로고    scopus 로고
    • Disruption of arterial perivascular drainage of amyloid-β from the brains of mice expressing the human APOE ε4 allele
    • doi:10.1371/journal.pone.0041636
    • Hawkes CA, Sullivan PM, Hands S, Weller RO, Nicoll JAR, et al. (2012) Disruption of arterial perivascular drainage of amyloid-β from the brains of mice expressing the human APOE ε4 allele. PLoS One 7: e41636. doi:10.1371/journal.pone.0041636
    • (2012) PLoS One , vol.7
    • Hawkes, C.A.1    Sullivan, P.M.2    Hands, S.3    Weller, R.O.4    Nicoll, J.A.R.5
  • 21
    • 84872713614 scopus 로고    scopus 로고
    • Apolipoprotein e sets the stage: Response to injury triggers neuropathology
    • doi:10.1016/j.neuron.2012.11.020
    • Mahley RW, Huang Y (2012) Apolipoprotein e sets the stage: response to injury triggers neuropathology. Neuron 76: 871-885. doi:10.1016/j.neuron.2012. 11.020
    • (2012) Neuron , vol.76 , pp. 871-885
    • Mahley, R.W.1    Huang, Y.2
  • 22
    • 77953248905 scopus 로고    scopus 로고
    • Formation and function of apolipoprotein E-containing lipoproteins in the nervous system
    • doi:10.1016/j.bbalip.2010.02.007
    • Vance JE, Hayashi H (2010) Formation and function of apolipoprotein E-containing lipoproteins in the nervous system. Biochim Biophys Acta 1801: 806-818. doi:10.1016/j.bbalip.2010.02.007
    • (2010) Biochim Biophys Acta , vol.1801 , pp. 806-818
    • Vance, J.E.1    Hayashi, H.2
  • 23
    • 84873722367 scopus 로고    scopus 로고
    • Apolipoprotein E and Alzheimer disease: Risk, mechanisms and therapy
    • doi:10.1038/nrneurol.2012.263
    • Liu C-C, Kanekiyo T, Xu H, Bu G (2013) Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy. Nat Rev Neurol 9: 106-118. doi:10.1038/nrneurol.2012.263
    • (2013) Nat Rev Neurol , vol.9 , pp. 106-118
    • Liu, C.-C.1    Kanekiyo, T.2    Xu, H.3    Bu, G.4
  • 24
    • 58149251844 scopus 로고    scopus 로고
    • Impact of apolipoprotein E (ApoE) polymorphism on brain ApoE levels
    • doi:10.1523/JNEUROSCI.1972-08.2008
    • Riddell DR, Zhou H, Atchison K, Warwick HK, Atkinson PJ, et al. (2008) Impact of apolipoprotein E (ApoE) polymorphism on brain ApoE levels. J Neurosci 28: 11445-11453. doi:10.1523/JNEUROSCI.1972-08.2008
    • (2008) J Neurosci , vol.28 , pp. 11445-11453
    • Riddell, D.R.1    Zhou, H.2    Atchison, K.3    Warwick, H.K.4    Atkinson, P.J.5
  • 25
    • 67849130946 scopus 로고    scopus 로고
    • Pathological synergism between amyloid-beta and apolipoprotein E4 - The most prevalent yet understudied genetic risk factor for Alzheimer's disease
    • doi:10.3233/JAD-2009-1065
    • Belinson H, Michaelson DM (2009) Pathological synergism between amyloid-beta and apolipoprotein E4-the most prevalent yet understudied genetic risk factor for Alzheimer's disease. J Alzheimers Dis 17: 469-481. doi:10.3233/JAD-2009-1065
    • (2009) J Alzheimers Dis , vol.17 , pp. 469-481
    • Belinson, H.1    Michaelson, D.M.2
  • 26
    • 79954585189 scopus 로고    scopus 로고
    • Reduced levels of human apoE4 protein in an animal model of cognitive impairment
    • doi:10.1016/j.neurobiolaging.2009.05.011
    • Sullivan PM, Han B, Liu F, Mace BE, Ervin JF, et al. (2011) Reduced levels of human apoE4 protein in an animal model of cognitive impairment. Neurobiol Aging 32: 791-801. doi:10.1016/j.neurobiolaging.2009.05.011
    • (2011) Neurobiol Aging , vol.32 , pp. 791-801
    • Sullivan, P.M.1    Han, B.2    Liu, F.3    Mace, B.E.4    Ervin, J.F.5
  • 28
    • 84861896052 scopus 로고    scopus 로고
    • In vivo human apolipoprotein E isoform fractional turnover rates in the CNS
    • doi:10.1371/journal.pone.0038013
    • Wildsmith KR, Basak JM, Patterson BW, Pyatkivskyy Y, Kim J, et al. (2012) In vivo human apolipoprotein E isoform fractional turnover rates in the CNS. PLoS One 7: e38013. doi:10.1371/journal.pone.0038013
    • (2012) PLoS One , vol.7
    • Wildsmith, K.R.1    Basak, J.M.2    Patterson, B.W.3    Pyatkivskyy, Y.4    Kim, J.5
  • 29
    • 78649817606 scopus 로고    scopus 로고
    • Isoform-specific proteolysis of apolipoprotein-E in the brain
    • doi:10.1016/j.neurobiolaging.2009.02.006
    • Elliott DA, Tsoi K, Holinkova S, Chan SL, Kim WS, et al. (2011) Isoform-specific proteolysis of apolipoprotein-E in the brain. Neurobiol Aging 32: 257-271. doi:10.1016/j.neurobiolaging.2009.02.006
    • (2011) Neurobiol Aging , vol.32 , pp. 257-271
    • Elliott, D.A.1    Tsoi, K.2    Holinkova, S.3    Chan, S.L.4    Kim, W.S.5
  • 30
    • 16544379360 scopus 로고    scopus 로고
    • Progress toward identification of protease activity involved in proteolysis of apolipoprotein E in human brain
    • Marques MA, Owens PA, Crutcher KA (2004) Progress toward identification of protease activity involved in proteolysis of apolipoprotein e in human brain. J Mol Neurosci 24: 73-80. doi:10.1385/JMN:24:1:073 (Pubitemid 41359170)
    • (2004) Journal of Molecular Neuroscience , vol.24 , Issue.1 , pp. 73-80
    • Marques, M.A.1    Owens, P.A.2    Crutcher, K.A.3
  • 31
    • 33750982682 scopus 로고    scopus 로고
    • Cathepsin D-mediated proteolysis of apolipoprotein E: Possible role in Alzheimer's disease
    • DOI 10.1016/j.neuroscience.2006.08.019, PII S0306452206010955
    • Zhou W, Scott SA, Shelton SB, Crutcher KA (2006) Cathepsin D-mediated proteolysis of apolipoprotein E: possible role in Alzheimer's disease. Neuroscience 143: 689-701. doi:10.1016/j.neuroscience.2006.08.019 (Pubitemid 44751361)
    • (2006) Neuroscience , vol.143 , Issue.3 , pp. 689-701
    • Zhou, W.1    Scott, S.A.2    Shelton, S.B.3    Crutcher, K.A.4
  • 34
    • 0030863380 scopus 로고    scopus 로고
    • Amino-terminus truncated apolipoprotein E is the major species in amyloid deposits in Alzheimer's disease-affected brains: A possible role for apolipoprotein E in Alzheimer's disease
    • DOI 10.1016/S0006-8993(97)00640-9, PII S0006899397006409
    • Aizawa Y, Fukatsu R, Takamaru Y, Tsuzuki K, Chiba H, et al. (1997) Amino-terminus truncated apolipoprotein E is the major species in amyloid deposits in Alzheimer's disease-affected brains: a possible role for apolipoprotein E in Alzheimer's disease. Brain Res 768: 208-214 (Pubitemid 27433493)
    • (1997) Brain Research , vol.768 , Issue.1-2 , pp. 208-214
    • Aizawa, Y.1    Fukatsu, R.2    Takamaru, Y.3    Tsuzuki, K.4    Chiba, H.5    Kobayashi, K.6    Fujii, N.7    Takahata, N.8
  • 36
    • 80051923301 scopus 로고    scopus 로고
    • Direct thrombin inhibitors
    • doi:10.1111/j.1365-2125.2011.03916.x
    • Lee CJ, Ansell JE (2011) Direct thrombin inhibitors. Br J Clin Pharmacol 72: 581-592. doi:10.1111/j.1365-2125.2011.03916.x
    • (2011) Br J Clin Pharmacol , vol.72 , pp. 581-592
    • Lee, C.J.1    Ansell, J.E.2
  • 37
    • 79955895395 scopus 로고    scopus 로고
    • Development of an SPR imaging biosensor for determination of cathepsin G in saliva and white blood cells
    • doi:10.1007/s00604-011-0569-4
    • Gorodkiewicz E, Regulska E, Wojtulewski K (2011) Development of an SPR imaging biosensor for determination of cathepsin G in saliva and white blood cells. Mikrochim Acta 173: 407-413. doi:10.1007/s00604-011-0569-4
    • (2011) Mikrochim Acta , vol.173 , pp. 407-413
    • Gorodkiewicz, E.1    Regulska, E.2    Wojtulewski, K.3
  • 38
    • 0030250789 scopus 로고    scopus 로고
    • 1-antichymotrypsin by murine primary astrocytes
    • DOI 10.1016/0197-4580(96)00111-X
    • Kanemaru K, Meckelein B, Marshall DC, Sipe JD, Abraham CR (1996.) Synthesis and secretion of active alpha 1-antichymotrypsin by murine primary astrocytes. Neurobiol Aging 17: 767-771. (Pubitemid 26348878)
    • (1996) Neurobiology of Aging , vol.17 , Issue.5 , pp. 767-771
    • Kanemaru, K.1    Meckelein, B.2    Marshall, D.C.L.3    Sipe, J.D.4    Abraham, C.R.5
  • 39
    • 0035543191 scopus 로고    scopus 로고
    • Reactive astrocytes and alpha1-antichymotrypsin in Alzheimer's disease
    • Abraham CR (2001) Reactive astrocytes and alpha1-antichymotrypsin in Alzheimer's disease. Neurobiol Aging 22: 931-936.
    • (2001) Neurobiol Aging , vol.22 , pp. 931-936
    • Abraham, C.R.1
  • 40
    • 33645078896 scopus 로고    scopus 로고
    • Neuroserpin: A serpin to think about
    • doi:10.1007/s00018-005-5077-4
    • Miranda E, Lomas DA (2006) Neuroserpin: a serpin to think about. Cell Mol Life Sci 63: 709-722. doi:10.1007/s00018-005-5077-4
    • (2006) Cell Mol Life Sci , vol.63 , pp. 709-722
    • Miranda, E.1    Lomas, D.A.2
  • 41
    • 0026782082 scopus 로고
    • Regulation of neutrophil superoxide by antichymotrypsin-chymotrypsin complexes
    • Schuster MG, Enriquez PM, Curran P, Cooperman BS, Rubin H (1992) Regulation of neutrophil superoxide by antichymotrypsin-chymotrypsin complexes. J Biol Chem 267: 5056-5059.
    • (1992) J Biol Chem , vol.267 , pp. 5056-5059
    • Schuster, M.G.1    Enriquez, P.M.2    Curran, P.3    Cooperman, B.S.4    Rubin, H.5
  • 42
    • 0025877852 scopus 로고
    • Inhibition of human neutrophil superoxide generation by alpha 1-antichymotrypsin
    • Kilpatrick L, Johnson JL, Nickbarg EB, Wang ZM, Clifford TF, et al. (1991) Inhibition of human neutrophil superoxide generation by alpha 1-antichymotrypsin. J Immunol 146: 2388-2393.
    • (1991) J Immunol , vol.146 , pp. 2388-2393
    • Kilpatrick, L.1    Johnson, J.L.2    Nickbarg, E.B.3    Wang, Z.M.4    Clifford, T.F.5
  • 43
    • 79551627202 scopus 로고    scopus 로고
    • Apolipoprotein E: Isoform specific differences in tertiary structure and interaction with amyloid-β in human Alzheimer brain
    • doi:10.1371/journal.pone.0014586
    • Jones PB, Adams KW, Rozkalne A, Spires-Jones TL, Hshieh TT, et al. (2011) Apolipoprotein E: isoform specific differences in tertiary structure and interaction with amyloid-β in human Alzheimer brain. PLoS One 6: e14586. doi:10.1371/journal.pone.0014586
    • (2011) PLoS One , vol.6
    • Jones, P.B.1    Adams, K.W.2    Rozkalne, A.3    Spires-Jones, T.L.4    Hshieh, T.T.5
  • 44
    • 0037016592 scopus 로고    scopus 로고
    • Rat brain expresses serum calcium-decreasing factor (caldecrin)
    • DOI 10.1016/S0304-3940(01)02409-0, PII S0304394001024090
    • Tomomura A, Yamada H, Itagaki K, Fujimoto K, Katoh S (2002) Rat brain expresses serum calcium-decreasing factor (caldecrin). Neurosci Lett 317: 17-20. (Pubitemid 34066507)
    • (2002) Neuroscience Letters , vol.317 , Issue.1 , pp. 17-20
    • Tomomura, A.1    Yamada, H.2    Itagaki, K.3    Fujimoto, K.4    Katoh, S.5
  • 45
    • 0033112711 scopus 로고    scopus 로고
    • Plasticity-related serine proteases in the brain (review)
    • Yoshida S, Shiosaka S (1999) Plasticity-related serine proteases in the brain (review). Int J Mol Med 3: 405-409.
    • (1999) Int J Mol Med , vol.3 , pp. 405-409
    • Yoshida, S.1    Shiosaka, S.2
  • 46
    • 38849143983 scopus 로고    scopus 로고
    • Neutrophil elastase, proteinase 3 and cathepsin G: Physicochemical properties, activity and physiopathological functions
    • DOI 10.1016/j.biochi.2007.10.009, PII S0300908407003033
    • Korkmaz B, Moreau T, Gauthier F (2008) Neutrophil elastase, proteinase 3 and cathepsin G: physicochemical properties, activity and physiopathological functions. Biochimie 90: 227-242. doi:10.1016/j.biochi.2007.10.009 (Pubitemid 351187763)
    • (2008) Biochimie , vol.90 , Issue.2 , pp. 227-242
    • Korkmaz, B.1    Moreau, T.2    Gauthier, F.3
  • 47
    • 67349270965 scopus 로고    scopus 로고
    • Apolipoprotein E and its receptors in Alzheimer's disease: Pathways, pathogenesis and therapy
    • doi:10.1038/nrn2620
    • Bu G (2009) Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy. Nat Rev Neurosci 10: 333-344. doi:10.1038/nrn2620
    • (2009) Nat Rev Neurosci , vol.10 , pp. 333-344
    • Bu, G.1
  • 49
    • 77956542058 scopus 로고    scopus 로고
    • Glycosylation and sialylation of macrophage-derived human apolipoprotein E analyzed by SDS-PAGE and mass spectrometry: Evidence for a novel site of glycosylation on Ser290
    • doi:10.1074/mcp.M900430-MCP200
    • Lee Y, Kockx M, Raftery MJ, Jessup W, Griffith R, et al. (2010) Glycosylation and sialylation of macrophage-derived human apolipoprotein E analyzed by SDS-PAGE and mass spectrometry: evidence for a novel site of glycosylation on Ser290. Mol Cell Proteomics 9: 1968-1981. doi:10.1074/mcp. M900430-MCP200
    • (2010) Mol Cell Proteomics , vol.9 , pp. 1968-1981
    • Lee, Y.1    Kockx, M.2    Raftery, M.J.3    Jessup, W.4    Griffith, R.5
  • 50
    • 0032813440 scopus 로고    scopus 로고
    • Glycation of apolipoprotein E impairs its binding to heparin: Identification of the major glycation site
    • doi:10.1016/S0925-4439(99)00047-2
    • Shuvaev V V., Fujii J, Kawasaki Y, Itoh H, Hamaoka R, et al. (1999) Glycation of apolipoprotein E impairs its binding to heparin: identification of the major glycation site. Biochim Biophys Acta - Mol Basis Dis 1454: 296-308. doi:10.1016/S0925-4439(99)00047-2
    • (1999) Biochim Biophys Acta - Mol Basis Dis , vol.1454 , pp. 296-308
    • Shuvaev, V.V.1    Fujii, J.2    Kawasaki, Y.3    Itoh, H.4    Hamaoka, R.5
  • 53
    • 57349151833 scopus 로고    scopus 로고
    • Elevated plasma levels of alpha-1-anti-chymotrypsin in age-related cognitive decline and Alzheimer's disease: A potential therapeutic target
    • Porcellini E, Davis EJ, Chiappelli M, Ianni E, Di Stefano G, et al. (2008) Elevated plasma levels of alpha-1-anti-chymotrypsin in age-related cognitive decline and Alzheimer's disease: a potential therapeutic target. Curr Pharm Des 14: 2659-2664.
    • (2008) Curr Pharm des , vol.14 , pp. 2659-2664
    • Porcellini, E.1    Davis, E.J.2    Chiappelli, M.3    Ianni, E.4    Di Stefano, G.5
  • 54
    • 0035696320 scopus 로고    scopus 로고
    • The inflammation-induced pathological chaperones ACT and apo-E are necessary catalysts of Alzheimer amyloid formation
    • DOI 10.1016/S0197-4580(01)00308-6, PII S0197458001003086
    • Potter H, Wefes IM, Nilsson LN (2001) The inflammation-induced pathological chaperones ACT and apo-E are necessary catalysts of Alzheimer amyloid formation. Neurobiol Aging 22: 923-930. (Pubitemid 34066560)
    • (2001) Neurobiology of Aging , vol.22 , Issue.6 , pp. 923-930
    • Potter, H.1    Wefes, I.M.2    Nilsson, L.N.G.3
  • 56
    • 67649104088 scopus 로고    scopus 로고
    • APOE genotype-specific differences in the innate immune response
    • doi:10.1016/j.neurobiolaging.2007.11.014
    • Vitek MP, Brown CM, Colton CA (2009) APOE genotype-specific differences in the innate immune response. Neurobiol Aging 30: 1350-1360. doi:10.1016/j.neurobiolaging.2007.11.014
    • (2009) Neurobiol Aging , vol.30 , pp. 1350-1360
    • Vitek, M.P.1    Brown, C.M.2    Colton, C.A.3
  • 57
    • 66249122077 scopus 로고    scopus 로고
    • Low-density lipoprotein receptors regulate microglial inflammation through c-Jun N-terminal kinase
    • doi:10.1002/glia.20772
    • Pocivavsek A, Burns MP, Rebeck GW (2009) Low-density lipoprotein receptors regulate microglial inflammation through c-Jun N-terminal kinase. Glia 57: 444-453. doi:10.1002/glia.20772
    • (2009) Glia , vol.57 , pp. 444-453
    • Pocivavsek, A.1    Burns, M.P.2    Rebeck, G.W.3
  • 58
    • 84863029161 scopus 로고    scopus 로고
    • APOE genotype alters glial activation and loss of synaptic markers in mice
    • doi:10.1002/glia.22289
    • Zhu Y, Nwabuisi-Heath E, Dumanis SB, Tai LM, Yu C, et al. (2012) APOE genotype alters glial activation and loss of synaptic markers in mice. Glia 60: 559-569. doi:10.1002/glia.22289
    • (2012) Glia , vol.60 , pp. 559-569
    • Zhu, Y.1    Nwabuisi-Heath, E.2    Dumanis, S.B.3    Tai, L.M.4    Yu, C.5
  • 59
    • 84872168596 scopus 로고    scopus 로고
    • Microglia: Scapegoat, saboteur, or something else?
    • doi:10.1126/science.1227901
    • Aguzzi A, Barres BA, Bennett ML (2013) Microglia: scapegoat, saboteur, or something else? Science 339: 156-161. doi:10.1126/science.1227901
    • (2013) Science , vol.339 , pp. 156-161
    • Aguzzi, A.1    Barres, B.A.2    Bennett, M.L.3
  • 61
    • 84859731658 scopus 로고    scopus 로고
    • The immunology of neurodegeneration
    • doi:10.1172/JCI58656
    • Czirr E, Wyss-Coray T (2012) The immunology of neurodegeneration. J Clin Invest 122: 1156-1163. doi:10.1172/JCI58656
    • (2012) J Clin Invest , vol.122 , pp. 1156-1163
    • Czirr, E.1    Wyss-Coray, T.2
  • 62
  • 63
    • 58149345003 scopus 로고    scopus 로고
    • Loss of gamma-secretase function impairs endocytosis of lipoprotein particles and membrane cholesterol homeostasis
    • doi:10.1523/JNEUROSCI.2635-08.2008
    • Tamboli IY, Prager K, Thal DR, Thelen KM, Dewachter I, et al. (2008) Loss of gamma-secretase function impairs endocytosis of lipoprotein particles and membrane cholesterol homeostasis. J Neurosci 28: 12097-12106. doi:10.1523/JNEUROSCI.2635-08.2008
    • (2008) J Neurosci , vol.28 , pp. 12097-12106
    • Tamboli, I.Y.1    Prager, K.2    Thal, D.R.3    Thelen, K.M.4    Dewachter, I.5
  • 66
    • 84862777666 scopus 로고    scopus 로고
    • ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models
    • doi:10.1126/science.1217697
    • Cramer PE, Cirrito JR, Wesson DW, Lee CYD, Karlo JC, et al. (2012) ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models. Science 335: 1503-1506. doi:10.1126/science.1217697
    • (2012) Science , vol.335 , pp. 1503-1506
    • Cramer, P.E.1    Cirrito, J.R.2    Wesson, D.W.3    Lee, C.Y.D.4    Karlo, J.C.5
  • 67
    • 84871887566 scopus 로고    scopus 로고
    • Anti-apoE immunotherapy inhibits amyloid accumulation in a transgenic mouse model of Ab amyloidosis
    • doi:10.1084/jem.20121274
    • Kim J, Eltorai AEM, Jiang H, Liao F, Verghese PB, et al. (2012) Anti-apoE immunotherapy inhibits amyloid accumulation in a transgenic mouse model of Ab amyloidosis. J Exp Med 209: 2149-2156. doi:10.1084/jem.20121274
    • (2012) J Exp Med , vol.209 , pp. 2149-2156
    • Kim, J.1    Eltorai, A.E.M.2    Jiang, H.3    Liao, F.4    Verghese, P.B.5
  • 68
    • 79956311751 scopus 로고    scopus 로고
    • Critical role of astroglial apolipoprotein E and liver X receptor-a expression for microglial Aβ phagocytosis
    • doi:10.1523/JNEUROSCI.6546-10.2011
    • Terwel D, Steffensen KR, Verghese PB, Kummer MP, Gustafsson J-Å, et al. (2011) Critical role of astroglial apolipoprotein E and liver X receptor-a expression for microglial Aβ phagocytosis. J Neurosci 31: 7049-7059. doi:10.1523/JNEUROSCI.6546-10.2011
    • (2011) J Neurosci , vol.31 , pp. 7049-7059
    • Terwel, D.1    Steffensen, K.R.2    Verghese, P.B.3    Kummer, M.P.4    Gustafsson, J.-Å.5
  • 69
    • 84864806543 scopus 로고    scopus 로고
    • Apolipoprotein E, amyloid-β clearance and therapeutic opportunities in Alzheimer's disease
    • doi:10.1186/alzrt135
    • Kline A (2012) Apolipoprotein E, amyloid-β clearance and therapeutic opportunities in Alzheimer's disease. Alzheimers Res Ther 4: 32. doi:10.1186/alzrt135
    • (2012) Alzheimers Res Ther , vol.4 , pp. 32
    • Kline, A.1
  • 70
    • 84861418194 scopus 로고    scopus 로고
    • Apolipoprotein E controls cerebrovascular integrity via cyclophilin A
    • doi:10.1038/nature11087
    • Bell RD, Winkler EA, Singh I, Sagare AP, Deane R, et al. (2012) Apolipoprotein E controls cerebrovascular integrity via cyclophilin A. Nature 485: 512-516. doi:10.1038/nature11087
    • (2012) Nature , vol.485 , pp. 512-516
    • Bell, R.D.1    Winkler, E.A.2    Singh, I.3    Sagare, A.P.4    Deane, R.5
  • 71
    • 70350668827 scopus 로고    scopus 로고
    • Apolipoprotein E4 (1-272) fragment is associated with mitochondrial proteins and affects mitochondrial function in neuronal cells
    • doi:10.1186/1750-1326-4-35
    • Nakamura T, Watanabe A, Fujino T, Hosono T, Michikawa M (2009) Apolipoprotein E4 (1-272) fragment is associated with mitochondrial proteins and affects mitochondrial function in neuronal cells. Mol Neurodegener 4: 35. doi:10.1186/1750-1326-4-35
    • (2009) Mol Neurodegener , vol.4 , pp. 35
    • Nakamura, T.1    Watanabe, A.2    Fujino, T.3    Hosono, T.4    Michikawa, M.5
  • 72
    • 84879418060 scopus 로고    scopus 로고
    • The Apolipoprotein-E-Mimetic COG112 Protects Amyloid Precursor Protein Intracellular Domain-Overexpressing Animals from Alzheimer's Disease-Like Pathological Features
    • doi:10.1159/000341299
    • Ghosal K, Stathopoulos A, Thomas D, Phenis D, Vitek MP, et al. (2012) The Apolipoprotein-E-Mimetic COG112 Protects Amyloid Precursor Protein Intracellular Domain-Overexpressing Animals from Alzheimer's Disease-Like Pathological Features. Neurodegener Dis. doi:10.1159/000341299
    • (2012) Neurodegener Dis
    • Ghosal, K.1    Stathopoulos, A.2    Thomas, D.3    Phenis, D.4    Vitek, M.P.5
  • 73
    • 84860217416 scopus 로고    scopus 로고
    • APOE-mimetic peptides reduce behavioral deficits, plaques and tangles in Alzheimer's disease transgenics
    • doi:10.1159/000334914
    • Vitek MP, Christensen DJ, Wilcock D, Davis J, Van Nostrand WE, et al. (2012) APOE-mimetic peptides reduce behavioral deficits, plaques and tangles in Alzheimer's disease transgenics. Neurodegener Dis 10: 122-126. doi:10.1159/000334914
    • (2012) Neurodegener Dis , vol.10 , pp. 122-126
    • Vitek, M.P.1    Christensen, D.J.2    Wilcock, D.3    Davis, J.4    Van Nostrand, W.E.5
  • 74
    • 77950929102 scopus 로고    scopus 로고
    • ApoE mimetic peptide decreases Abeta production in vitro and in vivo
    • doi:10.1186/1750-1326-5-16
    • Minami SS, Cordova A, Cirrito JR, Tesoriero JA, Babus LW, et al. (2010) ApoE mimetic peptide decreases Abeta production in vitro and in vivo. Mol Neurodegener 5: 16. doi:10.1186/1750-1326-5-16
    • (2010) Mol Neurodegener , vol.5 , pp. 16
    • Minami, S.S.1    Cordova, A.2    Cirrito, J.R.3    Tesoriero, J.A.4    Babus, L.W.5
  • 76
    • 71449125786 scopus 로고    scopus 로고
    • Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance
    • doi:10.1016/j.neuron.2009.11.013
    • Kim J, Castellano JM, Jiang H, Basak JM, Parsadanian M, et al. (2009) Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance. Neuron 64: 632-644. doi:10.1016/j.neuron.2009.11.013
    • (2009) Neuron , vol.64 , pp. 632-644
    • Kim, J.1    Castellano, J.M.2    Jiang, H.3    Basak, J.M.4    Parsadanian, M.5
  • 77
    • 84868597475 scopus 로고    scopus 로고
    • Small-molecule structure correctors target abnormal protein structure and function: Structure corrector rescue of apolipoprotein E4-associated neuropathology
    • doi:10.1021/jm3008618
    • Mahley RW, Huang Y (2012) Small-molecule structure correctors target abnormal protein structure and function: structure corrector rescue of apolipoprotein E4-associated neuropathology. J Med Chem 55: 8997-9008. doi:10.1021/jm3008618
    • (2012) J Med Chem , vol.55 , pp. 8997-9008
    • Mahley, R.W.1    Huang, Y.2


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