Angiotensin II depolarizes podocytes in the intact glomerulus of the rat

Journal of Clinical Investigation

Volumn 99, Issue 11, 1997, Pages 2772-2781

  Gloy, Joachim ^a   Henger, Anna ^a   Fischer, Karl Georg ^a   Nitschke, Roland ^a   Mundel, Peter ^b   Bleich, Markus ^a   Schollmeyer, Peter ^a   Greger, Rainer ^a   Pavenstädt, Hermann ^a,c  

^a UNIVERSITY OF FREIBURG   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Angiotensin 1 receptor; Angiotensin II; Isolated glomeruli; Membrane voltage; Podocytes

Indexed keywords

ANGIOTENSIN; ANGIOTENSIN 1 RECEPTOR;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CHLORIDE CONDUCTANCE; CONTROLLED STUDY; GLOMERULOSCLEROSIS; ION CURRENT; MESANGIUM CELL; NONHUMAN; PODOCYTE; PRIORITY JOURNAL; RAT; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM;

EID: 0030954434     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119467     Document Type: Article

References (33)

1. Blantz, R.C., K.S. Konnen, and B.J. Tucker. 1976. Angiotensin II effects upon the glomerular microcirculation and ultrafiltration coefficient of the rat. J. Clin. Invest. 57:419-434.
2. Denton, K.M., P.A. Fennessy, D. Alcorn, and W.P. Anderson. 1992. Morphometric analysis of the actions of angiotensin II on renal arterioles and glomeruli. Am. J Physiol. 262:F367-F372.
3. Kriz, W., M. Elger, K. Lemley, and T. Sakai. 1990. Structure of the glomerular mesangium: a biomechanical interpretation. Kidney Int. 38:S2-S9.
4. Fogo, A. 1994. Internephron heterogenity of growth factors and sclerosis. Kidney Int. 45:S24-S26.
5. Kriz, W., M. Elger, M. Nagata, M. Kretzler, S. Uiker, I. Koeppen-Hageman, S. Tenschert, and K.V. Lemley. 1994. The role of podocytes in the development of glomerular sclerosis. Kidney Int. 42:S64-S72.
6. Lafayette, R.A., G. Mayer, S.K. Park, and T.W. Meyer. 1992. Angiotensin II blockade limits glomerular injury in rats with reduced renal mass. J. Clin. Invest. 90:766-771.
7. Maschio, G., D. Alberti, G. Janin, F. Locatelli, J.F. Mann, M. Motolese, C. Ponticelli, E. Ritz, and P. Zucchelli. 1996. Effect of the angiotensin-converting-enzyme inhibitor benazepril on the progression of chronic renal insufficiency. N. Engl. J. Med. 334:939-945.
8. Lapinski, R., N. Perico, A. Remuzzi, F. Sangalli, A. Benigni, and G. Remuzzi. 1996. Angiotensin II modulates glomerular capillary permselectivity in rat isolated perfused kidney. J. Am. Soc. Nephrol. 7:653-660.
9. Rencke, H. 1994. How does glomerular epithelial injury contribute to progressive glomerular damage? Kidney Int. 45:S58-S63.
10. Kriz, W., E. Hackenthal. R. Nobiling, T. Sakai, and M. Elger. 1994. A role for podocytes to counteract capillary wall distension. Kidney Int. 45:369-376.
11. Chansel, D., P. Pham, M.P. Nivez, and R. Ardaillou. 1990. Characterization of atrial natriuretic factor receptors in human glomerular epithelial and mesangial cells. Am. J. Physiol. 259:F619-F627.
12. Rebibou, J.M., C.J. He, F. Delarue, M.N. Peraldi, C. Adida, E. Rondeau, and J.D. Sraer. 1992. Functional endothelin 1 receptors on human glomerular podocytes and mesangial cells. Nephrol. Dial. Transplant. 7:288-292.
13. Sharma, R., H.B. Lovell, T.B. Wiegmann, and V.J. Savin. 1992. Vasoactive substances induce cytoskeletal changes in cultured rat epithelial cells. J. Am. Soc. Nephrol. 3:1131-1138.
14. Floege, J., H.R. Radeke, and R.J. Johnson. 1994. Glomerular cells in vitro versus the glomerulus in vivo. Kidney Int. 45:360-368.
15. Holthöfer, H., K. Sainio, and A. Miettinen. 1991. Rat glomerular cells do not express podocytic markers when cultured in vitro. Lab. Invest. 65:548-557.
16. Nørgaard, J.O.R. 1978. Retraction of epithelial foot processes during culture of isolated glomeruli. Lab. Invest. 38:320-329.
17. Gloy, J., R. Greger, P. Schollmeyer, M. Huber, and H. Pavenstädt. 1994. Influence of cell culture conditions and passage number on the response of membrane voltage to ATP and angiotensin II in rat mesangial cells. Renal Biophys. Biochem. 17:62-72.
18. Mundel, P., M. Elger, T. Sakai, and W. Kriz. 1988. Microfibrils are a major component of the mesangial matrix in the glomerulus of the rat kidney. Cell Tissue Res. 254:183-187.
19. Mundlos, S., J. Pelletier, A. Darveau, M. Bachmann, A. Winterpracht, and B. Zabel. 1993. Nuclear localization of the protein encoded by the Wilm's tumor gene WT1 in embryonic and adult tissues. Development (Camb.). 119: 1329-1341.
20. Mundel, P., P. Gilbert, and W. Kriz. 1991. Podocytes in glomerulus of rat kidney express a characteristic 44 KD protein. J. Histochem. Cytochem. 39: 1047-1056.
21. Greger, R., and K. Kunzelmann. 1991. Simultaneous recording of the cell membrane potential and properties of the cell attached membrane of HT 29 colon carcinoma and CF-PAC cells. Pflügers Arch. 419:209-211.
22. Hamill, O.P., A. Marty, E. Neher, B. Sakmann, and F.J. Sigworth. 1981. Improved patch-clamp technique for high resolution current recording from cells and cell-free membrane patches. Pflügers Arch. 391:85-100.
23. Marty, A., and A. Finkelstein. 1975. Pores formed in lipid bilayer membranes by nystatin. J. Gen. Physiol. 65:315-326.
24. Kerjaschki, D. 1994. Dysfunction of cell biological mechanisms of visceral epithelial cells (podocytes) in glomerular diseases. Kidney Int. 45:300-313.
25. Pavenstädt, H., F. Bengen, M. Späth, P. Schollmeyer, and R. Greger. 1993. Effect of bradykinin and histamine on the membrane voltage, ion conductances and ion channels of human glomerular epithelial cells (hGEC) in culture. Pflügers Arch. 424:137-144.
26. Pavenstädt, H., J. Gloy, J. Leipziger, B. Klär, J. Pfeilschifter, P. Schollmeyer, and R. Greger. 1993. Effect of extracellular ATP on contraction, cytosolic calcium activity, membrane voltage and ion currents of rat mesangial cells in primary culture. Br. J. Pharmacol. 109:953-959.
27. Okuda, T., N. Yamashita, and K. Kurokawa. 1986. Angiotensin II and vasopressin stimulate calcium activated chloride conductance in rat mesangial cells. J. Clin. Invest. 78:1443-1448.
28. Timmermans, P.B., J.V. Duncia, D.J. Carini, A.T. Chiu, P.C. Wong, R.R. Wexler, and R.D. Smith. 1995. Discovery of losartan, the first angiotensin II receptor antagonist. J. Hum. Hypertens. 9(Suppl.):S3-S18.
29. Yamada, H., P.M. Sexton, S.Y. Chai, W.R. Adam, and F.A. Mendelsohn. 1990. Angiotensin II receptors in the kidney. Localization and physiological significance. Am. J. Hypertens. 3:250-255.
30. Seikaly, M.G., B.S. Arant, and F.D. Seney. 1990. Enhanced angiotensin concentrations in specific intrarenal fluid compartments of the rat. J. Clin. Invest. 86:1352-1357.
31. Kremer, S.G., W.V. Breuer, and K.L. Skorecki. 1989. Vasoconstrictor hormones depolarize renal glomerular mesangial cells by activating chloride channels. J. Cell Physiol. 138:97-105.
32. Yaoita, E., T. Yanamoto, N. Takashima, K. Kawasaki, H. Kawachi, F. Shimizu, and I. Kihara. 1995. Visceral epithelial cells in rat glomerular cell culture. Eur. J. Cell Biol. 67:136-144.
33. Mundel, P., J. Reiser, and W. Kriz. 1997. Differentiation of rat podocytes in vitro. J. Am. Soc. Nephrol. In press.