메뉴 건너뛰기




Volumn 77, Issue 8, 2010, Pages 662-668

Toward the development of podocyte-specific drugs

Author keywords

Glomerulopathy; Pathophysiology of renal disease and progression; Podocyte; Proteinuria; Renal protection

Indexed keywords

ANGIOTENSIN RECEPTOR ANTAGONIST; CALCINEURIN INHIBITOR; CATHEPSIN L; COMPLEMENTARY DNA; CYCLOPEPTIDE; CYCLOSPORIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DYNAMIN; GLUCOCORTICOID; GROWTH FACTOR; IMMUNOSUPPRESSIVE AGENT; ION CHANNEL; MEMBRANE RECEPTOR; NEPHRIN; NOTCH RECEPTOR; PROTEINASE; RNA; SHORT HAIRPIN RNA; SYNAPTOPODIN; TRANSFORMING GROWTH FACTOR BETA; TRANSIENT RECEPTOR POTENTIAL CHANNEL 6; VASCULOTROPIN A; VITRONECTIN RECEPTOR;

EID: 77950517549     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2009.559     Document Type: Short Survey
Times cited : (43)

References (45)
  • 1
    • 34250006557 scopus 로고    scopus 로고
    • The spectrum of podocytopathies: A unifying view of glomerular diseases
    • Wiggins RC. The spectrum of podocytopathies: a unifying view of glomerular diseases. Kidney Int 2007; 71: 1205-1214.
    • (2007) Kidney Int , vol.71 , pp. 1205-1214
    • Wiggins, R.C.1
  • 2
    • 0033958396 scopus 로고    scopus 로고
    • The glomerular slit diaphragm is a modified adherens junction
    • Reiser J, Kriz W, Kretzler M et al. The glomerular slit diaphragm is a modified adherens junction. J Am Soc Nephrol 2000; 11: 1-8.
    • (2000) J Am Soc Nephrol , vol.11 , pp. 1-8
    • Reiser, J.1    Kriz, W.2    Kretzler, M.3
  • 3
    • 33645403170 scopus 로고    scopus 로고
    • Hereditary proteinuria syndromes and mechanisms of proteinuria
    • Tryggvason K, Patrakka J, Wartiovaara J. Hereditary proteinuria syndromes and mechanisms of proteinuria. N Engl J Med 2006; 354: 1387-1401.
    • (2006) N Engl J Med , vol.354 , pp. 1387-1401
    • Tryggvason, K.1    Patrakka, J.2    Wartiovaara, J.3
  • 4
    • 34347357580 scopus 로고    scopus 로고
    • Podocytes in culture: Past, present, and future
    • Shankland SJ, Pippin JW, Reiser J et al. Podocytes in culture: past, present, and future. Kidney Int 2007; 72: 26-36.
    • (2007) Kidney Int , vol.72 , pp. 26-36
    • Shankland, S.J.1    Pippin, J.W.2    Reiser, J.3
  • 5
    • 67649708229 scopus 로고    scopus 로고
    • The promise of well-being: Stay in shape with N(i)ck
    • Benzing T. The promise of well-being: stay in shape with N(i)ck. J Am Soc Nephrol 2009; 20: 1425-1427.
    • (2009) J Am Soc Nephrol , vol.20 , pp. 1425-1427
    • Benzing, T.1
  • 6
    • 33749515477 scopus 로고    scopus 로고
    • Nephrin loss in experimental diabetic nephropathy is prevented by deletion of protein kinase C alpha signaling in-vivo
    • Menne J, Meier M, Park JK et al. Nephrin loss in experimental diabetic nephropathy is prevented by deletion of protein kinase C alpha signaling in-vivo. Kidney Int 2006; 70: 1456-1462.
    • (2006) Kidney Int , vol.70 , pp. 1456-1462
    • Menne, J.1    Meier, M.2    Park, J.K.3
  • 7
    • 41449115008 scopus 로고    scopus 로고
    • Decreased tyrosine phosphorylation of nephrin in rat and human nephrosis
    • Uchida K, Suzuki K, Iwamoto M et al. Decreased tyrosine phosphorylation of nephrin in rat and human nephrosis. Kidney Int 2008; 73: 926-932.
    • (2008) Kidney Int , vol.73 , pp. 926-932
    • Uchida, K.1    Suzuki, K.2    Iwamoto, M.3
  • 8
    • 85047691168 scopus 로고    scopus 로고
    • Induction of B7-1 in podocytes is associated with nephrotic syndrome
    • Reiser J, von Gersdorff G, Loos M et al. Induction of B7-1 in podocytes is associated with nephrotic syndrome. J Clin Invest 2004; 113: 1390-1397.
    • (2004) J Clin Invest , vol.113 , pp. 1390-1397
    • Reiser, J.1    Von Gersdorff, G.2    Loos, M.3
  • 9
    • 4544377833 scopus 로고    scopus 로고
    • Podocyte migration during nephrotic syndrome requires a coordinated interplay between cathepsin L and alpha3 integrin
    • Reiser J, Oh J, Shirato I et al. Podocyte migration during nephrotic syndrome requires a coordinated interplay between cathepsin L and alpha3 integrin. J Biol Chem 2004; 279: 34827-34832.
    • (2004) J Biol Chem , vol.279 , pp. 34827-34832
    • Reiser, J.1    Oh, J.2    Shirato, I.3
  • 10
    • 38049032013 scopus 로고    scopus 로고
    • Modification of kidney barrier function by the urokinase receptor
    • Wei C, Moller CC, Altintas MM et al. Modification of kidney barrier function by the urokinase receptor. Nat Med 2008; 14: 55-63.
    • (2008) Nat Med , vol.14 , pp. 55-63
    • Wei, C.1    Moller, C.C.2    Altintas, M.M.3
  • 11
    • 33947312487 scopus 로고    scopus 로고
    • Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron
    • Cheng HT, Kim M, Valerius MT et al. Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron. Development 2007; 134: 801-811.
    • (2007) Development , vol.134 , pp. 801-811
    • Cheng, H.T.1    Kim, M.2    Valerius, M.T.3
  • 12
    • 40449112321 scopus 로고    scopus 로고
    • The Notch pathway in podocytes plays a role in the development of glomerular disease
    • Niranjan T, Bielesz B, Gruenwald A et al. The Notch pathway in podocytes plays a role in the development of glomerular disease. Nat Med 2008; 14: 290-298.
    • (2008) Nat Med , vol.14 , pp. 290-298
    • Niranjan, T.1    Bielesz, B.2    Gruenwald, A.3
  • 13
    • 67649658244 scopus 로고    scopus 로고
    • M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy
    • Beck Jr LH, Bonegio RG, Lambeau G et al. M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy. N Engl J Med 2009; 361: 11-21.
    • (2009) N Engl J Med , vol.361 , pp. 11-21
    • Beck Jr, L.H.1    Bonegio, R.G.2    Lambeau, G.3
  • 14
    • 22844436647 scopus 로고    scopus 로고
    • TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function
    • Reiser J, Polu KR, Moller CC et al. TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function. Nat Genet 2005; 37: 739-744.
    • (2005) Nat Genet , vol.37 , pp. 744
    • Reiser, J.1    Polu, K.R.2    Moller, C.C.3
  • 15
    • 20844461826 scopus 로고    scopus 로고
    • A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis
    • Winn MP, Conlon PJ, Lynn KL et al. A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis. Science 2005; 308: 1801-1804.
    • (2005) Science , vol.308 , pp. 1801-1804
    • Winn, M.P.1    Conlon, P.J.2    Lynn, K.L.3
  • 16
    • 33751225687 scopus 로고    scopus 로고
    • Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels
    • Huber TB, Schermer B, Muller RU et al. Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels. Proc Natl Acad Sci USA 2006; 103: 17079-17086.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 17079-17086
    • Huber, T.B.1    Schermer, B.2    Muller, R.U.3
  • 17
    • 33846028228 scopus 로고    scopus 로고
    • Induction of TRPC6 channel in acquired forms of proteinuric kidney disease
    • Moller CC, Wei C, Altintas MM et al. Induction of TRPC6 channel in acquired forms of proteinuric kidney disease. J Am Soc Nephrol 2007; 18: 29-36.
    • (2007) J Am Soc Nephrol , vol.18 , pp. 29-36
    • Moller, C.C.1    Wei, C.2    Altintas, M.M.3
  • 18
    • 0034836835 scopus 로고    scopus 로고
    • Apoptosis in podocytes induced by TGF-beta and Smad7
    • Schiffer M, Bitzer M, Roberts IS et al. Apoptosis in podocytes induced by TGF-beta and Smad7. J Clin Invest 2001; 108: 807-816.
    • (2001) J Clin Invest , vol.108 , pp. 807-816
    • Schiffer, M.1    Bitzer, M.2    Roberts, I.S.3
  • 19
    • 0027479442 scopus 로고
    • Expression of transforming growth factor beta is elevated in human and experimental diabetic nephropathy
    • Yamamoto T, Nakamura T, Noble NA et al. Expression of transforming growth factor beta is elevated in human and experimental diabetic nephropathy. Proc Natl Acad Sci USA 1993; 90: 1814-1818.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 1814-1818
    • Yamamoto, T.1    Nakamura, T.2    Noble, N.A.3
  • 20
    • 0037370325 scopus 로고    scopus 로고
    • Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases
    • Eremina V, Sood M, Haigh J et al. Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases. J Clin Invest 2003; 111: 707-716.
    • (2003) J Clin Invest , vol.111 , pp. 707-716
    • Eremina, V.1    Sood, M.2    Haigh, J.3
  • 21
    • 40849130173 scopus 로고    scopus 로고
    • VEGF inhibition and renal thrombotic microangiopathy
    • Eremina V, Jefferson JA, Kowalewska J et al. VEGF inhibition and renal thrombotic microangiopathy. N Engl J Med 2008; 358: 1129-1136.
    • (2008) N Engl J Med , vol.358 , pp. 1129-1136
    • Eremina, V.1    Jefferson, J.A.2    Kowalewska, J.3
  • 22
    • 0037373006 scopus 로고    scopus 로고
    • Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia
    • Maynard SE, Min JY, Merchan J et al. Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. J Clin Invest 2003; 111: 649-658.
    • (2003) J Clin Invest , vol.111 , pp. 649-658
    • Maynard, S.E.1    Min, J.Y.2    Merchan, J.3
  • 24
    • 34547654202 scopus 로고    scopus 로고
    • Proteolytic processing of dynamin by cytoplasmic cathepsin L is a mechanism for proteinuric kidney disease
    • Sever S, Altintas MM, Nankoe SR et al. Proteolytic processing of dynamin by cytoplasmic cathepsin L is a mechanism for proteinuric kidney disease. J Clin Invest 2007; 117: 2095-2104.
    • (2007) J Clin Invest , vol.117 , pp. 2095-2104
    • Sever, S.1    Altintas, M.M.2    Nankoe, S.R.3
  • 25
    • 0038824700 scopus 로고    scopus 로고
    • Toward computer-based cleavage site prediction of cysteine endopeptidases
    • Lohmuller T, Wenzler D, Hagemann S et al. Toward computer-based cleavage site prediction of cysteine endopeptidases. Biol Chem 2003; 384: 899-909.
    • (2003) Biol Chem , vol.384 , pp. 899-909
    • Lohmuller, T.1    Wenzler, D.2    Hagemann, S.3
  • 26
    • 51349162919 scopus 로고    scopus 로고
    • The actin cytoskeleton of kidney podocytes is a direct target of the antiproteinuric effect of cyclosporine A
    • Faul C, Donnelly M, Merscher-Gomez S et al. The actin cytoskeleton of kidney podocytes is a direct target of the antiproteinuric effect of cyclosporine A. Nat Med 2008; 14: 931-938.
    • (2008) Nat Med , vol.14 , pp. 931-938
    • Faul, C.1    Donnelly, M.2    Merscher-Gomez, S.3
  • 27
    • 66849111134 scopus 로고    scopus 로고
    • Introduction: Cell-based assays for high-throughput screening
    • An WF, Tolliday NJ. Introduction: cell-based assays for high-throughput screening. Methods Mol Biol. 2009, 486; 1-12.
    • (2009) Methods Mol Biol , vol.486 , pp. 1-12
    • An, W.F.1    Tolliday, N.J.2
  • 28
    • 0031563832 scopus 로고    scopus 로고
    • Rearrangements of the cytoskeleton and cell contacts induce process formation during differentiation of conditionally immortalized mouse podocyte cell lines
    • Mundel P, Reiser J, Zuniga Mejia Borja A et al. Rearrangements of the cytoskeleton and cell contacts induce process formation during differentiation of conditionally immortalized mouse podocyte cell lines. Exp Cell Res 1997; 236: 248-258.
    • (1997) Exp Cell Res , vol.236 , pp. 248-258
    • Mundel, P.1    Reiser, J.2    Zuniga Mejia Borja, A.3
  • 29
    • 0036189998 scopus 로고    scopus 로고
    • A conditionally immortalized human podocyte cell line demonstrating nephrin and podocin expression
    • Saleem MA, O'Hare MJ, Reiser J et al. A conditionally immortalized human podocyte cell line demonstrating nephrin and podocin expression. J Am Soc Nephrol 2002; 13: 630-638.
    • (2002) J Am Soc Nephrol , vol.13 , pp. 630-638
    • Saleem, M.A.1    O'Hare, M.J.2    Reiser, J.3
  • 30
    • 20544470693 scopus 로고    scopus 로고
    • Kidney development and disease in the zebrafish
    • Drummond IA. Kidney development and disease in the zebrafish. J Am Soc Nephrol 2005; 16: 299-304.
    • (2005) J Am Soc Nephrol , vol.16 , pp. 299-304
    • Drummond, I.A.1
  • 31
    • 58249123367 scopus 로고    scopus 로고
    • The insect nephrocyte is a podocyte-like cell with a filtration slit diaphragm
    • Weavers H, Prieto-Sánchez S, Grawe F et al. The insect nephrocyte is a podocyte-like cell with a filtration slit diaphragm. Nature 2009; 457: 322-326.
    • (2009) Nature , vol.457 , pp. 322-326
    • Weavers, H.1    Prieto-Sánchez, S.2    Grawe, F.3
  • 32
    • 12144273121 scopus 로고    scopus 로고
    • In vivo drug discovery in the zebrafish
    • Zon LI, Peterson RT. In vivo drug discovery in the zebrafish. Nat Rev Drug Discov 2005; 4: 35-44.
    • (2005) Nat Rev Drug Discov , vol.4 , pp. 35-44
    • Zon, L.I.1    Peterson, R.T.2
  • 33
    • 0030733851 scopus 로고    scopus 로고
    • Induction of differentiation in cultured rat and human podocytes
    • Mundel P, Reiser J, Kriz W. Induction of differentiation in cultured rat and human podocytes. J Am Soc Nephrol 1997; 8: 697-705.
    • (1997) J Am Soc Nephrol , vol.8 , pp. 697-705
    • Mundel, P.1    Reiser, J.2    Kriz, W.3
  • 34
    • 34848907421 scopus 로고    scopus 로고
    • Actin up: Regulation of podocyte structure and function by components of the actin cytoskeleton
    • Faul C, Asanuma K, Yanagida-Asanuma E et al. Actin up: regulation of podocyte structure and function by components of the actin cytoskeleton. Trends Cell Biol 2007; 17: 428-437.
    • (2007) Trends Cell Biol , vol.17 , pp. 428-437
    • Faul, C.1    Asanuma, K.2    Yanagida-Asanuma, E.3
  • 35
    • 33747867771 scopus 로고    scopus 로고
    • Screening and identification of substances that regulate nephrin gene expression using engineered reporter podocytes
    • Yamauchi K, Takano Y, Kasai A et al. Screening and identification of substances that regulate nephrin gene expression using engineered reporter podocytes. Kidney Int 2006; 70: 892-900.
    • (2006) Kidney Int , vol.70 , pp. 892-900
    • Yamauchi, K.1    Takano, Y.2    Kasai, A.3
  • 36
    • 0037650079 scopus 로고    scopus 로고
    • Furin interacts with proMT1-MMP and integrin alphaV at specialized domains of renal cell plasma membrane
    • Mayer G, Boileau G, Bendayan M. Furin interacts with proMT1-MMP and integrin alphaV at specialized domains of renal cell plasma membrane. J Cell Sci 2003; 116: 1763-1773.
    • (2003) J Cell Sci , vol.116 , pp. 1763-1773
    • Mayer, G.1    Boileau, G.2    Bendayan, M.3
  • 37
    • 36849030228 scopus 로고    scopus 로고
    • Dual effects of RAS blockade on blood pressure and podocyte function
    • Reiser J, Mundel P. Dual effects of RAS blockade on blood pressure and podocyte function. Curr Hypertens Rep 2007; 9: 403-408.
    • (2007) Curr Hypertens Rep , vol.9 , pp. 403-408
    • Reiser, J.1    Mundel, P.2
  • 38
    • 32844469380 scopus 로고    scopus 로고
    • Glucocorticoids protect and enhance recovery of cultured murine podocytes via actin filament stabilization
    • Ransom RF, Lam NG, Hallett MA et al. Glucocorticoids protect and enhance recovery of cultured murine podocytes via actin filament stabilization. Kidney Int 2005; 68: 2473-2483.
    • (2005) Kidney Int , vol.68 , pp. 2473-2483
    • Ransom, R.F.1    Lam, N.G.2    Hallett, M.A.3
  • 39
    • 50049083279 scopus 로고    scopus 로고
    • Tetracycline-inducible gene expression in conditionally immortalized mouse podocytes
    • Kajiyama H, Titus S, Austin CP et al. Tetracycline-inducible gene expression in conditionally immortalized mouse podocytes. Am J Nephrol 2009; 29: 153-163.
    • (2009) Am J Nephrol , vol.29 , pp. 153-163
    • Kajiyama, H.1    Titus, S.2    Austin, C.P.3
  • 40
    • 42049095153 scopus 로고    scopus 로고
    • Cell-penetrating peptides: From molecular mechanisms to therapeutics
    • Morris MC, Deshayes S, Heitz F et al. Cell-penetrating peptides: from molecular mechanisms to therapeutics. Biol Cell 2008; 100: 201-217.
    • (2008) Biol Cell , vol.100 , pp. 201-217
    • Morris, M.C.1    Deshayes, S.2    Heitz, F.3
  • 41
  • 42
    • 33846857348 scopus 로고    scopus 로고
    • Statin-sensitive endocytosis of albumin by glomerular podocytes
    • Eyre J, Ioannou K, Grubb BD et al. Statin-sensitive endocytosis of albumin by glomerular podocytes. Am J Physiol Renal Physiol 2007; 292: F674-F681.
    • (2007) Am J Physiol Renal Physiol , vol.292
    • Eyre, J.1    Ioannou, K.2    Grubb, B.D.3
  • 43
    • 38949210805 scopus 로고    scopus 로고
    • Podocytes use FcRn to clear IgG from the glomerular basement membrane
    • Akilesh S, Huber TB, Wu H et al. Podocytes use FcRn to clear IgG from the glomerular basement membrane. Proc Natl Acad Sci USA 2008; 105: 967-972.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 967-972
    • Akilesh, S.1    Huber, T.B.2    Wu, H.3
  • 44
    • 0033549864 scopus 로고    scopus 로고
    • N-Methylated cyclic RGD peptides as highly active and selective alpha(V)beta(3) integrin antagonists
    • Dechantsreiter MA, Planker E, Matha B et al. N-Methylated cyclic RGD peptides as highly active and selective alpha(V)beta(3) integrin antagonists. J Med Chem 1999; 42: 3033-3040.
    • (1999) J Med Chem , vol.42 , pp. 3033-3040
    • Dechantsreiter, M.A.1    Planker, E.2    Matha, B.3
  • 45
    • 0037023363 scopus 로고    scopus 로고
    • Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand
    • Xiong JP, Stehle T, Zhang R et al. Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand. Science 2002; 296: 151-155.
    • (2002) Science , vol.296 , pp. 151-155
    • Xiong, J.P.1    Stehle, T.2    Zhang, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.