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Bioorganic and Medicinal Chemistry Letters

Volumn 25, Issue 4, 2015, Pages 834-840

The discovery of novel 3-(pyrazin-2-yl)-1H-indazoles as potent pan-Pim kinase inhibitors

(17) Wang, Hui Ling a Cee, Victor J a Chavez, Frank a Lanman, Brian A a Reed, Anthony B a Wu, Bin a Guerrero, Nadia a Lipford, J Russell a Sastri, Christine a Winston, Jeff a Andrews, Kristin L a Huang, Xin a Lee, Matthew R a Mohr, Christopher a Xu, Yang a Zhou, Yihong a Tasker, Andrew S a

a AMGEN INC (United States)

Author keywords

Hematologic malignancy; KMS 12; Multiple myeloma; Pim kinase inhibitor; Pim kinase pan

Indexed keywords

3 (PYRAZIN 2 YL) 1H INDAZOLE; PROTEIN SERINE THREONINE KINASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; DRUG CLEARANCE; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SYNTHESIS; ELIMINATION HALF-LIFE; ENZYME ACTIVITY; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IC50; LIVER MICROSOME; MALE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

EID: 84964203035 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2014.12.068 Document Type: Article

Times cited : (33)

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