SCOPUS 정보 검색 플랫폼

Bioorganic and Medicinal Chemistry Letters

Volumn 25, Issue 22, 2015, Pages 5258-5264

Discovery of 3,5-substituted 6-azaindazoles as potent pan-Pim inhibitors

(16) Hu, Huiyong a Wang, Xiaojing a Chan, Grace Ka Yan a Chang, Jae H a Do, Steven a Drummond, Jake a Ebens, Allen b Lee, Wendy a Ly, Justin a Lyssikatos, Joseph P c Murray, Jeremy a Moffat, John G a Chao, Qi d Tsui, Vickie a Wallweber, Heidi a Kolesnikov, Aleksandr a

a GENENTECH INC (United States)

b Juno Therapeutics (United States)

c BIOGEN (United States)

d BIOMARIN PHARMACEUTICAL INC (United States)

Author keywords

Fragment based screen; Kinase inhibitor; Lead optimization; Pim kinases; Screening; Structure based drug design

Indexed keywords

1H PYRAZOLO[3,4 C]PYRIDINE(6 AZAINDAZOLE); ADENOSINE TRIPHOSPHATE; INDAZOLE DERIVATIVE; PHOSPHOTRANSFERASE INHIBITOR; PROTEIN KINASE PIM 1; PROTEIN KINASE PIM 2; PROTEIN SERINE THREONINE KINASE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; PIM1 PROTEIN, HUMAN; PYRAZOLE DERIVATIVE; PYRIDINE DERIVATIVE;

ANIMAL CELL; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BINDING AFFINITY; BINDING SITE; CRYSTAL STRUCTURE; DRUG DESIGN; HYDROGEN BOND; IC50; METABOLIC STABILITY; MOUSE; MULTIPLE MYELOMA; MULTIPLE MYELOMA CELL LINE; NONHUMAN; PHYSICAL CHEMISTRY; STRUCTURE ACTIVITY RELATION; X RAY; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; HUMAN; SYNTHESIS; TUMOR CELL LINE; X RAY CRYSTALLOGRAPHY;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CRYSTALLOGRAPHY, X-RAY; HUMANS; INDAZOLES; MICE; MODELS, MOLECULAR; PROTO-ONCOGENE PROTEINS C-PIM-1; PYRAZOLES; PYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84945968564 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2015.09.052 Document Type: Article

Times cited : (27)

References (31)

1
- 0021233675
- H.T. Cuypers, G. Selten, W. Quint, M. Zijlstra, E.R. Maandag, W. Boelens, P. van Wezenbeek, C. Melief, and A. Berns Cell 37 1984 141
- (1984) Cell , vol.37 , pp. 141
- Cuypers, H.T.¹ Selten, G.² Quint, W.³ Zijlstra, M.⁴ Maandag, E.R.⁵ Boelens, W.⁶ Van Wezenbeek, P.⁷ Melief, C.⁸ Berns, A.⁹

2
- 0022100028
- G. Selten, H.T. Cuypers, and A. Berns EMBO J. 4 1985 1793
- (1985) EMBO J. , vol.4 , pp. 1793
- Selten, G.¹ Cuypers, H.T.² Berns, A.³

3
- 0025863346
- M. van Lohuizen, S. Verbeek, B. Scheijen, E. Wientjens, H. van der Gulden, and A. Berns Cell 65 1991 737
- (1991) Cell , vol.65 , pp. 737
- Van Lohuizen, M.¹ Verbeek, S.² Scheijen, B.³ Wientjens, E.⁴ Van Der Gulden, H.⁵ Berns, A.⁶

4
- 77957967569
- N.S. Magnuson, Z. Wang, G. Ding, and R. Reeves Future Oncol. 6 2010 1461
- (2010) Future Oncol. , vol.6 , pp. 1461
- Magnuson, N.S.¹ Wang, Z.² Ding, G.³ Reeves, R.⁴

5
- 84858238737
- A.L. Merkel, E. Meggers, and M. Ocker Expert Opin. Investig. Drugs 21 2012 425
- (2012) Expert Opin. Investig. Drugs , vol.21 , pp. 425
- Merkel, A.L.¹ Meggers, E.² Ocker, M.³

6
- 71049189242
- Z.-F. Tao, L.A. Hasvold, J.D. Leverson, E.K. Han, R. Guan, E.F. Johnson, V.S. Stoll, K.D. Stewart, G. Stamper, N. Soni, J.J. Bouska, Y. Luo, T.J. Sowin, N.-H. Lin, V.S. Giranda, S.H. Rosenberg, and T.D. Penning J. Med. Chem. 52 2009 6621
- (2009) J. Med. Chem. , vol.52 , pp. 6621
- Tao, Z.-F.¹ Hasvold, L.A.² Leverson, J.D.³ Han, E.K.⁴ Guan, R.⁵ Johnson, E.F.⁶ Stoll, V.S.⁷ Stewart, K.D.⁸ Stamper, G.⁹ Soni, N.¹⁰ Bouska, J.J.¹¹ Luo, Y.¹² Sowin, T.J.¹³ Lin, N.-H.¹⁴ Giranda, V.S.¹⁵ Rosenberg, S.H.¹⁶ Penning, T.D.¹⁷

7
- 84856663843
- J. Pastor, J. Oyarzabal, G. Saluste, R.M. Alvarez, V. Rivero, F. Ramos, E. Cendon, C. Blanco-Aparicio, N. Ajenjo, A. Cebria, M.I. Albarran, D. Cebrian, A. Corrionero, J. Fominaya, G. Montoya, and M. Mazzorana Bioorg. Med. Chem. Lett. 22 2012 1591
- (2012) Bioorg. Med. Chem. Lett. , vol.22 , pp. 1591
- Pastor, J.¹ Oyarzabal, J.² Saluste, G.³ Alvarez, R.M.⁴ Rivero, V.⁵ Ramos, F.⁶ Cendon, E.⁷ Blanco-Aparicio, C.⁸ Ajenjo, N.⁹ Cebria, A.¹⁰ Albarran, M.I.¹¹ Cebrian, D.¹² Corrionero, A.¹³ Fominaya, J.¹⁴ Montoya, G.¹⁵ Mazzorana, M.¹⁶

8
- 84861190659
- A.L. Tsuhako, D.S. Brown, E.S. Koltun, N. Aay, A. Arcalas, V. Chan, H. Du, S. Engst, M. Franzini, A. Galan, P. Huang, S. Johnston, B. Kane, M.H. Kim, A.D. Laird, R. Lin, L. Mock, I. Ngan, M. Pack, G. Stott, T.J. Stout, P. Yu, C. Zaharia, W. Zhang, P. Zhou, J.M. Nuss, P.C. Kearney, and W. Xu Bioorg. Med. Chem. Lett. 22 2012 3732
- (2012) Bioorg. Med. Chem. Lett. , vol.22 , pp. 3732
- Tsuhako, A.L.¹ Brown, D.S.² Koltun, E.S.³ Aay, N.⁴ Arcalas, A.⁵ Chan, V.⁶ Du, H.⁷ Engst, S.⁸ Franzini, M.⁹ Galan, A.¹⁰ Huang, P.¹¹ Johnston, S.¹² Kane, B.¹³ Kim, M.H.¹⁴ Laird, A.D.¹⁵ Lin, R.¹⁶ Mock, L.¹⁷ Ngan, I.¹⁸ Pack, M.¹⁹ Stott, G.²⁰ more..

9
- 79955556964
- Y. Xiang, B. Hirth, G. Asmussen, H.-P. Biemann, K.A. Bishop, A. Good, M. Fitzgerald, T. Gladysheva, A. Jain, K. Jancsics, J. Liu, M. Metz, A. Papoulis, R. Skerlj, J.D. Stepp, and R.R. Wei Bioorg. Med. Chem. Lett. 21 2011 3050
- (2011) Bioorg. Med. Chem. Lett. , vol.21 , pp. 3050
- Xiang, Y.¹ Hirth, B.² Asmussen, G.³ Biemann, H.-P.⁴ Bishop, K.A.⁵ Good, A.⁶ Fitzgerald, M.⁷ Gladysheva, T.⁸ Jain, A.⁹ Jancsics, K.¹⁰ Liu, J.¹¹ Metz, M.¹² Papoulis, A.¹³ Skerlj, R.¹⁴ Stepp, J.D.¹⁵ Wei, R.R.¹⁶

10
- 84863447425
- L.A. Dakin, M.H. Block, H. Chen, E. Code, J.E. Dowling, X. Feng, A.D. Ferguson, I. Green, A.W. Hird, T. Howard, E.K. Keeton, M.L. Lamb, P.D. Lyne, H. Pollard, J. Read, A.J. Wu, T. Zhang, and X. Zheng Bioorg. Med. Chem. Lett. 22 2012 4599
- (2012) Bioorg. Med. Chem. Lett. , vol.22 , pp. 4599
- Dakin, L.A.¹ Block, M.H.² Chen, H.³ Code, E.⁴ Dowling, J.E.⁵ Feng, X.⁶ Ferguson, A.D.⁷ Green, I.⁸ Hird, A.W.⁹ Howard, T.¹⁰ Keeton, E.K.¹¹ Lamb, M.L.¹² Lyne, P.D.¹³ Pollard, H.¹⁴ Read, J.¹⁵ Wu, A.J.¹⁶ Zhang, T.¹⁷ Zheng, X.¹⁸

11
- 84890522007
- M.T. Burger, W. Han, J. Lan, G. Naguchi, C. Bellamacina, M. Lindval, G. Atallah, Y. Ding, M. Mathur, C. McBride, E.L. Beans, K. Muller, V. Tamez, Y. Zhang, K. Huh, P. Feucht, T. Zavorotinskaya, Y. Dai, J. Holash, J. Castillo, J. Langowski, Y. Wang, M.Y. Chen, and P. Garcia ACS Med. Chem. 4 2013 1193
- (2013) ACS Med. Chem. , vol.4 , pp. 1193
- Burger, M.T.¹ Han, W.² Lan, J.³ Naguchi, G.⁴ Bellamacina, C.⁵ Lindval, M.⁶ Atallah, G.⁷ Ding, Y.⁸ Mathur, M.⁹ McBride, C.¹⁰ Beans, E.L.¹¹ Muller, K.¹² Tamez, V.¹³ Zhang, Y.¹⁴ Huh, K.¹⁵ Feucht, P.¹⁶ Zavorotinskaya, T.¹⁷ Dai, Y.¹⁸ Holash, J.¹⁹ Castillo, J.²⁰ more..

12
- 84886953247
- F. Casuscelli, E. Ardini, N. Avanzi, E. Casale, G. Cervi, M. D'Anello, D. Donati, D. Faiardi, R.D. Ferguson, G. Fogliatto, A. Galvani, A. Marsiglio, D.G. Mirizzi, M. Montemartini, C. Orrenius, G. Papeo, C. Piutti, B. Salom, and E.R. Felder Bioorg. Med. Chem. Lett. 21 2013 7364
- (2013) Bioorg. Med. Chem. Lett. , vol.21 , pp. 7364
- Casuscelli, F.¹ Ardini, E.² Avanzi, N.³ Casale, E.⁴ Cervi, G.⁵ D'Anello, M.⁶ Donati, D.⁷ Faiardi, D.⁸ Ferguson, R.D.⁹ Fogliatto, G.¹⁰ Galvani, A.¹¹ Marsiglio, A.¹² Mirizzi, D.G.¹³ Montemartini, M.¹⁴ Orrenius, C.¹⁵ Papeo, G.¹⁶ Piutti, C.¹⁷ Salom, B.¹⁸ Felder, E.R.¹⁹

13
- 84885957223
- M.P. Dwyer, K. Keertikar, K. Paruch, C. Alvarez, M. Labroli, C. Poker, T.O. Fischmann, R. Mayer-Ezell, R. Bond, Y. Wang, R. Azevedo, and T.J. Guzi Bioorg. Med. Chem. Lett. 23 2013 6178
- (2013) Bioorg. Med. Chem. Lett. , vol.23 , pp. 6178
- Dwyer, M.P.¹ Keertikar, K.² Paruch, K.³ Alvarez, C.⁴ Labroli, M.⁵ Poker, C.⁶ Fischmann, T.O.⁷ Mayer-Ezell, R.⁸ Bond, R.⁹ Wang, Y.¹⁰ Azevedo, R.¹¹ Guzi, T.J.¹²

14
- 84964293366
- R.P. Wurz, L.H. Pettus, C. Jackson, B. Wu, H. Wang, B. Herberich, V. Cee, B.A. Lanman, A.B. Reed, F. Chavez Jr., T. Nixey, J. Laszlo III, P. Wang, Y. Nguyen, C. Sastri, N. Guerrero, J. Winston, J.R. Lipford, M.R. Lee, K.L. Andrews, C. Mohr, Y. Xu, Y. Zhou, D.L. Reid, and A.S. Tasker Bioorg. Med. Chem. Lett. 25 2015 847
- (2015) Bioorg. Med. Chem. Lett. , vol.25 , pp. 847
- Wurz, R.P.¹ Pettus, L.H.² Jackson, C.³ Wu, B.⁴ Wang, H.⁵ Herberich, B.⁶ Cee, V.⁷ Lanman, B.A.⁸ Reed, A.B.⁹ Chavez, F.¹⁰ Nixey, T.¹¹ Laszlo, J.¹² Wang, P.¹³ Nguyen, Y.¹⁴ Sastri, C.¹⁵ Guerrero, N.¹⁶ Winston, J.¹⁷ Lipford, J.R.¹⁸ Lee, M.R.¹⁹ Andrews, K.L.²⁰ more..

15
- 84920849898
- A. Ishchenko, L. Zhang, J. Le Brazidec, J. Fan, J.H. Chong, A. Hingway, A. Raditsis, L. Singh, B. Elenbaas, V.S. Hong, D. Marcotte, L. Silvian, I. Enyedy, and J. Chao Bioorg. Med. Chem. Lett. 25 2015 474
- (2015) Bioorg. Med. Chem. Lett. , vol.25 , pp. 474
- Ishchenko, A.¹ Zhang, L.² Le Brazidec, J.³ Fan, J.⁴ Chong, J.H.⁵ Hingway, A.⁶ Raditsis, A.⁷ Singh, L.⁸ Elenbaas, B.⁹ Hong, V.S.¹⁰ Marcotte, D.¹¹ Silvian, L.¹² Enyedy, I.¹³ Chao, J.¹⁴

16
- 84964203035
- H. Wang, V.J. Cee, F. Chavez, B.A. Lanman, A.B. Reed, B. Wu, N. Guerrero, J.R. Lipford, C. Sastri, J. Winston, K.L. Andrews, Xin Huang, R. Matthew, C. Mohr, Y. Xu, Y. Zhou, and A.S. Tasker Bioorg. Med. Chem. Lett. 25 2015 834
- (2015) Bioorg. Med. Chem. Lett. , vol.25 , pp. 834
- Wang, H.¹ Cee, V.J.² Chavez, F.³ Lanman, B.A.⁴ Reed, A.B.⁵ Wu, B.⁶ Guerrero, N.⁷ Lipford, J.R.⁸ Sastri, C.⁹ Winston, J.¹⁰ Andrews, K.L.¹¹ Huang, X.¹² Matthew, R.¹³ Mohr, C.¹⁴ Xu, Y.¹⁵ Zhou, Y.¹⁶ Tasker, A.S.¹⁷

17
- 84964219506
- B. Wu, H. Wang, V.J. Cee, B.A. Lanman, T. Nixey, L. Pettus, A.B. Reed, R.P. Wurz, N. Guerrero, C. Sastri, J. Winston, J.R. Lipford, M.R. Lee, C. Mohr, K.L. Andrews, and A.S. Tasker Bioorg. Med. Chem. Lett. 25 2015 775
- (2015) Bioorg. Med. Chem. Lett. , vol.25 , pp. 775
- Wu, B.¹ Wang, H.² Cee, V.J.³ Lanman, B.A.⁴ Nixey, T.⁵ Pettus, L.⁶ Reed, A.B.⁷ Wurz, R.P.⁸ Guerrero, N.⁹ Sastri, C.¹⁰ Winston, J.¹¹ Lipford, J.R.¹² Lee, M.R.¹³ Mohr, C.¹⁴ Andrews, K.L.¹⁵ Tasker, A.S.¹⁶

18
- 84856261206
- V. Munugalavadla, L. Berry, Y.-H. Chen, G. Deshmukh, J. Drummond, C. Du, M. Eby, K. Fitzgerald, L.S. Friedman, S.E. Gould, J.R. Kenny, H. Maecker, J. Moffat, M. Moskalenko, P. Pacheco, A. Saadat, D. Slaga, L. Sun, X. Wang, Y. Yang, and A.J. Ebens Blood 116 2010 4084
- (2010) Blood , vol.116 , pp. 4084
- Munugalavadla, V.¹ Berry, L.² Chen, Y.-H.³ Deshmukh, G.⁴ Drummond, J.⁵ Du, C.⁶ Eby, M.⁷ Fitzgerald, K.⁸ Friedman, L.S.⁹ Gould, S.E.¹⁰ Kenny, J.R.¹¹ Maecker, H.¹² Moffat, J.¹³ Moskalenko, M.¹⁴ Pacheco, P.¹⁵ Saadat, A.¹⁶ Slaga, D.¹⁷ Sun, L.¹⁸ Wang, X.¹⁹ Yang, Y.²⁰ Ebens, A.J.²¹ more..

19
- 84856249538
- A.J. Ebens, L. Berry, Y.-H. Chen, G. Deshmukh, J. Drummond, C. Du, M. Eby, K. Fitzgerald, L.S. Friedman, S.E. Gould, J.R. Kenny, H. Maecker, J. Moffat, M. Moskalenko, P. Pacheco, A. Saadat, D. Slaga, L. Sun, X. Wang, Y. Yang, and V. Munugalavadla Blood 116 2010 3001
- (2010) Blood , vol.116 , pp. 3001
- Ebens, A.J.¹ Berry, L.² Chen, Y.-H.³ Deshmukh, G.⁴ Drummond, J.⁵ Du, C.⁶ Eby, M.⁷ Fitzgerald, K.⁸ Friedman, L.S.⁹ Gould, S.E.¹⁰ Kenny, J.R.¹¹ Maecker, H.¹² Moffat, J.¹³ Moskalenko, M.¹⁴ Pacheco, P.¹⁵ Saadat, A.¹⁶ Slaga, D.¹⁷ Sun, L.¹⁸ Wang, X.¹⁹ Yang, Y.²⁰ Munugalavadla, V.²¹ more..

20
- 84867390193
- D. Drygin, M. Haddach, F. Pierre, and D.M. Ryckman J. Med. Chem. 55 2012 8199
- (2012) J. Med. Chem. , vol.55 , pp. 8199
- Drygin, D.¹ Haddach, M.² Pierre, F.³ Ryckman, D.M.⁴

21
- 78650647009
- F.S. Anizon, A.A. Shtil, V.N. Danilenko, and P. Moreau Curr. Med. Chem. 17 2010 4114
- (2010) Curr. Med. Chem. , vol.17 , pp. 4114
- Anizon, F.S.¹ Shtil, A.A.² Danilenko, V.N.³ Moreau, P.⁴

22
- 76149130727
- T. Morwick Expert Opin. Ther. Pat. 20 2010 193
- (2010) Expert Opin. Ther. Pat. , vol.20 , pp. 193
- Morwick, T.¹

23
- 84945916143
- P.D. Garcia, J.L. Langowski, Y. Wang, M. Chen, J. Castillo, C. Fanton, M. Ison, T. Zavorotinskaya, Y. Dai, J. Lu, X.-H. Niu, S. Basham, J. Chan, J. Yu, M. Doyle, P. Feucht, R. Warne, J. Narberes, T. Tsang, C. Fritsch, A. Kauffmann, E. Pfister, P. Drueckes, J. Trappe, C. Wilson, W. Han, J. Lan, G. Nishiguchi, M. Lindvall, C. Bellamacina, J. Alex Aycinena, R. Zang, J. Holash, and Matthew T. Burger Clin. Cancer Res. 2014 1834 20
- (1834) Clin. Cancer Res. , vol.2014 , pp. 20
- Garcia, P.D.¹ Langowski, J.L.² Wang, Y.³ Chen, M.⁴ Castillo, J.⁵ Fanton, C.⁶ Ison, M.⁷ Zavorotinskaya, T.⁸ Dai, Y.⁹ Lu, J.¹⁰ Niu, X.-H.¹¹ Basham, S.¹² Chan, J.¹³ Yu, J.¹⁴ Doyle, M.¹⁵ Feucht, P.¹⁶ Warne, R.¹⁷ Narberes, J.¹⁸ Tsang, T.¹⁹ Fritsch, C.²⁰ more..

24
- 84877582049
- X. Wang, S. Magnuson, R. Pastor, E. Fan, H. Hu, V. Tsui, W. Deng, J. Murray, M. Steffek, H. Wallweber, J. Moffat, J. Drummond, G. Chan, E. Harstad, and A.J. Ebens Bioorg. Med. Chem. Lett. 23 2013 3149
- (2013) Bioorg. Med. Chem. Lett. , vol.23 , pp. 3149
- Wang, X.¹ Magnuson, S.² Pastor, R.³ Fan, E.⁴ Hu, H.⁵ Tsui, V.⁶ Deng, W.⁷ Murray, J.⁸ Steffek, M.⁹ Wallweber, H.¹⁰ Moffat, J.¹¹ Drummond, J.¹² Chan, G.¹³ Harstad, E.¹⁴ Ebens, A.J.¹⁵

25
- 33748102816
- K.W. Woods, J.P. Fischer, A. Claiborne, T. Li, S.A. Thomas, G.-D. Zhu, R.B. Diebold, X. Liu, Y. Shi, V. Klinghofer, E.K. Han, R. Guan, S.R. Magnone, E.F. Johnson, J.J. Bouska, A.M. Olson, R. de Jong, T. Oltersdorf, Y. Luo, S.H. Rosenberg, V.L. Giranda, and Q. Li Bioorg. Med. Chem. 14 2006 6832
- (2006) Bioorg. Med. Chem. , vol.14 , pp. 6832
- Woods, K.W.¹ Fischer, J.P.² Claiborne, A.³ Li, T.⁴ Thomas, S.A.⁵ Zhu, G.-D.⁶ Diebold, R.B.⁷ Liu, X.⁸ Shi, Y.⁹ Klinghofer, V.¹⁰ Han, E.K.¹¹ Guan, R.¹² Magnone, S.R.¹³ Johnson, E.F.¹⁴ Bouska, J.J.¹⁵ Olson, A.M.¹⁶ De Jong, R.¹⁷ Oltersdorf, T.¹⁸ Luo, Y.¹⁹ Rosenberg, S.H.²⁰ Giranda, V.L.²¹ Li, Q.²² more..

26
- 20344384859
- Y. Luo, A.R. Shoemaker, X. Liu, K.W. Woods, S.A. Thomas, R. de Jong, E.K. Han, T. Li, V.S. Stoll, J.A. Powlas, A. Oleksijew, M.J. Mitten, Y. Shi, R. Guan, T.P. McGonigal, V. Klinghofer, E.F. Johnson, J.D. Leverson, J.J. Bouska, M. Mamo, R.A. Smith, E.E. Gramling-Evans, B.A. Zinker, A.K. Mika, P.T. Nguyen, T. Oltersdorf, S.H. Rosenberg, Q. Li, and V.L. Giranda Mol. Cancer Ther. 4 2005 977
- (2005) Mol. Cancer Ther. , vol.4 , pp. 977
- Luo, Y.¹ Shoemaker, A.R.² Liu, X.³ Woods, K.W.⁴ Thomas, S.A.⁵ De Jong, R.⁶ Han, E.K.⁷ Li, T.⁸ Stoll, V.S.⁹ Powlas, J.A.¹⁰ Oleksijew, A.¹¹ Mitten, M.J.¹² Shi, Y.¹³ Guan, R.¹⁴ McGonigal, T.P.¹⁵ Klinghofer, V.¹⁶ Johnson, E.F.¹⁷ Leverson, J.D.¹⁸ Bouska, J.J.¹⁹ Mamo, M.²⁰ more..

27
- 1942453243
- i in molar)/(no. of heavy atoms). A.L. Hopkins, C.R. Groom, and A. Alex Drug Discovery Today 9 2004 430
- (2004) Drug Discovery Today , vol.9 , pp. 430
- Hopkins, A.L.¹ Groom, C.R.² Alex, A.³

28
- 35748934487
- P.D. Leeson, and B. Springthorpe Nat. Rev. Drug Disc. 6 2007 881
- (2007) Nat. Rev. Drug Disc. , vol.6 , pp. 881
- Leeson, P.D.¹ Springthorpe, B.²

29
- 84885172160
- M.D. Shultz Bioorg. Med. Chem. Lett. 23 2013 5980
- (2013) Bioorg. Med. Chem. Lett. , vol.23 , pp. 5980
- Shultz, M.D.¹

30
- 84945920844
- Synthesis of selected compounds 11, 12, and 14 is shown in Scheme 1S in Supplemental material
- Synthesis of selected compounds 11, 12, and 14 is shown in Scheme 1S in Supplemental material.

31
- 84945938155
- Synthesis of 39 is shown in Scheme 2S in Supplemental material
- Synthesis of 39 is shown in Scheme 2S in Supplemental material.

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.