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Bioorganic and Medicinal Chemistry Letters

Volumn 25, Issue 3, 2015, Pages 474-480

Structure-based design of low-nanomolar PIM kinase inhibitors

(14) Ishchenko, Alexey a Zhang, Lin a Le Brazidec, Jean Yves a Fan, Junhua a Chong, Jer Hong a Hingway, Aparna a Raditsis, Annie a Singh, Latika a Elenbaas, Brian a,b Hong, Victor Sukbong a,c Marcotte, Doug a Silvian, Laura a Enyedy, Istvan a Chao, Jianhua a

a BIOGEN (United States)

b EMD Serono Research Institute (United States)

c Keimyung University (South Korea)

Author keywords

De novo design; Kinase inhibitors; PIM; PIM inhibitors; Rational design

Indexed keywords

ANTINEOPLASTIC AGENT; PROTEIN KINASE; PROTEIN KINASE INHIBITOR; PROTEIN KINASE PIM 1; PROTEIN KINASE PIM 2; PROTEIN KINASE PIM INHIBITOR; UNCLASSIFIED DRUG; ISOPROTEIN; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS PIM;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CRYSTAL STRUCTURE; HUMAN; HYDROGEN BOND; PHARMACOPHORE; STRUCTURE ACTIVITY RELATION; ANTAGONISTS AND INHIBITORS; BINDING SITE; CHEMISTRY; DRUG DESIGN; METABOLISM; MOLECULAR DYNAMICS; PROTEIN TERTIARY STRUCTURE; STATIC ELECTRICITY; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; HYDROGEN BONDING; MOLECULAR DYNAMICS SIMULATION; PROTEIN BINDING; PROTEIN ISOFORMS; PROTEIN KINASE INHIBITORS; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-PIM-1; STATIC ELECTRICITY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84920849898 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2014.12.041 Document Type: Article

Times cited : (22)

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