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Volumn 102, Issue 3, 2015, Pages 241-251

Regulation of TRPC6 ion channels in podocytes - Implications for focal segmental glomerulosclerosis and acquired forms of proteinuric diseases (Review)

Author keywords

Angiotensin II; Diabetic nephropathy; Focal segmental glomerulosclerosis (FSGS); Podocyte; Proteinuric disease; TRPC6

Indexed keywords

ANGIOTENSIN II; TRANSIENT RECEPTOR POTENTIAL CHANNEL 6; TRANSIENT RECEPTOR POTENTIAL CHANNEL C; TRPC6 PROTEIN, HUMAN;

EID: 84946032549     PISSN: 0231424X     EISSN: 15882683     Source Type: Journal    
DOI: 10.1556/036.102.2015.3.2     Document Type: Article
Times cited : (11)

References (77)
  • 1
    • 67649652168 scopus 로고    scopus 로고
    • Cardiovascular implications of proteinuria: An indicator of chronic kidney disease
    • Agrawal V, Marinescu V, Agarwal M, Mc Cullough PA: Cardiovascular implications of proteinuria: An indicator of chronic kidney disease. Nat. Rev. Cardiol. 6, 301-311 (2009).
    • (2009) Nat. Rev. Cardiol , vol.6 , pp. 301-311
    • Agrawal, V.1    Marinescu, V.2    Agarwal, M.3    Mc Cullough, P.A.4
  • 2
    • 33744969296 scopus 로고    scopus 로고
    • Synaptopodin orchestrates actin organization and cell motility via regulation of RhoA signalling
    • Asanuma K, Yanagida-Asanuma E, Faul C, Tomino Y, Kim K, Mundel P: Synaptopodin orchestrates actin organization and cell motility via regulation of RhoA signalling. Nat. Cell Biol. 8, 485-491 (2006).
    • (2006) Nat. Cell Biol , vol.8 , pp. 485-491
    • Asanuma, K.1    Yanagida-Asanuma, E.2    Faul, C.3    Tomino, Y.4    Kim, K.5    Mundel, P.6
  • 3
    • 77950353855 scopus 로고    scopus 로고
    • Analysis of recessive CD2AP and ACTN4 mutations in steroid-resistant nephrotic syndrome
    • Benoit G, Machuca E, Nevo F, Gribouval O, Lepage D, Antignac C: Analysis of recessive CD2AP and ACTN4 mutations in steroid-resistant nephrotic syndrome. Pediatr. Nephrol. 25, 445-451 (2010).
    • (2010) Pediatr. Nephrol , vol.25 , pp. 445-451
    • Benoit, G.1    Machuca, E.2    Nevo, F.3    Gribouval, O.4    Lepage, D.5    Antignac, C.6
  • 4
    • 77954534869 scopus 로고    scopus 로고
    • Non-immunologic mechanisms of calcineurin inhibitors explain its antiproteinuric effects in genetic glomerulopathies
    • Bensman A, Niaudet P: Non-immunologic mechanisms of calcineurin inhibitors explain its antiproteinuric effects in genetic glomerulopathies. Pediatr. Nephrol. 25, 1197-1199 (2010).
    • (2010) Pediatr. Nephrol , vol.25 , pp. 1197-1199
    • Bensman, A.1    Niaudet, P.2
  • 5
    • 78650355289 scopus 로고    scopus 로고
    • Protein kinase C-dependent phosphorylation of transient receptor potential canonical 6 (TRPC6) on serine 448 causes channel inhibition
    • Bousquet SM, Monet M, Boulay G: Protein kinase C-dependent phosphorylation of transient receptor potential canonical 6 (TRPC6) on serine 448 causes channel inhibition. J. Biol. Chem. 285, 40534-40543 (2010).
    • (2010) J. Biol. Chem , vol.285 , pp. 40534-40543
    • Bousquet, S.M.1    Monet, M.2    Boulay, G.3
  • 6
    • 28844504752 scopus 로고    scopus 로고
    • Effect of inhibitors of the renin-angiotensin system and other antihypertensive drugs on renal outcomes: Systematic review and meta-analysis
    • Casas JP, Chua W, Loukogeorgakis S, Vallance P, Smeeth L, Hingorani AD, MacAllister RJ: Effect of inhibitors of the renin-angiotensin system and other antihypertensive drugs on renal outcomes: systematic review and meta-analysis. Lancet 366, 2026-2033 (2005).
    • (2005) Lancet , vol.366 , pp. 2026-2033
    • Casas, J.P.1    Chua, W.2    Loukogeorgakis, S.3    Vallance, P.4    Smeeth, L.5    Hingorani, A.D.6    MacAllister, R.J.7
  • 10
    • 0347504835 scopus 로고    scopus 로고
    • TRP channels as cellular sensors
    • Clapham DE: TRP channels as cellular sensors. Nature 426, 517-524 (2003).
    • (2003) Nature , vol.426 , pp. 517-524
    • Clapham, D.E.1
  • 11
    • 0035951849 scopus 로고    scopus 로고
    • Calcium, calcineurin, and the control of transcription
    • Crabtree GR: Calcium, calcineurin, and the control of transcription. J. Biol. Chem. 276, 2313-2316 (2001).
    • (2001) J. Biol. Chem , vol.276 , pp. 2313-2316
    • Crabtree, G.R.1
  • 13
    • 33750887047 scopus 로고    scopus 로고
    • Focal and segmental glomerulosclerosis
    • Daskalakis N, Winn MP: Focal and segmental glomerulosclerosis. Cell. Mol. Life Sci. 63, 2506-2511 (2006).
    • (2006) Cell. Mol. Life Sci , vol.63 , pp. 2506-2511
    • Daskalakis, N.1    Winn, M.P.2
  • 16
    • 44949105469 scopus 로고    scopus 로고
    • Activation of a local renin angiotensin system in podocytes by glucose
    • Durvasula RV, Shankland SJ: Activation of a local renin angiotensin system in podocytes by glucose. Am. J. Physiol. Renal. Physiol. 294, F830-F839 (2008).
    • (2008) Am. J. Physiol. Renal. Physiol , vol.294 , pp. F830-F839
    • Durvasula, R.V.1    Shankland, S.J.2
  • 17
    • 80052501424 scopus 로고    scopus 로고
    • TRPC channel modulation in podocytes-inching toward novel treatments for glomerular disease
    • El Hindi S, Reiser J: TRPC channel modulation in podocytes-inching toward novel treatments for glomerular disease. Pediatr. Nephrol. 26, 1057-1064 (2011).
    • (2011) Pediatr. Nephrol , vol.26 , pp. 1057-1064
    • El, H.S.1    Reiser, J.2
  • 18
    • 33644948998 scopus 로고    scopus 로고
    • Stretch, tension and adhesion - Adaptive mechanisms of the actin cytoskeleton in podocytes
    • Endlich N, Endlich K: Stretch, tension and adhesion - Adaptive mechanisms of the actin cytoskeleton in podocytes. Eur. J. Cell Biol. 85, 229-234 (2006).
    • (2006) Eur. J. Cell Biol , vol.85 , pp. 229-234
    • Endlich, N.1    Endlich, K.2
  • 20
    • 34848907421 scopus 로고    scopus 로고
    • Actin up: Regulation of podocyte structure and function by components of the actin cytoskeleton
    • Faul C, Asanuma K, Yanagida-Asanuma E, Kim K, Mundel P: Actin up: Regulation of podocyte structure and function by components of the actin cytoskeleton. Trends Cell Biol 17, 428-437 (2007).
    • (2007) Trends Cell Biol , vol.17 , pp. 428-437
    • Faul, C.1    Asanuma, K.2    Yanagida-Asanuma, E.3    Kim, K.4    Mundel, P.5
  • 22
    • 33745444308 scopus 로고    scopus 로고
    • Transactivation of the epidermal growth factor receptor by angiotensin II in glomerular podocytes
    • Flannery PJ, Spurney RF: Transactivation of the epidermal growth factor receptor by angiotensin II in glomerular podocytes. Nephron Exp. Nephrol. 103, e109-e118 (2006).
    • (2006) Nephron Exp. Nephrol , vol.103 , pp. e109-e118
    • Flannery, P.J.1    Spurney, R.F.2
  • 24
    • 80555134770 scopus 로고    scopus 로고
    • Balancing calcium signals through TRPC5 and TRPC6 in podocytes
    • Greka A, Mundel P: Balancing calcium signals through TRPC5 and TRPC6 in podocytes. J. Am. Soc. Nephrol. 22, 1969-1980 (2011).
    • (2011) J. Am. Soc. Nephrol , vol.22 , pp. 1969-1980
    • Greka, A.1    Mundel, P.2
  • 25
    • 22844434012 scopus 로고    scopus 로고
    • A new TRP to kidney disease
    • Gudermann T: A new TRP to kidney disease. Nat. Genet. 37, 663-664 (2005).
    • (2005) Nat. Genet , vol.37 , pp. 663-664
    • Gudermann, T.1
  • 26
    • 0028834520 scopus 로고
    • Increasing incidence of focal-segmental glomerulosclerosis among adult nephropathies: A 20-year renal biopsy study
    • Haas M, Spargo BH, Coventry S: Increasing incidence of focal-segmental glomerulosclerosis among adult nephropathies: A 20-year renal biopsy study. Am. J. Kidney Dis. 26, 740-750 (1995).
    • (1995) Am. J. Kidney Dis , vol.26 , pp. 740-750
    • Haas, M.1    Spargo, B.H.2    Coventry, S.3
  • 28
    • 62349086524 scopus 로고    scopus 로고
    • Specific podocin mutations determine age of onset of nephrotic syndrome all the way into adult life
    • Hildebrandt F, Heeringa SF: Specific podocin mutations determine age of onset of nephrotic syndrome all the way into adult life. Kidney Int. 75, 669-671 (2009).
    • (2009) Kidney Int , vol.75 , pp. 669-671
    • Hildebrandt, F.1    Heeringa, S.F.2
  • 29
    • 34147096001 scopus 로고    scopus 로고
    • Arbeitsgemeinschaft für Paediatrische Nephrologie Study Group: Nephrotic syndrome in the first year of life: Two thirds of cases are caused by mutations in 4 genes (NPHS1, NPHS2, WT1, and LAMB2)
    • Hinkes BG, Mucha B, Vlangos CN, Gbadegesin R, Liu J, Hasselbacher K, Hangan D, Ozaltin F, Zenker M, Hildebrandt F; Arbeitsgemeinschaft für Paediatrische Nephrologie Study Group: Nephrotic syndrome in the first year of life: Two thirds of cases are caused by mutations in 4 genes (NPHS1, NPHS2, WT1, and LAMB2). Pediatrics 119, e907-e919 (2007).
    • (2007) Pediatrics , vol.119 , pp. e907-e919
    • Hinkes, B.G.1    Mucha, B.2    Vlangos, C.N.3    Gbadegesin, R.4    Liu, J.5    Hasselbacher, K.6    Hangan, D.7    Ozaltin, F.8    Zenker, M.9    Hildebrandt, F.10
  • 30
    • 2542455650 scopus 로고    scopus 로고
    • Angiotensin II type 1 receptor overexpression in podocytes induces glomerulosclerosis in transgenic rats
    • Hoffmann S, Podlich D, Hähnel B, Kriz W, Gretz N: Angiotensin II type 1 receptor overexpression in podocytes induces glomerulosclerosis in transgenic rats. J. Am. Soc. Nephrol. 15, 1475-1487 (2004).
    • (2004) J. Am. Soc. Nephrol , vol.15 , pp. 1475-1487
    • Hoffmann, S.1    Podlich, D.2    Hähnel, B.3    Kriz, W.4    Gretz, N.5
  • 32
    • 30944469631 scopus 로고    scopus 로고
    • Renin increases mesangial cell transforming growth factor-beta1 and matrix proteins through receptor-mediated, angiotensin II-independent mechanisms
    • Huang Y, Wongamorntham S, Kasting J, McQuillan D, Owens RT, Yu L, Noble NA, Border W: Renin increases mesangial cell transforming growth factor-beta1 and matrix proteins through receptor-mediated, angiotensin II-independent mechanisms. Kidney Int. 69, 105-113 (2006).
    • (2006) Kidney Int , vol.69 , pp. 105-113
    • Huang, Y.1    Wongamorntham, S.2    Kasting, J.3    McQuillan, D.4    Owens, R.T.5    Yu, L.6    Noble, N.A.7    Border, W.8
  • 35
    • 73349123852 scopus 로고    scopus 로고
    • Role of altered insulin signaling pathways in the pathogenesis of podocyte malfunction and microalbuminuria
    • Jauregui A, Mintz DH, Mundel P, Fornoni A: Role of altered insulin signaling pathways in the pathogenesis of podocyte malfunction and microalbuminuria. Curr. Opin. Nephrol. Hypertens. 18, 539-545 (2009).
    • (2009) Curr. Opin. Nephrol. Hypertens , vol.18 , pp. 539-545
    • Jauregui, A.1    Mintz, D.H.2    Mundel, P.3    Fornoni, A.4
  • 36
    • 79951617575 scopus 로고    scopus 로고
    • Over-expressing transient receptor potential cation channel 6 in podocytes induces cytoskeleton rearrangement through increases of intracellular Ca2+ and RhoA activation
    • Jiang L, Ding J, Tsai H, Li L, Feng Q, Miao J, Fan Q: Over-expressing transient receptor potential cation channel 6 in podocytes induces cytoskeleton rearrangement through increases of intracellular Ca2+ and RhoA activation. Exp. Biol. Med. (Maywood) 236, 184-193 (2011).
    • (2011) Exp. Biol. Med. (Maywood) , vol.236 , pp. 184-193
    • Jiang, L.1    Ding, J.2    Tsai, H.3    Li, L.4    Feng, Q.5    Miao, J.6    Fan, Q.7
  • 37
    • 79957605758 scopus 로고    scopus 로고
    • Tyrosine phosphorylation-dependent activation of TRPC6 regulated by PLC-γ1 and nephrin: Effect of mutations associated with focal segmental glomerulosclerosis
    • Kanda S, Harita Y, Shibagaki Y, Sekine T, Igarashi T, Inoue T, Hattori S: Tyrosine phosphorylation-dependent activation of TRPC6 regulated by PLC-γ1 and nephrin: effect of mutations associated with focal segmental glomerulosclerosis. Mol. Biol. Cell 22, 1824-1835 (2011).
    • (2011) Mol. Biol. Cell , vol.22 , pp. 1824-1835
    • Kanda, S.1    Harita, Y.2    Shibagaki, Y.3    Sekine, T.4    Igarashi, T.5    Inoue, T.6    Hattori, S.7
  • 39
  • 41
    • 0036433059 scopus 로고    scopus 로고
    • Proteinuria and the expression of the podocyte slit diaphragm protein, nephrin, in diabetic nephropathy: Effects of angiotensin converting enzyme inhibition
    • Langham RG, Kelly DJ, Cox AJ, Thomson NM, Holthöfer H, Zaoui P, Pinel N, Cordonnier DJ, Gilbert RE: Proteinuria and the expression of the podocyte slit diaphragm protein, nephrin, in diabetic nephropathy: effects of angiotensin converting enzyme inhibition. Diabetologia 45, 1572-1576 (2002).
    • (2002) Diabetologia , vol.45 , pp. 1572-1576
    • Langham, R.G.1    Kelly, D.J.2    Cox, A.J.3    Thomson, N.M.4    Holthöfer, H.5    Zaoui, P.6    Pinel, N.7    Cordonnier, D.J.8    Gilbert, R.E.9
  • 42
    • 0027517659 scopus 로고
    • The effect of angiotensin-converting-enzyme inhibition on diabetic nephropathy
    • The Collaborative Study Group
    • Lewis EJ, Hunsicker LG, Bain RP, Rohde RD: The effect of angiotensin-converting-enzyme inhibition on diabetic nephropathy. The Collaborative Study Group. N. Engl. J. Med. 329, 1456-1462 (1993).
    • (1993) N. Engl. J. Med , vol.329 , pp. 1456-1462
    • Lewis, E.J.1    Hunsicker, L.G.2    Bain, R.P.3    Rohde, R.D.4
  • 43
    • 34250615503 scopus 로고    scopus 로고
    • Calcineurin-NFATc signaling pathway regulates AQP2 expression in response to calcium signals and osmotic stress
    • Li SZ, McDill BW, Kovach PA, Ding L, Go WY, Ho SN, Chen F: Calcineurin-NFATc signaling pathway regulates AQP2 expression in response to calcium signals and osmotic stress. Am. J. Physiol. Cell Physiol. 292, C1606-C1616 (2007).
    • (2007) Am. J. Physiol. Cell Physiol , vol.292 , pp. C1606-C1616
    • Li, S.Z.1    McDill, B.W.2    Kovach, P.A.3    Ding, L.4    Go, W.Y.5    Ho, S.N.6    Chen, F.7
  • 44
    • 84872004572 scopus 로고    scopus 로고
    • Wnt/β-catenin signalling pathway mediates high glucose induced cell injury through activation of TRPC6 in podocytes
    • Li Z, Xu J, Xu P, Liu S, Yang Z: Wnt/β-catenin signalling pathway mediates high glucose induced cell injury through activation of TRPC6 in podocytes. Cell Prolif. 46, 76-85 (2013).
    • (2013) Cell Prolif , vol.46 , pp. 76-85
    • Li, Z.1    Xu, J.2    Xu, P.3    Liu, S.4    Yang, Z.5
  • 45
    • 84455208254 scopus 로고    scopus 로고
    • The podocyte as a target for therapies - new and old
    • Mathieson PW: The podocyte as a target for therapies - new and old. Nat. Rev. Nephrol. 8, 52-56 (2011).
    • (2011) Nat. Rev. Nephrol , vol.8 , pp. 52-56
    • Mathieson, P.W.1
  • 47
    • 0021322084 scopus 로고
    • Microalbuminuria predicts clinical proteinuria and early mortality in maturity-onset diabetes
    • Mogensen CE: Microalbuminuria predicts clinical proteinuria and early mortality in maturity-onset diabetes. N. Engl. J. Med. 310, 356-360 (1984).
    • (1984) N. Engl. J. Med , vol.310 , pp. 356-360
    • Mogensen, C.E.1
  • 50
    • 0036266596 scopus 로고    scopus 로고
    • Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin
    • Nguyen G, Delarue F, Burcklé C, Bouzhir L, Giller T, Sraer JD: Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin. J. Clin. Invest. 109, 1417-1427 (2002).
    • (2002) J. Clin. Invest , vol.109 , pp. 1417-1427
    • Nguyen, G.1    Delarue, F.2    Burcklé, C.3    Bouzhir, L.4    Giller, T.5    Sraer, J.D.6
  • 52
    • 84907515649 scopus 로고    scopus 로고
    • Transient receptor potential channels as drug targets: From the science of basic research to the art of medicine
    • Nilius B, Szallasi A: Transient receptor potential channels as drug targets: from the science of basic research to the art of medicine. Pharmacol. Rev. 66, 676-814 (2014).
    • (2014) Pharmacol. Rev , vol.66 , pp. 676-814
    • Nilius, B.1    Szallasi, A.2
  • 53
    • 0034004798 scopus 로고    scopus 로고
    • Angiotensin II increases the intracellular calcium activity in podocytes of the intact glomerulus
    • Nitschke R, Henger A, Ricken S, Gloy J, Müller V, Greger R, Pavenstädt H: Angiotensin II increases the intracellular calcium activity in podocytes of the intact glomerulus. Kidney Int. 57, 41-49 (2000).
    • (2000) Kidney Int , vol.57 , pp. 41-49
    • Nitschke, R.1    Henger, A.2    Ricken, S.3    Gloy, J.4    Müller, V.5    Greger, R.6    Pavenstädt, H.7
  • 56
    • 84860787585 scopus 로고    scopus 로고
    • Gesellschaft für Pädiatrische Nephrologie (GPN) Study Group: Mutation analysis of NPHS1 in a worldwide cohort of congenital nephrotic syndrome patients
    • Ovunc B, Ashraf S, Vega-Warner V, Bockenhauer D, Elshakhs NA, Joseph M, Hildebrandt F, Gesellschaft für Pädiatrische Nephrologie (GPN) Study Group: Mutation analysis of NPHS1 in a worldwide cohort of congenital nephrotic syndrome patients. Nephron Clin. Pract. 120, c139-c146 (2012).
    • (2012) Nephron Clin. Pract , vol.120 , pp. c139-c146
    • Ovunc, B.1    Ashraf, S.2    Vega-Warner, V.3    Bockenhauer, D.4    Elshakhs, N.A.5    Joseph, M.6    Hildebrandt, F.7
  • 59
    • 37349120735 scopus 로고    scopus 로고
    • The podocyte and diabetes mellitus: Is the podocyte the key to the origins of diabetic nephropathy?
    • Reddy GR, Kotlyarevska K, Ransom RF, Menon RK: The podocyte and diabetes mellitus: is the podocyte the key to the origins of diabetic nephropathy? Curr. Opin. Nephrol. Hypertens. 17, 32-36 (2008).
    • (2008) Curr. Opin. Nephrol. Hypertens , vol.17 , pp. 32-36
    • Reddy, G.R.1    Kotlyarevska, K.2    Ransom, R.F.3    Menon, R.K.4
  • 60
    • 77950517549 scopus 로고    scopus 로고
    • Toward the development of podocyte-specific drugs
    • Reiser J, Gupta V, Kistler AD: Toward the development of podocyte-specific drugs. Kidney Int. 77, 662-668 (2010).
    • (2010) Kidney Int , vol.77 , pp. 662-668
    • Reiser, J.1    Gupta, V.2    Kistler, A.D.3
  • 62
    • 84880573499 scopus 로고    scopus 로고
    • New developments in steroid-resistant nephrotic syndrome
    • Saleem MA: New developments in steroid-resistant nephrotic syndrome. Pediatr. Nephrol. 28, 699-709 (2013).
    • (2013) Pediatr. Nephrol , vol.28 , pp. 699-709
    • Saleem, M.A.1
  • 64
    • 65249099647 scopus 로고    scopus 로고
    • TRPC6 mutations associated with focal segmental glomerulosclerosis cause constitutive activation of NFAT-dependent transcription
    • Schlöndorff J, Del Camino D, Carrasquillo R, Lacey V, Pollak MR: TRPC6 mutations associated with focal segmental glomerulosclerosis cause constitutive activation of NFAT-dependent transcription. Am. J. Physiol. Cell Physiol. 296, C558-C569 (2009).
    • (2009) Am. J. Physiol. Cell Physiol , vol.296 , pp. C558-C569
    • Schlöndorff, J.1    Del Camino, D.2    Carrasquillo, R.3    Lacey, V.4    Pollak, M.R.5
  • 65
    • 0034126357 scopus 로고    scopus 로고
    • Getting a foothold in nephrotic syndrome
    • Somlo S, Mundel P: Getting a foothold in nephrotic syndrome. Nat. Genet. 24, 333-335 (2000).
    • (2000) Nat. Genet , vol.24 , pp. 333-335
    • Somlo, S.1    Mundel, P.2
  • 66
    • 0035008793 scopus 로고    scopus 로고
    • International diabetic nephropathy study group: Glomerular cell number in normal subjects and in type 1 diabetic patients
    • Steffes MW, Schmidt D, McCrery R, Basgen JM: International Diabetic Nephropathy Study Group: Glomerular cell number in normal subjects and in type 1 diabetic patients. Kidney Int. 59, 2104-2113 (2001).
    • (2001) Kidney Int , vol.59 , pp. 2104-2113
    • Steffes, M.W.1    Schmidt, D.2    McCrery, R.3    Basgen, J.M.4
  • 67
    • 4644293836 scopus 로고    scopus 로고
    • The canonical transient receptor potential 6 channel as a putative phosphatidylinositol 3, 4, 5-trisphosphate-sensitive calcium entry system
    • Tseng PH, Lin HP, Hu H, Wang C, Zhu MX, Chen CS: The canonical transient receptor potential 6 channel as a putative phosphatidylinositol 3, 4, 5-trisphosphate-sensitive calcium entry system. Biochemistry 43, 11701- 11708 (2004).
    • (2004) Biochemistry , vol.43 , pp. 11701-11708
    • Tseng, P.H.1    Lin, H.P.2    Hu, H.3    Wang, C.4    Zhu, M.X.5    Chen, C.S.6
  • 68
    • 20544465592 scopus 로고    scopus 로고
    • New insights into the pathogenesis and the therapy of recurrent focal glomerulosclerosis
    • Vincenti F, Ghiggeri GM: New insights into the pathogenesis and the therapy of recurrent focal glomerulosclerosis. Am. J. Transplant. 5, 1179-1185 (2005).
    • (2005) Am. J. Transplant , vol.5 , pp. 1179-1185
    • Vincenti, F.1    Ghiggeri, G.M.2
  • 69
    • 66849104240 scopus 로고    scopus 로고
    • Pharmacology of vanilloid transient receptor potential cation channels
    • Vriens J, Appendino G, Nilius B: Pharmacology of vanilloid transient receptor potential cation channels. Mol. Pharmacol. 75, 1262-1279 (2009).
    • (2009) Mol. Pharmacol , vol.75 , pp. 1262-1279
    • Vriens, J.1    Appendino, G.2    Nilius, B.3
  • 72
    • 2942720686 scopus 로고    scopus 로고
    • Diabiopsies study group: Structural alterations to the podocyte are related to proteinuria in type 2 diabetic patients
    • White KE, Bilous RW: Diabiopsies Study Group: Structural alterations to the podocyte are related to proteinuria in type 2 diabetic patients. Nephrol. Dial. Transplant. 19, 1437-1440 (2004).
    • (2004) Nephrol. Dial. Transplant , vol.19 , pp. 1437-1440
    • White, K.E.1    Bilous, R.W.2
  • 74
    • 20844461871 scopus 로고    scopus 로고
    • Angiotensin II receptor blocker inhibits p27Kip1 expression in glucose-stimulated podocytes and in diabetic glomeruli
    • Xu ZG, Yoo TH, Ryu DR, Cheon Park H, Ha SK, Han DS, Adler SG, Natarajan R, Kang SW: Angiotensin II receptor blocker inhibits p27Kip1 expression in glucose-stimulated podocytes and in diabetic glomeruli. Kidney Int. 67, 944-952 (2005).
    • (2005) Kidney Int , vol.67 , pp. 944-952
    • Xu, Z.G.1    Yoo, T.H.2    Ryu, D.R.3    Cheon, P.H.4    Ha, S.K.5    Han, D.S.6    Adler, S.G.7    Natarajan, R.8    Kang, S.W.9
  • 76
    • 84866170769 scopus 로고    scopus 로고
    • Is the antiproteinuric effect of cyclosporine a independent of its immunosuppressive function in T cells?
    • Zhang B, Shi W: Is the antiproteinuric effect of cyclosporine a independent of its immunosuppressive function in T cells? Int. J. Nephrol. 2012, 809456 (2012).
    • (2012) Int. J. Nephrol , vol.2012 , pp. 809456
    • Zhang, B.1    Shi, W.2
  • 77
    • 70349149065 scopus 로고    scopus 로고
    • TRPC6 up-regulation in Ang II-induced podocyte apoptosis might result from ERK activation and NF-kappaB translocation
    • Zhang H, Ding J, Liu S: TRPC6 up-regulation in Ang II-induced podocyte apoptosis might result from ERK activation and NF-kappaB translocation. Exp. Biol. Med. (Maywood) 234, 1029-1036 (2009).
    • (2009) Exp. Biol. Med. (Maywood) , vol.234 , pp. 1029-1036
    • Zhang, H.1    Ding, J.2    Liu, S.3


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